Annotations for selected genes

Probe Symbol Description Chromosome Chromosome Location GenBank Gene PubMed Gene Ontology Pathway
1436530_at Wfdc17 WAP four-disulfide core domain 17 11 83704055 AA666504 7

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

extracellular space

antibacterial humoral response

innate immune response

 
1457728_at Niban3 niban apoptosis regulator 3 8 71597707 BB763642 11

molecular_function

cellular_component

biological_process

 
1446929_at D130062J21Rik RIKEN cDNA D130062J21 gene 4   BB459664 9

molecular_function

cellular_component

biological_process

 
1426113_x_at Trav9d-3 T cell receptor alpha variable 9D-3 14   U07662 10

molecular_function

cellular_component

biological_process

 
1436040_at Snhg12 small nucleolar RNA host gene 12 4 132308677 BI180630 26

molecular_function

cellular_component

biological_process

 
1456765_at Nhsl2 NHS like 2 X 101849384 AV339861 12

molecular_function

cellular_component

cell differentiation

 
1428562_at Mir22hg Mir22 host gene (non-protein coding) 11 75461538 AK008813 16

response to wounding

 
1440451_at Ankrd66 ankyrin repeat domain 66 17 -43534173 BG085035 10

molecular_function

cellular_component

biological_process

 
1426168_a_at Trac T cell receptor alpha constant 14   U95921 53

plasma membrane

response to bacterium

signaling receptor activity

alpha-beta T cell receptor complex

 
1426716_at Tdrd7 tudor domain containing 7 4 45965334, 45972296, 45972830 BC025099 30

lens morphogenesis in camera-type eye

lens morphogenesis in camera-type eye

lens morphogenesis in camera-type eye

RNA binding

mRNA binding

protein binding

cytoplasm

multicellular organism development

germ cell development

spermatogenesis

spermatogenesis

post-transcriptional regulation of gene expression

cell differentiation

P granule organization

chromatoid body

piRNA processing

ribonucleoprotein granule

P granule

P granule

lens fiber cell differentiation

lens fiber cell differentiation

lens fiber cell differentiation

ribonucleoprotein complex

 
1427765_a_at Trbv14 T cell receptor beta, variable 14 6   M31648 14

plasma membrane

cell surface receptor signaling pathway

 
1427752_a_at Trbv29 T cell receptor beta, variable 29 6   U63547 14

plasma membrane

cell surface receptor signaling pathway

peptide antigen binding

 
1433735_a_at Tmem64 transmembrane protein 64 4 15265819 BG075363 22

protein binding

endoplasmic reticulum

endoplasmic reticulum

membrane

osteoclast differentiation

regulation of ATP-dependent activity

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

positive regulation of osteoclast differentiation

positive regulation of osteoclast differentiation

positive regulation of bone resorption

positive regulation of bone resorption

regulation of cytosolic calcium ion concentration

regulation of cytosolic calcium ion concentration

negative regulation of canonical Wnt signaling pathway

 
1417300_at Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B 4 -132732965 NM_133888 28

immune system process

sphingomyelin phosphodiesterase activity

protein binding

extracellular region

extracellular space

extracellular space

plasma membrane

lipid metabolic process

sphingomyelin catabolic process

inflammatory response

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

metabolic process

zinc ion binding

membrane

lipid catabolic process

hydrolase activity

hydrolase activity, acting on glycosyl bonds

negative regulation of toll-like receptor signaling pathway

innate immune response

negative regulation of innate immune response

membrane lipid catabolic process

metal ion binding

negative regulation of inflammatory response

side of membrane

 
1456393_at Bbip1 BBSome interacting protein 1 19 -53929658 AI642124 20

molecular_function

cytoplasm

BBSome

BBSome

eating behavior

ciliary membrane

cilium assembly

cilium assembly

receptor localization to non-motile cilium

receptor localization to non-motile cilium

 
1440967_at Gm15708 predicted gene 15708 5 144277060 AI666381 8

molecular_function

cellular_component

biological_process

 
1422892_s_at H2-Ea histocompatibility 2, class II antigen E alpha 17 -34341951 U13648 69

immunological synapse

positive regulation of T cell mediated cytotoxicity

myeloid dendritic cell antigen processing and presentation

antigen processing and presentation of endogenous peptide antigen via MHC class II

peptide antigen assembly with MHC class II protein complex

peptide antigen assembly with MHC class II protein complex

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

lysosome

lysosomal membrane

lysosomal membrane

plasma membrane

external side of plasma membrane

cell surface

immunoglobulin mediated immune response

immunoglobulin mediated immune response

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

polysaccharide binding

late endosome membrane

late endosome membrane

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

peptide antigen binding

peptide antigen binding

T cell receptor binding

MHC class II protein complex

MHC class II protein complex

positive regulation of memory T cell differentiation

regulation of T-helper cell differentiation

positive regulation of immune response

positive regulation of immune response

positive regulation of immune response

positive regulation of T cell activation

cognition

positive regulation of CD4-positive, alpha-beta T cell activation

 
1420342_at Gdap10 ganglioside-induced differentiation-associated-protein 10 12 32824115 NM_010268 5

molecular_function

cellular_component

response to bacterium

 
1430622_at 4833423F13Rik RIKEN cDNA 4833423F13 gene 16   AW764291 7

molecular_function

cellular_component

biological_process

 
1438676_at Gbp6 guanylate binding protein 6 5 -105270701 BM241485 17

nucleotide binding

immune system process

GTPase activity

GTPase activity

GTP binding

GTP binding

response to bacterium

hydrolase activity

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

innate immune response

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cellular response to lipopolysaccharide

cellular response to type II interferon

cellular response to type II interferon

 
1416414_at Emilin1 elastin microfibril interfacer 1 5 30913785 NM_133918 61

aortic valve morphogenesis

protein binding

extracellular region

extracellular region

collagen trimer

extracellular space

extracellular space

cell adhesion

cell-matrix adhesion

regulation of blood pressure

positive regulation of gene expression

negative regulation of gene expression

positive regulation of cell-substrate adhesion

cell migration

negative regulation of angiogenesis

extracellular matrix constituent conferring elasticity

extracellular matrix constituent conferring elasticity

extracellular matrix constituent conferring elasticity

extracellular matrix organization

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of vascular endothelial growth factor receptor signaling pathway

extracellular matrix

negative regulation of collagen biosynthetic process

cell adhesion mediated by integrin

integrin alpha4-beta1 complex

regulation of cell population proliferation

identical protein binding

identical protein binding

positive regulation of angiogenesis

elastic fiber assembly

negative regulation of cell activation

molecular adaptor activity

negative regulation of SMAD protein signal transduction

collagen-containing extracellular matrix

collagen-containing extracellular matrix

collagen-containing extracellular matrix

negative regulation of ERK1 and ERK2 cascade

integrin binding involved in cell-matrix adhesion

positive regulation of defense response to bacterium

negative regulation of vascular endothelial growth factor signaling pathway

positive regulation of extracellular matrix assembly

negative regulation of collagen fibril organization

negative regulation of macrophage migration

EMILIN complex

 
1418201_at Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 7 -28359603 NM_138752 19

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

regulation of actin filament polymerization

regulation of actin filament polymerization

small GTPase binding

 
1434333_a_at Prkd2 protein kinase D2 7 16843064, 16842901 AW557946 44

nucleotide binding

angiogenesis

positive regulation of endothelial cell proliferation

adaptive immune response

immune system process

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

diacylglycerol-dependent serine/threonine kinase activity

protein kinase C binding

ATP binding

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

cytosol

plasma membrane

protein phosphorylation

cell adhesion

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of endothelial cell migration

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

positive regulation of vascular endothelial growth factor receptor signaling pathway

positive regulation of interleukin-2 production

positive regulation of interleukin-8 production

intracellular signal transduction

intracellular signal transduction

cellular response to vascular endothelial growth factor stimulus

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

positive regulation of blood vessel endothelial cell migration

positive regulation of fibroblast growth factor receptor signaling pathway

positive regulation of angiogenesis

positive regulation of cell adhesion

positive regulation of transcription by RNA polymerase II

protein autophosphorylation

metal ion binding

vascular endothelial growth factor receptor signaling pathway

T cell receptor signaling pathway

positive regulation of T cell receptor signaling pathway

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

regulation of T cell apoptotic process

positive regulation of ERK1 and ERK2 cascade

protein serine kinase activity

positive regulation of intracellular signal transduction

positive regulation of DNA biosynthetic process

positive regulation of endothelial cell chemotaxis

 
1423975_s_at Numa1 nuclear mitotic apparatus protein 1 7 101969842 BC006631 63

establishment of mitotic spindle orientation

establishment of mitotic spindle orientation

establishment of mitotic spindle orientation

spindle pole

spindle pole

microtubule bundle formation

protein binding

nucleus

nucleoplasm

chromosome

cytoplasm

centrosome

centrosome

cytosol

cytoskeleton

microtubule

spindle microtubule

spindle microtubule

plasma membrane

cell cortex

cell cycle

chromosome segregation

microtubule binding

microtubule binding

lipid binding

tubulin binding

membrane

nuclear matrix

nuclear matrix

protein domain specific binding

dendrite

positive regulation of BMP signaling pathway

astral microtubule organization

positive regulation of microtubule polymerization

spindle pole centrosome

positive regulation of intracellular transport

protein-containing complex

phosphatidylinositol binding

microtubule plus-end

microtubule minus-end

neuronal cell body

protein-containing complex binding

apical part of cell

positive regulation of keratinocyte differentiation

microtubule plus-end binding

microtubule minus-end binding

cell division

positive regulation of hair follicle development

positive regulation of chromosome segregation

cortical microtubule

anastral spindle assembly

regulation of mitotic spindle organization

lung epithelial cell differentiation

mitotic spindle astral microtubule

dynein complex binding

mitotic spindle

regulation of metaphase plate congression

microtubule bundle

mitotic spindle pole

mitotic spindle pole

lateral cell cortex

disordered domain specific binding

cell cortex region

cell cortex region

positive regulation of protein localization to spindle pole body

positive regulation of mitotic spindle elongation

positive regulation of protein localization to cell cortex

cytoplasmic microtubule bundle

positive regulation of chromosome separation

positive regulation of spindle assembly

mitotic spindle midzone

 
1460403_at Psip1 PC4 and SFRS1 interacting protein 1 4 -83461878, -83455680 BF117241 44

mRNA 5'-splice site recognition

euchromatin

heterochromatin

DNA binding

chromatin binding

transcription coactivator activity

nucleus

nucleus

nucleoplasm

chromatin remodeling

response to oxidative stress

response to heat

nuclear periphery

positive regulation of transcription by RNA polymerase II

supercoiled DNA binding

DNA-binding transcription factor binding

 
1423806_at Ints4 integrator complex subunit 4 7 97480955 BC013813 24

molecular_function

nucleus

nucleolus

snRNA processing

snRNA processing

integrator complex

integrator complex

 
1430075_at Sf3b3 splicing factor 3b, subunit 3 8 -110810491 AK017529 38

SAGA complex

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

protein binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

U2-type spliceosomal complex

U2 snRNP

U12-type spliceosomal complex

nucleolus

regulation of DNA repair

mRNA processing

RNA splicing

U2 snRNA binding

negative regulation of protein catabolic process

regulation of RNA splicing

protein-containing complex binding

positive regulation of DNA-templated transcription

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

03040

1418553_at Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 8 3393007, 3353436 NM_133962 35

guanyl-nucleotide exchange factor activity

cytoplasm

cytosol

cytoskeleton

plasma membrane

plasma membrane

small GTPase-mediated signal transduction

regulation of cell shape

membrane

actin cytoskeleton organization

regulation of Rho protein signal transduction

apical part of cell

metal ion binding

negative regulation of stress fiber assembly

protein localization to cell-cell junction

 
1436501_at Mtus1 mitochondrial tumor suppressor 1 8 -40990911, -40990911, -40990911, -40990911 BB747681 30

nucleus

nucleus

nucleolus

cytoplasm

mitochondrion

Golgi apparatus

plasma membrane

cell cycle

microtubule binding

regulation of macrophage chemotaxis

regulation of macrophage chemotaxis

microtubule cytoskeleton

membrane

 
1416065_a_at Ankrd10 ankyrin repeat domain 10 8 -11613840, -11611580, -11613840 NM_133971 20

molecular_function

nucleoplasm

 
1416210_at Imp3 IMP3, U3 small nucleolar ribonucleoprotein 9 56937499 NM_133976 21

RNA binding

structural constituent of ribosome

nucleus

nucleoplasm

nucleolus

rRNA processing

rRNA processing

small ribosomal subunit

rRNA binding

snoRNA binding

preribosome

small-subunit processome

small-subunit processome

Mpp10 complex

Mpp10 complex

ribosome biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

ribonucleoprotein complex

03008

1458206_at Gm30054 predicted gene, 30054 14   BB201845      
1441589_at Gm38448 predicted gene, 38448 11   BB634277 7    
1430479_at Gm32819 predicted gene, 32819 9   AK008147 8    
1451190_a_at Sbk1 SH3-binding kinase 1 7 126272495, 126248396 BC025837 25

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

cellular_component

cytoplasm

protein phosphorylation

kinase activity

phosphorylation

transferase activity

 
1428750_at Cdc42ep2 CDC42 effector protein 2 19 -5917555 BF453885 20

opioid peptide activity

GTPase activator activity

cytoplasm

cytoplasm

cytosol

cytoskeleton

cytoskeleton

plasma membrane

plasma membrane

Rho protein signal transduction

regulation of cell shape

regulation of cell shape

microtubule cytoskeleton

membrane

actin cytoskeleton organization

positive regulation of actin filament polymerization

positive regulation of actin filament polymerization

small GTPase binding

small GTPase binding

positive regulation of pseudopodium assembly

positive regulation of pseudopodium assembly

phagocytic vesicle

cellular response to type II interferon

 
1455643_s_at Tsr1 TSR1 20S rRNA accumulation 11 74898079 BF228294 25

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

GTPase activity

GTP binding

nucleus

preribosome, small subunit precursor

U3 snoRNA binding

ribosome biogenesis

 
1437956_at Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 11 68503018 AV281292 31

angiogenesis

protein binding

cytoplasm

plasma membrane

phosphatidylinositol 3-kinase complex

phosphatidylinositol 3-kinase complex, class IA

phosphatidylinositol 3-kinase complex, class IB

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

membrane

regulation of natural killer cell mediated cytotoxicity

positive regulation of MAP kinase activity

positive regulation of MAP kinase activity

positive regulation of T cell differentiation

positive regulation of angiogenesis

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity

1-phosphatidylinositol-3-kinase regulator activity

1-phosphatidylinositol-3-kinase regulator activity

 
1448104_at Aldh6a1 aldehyde dehydrogenase family 6, subfamily A1 12 -84430720, -84430720 NM_134042 26

methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

nucleoplasm

mitochondrion

mitochondrion

mitochondrion

thymine catabolic process

thymine catabolic process

valine metabolic process

valine catabolic process

valine catabolic process

oxidoreductase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

thiolester hydrolase activity

beta-alanine catabolic process

thymine metabolic process

brown fat cell differentiation

00280

00562

00640

01100

1453864_at Rdh14 retinol dehydrogenase 14 (all-trans and 9-cis) 12 10390779 AK014097 21

nucleoplasm

mitochondrion

endoplasmic reticulum

cytosol

lipid metabolic process

alcohol dehydrogenase (NADP+) activity

oxidoreductase activity

retinol metabolic process

NADP-retinol dehydrogenase activity

NADP-retinol dehydrogenase activity

 
1418772_at Tasor2 transcription activation suppressor family member 2 13 -3566034 NM_134063 19

molecular_function

nucleoplasm

nucleoplasm

cytosol

biological_process

negative regulation of gene expression, epigenetic

 
1423746_at Txndc5 thioredoxin domain containing 5 13 -38500270, -38500270, -38500270 BC016252 52

protein disulfide isomerase activity

protein disulfide isomerase activity

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum lumen

protein folding

protein-disulfide reductase activity

oxidoreductase activity

isomerase activity

04141

1424824_at Slain1 SLAIN motif family, member 1 14 103650227 BB704967 17

molecular_function

cytoplasm

cytoskeleton

microtubule nucleation

positive regulation of microtubule polymerization

cytoplasmic microtubule organization

microtubule plus-end

 
1426459_s_at Rimoc1 RAB7A interacting MON1-CCZ1 complex subunit 1 15 -3982034 BG073457 14

mitophagy

molecular_function

nucleoplasm

cytoplasm

cytosol

autophagy

 
1451199_at Qtrt2 queuine tRNA-ribosyltransferase accessory subunit 2 16 -43861412 BC017628 18

tRNA binding

protein binding

cytoplasm

mitochondrion

mitochondrial outer membrane

tRNA modification

tRNA processing

zinc ion binding

tRNA-guanosine(34) queuine transglycosylase activity

membrane

pentosyltransferase activity

protein-containing complex

protein-containing complex

protein homodimerization activity

metal ion binding

protein heterodimerization activity

tRNA-guanine transglycosylation

tRNA-guanine transglycosylation

tRNA-guanine transglycosylation

transferase complex

 
1448722_s_at Ppcs phosphopantothenoylcysteine synthetase 4 -119418526 NM_026494 19

nucleotide binding

heart process

phosphopantothenate--cysteine ligase activity

phosphopantothenate--cysteine ligase activity

ATP binding

nucleus

cytoplasm

acetyl-CoA biosynthetic process

coenzyme A biosynthetic process

coenzyme A biosynthetic process

ligase activity

identical protein binding

protein homodimerization activity

00770

01100

1416165_at Rab31 RAB31, member RAS oncogene family 17 -65651725 NM_133685 26

nucleotide binding

phagocytic cup

GTPase activity

GTPase activity

protein binding

GTP binding

cytoplasm

endosome

early endosome

late endosome

Golgi apparatus

trans-Golgi network

intracellular protein transport

endomembrane system

membrane

GDP binding

cytoplasmic vesicle

receptor internalization

trans-Golgi network membrane

trans-Golgi network membrane

cellular response to insulin stimulus

early phagosome membrane

Golgi to plasma membrane protein transport

Golgi to plasma membrane protein transport

regulated exocytosis

phagocytic vesicle

Golgi vesicle transport

positive regulation of phagocytosis, engulfment

phagosome maturation

04144

1417971_at Nrm nurim (nuclear envelope membrane protein) 17 35861317 NM_134122 20

molecular_function

nucleus

nuclear envelope

nuclear inner membrane

nuclear lamina

biological_process

membrane

nuclear membrane

nuclear membrane

 
1428736_at Gramd2b GRAM domain containing 2B 18 56432131, 56400339 AV259880 16

molecular_function

cytoplasmic microtubule

cytoplasmic microtubule

biological_process

identical protein binding

 
1427146_at Carns1 carnosine synthase 1 19 -4164323 BB356222 16

nucleotide binding

ATP binding

cellular_component

ligase activity

ATP hydrolysis activity

ATP hydrolysis activity

ATP hydrolysis activity

carnosine biosynthetic process

carnosine biosynthetic process

carnosine biosynthetic process

metal ion binding

carnosine synthase activity

carnosine synthase activity

carnosine synthase activity

homocarnosine synthase activity

homocarnosine synthase activity

homocarnosine synthase activity

 
1434372_at AW112010 expressed sequence AW112010 19 -11047611 BE688358 10

molecular_function

cellular_component

biological_process

 
1425927_a_at Atf5 activating transcription factor 5 7 -44812255, -44812255 AF375476 66

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

chromatin binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

centrosome

cytosol

cytoskeleton

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

circadian rhythm

negative regulation of cell population proliferation

post-embryonic development

regulation of gene expression

tubulin binding

kinase binding

olfactory bulb interneuron differentiation

olfactory bulb interneuron development

cerebellar granule cell precursor proliferation

olfactory lobe development

heat shock protein binding

multicellular organism growth

negative regulation of apoptotic process

negative regulation of apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

fat cell differentiation

fat cell differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

regulation of centrosome cycle

negative regulation of astrocyte differentiation

negative regulation of neurogenesis

RNA polymerase II transcription regulator complex

negative regulation of cell cycle G2/M phase transition

 
1424375_s_at Gimap4 GTPase, IMAP family member 4 6 48684577 BC005577 22

nucleotide binding

GTP binding

cytoplasm

cytosol

cytosol

intracellular membrane-bounded organelle

 
1452367_at Coro2a coronin, actin binding protein 2A 4 -46536936, -46536936 AI316747 22

actin binding

brush border

transcription repressor complex

actin filament binding

 
1432492_a_at Haao 3-hydroxyanthranilate 3,4-dioxygenase 17 -83831353 AK002295 24

3-hydroxyanthranilate 3,4-dioxygenase activity

3-hydroxyanthranilate 3,4-dioxygenase activity

3-hydroxyanthranilate 3,4-dioxygenase activity

iron ion binding

cytoplasm

cytoplasm

cytosol

ferrous iron binding

NAD biosynthetic process

response to zinc ion

oxidoreductase activity

pyridine nucleotide biosynthetic process

quinolinate biosynthetic process

oxygen binding

mitochondrial membrane

'de novo' NAD biosynthetic process from tryptophan

response to cadmium ion

metal ion binding

quinolinate metabolic process

quinolinate metabolic process

dioxygenase activity

neuron cellular homeostasis

00380

01100

1426775_s_at Scamp1 secretory carrier membrane protein 1 13 -94201309, -94201432 BM115445 26

protein binding

endosome

Golgi apparatus

trans-Golgi network

exocytosis

endocytosis

synaptic vesicle

protein transport

protein transport

membrane

protein domain specific binding

clathrin-coated vesicle

cytoplasmic vesicle membrane

synaptic vesicle membrane

synaptic vesicle membrane

trans-Golgi network membrane

zymogen granule membrane

synapse

establishment of localization in cell

recycling endosome membrane

recycling endosome membrane

 
1428669_at Bmyc brain expressed myelocytomatosis oncogene 2 25706878 AK012810 31

G1/S transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

MAPK cascade

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

core promoter sequence-specific DNA binding

transcription coregulator binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity

nucleus

nucleoplasm

nucleolus

spindle

chromatin remodeling

DNA methylation-dependent heterochromatin formation

regulation of DNA-templated transcription

intracellular iron ion homeostasis

DNA damage response

response to gamma radiation

regulation of cell cycle process

positive regulation of gene expression

regulation of telomere maintenance

protein-DNA complex disassembly

protein-containing complex

identical protein binding

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein-containing complex binding

negative regulation of monocyte differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of fibroblast proliferation

negative regulation of fibroblast proliferation

positive regulation of epithelial cell proliferation

chromosome organization

negative regulation of cell division

molecular adaptor activity

negative regulation of transcription initiation by RNA polymerase II

ERK1 and ERK2 cascade

E-box binding

cellular response to hypoxia

cellular response to xenobiotic stimulus

Myc-Max complex

RNA polymerase II transcription repressor complex

DNA-binding transcription factor binding

positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

positive regulation of miRNA transcription

SCF ubiquitin ligase complex binding

 
1425706_a_at Ddb2 damage specific DNA binding protein 2 2 -91211581, -91211580 AY027937 35

protein polyubiquitination

DNA binding

damaged DNA binding

damaged DNA binding

ubiquitin-protein transferase activity

nucleus

nucleus

nucleus

nucleoplasm

chromosome

DNA repair

DNA repair

nucleotide-excision repair

pyrimidine dimer repair

DNA damage response

DNA damage response

response to UV

response to UV

cell junction

Cul4A-RING E3 ubiquitin ligase complex

Cul4A-RING E3 ubiquitin ligase complex

Cul4B-RING E3 ubiquitin ligase complex

protein-containing complex

cellular response to UV

cellular response to UV

protein-containing complex binding

protein autoubiquitination

UV-damage excision repair

Cul4-RING E3 ubiquitin ligase complex

site of DNA damage

03420

04115

04120

1427860_at Igkv6-15 immunoglobulin kappa variable 6-15 6   U55641 4

immunoglobulin production

extracellular space

immune response

 
1451962_at Igkv6-20 immunoglobulin kappa variable 6-20 6   L41881 6

immunoglobulin production

extracellular space

immune response

 
1419645_at Cstf2 cleavage stimulation factor, 3' pre-RNA subunit 2 X 134059175, 134059175 BM120662 40

nucleic acid binding

RNA binding

mRNA binding

nucleus

nucleoplasm

mRNA cleavage and polyadenylation specificity factor complex

mRNA cleavage and polyadenylation specificity factor complex

mRNA processing

nuclear body

mRNA 3'-end processing

cleavage body

03015

1420994_at B3gnt5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 16 19760233 BM214359 23

Golgi membrane

Golgi apparatus

protein glycosylation

protein O-linked glycosylation

lipid metabolic process

multicellular organism development

central nervous system development

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity

membrane

transferase activity

glycosyltransferase activity

hexosyltransferase activity

sphingolipid biosynthetic process

lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity

00601

01100

1437506_at Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 13 104287834 AV286717 19

kidney development

cardiac septum development

metalloendopeptidase activity

proteolysis

heart development

extracellular matrix organization

extracellular matrix

aorta development

coronary vasculature development

 
1436780_at Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) X 101640217, 101640050 BG065325 161

negative regulation of transcription by RNA polymerase II

histone acetyltransferase complex

mitophagy

positive regulation of transcription from RNA polymerase II promoter by glucose

euchromatin

negative regulation of protein phosphorylation

positive regulation of protein phosphorylation

catalytic activity

protein binding

phosphatidylinositol-3,4,5-trisphosphate binding

intracellular anatomical structure

nucleus

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

plasma membrane

glucosamine metabolic process

regulation of glycolytic process

regulation of gluconeogenesis

chromatin organization

regulation of transcription by RNA polymerase II

protein O-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation

protein O-linked glycosylation

apoptotic process

N-acetyltransferase activity

lipid binding

positive regulation of gene expression

negative regulation of peptidyl-threonine phosphorylation

membrane

protein N-acetylglucosaminyltransferase activity

protein processing

transferase activity

glycosyltransferase activity

protein N-acetylglucosaminyltransferase complex

protein domain specific binding

hemopoiesis

negative regulation of cell migration

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of protein ubiquitination

negative regulation of protein ubiquitination

chromatin DNA binding

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

response to insulin

circadian regulation of gene expression

protein-containing complex

negative regulation of peptidyl-serine phosphorylation

regulation of Rac protein signal transduction

peptide binding

zymogen granule

identical protein binding

cell projection

neuronal cell body

NSL complex

protein-containing complex binding

synapse

synapse

positive regulation of translation

positive regulation of cell size

positive regulation of proteolysis

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

regulation of insulin receptor signaling pathway

positive regulation of lipid biosynthetic process

intracellular distribution of mitochondria

rhythmic process

regulation of synapse assembly

regulation of synapse assembly

regulation of synapse assembly

cellular response to lipopolysaccharide

cellular response to glucose stimulus

negative regulation of protein targeting to membrane

protein O-acetylglucosaminyltransferase activity

protein O-acetylglucosaminyltransferase activity

protein O-acetylglucosaminyltransferase activity

protein O-acetylglucosaminyltransferase activity

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

presynaptic cytosol

postsynaptic cytosol

positive regulation of cold-induced thermogenesis

cerebellar granule cell to Purkinje cell synapse

negative regulation of cellular response to hypoxia

positive regulation of protein localization to nucleus

negative regulation of stem cell population maintenance

positive regulation of stem cell population maintenance

positive regulation of reactive oxygen species biosynthetic process

positive regulation of TORC1 signaling

00514

1435222_at Foxp1 forkhead box P1 6 -98925341, -98925341, -98925341, -98925341 BM220880 301

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

core promoter sequence-specific DNA binding

transcription coregulator binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

positive regulation of mesenchymal cell proliferation

pre-B cell differentiation

positive regulation of immunoglobulin production

negative regulation of B cell apoptotic process

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleus

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

DNA damage response

heart development

skeletal muscle tissue development

motor neuron axon guidance

embryo development

embryo development

regulation of gene expression

positive regulation of endothelial cell migration

negative regulation of gene expression

ventral spinal cord development

osteoclast differentiation

lung development

response to lipopolysaccharide

regulation of interleukin-1 beta production

regulation of interleukin-12 production

regulation of tumor necrosis factor production

positive regulation of interleukin-21 production

immunoglobulin V(D)J recombination

osteoclast development

macrophage activation

monocyte activation

endothelial cell activation

identical protein binding

identical protein binding

sequence-specific DNA binding

protein self-association

regulation of monocyte differentiation

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

metal ion binding

positive regulation of smooth muscle cell proliferation

smooth muscle tissue development

positive regulation of epithelial cell proliferation

nuclear androgen receptor binding

regulation of inflammatory response

positive regulation of B cell receptor signaling pathway

cardiac muscle cell differentiation

regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation

negative regulation of androgen receptor signaling pathway

negative regulation of cell growth involved in cardiac muscle cell development

lung secretory cell differentiation

T follicular helper cell differentiation

innate vocalization behavior

regulation of action potential

regulation of defense response to bacterium

regulation of lung goblet cell differentiation

negative regulation of lung goblet cell differentiation

regulation of macrophage colony-stimulating factor production

positive regulation of hydrogen peroxide-mediated programmed cell death

regulation of endothelial tube morphogenesis

cellular response to ionomycin

sequence-specific double-stranded DNA binding

regulation of chemokine (C-X-C motif) ligand 2 production

 
1426473_at Dnajc9 DnaJ heat shock protein family (Hsp40) member C9 14 -20384637 BM942465 26

extracellular space

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

plasma membrane

nucleosome assembly

membrane

heat shock protein binding

heat shock protein binding

positive regulation of ATP-dependent activity

histone binding

protein-folding chaperone binding

protein folding chaperone complex

 
1435996_at Card11 caspase recruitment domain family, member 11 5 -140872998 AV095659 92

immunological synapse

immune system process

immunoglobulin production

protein binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

plasma membrane

signal transduction

canonical NF-kappaB signal transduction

membrane

B cell differentiation

positive regulation of B cell proliferation

T cell costimulation

CBM complex

interleukin-2 production

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

CD4-positive, alpha-beta T cell proliferation

TORC1 signaling

B cell proliferation

T cell activation

regulation of apoptotic process

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

protein self-association

thymic T cell selection

membrane raft

regulation of B cell differentiation

regulation of T cell differentiation

lymphocyte activation

homeostasis of number of cells

CARD domain binding

CARD domain binding

regulation of immune response

positive regulation of T cell receptor signaling pathway

positive regulation of T cell receptor signaling pathway

positive regulation of T cell activation

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

protein homooligomerization

positive regulation of CD4-positive, alpha-beta T cell proliferation

04660

04662

1437152_at Mex3b mex3 RNA binding family member B 7 82867332 BG072837 22

P-body

nucleic acid binding

RNA binding

nucleus

nucleoplasm

cytoplasm

cytosol

phagocytosis

positive regulation of cell-cell adhesion

GTPase activating protein binding

positive regulation of GTPase activity

metal ion binding

positive regulation of phagocytosis

establishment of localization in cell

protein localization to cell cortex

cell-cell adhesion

 
1456541_x_at Atad3a ATPase family, AAA domain containing 3A 4 -155740639 BB357220 53

nucleotide binding

protein binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrion organization

membrane

ATP hydrolysis activity

mitochondrial nucleoid

identical protein binding

 
1426897_at Rcc2 regulator of chromosome condensation 2 4 140701472 AV122997 37

chromosome, centromeric region

guanyl-nucleotide exchange factor activity

nucleus

chromosome

cytoplasm

cytoskeleton

microtubule

plasma membrane

cell cycle

integrin-mediated signaling pathway

microtubule binding

regulation of fibroblast migration

positive regulation of G2/M transition of mitotic cell cycle

membrane

membrane

protein kinase binding

protein domain specific binding

regulation of cell migration

midbody

small GTPase binding

small GTPase binding

small GTPase binding

early endosome membrane

negative regulation of GTPase activity

negative regulation of GTPase activity

negative regulation of GTPase activity

chromosome, centromeric core domain

establishment of protein localization

focal adhesion assembly

cell division

negative regulation of focal adhesion assembly

positive regulation of attachment of spindle microtubules to kinetochore

chromosome passenger complex localization to kinetochore

activation of GTPase activity

negative regulation of substrate adhesion-dependent cell spreading

regulation of ruffle assembly

regulation of ruffle assembly

mitotic spindle midzone

 
1433776_at Lhfpl6 LHFPL tetraspan subfamily member 6 3 53041546 AV149705 16

molecular_function

biological_process

membrane

membrane

 
1438487_s_at Zzz3 zinc finger, ZZ domain containing 3 3 152396683, 152396002, 152395472 BB724567 28

DNA binding

nucleus

nucleoplasm

nucleolus

chromatin organization

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

zinc ion binding

methylated histone binding

regulation of embryonic development

metal ion binding

regulation of cell division

regulation of cell division

regulation of cell cycle

regulation of cell cycle

lysine-acetylated histone binding

mitotic spindle

regulation of tubulin deacetylation

histone reader activity

ATAC complex

ATAC complex

 
1454850_at Tbc1d10c TBC1 domain family, member 10c 19 -4184356 AV060417 21

GTPase activator activity

GTPase activator activity

plasma membrane

filopodium membrane

calcineurin-NFAT signaling cascade

B cell activation

retrograde transport, endosome to Golgi

negative regulation of B cell activation

negative regulation of B cell activation

ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

negative regulation of calcineurin-NFAT signaling cascade

activation of GTPase activity

 
1440202_at 5930412I24Rik RIKEN cDNA 5930412I24 gene 13   BB036159 1

molecular_function

cellular_component

biological_process

 
1427957_at Adtrp androgen dependent TFPI regulating protein 13 -41763147, -41763147 AI256077 16

positive regulation of protein phosphorylation

cell migration involved in sprouting angiogenesis

negative regulation of leukocyte migration

negative regulation of extracellular matrix constituent secretion

plasma membrane

caveola

lipid metabolic process

cell surface

positive regulation of gene expression

endomembrane system

membrane

hydrolase activity

negative regulation of blood coagulation

long-chain fatty acid catabolic process

negative regulation of protein secretion

cellular response to oxidised low-density lipoprotein particle stimulus

negative regulation of leukocyte cell-cell adhesion

negative regulation of lymphocyte migration

 
1424108_at Glo1 glyoxalase 1 17 -30592861 BC024663 110

lactoylglutathione lyase activity

lactoylglutathione lyase activity

nucleoplasm

cytosol

plasma membrane

regulation of transcription by RNA polymerase II

glutathione metabolic process

zinc ion binding

zinc ion binding

methylglyoxal metabolic process

lyase activity

methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

osteoclast differentiation

negative regulation of apoptotic process

metal ion binding

00620

1417741_at Pygl liver glycogen phosphorylase 12 -70190814 NM_133198 42

nucleotide binding

purine nucleobase binding

catalytic activity

1,4-alpha-oligoglucan phosphorylase activity

protein binding

ATP binding

glucose binding

cytoplasm

cytoplasm

carbohydrate metabolic process

glycogen metabolic process

glycogen catabolic process

glycogen catabolic process

glycogen catabolic process

5-phosphoribose 1-diphosphate biosynthetic process

metabolic process

glycogen phosphorylase activity

glycogen phosphorylase activity

glycogen phosphorylase activity

response to bacterium

AMP binding

transferase activity

glycosyltransferase activity

vitamin binding

pyridoxal phosphate binding

pyridoxal phosphate binding

carbohydrate binding

bile acid binding

glucose homeostasis

identical protein binding

necroptotic process

linear malto-oligosaccharide phosphorylase activity

SHG alpha-glucan phosphorylase activity

00500

04910

1439141_at Gpr18 G protein-coupled receptor 18 14 -121911433 BG145550 27

CD8-positive, alpha-beta intraepithelial T cell differentiation

CD8-positive, alpha-beta intraepithelial T cell differentiation

CD8-positive, gamma-delta intraepithelial T cell differentiation

CD8-positive, gamma-delta intraepithelial T cell differentiation

negative regulation of leukocyte chemotaxis

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

cytoplasmic vesicle

negative regulation of tumor necrosis factor production

positive regulation of Rho protein signal transduction

 
1437380_x_at Pgd phosphogluconate dehydrogenase 4 -149149990, -149149990 BB558114 56

phosphogluconate dehydrogenase (decarboxylating) activity

phosphogluconate dehydrogenase (decarboxylating) activity

phosphogluconate dehydrogenase (decarboxylating) activity

cytoplasm

cytosol

cytosol

pentose-phosphate shunt

NADP metabolic process

phosphogluconate 2-dehydrogenase activity

pentose-phosphate shunt, oxidative branch

pentose-phosphate shunt, oxidative branch

pentose-phosphate shunt, oxidative branch

oxidoreductase activity

pentose biosynthetic process

D-gluconate metabolic process

carbohydrate binding

carboxylic acid binding

D-gluconate catabolic process

NADP binding

NADP binding

00030

00480

01100

1448856_a_at Msra methionine sulfoxide reductase A 14 -64122620, -64122620, -64122620, -64122620, -64122620 NM_026322 84

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

plasma membrane

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

peptide-methionine (S)-S-oxide reductase activity

actin cytoskeleton

membrane

oxidoreductase activity

midbody

cellular response to oxidative stress

L-methionine-(S)-S-oxide reductase activity

intracellular membrane-bounded organelle

 
1437993_x_at Qdpr quinoid dihydropteridine reductase 5 -45434031 BB221333 48

6,7-dihydropteridine reductase activity

6,7-dihydropteridine reductase activity

cytoplasm

cytoplasm

mitochondrion

L-phenylalanine catabolic process

tetrahydrobiopterin biosynthetic process

tetrahydrobiopterin biosynthetic process

oxidoreductase activity

identical protein binding

NADPH binding

NADPH binding

NADH binding

NADH binding

00790

01100

1417185_at Ly6a lymphocyte antigen 6 family member A 15 -74994876 BC002070 192

protein binding

intracellular anatomical structure

plasma membrane

plasma membrane

response to bacterium

external side of plasma membrane

membrane

acetylcholine receptor inhibitor activity

acetylcholine receptor binding

acetylcholine receptor signaling pathway

side of membrane

 
1454843_at Prps2 phosphoribosyl pyrophosphate synthetase 2 X -167346319 BM934034 26

nucleotide binding

magnesium ion binding

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase complex

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ribose phosphate diphosphokinase activity

ATP binding

ATP binding

cytoplasm

cytosol

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

5-phosphoribose 1-diphosphate biosynthetic process

pentose-phosphate shunt

purine nucleotide biosynthetic process

AMP biosynthetic process

ribonucleoside monophosphate biosynthetic process

nucleotide biosynthetic process

AMP binding

kinase activity

phosphorylation

transferase activity

GDP binding

carbohydrate binding

protein-containing complex

identical protein binding

ADP binding

cellular biosynthetic process

metal ion binding

00030

00230

01100

1428719_at Iglc2 immunoglobulin lambda constant 2 16   AK008551 29

antigen binding

extracellular region

plasma membrane

immunoglobulin mediated immune response

IgG immunoglobulin complex

IgG immunoglobulin complex

 
1427233_at Tshz1 teashirt zinc finger family member 1 18 -84011626, -84011626 AV291373 52

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA binding

protein binding

nucleus

nucleus

regulation of transcription by RNA polymerase II

multicellular organism development

anterior/posterior pattern specification

regulation of gene expression

middle ear morphogenesis

metal ion binding

soft palate development

 
1452430_s_at Srsf1 serine and arginine-rich splicing factor 1 11 88047372 X66091 110

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

mRNA 5'-splice site recognition

in utero embryonic development

nucleic acid binding

RNA binding

mRNA binding

mRNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

mRNA processing

RNA splicing

RNA splicing

nuclear speck

nuclear speck

nuclear speck

signal transduction involved in regulation of gene expression

signal transduction involved in regulation of gene expression

positive regulation of RNA splicing

protein localization to nucleus

exon-exon junction complex

protein kinase B binding

regulation of RNA splicing

DNA topoisomerase binding

mRNA stabilization

mRNA stabilization

RS domain binding

mRNA transport

cardiac muscle contraction

catalytic step 2 spliceosome

cellular response to interleukin-17

interleukin-17-mediated signaling pathway

interleukin-17-mediated signaling pathway

molecular function regulator activity

protein localization to P-body

03040

1418231_at Lims1 LIM and senescent cell antigen-like domains 1 10 58323546, 58351962, 58394372, 58371453 BC005621 73

protein binding

cytoplasm

plasma membrane

cell-cell junction

cell-cell junction

focal adhesion

focal adhesion

focal adhesion

cell-matrix adhesion

establishment or maintenance of cell polarity

integrin-mediated signaling pathway

zinc ion binding

positive regulation of gene expression

positive regulation of cell-substrate adhesion

membrane

protein kinase binding

protein-containing complex

tumor necrosis factor-mediated signaling pathway

chordate embryonic development

positive regulation of canonical NF-kappaB signal transduction

positive regulation of GTPase activity

protein-containing complex binding

establishment of protein localization

cell-cell junction organization

cell-cell junction organization

negative regulation of DNA-templated transcription

metal ion binding

perinuclear region of cytoplasm

positive regulation of focal adhesion assembly

neural precursor cell proliferation

anchoring junction

hepatocyte apoptotic process

cell-cell adhesion

cell-cell adhesion

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

negative regulation of hepatocyte apoptotic process

negative regulation of cholangiocyte proliferation

cholangiocyte proliferation

negative regulation of neural precursor cell proliferation

negative regulation of hepatocyte proliferation

positive regulation of integrin-mediated signaling pathway

positive regulation of integrin-mediated signaling pathway

 
1448138_at Ptpa protein phosphatase 2 protein activator 2 30441852, 30416049 NM_138748 33

protein phosphatase type 2A complex

protein phosphatase type 2A complex

nucleotide binding

peptidyl-prolyl cis-trans isomerase activity

peptidyl-prolyl cis-trans isomerase activity

phosphoprotein phosphatase activity

signaling receptor binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitotic spindle organization

protein tyrosine phosphatase activator activity

protein tyrosine phosphatase activator activity

isomerase activity

phosphatase activator activity

protein phosphatase regulator activity

negative regulation of phosphoprotein phosphatase activity

positive regulation of phosphoprotein phosphatase activity

calcium channel complex

positive regulation of protein dephosphorylation

negative regulation of protein dephosphorylation

protein homodimerization activity

positive regulation of apoptotic process

regulation of phosphoprotein phosphatase activity

protein phosphatase 2A binding

ATPase complex

 
1421840_at Abca1 ATP-binding cassette, sub-family A member 1 4 -53030788 BB144704 455

nucleotide binding

peptide secretion

signaling receptor binding

protein binding

ATP binding

phospholipid transporter activity

phospholipid transporter activity

phospholipid transporter activity

endosome

Golgi apparatus

plasma membrane

plasma membrane

protein lipidation

phagocytosis, engulfment

lysosome organization

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

high-density lipoprotein particle binding

cholesterol metabolic process

cholesterol metabolic process

protein transmembrane transporter activity

protein secretion

protein secretion

external side of plasma membrane

cell surface

positive regulation of cholesterol efflux

phospholipid transport

membrane

endosomal transport

basolateral plasma membrane

ATP hydrolysis activity

syntaxin binding

signal release

signal release

endocytic vesicle

cholesterol transport

phosphatidylcholine binding

small GTPase binding

intracellular cholesterol transport

regulation of Cdc42 protein signal transduction

cholesterol efflux

cholesterol efflux

cholesterol efflux

phospholipid efflux

phospholipid efflux

phospholipid efflux

phospholipid efflux

apolipoprotein binding

apolipoprotein A-I binding

apolipoprotein A-I receptor activity

high-density lipoprotein particle assembly

response to laminar fluid shear stress

lipoprotein metabolic process

lipoprotein biosynthetic process

lipoprotein biosynthetic process

ATPase-coupled transmembrane transporter activity

ATPase-coupled transmembrane transporter activity

cholesterol homeostasis

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

reverse cholesterol transport

reverse cholesterol transport

membrane raft

phospholipid translocation

phospholipid translocation

phagocytic vesicle

sphingolipid floppase activity

perinuclear region of cytoplasm

ATPase binding

establishment of localization in cell

transmembrane transport

phospholipid homeostasis

platelet dense granule organization

cellular response to lipopolysaccharide

cellular response to retinoic acid

protein transmembrane transport

positive regulation of high-density lipoprotein particle assembly

phosphatidylcholine floppase activity

phosphatidylcholine floppase activity

phosphatidylserine floppase activity

phosphatidylserine floppase activity

intracellular vesicle

cholesterol transfer activity

cholesterol transfer activity

cholesterol transfer activity

export across plasma membrane

ATPase-coupled intramembrane lipid transporter activity

floppase activity

ABC-type transporter activity

02010

04975

1428847_a_at Macf1 microtubule-actin crosslinking factor 1 4 -123349632 BM248206 95

mesoderm formation

actin binding

actin binding

structural molecule activity

calcium ion binding

protein binding

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytoskeleton

microtubule

microtubule

microtubule

intermediate filament

plasma membrane

cell cortex

post-translational protein targeting to endoplasmic reticulum membrane

establishment or maintenance of cell polarity

microtubule binding

protein localization

regulation of epithelial cell migration

postsynaptic density

actin cytoskeleton

actin cytoskeleton

microtubule cytoskeleton

membrane

membrane

Wnt signaling pathway

Wnt signaling pathway

cell migration

ATP hydrolysis activity

positive regulation of Wnt signaling pathway

positive regulation of Wnt signaling pathway

regulation of cell migration

ruffle membrane

regulation of microtubule-based process

regulation of microtubule-based process

regulation of microtubule-based process

wound healing

wound healing

cell projection

Golgi to plasma membrane protein transport

intermediate filament cytoskeleton organization

intermediate filament cytoskeleton organization

positive regulation of axon extension

metal ion binding

microtubule minus-end binding

actin filament binding

regulation of focal adhesion assembly

regulation of focal adhesion assembly

regulation of focal adhesion assembly

regulation of neuron projection arborization

 
1424654_at Acp2 acid phosphatase 2, lysosomal 2 91202911 BB022890 43

skeletal system development

phosphotyrosine residue binding

acid phosphatase activity

acid phosphatase activity

acid phosphatase activity

acid phosphatase activity

phosphoprotein phosphatase activity

lysosome

lysosome

lysosome

lysosome

lysosome organization

lysosome organization

response to organic substance

membrane

dephosphorylation

hydrolase activity

autophagic cell death

00740

04142

1431609_a_at Acp5 acid phosphatase 5, tartrate resistant 9 -22126726, -22126726, -22126726 AK008391 113

acid phosphatase activity

acid phosphatase activity

acid phosphatase activity

acid phosphatase activity

extracellular space

lysosome

lysosome

nitric oxide biosynthetic process

negative regulation of cell adhesion

ferrous iron binding

ferrous iron binding

ferric iron binding

ferric iron binding

macrophage cytokine production

negative regulation of macrophage cytokine production

dephosphorylation

hydrolase activity

positive regulation of cell migration

response to lipopolysaccharide

interleukin-1 beta production

interleukin-12 production

tumor necrosis factor production

negative regulation of interleukin-1 beta production

negative regulation of interleukin-12 production

negative regulation of tumor necrosis factor production

negative regulation of superoxide anion generation

response to cytokine

superoxide anion generation

negative regulation of nitric oxide biosynthetic process

bone resorption

bone resorption

metal ion binding

negative regulation of inflammatory response

defense response to Gram-positive bacterium

bone morphogenesis

00740

04142

04380

05323

1429379_at Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 7 -110850606 AV124537 389

positive regulation of cellular extravasation

transmembrane signaling receptor activity

transmembrane signaling receptor activity

hyaluronic acid binding

hyaluronic acid binding

hyaluronic acid binding

plasma membrane

plasma membrane

plasma membrane

glycosaminoglycan catabolic process

receptor-mediated endocytosis

receptor-mediated endocytosis

cell adhesion

membrane

hyaluronan catabolic process

cargo receptor activity

cargo receptor activity

cell periphery

 
1416871_at Adam8 a disintegrin and metallopeptidase domain 8 7 -139978931 NM_007403 76

cell morphogenesis

angiogenesis

podosome

podosome

leukocyte migration involved in inflammatory response

positive regulation of acute inflammatory response

positive regulation of cellular extravasation

positive regulation of cellular extravasation

metalloendopeptidase activity

metalloendopeptidase activity

integrin binding

calcium ion binding

protein binding

cytoplasm

plasma membrane

plasma membrane

proteolysis

proteolysis

inflammatory response

inflammatory response

cell-matrix adhesion

canonical NF-kappaB signal transduction

peptidase activity

metallopeptidase activity

metallopeptidase activity

zinc ion binding

cell surface

positive regulation of epithelial to mesenchymal transition

membrane

hydrolase activity

regulation of cell-cell adhesion

regulation of cell-cell adhesion

phagolysosome

dense core granule membrane

positive regulation of T cell differentiation in thymus

specific granule

positive regulation of MAPK cascade

negative regulation of neuron apoptotic process

blood vessel endothelial cell migration

positive regulation of innate immune response

regulation of osteoclast differentiation

positive regulation of bone resorption

positive regulation of bone resorption

positive regulation of cell adhesion

metal ion binding

lymphocyte chemotaxis

tissue morphogenesis

positive regulation of inflammatory response

cell adhesion molecule binding

cell adhesion molecule binding

cell adhesion molecule binding

positive regulation of membrane protein ectodomain proteolysis

positive regulation of membrane protein ectodomain proteolysis

positive regulation of membrane protein ectodomain proteolysis

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

membrane fusion

positive regulation of thymocyte apoptotic process

tertiary granule

alpha9-beta1 integrin-ADAM8 complex

cellular response to hypoxia

osteoclast fusion

cell-cell adhesion

positive regulation of transforming growth factor beta1 activation

positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

positive regulation of neutrophil extravasation

negative regulation of thymocyte aggregation

positive regulation of T cell migration

positive regulation of fibronectin-dependent thymocyte migration

positive regulation of eosinophil migration

 
1450065_at Adcy7 adenylate cyclase 7 8 88282991, 88289065, 88272402, 88294203 NM_007406 34

nucleotide binding

regulation of adaptive immune response

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

adenylate cyclase activity

ATP binding

plasma membrane

cAMP biosynthetic process

cAMP biosynthetic process

cAMP biosynthetic process

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

activation of adenylate cyclase activity

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

cyclic nucleotide biosynthetic process

membrane

lyase activity

phosphorus-oxygen lyase activity

intracellular signal transduction

metal ion binding

cellular response to lithium ion

cellular response to ethanol

negative regulation of cytokine production involved in inflammatory response

00230

04020

04062

04114

04270

04540

04912

04914

04916

04970

04971

04972

04976

05414

1435287_at Add2 adducin 2 6 86028680, 86078047, 86028680, 86078047 AV298858 67

actin binding

structural constituent of cytoskeleton

calmodulin binding

cytoplasm

cytoskeleton

cytoskeleton

plasma membrane

plasma membrane

monoatomic ion transport

synapse assembly

synapse assembly

synapse assembly

F-actin capping protein complex

postsynaptic density

postsynaptic density

membrane

protein kinase binding

hemopoiesis

spectrin binding

cytoplasmic vesicle

positive regulation of protein binding

protein homodimerization activity

plasma membrane raft

protein heterodimerization activity

protein dimerization activity

leukocyte migration

leukocyte tethering or rolling

actin filament binding

actin filament binding

barbed-end actin filament capping

barbed-end actin filament capping

actin filament bundle assembly

protein-containing complex assembly

postsynapse

glutamatergic synapse

 
1448318_at Plin2 perilipin 2 4 -86656564 NM_007408 154

protein binding

nucleus

cytoplasm

lipid droplet

lipid droplet

lipid droplet

lipid droplet

cytosol

cytosol

cytosol

plasma membrane

positive regulation of sequestering of triglyceride

long-chain fatty acid transport

membrane

lipid storage

lipid storage

lipid storage

cellular response to glucose starvation

lipid droplet disassembly

 
1435368_a_at Parp1 poly (ADP-ribose) polymerase family, member 1 1 180568890 BB767586 673

negative regulation of transcription by RNA polymerase II

telomere maintenance

chromatin

chromatin

immune system process

DNA binding

chromatin binding

chromatin binding

damaged DNA binding

catalytic activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

protein binding

nucleus

nucleus

nucleus

nuclear envelope

nucleoplasm

nucleoplasm

transcription regulator complex

chromosome

nucleolus

nucleolus

nucleolus

cytoplasm

mitochondrion

cytosol

DNA metabolic process

DNA repair

DNA repair

DNA repair

base-excision repair

double-strand break repair

double-strand break repair

double-strand break repair

apoptotic process

DNA damage response

mitochondrion organization

mitochondrion organization

transforming growth factor beta receptor signaling pathway

metabolic process

zinc ion binding

positive regulation of cardiac muscle hypertrophy

carbohydrate biosynthetic process

protein autoprocessing

nuclear body

transferase activity

glycosyltransferase activity

nucleotidyltransferase activity

enzyme binding

protein kinase binding

signal transduction involved in regulation of gene expression

nuclear estrogen receptor binding

DNA ADP-ribosylation

nucleosome binding

ubiquitin protein ligase binding

mitochondrial DNA metabolic process

negative regulation of interleukin-17 production

positive regulation of DNA-templated transcription, elongation

cellular response to insulin stimulus

regulation of protein localization

protein-containing complex

protein-containing complex

protein-DNA complex

positive regulation of intracellular estrogen receptor signaling pathway

negative regulation of transcription elongation by RNA polymerase II

cellular response to oxidative stress

cellular response to UV

site of double-strand break

protein modification process

regulation of growth rate

identical protein binding

protein homodimerization activity

histone deacetylase binding

positive regulation of canonical NF-kappaB signal transduction

mitochondrial DNA repair

nuclear replication fork

regulation of DNA methylation

innate immune response

regulation of circadian sleep/wake cycle, non-REM sleep

negative regulation of innate immune response

negative regulation of innate immune response

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

decidualization

metal ion binding

behavioral response to cocaine

regulation of catalytic activity

voluntary musculoskeletal movement

NAD binding

positive regulation of mitochondrial depolarization

positive regulation of SMAD protein signal transduction

positive regulation of necroptotic process

RNA polymerase II-specific DNA-binding transcription factor binding

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

protein auto-ADP-ribosylation

R-SMAD binding

protein localization to chromatin

cellular response to superoxide

replication fork reversal

site of DNA damage

site of DNA damage

NAD DNA ADP-ribosyltransferase activity

transcription regulator activator activity

NAD+-protein-serine ADP-ribosyltransferase activity

NAD+- protein-aspartate ADP-ribosyltransferase activity

NAD+- protein-aspartate ADP-ribosyltransferase activity

NAD+-protein-glutamate ADP-ribosyltransferase activity

NAD+-protein-glutamate ADP-ribosyltransferase activity

NAD+-protein-glutamate ADP-ribosyltransferase activity

NAD+-protein-tyrosine ADP-ribosyltransferase activity

NAD+-protein-histidine ADP-ribosyltransferase activity

NAD+-histone H2BS6 serine ADP-ribosyltransferase activity

NAD+-histone H3S10 serine ADP-ribosyltransferase activity

NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity

negative regulation of cGAS/STING signaling pathway

positive regulation of protein localization to nucleus

regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

regulation of single strand break repair

positive regulation of single strand break repair

positive regulation of single strand break repair

negative regulation of adipose tissue development

negative regulation of telomere maintenance via telomere lengthening

cellular response to amyloid-beta

positive regulation of myofibroblast differentiation

regulation of base-excision repair

positive regulation of double-strand break repair via homologous recombination

cellular response to nerve growth factor stimulus

NAD+-protein ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

ATP generation from poly-ADP-D-ribose

negative regulation of ATP biosynthetic process

03410

1449383_at Adss1 adenylosuccinate synthase 1 12 112620046 NM_007421 32

nucleotide binding

GTPase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

adenylosuccinate synthase activity

protein binding

GTP binding

cytoplasm

cytoplasm

cytoplasm

purine nucleotide metabolic process

purine nucleotide biosynthetic process

AMP biosynthetic process

aspartate metabolic process

membrane

ligase activity

identical protein binding

'de novo' AMP biosynthetic process

AMP salvage

AMP salvage

IMP metabolic process

IMP metabolic process

metal ion binding

actin filament binding

00230

00250

01100

1449838_at Crisp3 cysteine-rich secretory protein 3 17 -40221776 NM_009639 18

extracellular region

extracellular space

cytoplasmic vesicle

 
1418204_s_at Aif1 allograft inflammatory factor 1 17 -35170985 NM_019467 273

ruffle

microglial cell activation

phagocytic cup

positive regulation of protein phosphorylation

actin binding

calcium ion binding

calcium ion binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytoskeleton

actin filament

actin filament

plasma membrane

phagocytosis, engulfment

positive regulation of cell population proliferation

negative regulation of gene expression

positive regulation of muscle hyperplasia

membrane

Rac protein signal transduction

lamellipodium

lamellipodium

actin filament polymerization

parallel actin filament bundle assembly

positive regulation of cell migration

ruffle membrane

ruffle membrane

ruffle membrane

positive regulation of chemokine production

positive regulation of interleukin-6 production

cellular response to oxidative stress

positive regulation of T cell proliferation

cell projection

negative regulation of apoptotic process

perikaryon

positive regulation of nitric oxide biosynthetic process

metal ion binding

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

negative regulation of smooth muscle cell proliferation

positive regulation of chemotaxis

actin filament binding

actin filament binding

actin filament binding

actin filament bundle assembly

actin filament bundle assembly

actin filament bundle assembly

actin crosslink formation

negative regulation of smooth muscle cell chemotaxis

positive regulation of smooth muscle cell chemotaxis

positive regulation of mononuclear cell migration

positive regulation of monocyte chemotaxis

positive regulation of fibroblast growth factor production

ruffle assembly

ruffle assembly

ruffle assembly

glial cell projection

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of T cell migration

 
1452016_at Alox5ap arachidonate 5-lipoxygenase activating protein 5 149265003 BC026209 44

leukotriene production involved in inflammatory response

positive regulation of acute inflammatory response

arachidonate 5-lipoxygenase activity

glutathione transferase activity

leukotriene-C4 synthase activity

glutathione peroxidase activity

protein binding

nucleus

nuclear envelope

nuclear envelope

endoplasmic reticulum

endoplasmic reticulum

leukotriene metabolic process

enzyme activator activity

membrane

leukotriene biosynthetic process

leukotriene biosynthetic process

leukotriene biosynthetic process

leukotriene biosynthetic process

lipoxygenase pathway

enzyme binding

nuclear membrane

identical protein binding

protein-containing complex binding

arachidonic acid binding

protein homotrimerization

cellular response to calcium ion

 
1418685_at Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein 9 -35184390, -35184390, -35184390 NM_054096 130

immune system process

protein kinase C binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

inflammatory response

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

response to bacterium

cell surface

macrophage cytokine production

membrane

myeloid cell differentiation

endocytic vesicle

positive regulation of B cell proliferation

extrinsic component of cytoplasmic side of plasma membrane

positive regulation of protein-containing complex assembly

response to lipopolysaccharide

ruffle membrane

tumor necrosis factor production

regulation of interferon-beta production

regulation of interleukin-15 production

positive regulation of interleukin-12 production

positive regulation of interleukin-15 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

regulation of stress-activated MAPK cascade

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of toll-like receptor 3 signaling pathway

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

positive regulation of toll-like receptor 4 signaling pathway

signaling adaptor activity

signaling adaptor activity

Toll-like receptor 4 binding

Toll-like receptor 4 binding

Toll-like receptor 2 binding

Toll-like receptor 2 binding

Toll-like receptor 2 binding

TIRAP-dependent toll-like receptor 4 signaling pathway

identical protein binding

identical protein binding

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of JUN kinase activity

innate immune response

regulation of innate immune response

positive regulation of innate immune response

positive regulation of JNK cascade

defense response to Gram-positive bacterium

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

molecular adaptor activity

positive regulation of macrophage cytokine production

positive regulation of ERK1 and ERK2 cascade

3'-UTR-mediated mRNA stabilization

cellular response to bacterial lipopeptide

cellular response to lipoteichoic acid

positive regulation of neutrophil chemotaxis

positive regulation of chemokine (C-X-C motif) ligand 1 production

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of chemokine (C-X-C motif) ligand 2 production

04620

1460197_a_at Steap4 STEAP family member 4 5 7960471 NM_054098 39

nucleoplasm

endosome

endosome

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

plasma membrane

monoatomic ion transport

iron ion transport

cupric reductase activity

cupric reductase activity

electron transfer activity

copper ion import

copper ion import

membrane

oxidoreductase activity

heme binding

iron import into cell

fat cell differentiation

metal ion binding

ferric-chelate reductase (NADPH) activity

ferric-chelate reductase (NADPH) activity

ferric-chelate reductase (NADPH) activity

protein homotrimerization

FAD binding

iron ion import across cell outer membrane

 
1422573_at Ampd3 adenosine monophosphate deaminase 3 7 110772603, 110768205, 110773635, 110768621 D85596 39

AMP deaminase activity

AMP deaminase activity

AMP deaminase activity

AMP deaminase activity

cytosol

IMP biosynthetic process

IMP biosynthetic process

IMP biosynthetic process

AMP catabolic process

nucleotide metabolic process

purine ribonucleoside monophosphate biosynthetic process

hydrolase activity

deaminase activity

IMP salvage

erythrocyte homeostasis

ADP metabolic process

ADP catabolic process

AMP metabolic process

AMP metabolic process

ATP metabolic process

ATP metabolic process

GTP metabolic process

GTP metabolic process

metal ion binding

energy homeostasis

00230

01100

1425718_a_at Ivns1abp influenza virus NS1A binding protein 1 151344485, 151344497, 151344497 BC004092 29

protein binding

nucleus

cytoplasm

cytosol

cytoskeleton

RNA splicing

response to virus

negative regulation of protein ubiquitination

intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway

 
1450627_at Ank progressive ankylosis 15 27466676 NM_020332 84

inorganic phosphate transmembrane transporter activity

inorganic phosphate transmembrane transporter activity

ATP transmembrane transporter activity

extracellular region

plasma membrane

plasma membrane

gene expression

gene expression

phosphate ion transmembrane transporter activity

membrane

membrane

bone mineralization

bone mineralization

regulation of bone mineralization

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transmembrane transporter activity

inorganic diphosphate transport

phosphate ion transmembrane transport

muscle cell cellular homeostasis

phosphate ion homeostasis

calcium ion homeostasis

diphosphate metabolic process

diphosphate metabolic process

cementum mineralization

cementum mineralization

inhibition of non-skeletal tissue mineralization

inhibition of non-skeletal tissue mineralization

response to sodium phosphate

ATP export

 
1418468_at Anxa11 annexin A11 14 25842154 NM_013469 34

phosphatidylserine binding

calcium ion binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

nucleus

nuclear envelope

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

spindle

cytosol

cytoskeleton

plasma membrane

phagocytosis

cell cycle

phosphatidylethanolamine binding

midbody

cytokinetic process

cytokinetic process

specific granule

azurophil granule

S100 protein binding

phagocytic vesicle

calcium-dependent protein binding

cell division

response to calcium ion

collagen-containing extracellular matrix

 
1460330_at Anxa3 annexin A3 5 96793384 AW702161 33

phosphatidylserine binding

phospholipase inhibitor activity

calcium ion binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

phagocytosis

positive regulation of endothelial cell migration

membrane

phospholipase A2 inhibitor activity

axon

dendrite

phagocytic vesicle membrane

specific granule

defense response to bacterium

neuronal cell body

neutrophil degranulation

positive regulation of angiogenesis

calcium-dependent protein binding

positive regulation of DNA metabolic process

positive regulation of DNA-binding transcription factor activity

collagen-containing extracellular matrix

 
1421223_a_at Anxa4 annexin A4 6 -86736839, -86736839 NM_013471 42

phosphatidylserine binding

kidney development

calcium ion binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

nucleus

cytoplasm

cytoplasm

plasma membrane

plasma membrane

regulation of transcription by RNA polymerase II

Notch signaling pathway

cell surface

vesicle membrane

membrane

apical plasma membrane

cytoplasmic vesicle

nuclear membrane

negative regulation of NF-kappaB transcription factor activity

negative regulation of interleukin-8 production

identical protein binding

calcium-dependent protein binding

perinuclear region of cytoplasm

NF-kappaB binding

collagen-containing extracellular matrix

 
1452342_at Apbb2 amyloid beta precursor protein binding family B member 2 5 -66298724, -66298724 AW542721 41

negative regulation of transcription by RNA polymerase II

amyloid-beta binding

amyloid-beta binding

neuron migration

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

endosome

early endosome

endoplasmic reticulum

Golgi apparatus

regulation of DNA-templated transcription

smooth muscle contraction

axon guidance

transcription factor binding

extracellular matrix organization

maintenance of lens transparency

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of transcription by RNA polymerase II

protein stabilization

negative regulation of cell cycle phase transition

 
1435543_at Apc APC, WNT signaling pathway regulator 18 34247693, 34220983 BM124893 1824

MAPK cascade

MAPK cascade

mitotic cytokinesis

mitotic cytokinesis

kinetochore

cell fate specification

kidney development

endothelial cell proliferation

endothelial cell proliferation

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

hair follicle development

protease binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

Golgi apparatus

centrosome

cytoskeleton

microtubule

cytoplasmic microtubule

plasma membrane

adherens junction

bicellular tight junction

cell cortex

apoptotic process

DNA damage response

microtubule depolymerization

negative regulation of microtubule depolymerization

negative regulation of microtubule depolymerization

negative regulation of microtubule depolymerization

metaphase/anaphase transition of mitotic cell cycle

metaphase/anaphase transition of mitotic cell cycle

mitotic spindle assembly checkpoint signaling

cell adhesion

establishment or maintenance of cell polarity

pattern specification process

pattern specification process

nervous system development

axonogenesis

axonogenesis

beta-catenin binding

beta-catenin binding

beta-catenin binding

beta-catenin binding

microtubule binding

microtubule binding

cell population proliferation

cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

insulin receptor signaling pathway

insulin receptor signaling pathway

axis specification

anterior/posterior pattern specification

dorsal/ventral pattern formation

proximal/distal pattern formation

regulation of epithelial cell migration

fibroblast migration

positive regulation of fibroblast migration

microtubule cytoskeleton

membrane

Wnt signaling pathway

Wnt signaling pathway

Wnt signaling pathway

lateral plasma membrane

catenin complex

catenin complex

cell migration

cell migration

cell migration

stem cell population maintenance

protein kinase regulator activity

protein kinase binding

protein kinase binding

lamellipodium

protein catabolic process

negative regulation of Wnt signaling pathway

negative regulation of Wnt signaling pathway

regulation of cell migration

positive regulation of cell migration

axon

dendrite

growth cone

growth cone

synaptic vesicle membrane

regulation of epithelial cell differentiation

beta-catenin destruction complex

beta-catenin destruction complex

beta-catenin destruction complex

positive regulation of microtubule polymerization

cytoplasmic microtubule organization

neuron projection development

cell projection membrane

positive regulation of pseudopodium assembly

ubiquitin protein ligase binding

nuclear membrane

ruffle membrane

regulation of microtubule-based process

protein-containing complex

T cell differentiation in thymus

Scrib-APC-beta-catenin complex

somatic stem cell population maintenance

somatic stem cell population maintenance

odontogenesis

negative regulation of odontogenesis

cell projection

neuronal cell body

positive regulation of apoptotic process

negative regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

negative regulation of MAPK cascade

negative regulation of MAPK cascade

skin development

axonal growth cone

axonal growth cone

neuron projection terminus

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

canonical Wnt signaling pathway involved in positive regulation of apoptotic process

fibroblast apoptotic process

protein-containing complex binding

gamma-catenin binding

gamma-catenin binding

regulation of cell differentiation

regulation of cell differentiation

positive regulation of cell differentiation

regulation of osteoblast differentiation

regulation of osteoclast differentiation

positive regulation of protein catabolic process

positive regulation of protein catabolic process

positive regulation of protein catabolic process

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of cell adhesion

muscle cell cellular homeostasis

microtubule polymerization

perinuclear region of cytoplasm

thymus development

epithelial cell proliferation

epithelial cell proliferation

negative regulation of epithelial cell proliferation

negative regulation of epithelial cell proliferation

microtubule plus-end binding

microtubule plus-end binding

regulation of nitrogen compound metabolic process

chromosome organization

chromosome organization

cell division

regulation of cell cycle

positive regulation of cell division

regulation of attachment of spindle microtubules to kinetochore

regulation of attachment of spindle microtubules to kinetochore

retina development in camera-type eye

negative regulation of cardiac muscle cell proliferation

canonical Wnt signaling pathway

epithelial cell proliferation involved in prostate gland development

negative regulation of epithelial cell proliferation involved in prostate gland development

protein-containing complex assembly

anchoring junction

dynein complex binding

dynein complex binding

cell body fiber

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

positive regulation of cold-induced thermogenesis

negative regulation of cell cycle G1/S phase transition

epithelial cell apoptotic process

negative regulation of epithelial cell apoptotic process

negative regulation of acinar cell proliferation

negative regulation of acinar cell proliferation

positive regulation of protein localization to centrosome

positive regulation of protein localization to centrosome

acinar cell proliferation

acinar cell proliferation

negative regulation of G1/S transition of mitotic cell cycle

regulation of glutamate metabolic process

positive regulation of fibroblast apoptotic process

04310

04810

05200

05210

05213

05217

1449193_at Cd5l CD5 antigen-like 3 87357880 NM_009690 54

immune system process

serine-type endopeptidase activity

extracellular region

cytoplasm

plasma membrane

plasma membrane

apoptotic process

inflammatory response

cell surface

cell surface

membrane

regulation of complement activation

zymogen activation

positive regulation of complement-dependent cytotoxicity

 
1427442_a_at App amyloid beta precursor protein 16 -84954435 BC005490 1463

G2/M transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

mitotic cell cycle

RNA polymerase II cis-regulatory region sequence-specific DNA binding

G protein-coupled receptor binding

microglial cell activation

response to yeast

positive regulation of protein phosphorylation

suckling behavior

astrocyte activation involved in immune response

chromatin binding

serine-type endopeptidase inhibitor activity

signaling receptor binding

signaling receptor binding

frizzled binding

insulin receptor binding

integrin binding

protein binding

extracellular region

extracellular space

nucleus

nuclear envelope lumen

cytoplasm

cytoplasm

mitochondrion

lysosome

endosome

early endosome

early endosome

early endosome

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

Golgi apparatus

Golgi-associated vesicle

plasma membrane

plasma membrane

plasma membrane

clathrin-coated pit

cell-cell junction

regulation of transcription by RNA polymerase II

regulation of translation

protein phosphorylation

intracellular copper ion homeostasis

intracellular copper ion homeostasis

endocytosis

apoptotic process

response to oxidative stress

cell adhesion

regulation of epidermal growth factor-activated receptor activity

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

Notch signaling pathway

axonogenesis

axonogenesis

central nervous system development

learning or memory

learning

memory

memory

mating behavior

locomotory behavior

synaptic vesicle

axo-dendritic transport

axo-dendritic transport

heparin binding

cholesterol metabolic process

cholesterol metabolic process

negative regulation of cell population proliferation

associative learning

adult locomotory behavior

visual learning

cell surface

cell surface

cell surface

negative regulation of peptidase activity

regulation of gene expression

regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of protein kinase A signaling

positive regulation of peptidyl-threonine phosphorylation

positive regulation of G2/M transition of mitotic cell cycle

microglia development

membrane

membrane

membrane

axon midline choice point recognition

neuron remodeling

dendrite development

dendrite development

peptidase activator activity

calcium-mediated signaling

antibacterial humoral response

antifungal humoral response

enzyme binding

COPII-coated ER to Golgi transport vesicle

neuron differentiation

neuron differentiation

extracellular matrix organization

peptidase inhibitor activity

axon

axon

growth cone

signaling receptor activator activity

signaling receptor activator activity

signaling receptor activator activity

forebrain development

forebrain development

neuron projection development

cytoplasmic vesicle

neuromuscular junction

positive regulation of protein binding

positive regulation of chemokine production

positive regulation of type II interferon production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of superoxide anion generation

protein-containing complex

acetylcholine receptor binding

positive regulation of peptidyl-serine phosphorylation

regulation of toll-like receptor signaling pathway

apolipoprotein binding

very-low-density lipoprotein particle

low-density lipoprotein particle

intermediate-density lipoprotein particle

high-density lipoprotein particle

ionotropic glutamate receptor signaling pathway

ciliary rootlet

regulation of multicellular organism growth

chemoattractant activity

identical protein binding

protein homodimerization activity

cell projection

neuron projection

neuron projection

positive regulation of apoptotic process

ion binding

receptor complex

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

regulation of protein binding

regulation of protein binding

heparan sulfate proteoglycan binding

positive regulation of MAPK cascade

positive regulation of neuron apoptotic process

positive regulation of cAMP-mediated signaling

cell body

main axon

innate immune response

membrane raft

membrane raft

apical part of cell

positive regulation of nitric oxide biosynthetic process

negative regulation of neuron differentiation

negative regulation of neuron differentiation

positive regulation of neuron differentiation

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of glycolytic process

positive regulation of mitotic cell cycle

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

metal ion binding

ephrin receptor binding

transition metal ion binding

protein heterodimerization activity

receptor ligand activity

astrocyte activation

regulation of long-term neuronal synaptic plasticity

perinuclear region of cytoplasm

perinuclear region of cytoplasm

collateral sprouting in absence of injury

presynaptic active zone

presynaptic active zone

positive regulation of inflammatory response

regulation of peptidyl-tyrosine phosphorylation

low-density lipoprotein particle receptor binding

RAGE receptor binding

regulation of synapse structure or activity

synapse organization

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

positive regulation of calcium-mediated signaling

neuromuscular process controlling balance

cognition

positive regulation of membrane protein ectodomain proteolysis

protein-folding chaperone binding

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

synaptic assembly at neuromuscular junction

spindle midzone

positive regulation of protein metabolic process

protein homooligomerization

protein tetramerization

neuron apoptotic process

neuron apoptotic process

PTB domain binding

smooth endoplasmic reticulum calcium ion homeostasis

recycling endosome

long-term synaptic potentiation

positive regulation of protein tyrosine kinase activity

antimicrobial humoral immune response mediated by antimicrobial peptide

neuron cellular homeostasis

protein trimerization

positive regulation of ERK1 and ERK2 cascade

endosome to plasma membrane transport vesicle

response to interleukin-1

growth factor receptor binding

cellular response to norepinephrine stimulus

positive regulation of monocyte chemotaxis

negative regulation of canonical Wnt signaling pathway

astrocyte projection

presynapse

postsynapse

modulation of excitatory postsynaptic potential

neuronal dense core vesicle

amyloid-beta complex

regulation of spontaneous synaptic transmission

cytoplasmic polyadenylation

positive regulation of receptor binding

negative regulation of protein localization to nucleus

regulation of amyloid-beta clearance

negative regulation of long-term synaptic potentiation

positive regulation of long-term synaptic potentiation

positive regulation of non-canonical NF-kappaB signal transduction

negative regulation of miRNA transcription

regulation of dendritic spine maintenance

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

regulation of acetylcholine-gated cation channel activity

regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of blood circulation

negative regulation of blood circulation

positive regulation of G protein-coupled receptor internalization

positive regulation of endothelin production

positive regulation of endothelin production

positive regulation of protein import

cellular response to amyloid-beta

regulation of presynapse assembly

positive regulation of response to endoplasmic reticulum stress

regulation of amyloid fibril formation

positive regulation of amyloid fibril formation

regulation of response to calcium ion

amyloid fibril formation

neuron projection maintenance

growth cone lamellipodium

lipoprotein particle

growth cone filopodium

positive regulation of T cell migration

positive regulation of excitatory postsynaptic potential

positive regulation of extrinsic apoptotic signaling pathway

05010

1419549_at Arg1 arginase, liver 10 -24915206 NM_007482 276

urea cycle

positive regulation of endothelial cell proliferation

adaptive immune response

immune system process

arginase activity

arginase activity

arginase activity

extracellular space

cytoplasm

cytoplasm

mitochondrial outer membrane

cytosol

arginine metabolic process

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

arginine catabolic process to ornithine

arginine catabolic process to ornithine

manganese ion binding

manganese ion binding

collagen biosynthetic process

negative regulation of T cell proliferation

identical protein binding

defense response to protozoan

neuronal cell body

innate immune response

negative regulation of activated T cell proliferation

metal ion binding

negative regulation of type II interferon-mediated signaling pathway

positive regulation of neutrophil mediated killing of fungus

regulation of L-arginine import across plasma membrane

negative regulation of T-helper 2 cell cytokine production

00330

01100

05146

1418847_at Arg2 arginase type II 12 79130787 NM_009705 119

urea cycle

ureteric bud development

adaptive immune response

immune system process

negative regulation of type 2 immune response

arginase activity

arginase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

arginine metabolic process

striated muscle contraction

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

arginine catabolic process to ornithine

arginine catabolic process to ornithine

manganese ion binding

regulation of interleukin-1 beta production

negative regulation of interleukin-13 production

negative regulation of interleukin-17 production

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor production

innate immune response

negative regulation of striated muscle contraction

metal ion binding

nitric-oxide synthase binding

negative regulation of macrophage inflammatory protein 1 alpha production

negative regulation of chemokine (C-C motif) ligand 4 production

negative regulation of chemokine (C-C motif) ligand 5 production

negative regulation of defense response to bacterium

regulation of reactive oxygen species biosynthetic process

negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process

regulation of L-arginine import across plasma membrane

negative regulation of CD4-positive, alpha-beta T cell proliferation

positive regulation of cellular senescence

00330

01100

05146

1448605_at Rhoc ras homolog family member C 3 104789033 NM_007484 46

nucleotide binding

mitotic cytokinesis

mitotic cytokinesis

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

nucleus

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

actin filament organization

signal transduction

small GTPase-mediated signal transduction

membrane

protein kinase binding

positive regulation of cell migration

positive regulation of protein-containing complex assembly

cleavage furrow

stereocilium

regulation of actin cytoskeleton organization

apical junction assembly

apical junction assembly

positive regulation of stress fiber assembly

positive regulation of lipase activity

 
1450897_at Arhgap5 Rho GTPase activating protein 5 12 52516076 BM248774 40

positive regulation of mesenchymal cell proliferation

GTPase activity

GTPase activator activity

GTPase activator activity

GTP binding

cytoplasm

endoplasmic reticulum

cytosol

cytosol

plasma membrane

signal transduction

Rho protein signal transduction

regulation of cell size

regulation of cell size

epithelial cell migration

positive regulation of epithelial cell migration

membrane

cell migration

mammary gland development

SH2 domain binding

04510

04670

1416735_at Asah1 N-acylsphingosine amidohydrolase 1 8 -41340645 NM_019734 64

transcription corepressor activity

extracellular region

extracellular space

nucleus

nucleus

lysosome

lipid metabolic process

fatty acid metabolic process

sphingolipid metabolic process

response to organic substance

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

nuclear receptor binding

N-acylsphingosine amidohydrolase activity

N-acylsphingosine amidohydrolase activity

N-acylsphingosine amidohydrolase activity

fatty acid amide hydrolase activity

keratinocyte differentiation

lung development

sphingosine biosynthetic process

sphingosine biosynthetic process

ceramide biosynthetic process

ceramide catabolic process

ceramide catabolic process

ceramide catabolic process

regulation of steroid biosynthetic process

regulation of programmed necrotic cell death

cellular response to tumor necrosis factor

ceramidase activity

00600

01100

04142

1429123_at Rab27a RAB27A, member RAS oncogene family 9 73064147, 73044809 BB025283 157

nucleotide binding

photoreceptor outer segment

GTPase activity

GTPase activity

G protein activity

protein binding

GTP binding

GTP binding

GTP binding

intracellular anatomical structure

lysosome

endosome

late endosome

Golgi apparatus

Golgi apparatus

exocytosis

exocytosis

blood coagulation

protein secretion

positive regulation of gene expression

membrane

vesicle-mediated transport

apical plasma membrane

apical plasma membrane

hydrolase activity

GDP binding

antigen processing and presentation

protein domain specific binding

secretory granule

secretory granule

secretory granule

melanocyte differentiation

dendrite

myosin V binding

melanosome localization

melanosome transport

multivesicular body membrane

Weibel-Palade body

multivesicular body organization

melanosome

melanosome

melanosome

cytotoxic T cell degranulation

natural killer cell degranulation

pigmentation

positive regulation of exocytosis

positive regulation of exocytosis

positive regulation of phagocytosis

pigment granule localization

pigment granule transport

exocytic vesicle

exocytic vesicle

multivesicular body sorting pathway

complement-dependent cytotoxicity

positive regulation of regulated secretory pathway

positive regulation of reactive oxygen species biosynthetic process

positive regulation of constitutive secretory pathway

exosomal secretion

 
1421205_at Atm ataxia telangiectasia mutated 9 -53437121 NM_007499 660

DNA damage checkpoint signaling

DNA damage checkpoint signaling

DNA damage checkpoint signaling

nucleotide binding

pexophagy

telomere maintenance

double-strand break repair via homologous recombination

chromosome, telomeric region

ovarian follicle development

response to hypoxia

somitogenesis

pre-B cell allelic exclusion

immune system process

immunoglobulin production

DNA binding

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

DNA-dependent protein kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

peroxisome

peroxisomal matrix

centrosome

spindle

cytoskeleton

DNA repair

DNA repair

protein phosphorylation

protein phosphorylation

protein phosphorylation

DNA damage response

DNA damage response

DNA damage response

cell cycle

mitotic spindle assembly checkpoint signaling

mitotic G2 DNA damage checkpoint signaling

male meiotic nuclear division

female meiotic nuclear division

female gamete generation

brain development

heart development

determination of adult lifespan

female gonad development

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

post-embryonic development

response to ionizing radiation

response to ionizing radiation

regulation of autophagy

regulation of autophagy

positive regulation of gene expression

kinase activity

1-phosphatidylinositol-3-kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

positive regulation of cell migration

negative regulation of B cell proliferation

cytoplasmic vesicle

regulation of telomere maintenance via telomerase

positive regulation of telomere maintenance via telomerase

V(D)J recombination

cellular response to reactive oxygen species

multicellular organism growth

histone H2AXS139 kinase activity

peptidyl-serine autophosphorylation

lipoprotein catabolic process

signal transduction in response to DNA damage

identical protein binding

positive regulation of apoptotic process

intracellular membrane-bounded organelle

positive regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of neuron apoptotic process

positive regulation of neuron apoptotic process

protein-containing complex binding

meiotic telomere clustering

positive regulation of cell adhesion

positive regulation of transcription by RNA polymerase II

protein autophosphorylation

thymus development

oocyte development

neuron apoptotic process

regulation of cell cycle

chromosome organization involved in meiotic cell cycle

histone mRNA catabolic process

cellular response to retinoic acid

cellular response to ionizing radiation

cellular response to gamma radiation

cellular response to X-ray

cellular response to nitrosative stress

replicative senescence

establishment of RNA localization to telomere

establishment of protein-containing complex localization to telomere

positive regulation of DNA catabolic process

regulation of microglial cell activation

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

negative regulation of telomere capping

positive regulation of telomere maintenance via telomere lengthening

positive regulation of telomerase catalytic core complex assembly

DNA repair complex

04110

04115

04210

1439036_a_at Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1 -164437098 AV152334 93

response to hypoxia

ATPase activator activity

ATPase activator activity

ATPase activator activity

blastocyst development

P-type sodium:potassium-exchanging transporter activity

protein binding

plasma membrane

plasma membrane

sodium:potassium-exchanging ATPase complex

sodium:potassium-exchanging ATPase complex

sodium:potassium-exchanging ATPase complex

caveola

monoatomic ion transport

potassium ion transport

sodium ion transport

intracellular calcium ion homeostasis

intracellular sodium ion homeostasis

intracellular sodium ion homeostasis

cell adhesion

establishment or maintenance of transmembrane electrochemical gradient

regulation of gene expression

regulation of cardiac muscle contraction by calcium ion signaling

intercalated disc

membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

lateral plasma membrane

protein kinase binding

metal ion transport

intracellular potassium ion homeostasis

intracellular potassium ion homeostasis

T-tubule

protein-macromolecule adaptor activity

organelle membrane

positive regulation of ATP-dependent activity

sodium ion transmembrane transport

sperm flagellum

sodium ion export across plasma membrane

sodium ion export across plasma membrane

sodium ion export across plasma membrane

sarcolemma

myelin sheath

ATP metabolic process

protein heterodimerization activity

protein stabilization

protein stabilization

ATPase binding

relaxation of cardiac muscle

cardiac muscle contraction

protein localization to plasma membrane

membrane repolarization

monoatomic cation transmembrane transport

positive regulation of potassium ion transmembrane transporter activity

proton transmembrane transport

regulation of calcium ion transmembrane transport

positive regulation of sodium ion export across plasma membrane

positive regulation of calcium:sodium antiporter activity

positive regulation of potassium ion import across plasma membrane

positive regulation of P-type sodium:potassium-exchanging transporter activity

positive regulation of P-type sodium:potassium-exchanging transporter activity

potassium ion import across plasma membrane

potassium ion import across plasma membrane

04260

04960

04964

04970

04971

04972

04973

04974

04976

1423126_at Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 9 -96332655, -96332655 BI080505 32

ATPase activator activity

ATPase activator activity

P-type sodium:potassium-exchanging transporter activity

protein binding

cytoplasm

plasma membrane

sodium:potassium-exchanging ATPase complex

sodium:potassium-exchanging ATPase complex

caveola

monoatomic ion transport

potassium ion transport

sodium ion transport

intracellular sodium ion homeostasis

intracellular sodium ion homeostasis

membrane

basolateral plasma membrane

apical plasma membrane

metal ion transport

intracellular potassium ion homeostasis

intracellular potassium ion homeostasis

protein-macromolecule adaptor activity

positive regulation of ATP-dependent activity

sodium ion transmembrane transport

sperm flagellum

sodium ion export across plasma membrane

sodium ion export across plasma membrane

protein stabilization

ATPase binding

potassium ion transmembrane transport

protein localization to plasma membrane

membrane repolarization

positive regulation of potassium ion transmembrane transporter activity

positive regulation of sodium ion export across plasma membrane

positive regulation of potassium ion import across plasma membrane

potassium ion import across plasma membrane

potassium ion import across plasma membrane

04260

04960

04964

04970

04971

04972

04973

04974

04976

1438809_at Atp5f1c ATP synthase F1 subunit gamma 2 -10056030, -10056030 AI644507 53

mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

protein binding

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

mitochondrial proton-transporting ATP synthase complex

ATP biosynthetic process

monoatomic ion transport

proton motive force-driven ATP synthesis

proton motive force-driven ATP synthesis

membrane

ATP hydrolysis activity

proton motive force-driven mitochondrial ATP synthesis

myelin sheath

proton-transporting ATP synthase complex, catalytic core F(1)

proton-transporting ATP synthase activity, rotational mechanism

proton-transporting ATP synthase activity, rotational mechanism

proton transmembrane transport

00190

01100

05010

05012

05016

1422508_at Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 16 -44085403 NM_007508 50

nucleotide binding

vacuolar proton-transporting V-type ATPase, V1 domain

ATP binding

nucleoplasm

cytoplasm

mitochondrion

lysosome

cytosol

cytosol

plasma membrane

microvillus

monoatomic ion transport

intracellular iron ion homeostasis

membrane

apical plasma membrane

ATP hydrolysis activity

secretory granule

cytoplasmic vesicle

proton-transporting V-type ATPase complex

proton-transporting V-type ATPase, V1 domain

cellular response to increased oxygen levels

myelin sheath

intracellular membrane-bounded organelle

ATP metabolic process

proton-transporting ATP synthase activity, rotational mechanism

proton-transporting ATPase activity, rotational mechanism

proton-transporting ATPase activity, rotational mechanism

synaptic vesicle lumen acidification

synaptic vesicle lumen acidification

synaptic vesicle lumen acidification

extrinsic component of synaptic vesicle membrane

transmembrane transporter complex

proton transmembrane transport

proton transmembrane transport

ATPase complex

00190

01100

04145

04966

05323

1436515_at Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 4 32417434 BB529913 101

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

cytoplasm

cytosol

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

ion binding

import into nucleus

RNA polymerase II transcription regulator complex

primary adaptive immune response involving T cells and B cells

sequence-specific double-stranded DNA binding

 
1440770_at Bcl2 B cell leukemia/lymphoma 2 1 -106538175, -106712164 AI505544 792

G1/S transition of mitotic cell cycle

protein polyubiquitination

mitotic cell cycle

cell morphogenesis

cell morphogenesis

response to acid chemical

ossification

ovarian follicle development

metanephros development

ureteric bud development

branching involved in ureteric bud morphogenesis

branching involved in ureteric bud morphogenesis

behavioral fear response

leukocyte homeostasis

B cell homeostasis

B cell apoptotic process

B cell apoptotic process

kidney development

kidney development

release of cytochrome c from mitochondria

regulation of cell-matrix adhesion

protease binding

lymphocyte homeostasis

lymphocyte homeostasis

lymphoid progenitor cell differentiation

B cell lineage commitment

T cell lineage commitment

immune system development

negative regulation of B cell apoptotic process

response to ischemia

renal system process

protein binding

intracellular anatomical structure

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

cytosol

protein dephosphorylation

melanin metabolic process

regulation of nitrogen utilization

intracellular calcium ion homeostasis

apoptotic process

apoptotic process

DNA damage response

response to oxidative stress

actin filament organization

axonogenesis

transcription factor binding

cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

male gonad development

extrinsic apoptotic signaling pathway via death domain receptors

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to oxidative stress

apoptotic mitochondrial changes

response to xenobiotic stimulus

response to xenobiotic stimulus

response to toxic substance

response to toxic substance

post-embryonic development

post-embryonic development

post-embryonic development

animal organ morphogenesis

response to iron ion

response to UV-B

response to gamma radiation

regulation of gene expression

regulation of autophagy

negative regulation of autophagy

negative regulation of autophagy

negative regulation of calcium ion transport into cytosol

regulation of glycoprotein biosynthetic process

negative regulation of cardiac muscle cell apoptotic process

mesenchymal cell development

positive regulation of neuron maturation

smooth muscle cell migration

positive regulation of smooth muscle cell migration

channel activity

membrane

membrane

cell growth

channel inhibitor activity

cell migration

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

protein phosphatase binding

cochlear nucleus development

gland morphogenesis

regulation of transmembrane transporter activity

mitochondrial crista

hemopoiesis

B cell differentiation

T cell differentiation

T cell differentiation

negative regulation of ossification

positive regulation of cell growth

negative regulation of cell growth

melanocyte differentiation

melanocyte differentiation

negative regulation of cell migration

positive regulation of B cell proliferation

hair follicle morphogenesis

axon regeneration

ubiquitin protein ligase binding

regulation of protein stability

nuclear membrane

nuclear membrane

mitochondrial membrane

endoplasmic reticulum calcium ion homeostasis

glomerulus development

negative regulation of cellular pH reduction

regulation of protein localization

protein-containing complex

myeloid cell apoptotic process

negative regulation of myeloid cell apoptotic process

T cell differentiation in thymus

positive regulation of peptidyl-serine phosphorylation

osteoblast proliferation

negative regulation of osteoblast proliferation

response to cytokine

response to cytokine

response to nicotine

organ growth

regulation of growth

positive regulation of multicellular organism growth

B cell proliferation

cellular response to glucose starvation

response to hydrogen peroxide

neuron maturation

identical protein binding

protein homodimerization activity

regulation of apoptotic process

T cell homeostasis

T cell homeostasis

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

regulation of programmed cell death

positive regulation of catalytic activity

myelin sheath

CD8-positive, alpha-beta T cell lineage commitment

pigmentation

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

ear development

ear development

protein-containing complex binding

regulation of viral genome replication

response to ethanol

positive regulation of melanocyte differentiation

negative regulation of mitotic cell cycle

retinal cell programmed cell death

negative regulation of retinal cell programmed cell death

regulation of mitochondrial membrane permeability

pore complex

protein heterodimerization activity

protein heterodimerization activity

focal adhesion assembly

developmental pigmentation

developmental pigmentation

developmental pigmentation

regulation of developmental pigmentation

positive regulation of developmental pigmentation

positive regulation of developmental pigmentation

perinuclear region of cytoplasm

spleen development

spleen development

thymus development

thymus development

response to steroid hormone

digestive tract morphogenesis

developmental growth

oocyte development

skeletal muscle fiber development

positive regulation of skeletal muscle fiber development

pigment granule organization

stem cell development

homeostasis of number of cells within a tissue

regulation of catalytic activity

B cell receptor signaling pathway

response to glucocorticoid

response to glucocorticoid

BH domain binding

neuron apoptotic process

neuron apoptotic process

neuron apoptotic process

BH3 domain binding

defense response to virus

establishment of localization in cell

protein phosphatase 2A binding

regulation of cell cycle

regulation of mitochondrial membrane potential

regulation of calcium ion transport

molecular adaptor activity

hematopoietic stem cell differentiation

calcium ion transport into cytosol

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

lymphocyte apoptotic process

negative regulation of lymphocyte apoptotic process

T cell apoptotic process

T cell apoptotic process

negative regulation of T cell apoptotic process

cellular response to organic substance

cellular response to hypoxia

reactive oxygen species metabolic process

dendritic cell apoptotic process

motor neuron apoptotic process

BAD-BCL-2 complex

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway in absence of ligand

cell-cell adhesion

DNA-binding transcription factor binding

epithelial cell apoptotic process

negative regulation of epithelial cell apoptotic process

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of reactive oxygen species metabolic process

negative regulation of dendritic cell apoptotic process

negative regulation of motor neuron apoptotic process

negative regulation of anoikis

negative regulation of apoptotic signaling pathway

negative regulation of apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway

04141

04210

04510

04722

05014

05145

05200

05210

05215

05222

1418133_at Bcl3 B cell leukemia/lymphoma 3 7 -19808461 NM_033601 93

follicular dendritic cell differentiation

marginal zone B cell differentiation

humoral immune response mediated by circulating immunoglobulin

germinal center formation

transcription coactivator activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

plasma membrane

protein import into nucleus

DNA damage response

canonical NF-kappaB signal transduction

response to virus

response to UV-C

antimicrobial humoral response

extracellular matrix organization

DNA damage response, signal transduction by p53 class mediator

midbody

protein-macromolecule adaptor activity

negative regulation of NF-kappaB transcription factor activity

type II interferon production

negative regulation of interleukin-8 production

negative regulation of tumor necrosis factor production

positive regulation of type II interferon production

positive regulation of interleukin-10 production

protein-containing complex

Bcl3-Bcl10 complex

Bcl3/NF-kappaB2 complex

Bcl3/NF-kappaB2 complex

T-helper 1 type immune response

defense response to bacterium

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

histone deacetylase binding

histone deacetylase binding

defense response to protozoan

regulation of apoptotic process

regulation of apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

T-helper 2 cell differentiation

positive regulation of translation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of receptor signaling pathway via JAK-STAT

spleen development

T cell apoptotic process

T cell apoptotic process

negative regulation of T cell apoptotic process

negative regulation of T cell apoptotic process

DNA-binding transcription factor binding

DNA-binding transcription factor binding

 
1450624_at Bhmt betaine-homocysteine methyltransferase 13 -93616890 NM_016668 46

nucleus

cytosol

cytosol

amino-acid betaine metabolic process

methyltransferase activity

zinc ion binding

methionine biosynthetic process

methionine biosynthetic process

protein-containing complex

identical protein binding

protein-containing complex binding

betaine-homocysteine S-methyltransferase activity

betaine-homocysteine S-methyltransferase activity

betaine-homocysteine S-methyltransferase activity

extracellular exosome

'de novo' L-methionine biosynthetic process

L-methionine salvage

L-methionine salvage

00260

00270

01100

1450779_at Fabp7 fatty acid binding protein 7, brain 10 57784922 NM_021272 376

startle response

fatty acid binding

fatty acid binding

nucleus

cytoplasm

cytosol

cytosol

cell-cell junction

lipid binding

fatty acid transport

cell proliferation in forebrain

neurogenesis

cell projection

neuronal cell body

epithelial cell proliferation

prepulse inhibition

cell periphery

03320

1422775_at Blk B lymphoid kinase 14 -63372836 NM_007549 44

nucleotide binding

protein kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

signaling receptor binding

protein binding

ATP binding

cytosol

plasma membrane

protein phosphorylation

protein phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

cell differentiation

positive regulation of insulin secretion

positive regulation of protein binding

innate immune response

B cell receptor signaling pathway

 
1422003_at Cxcr5 C-X-C motif chemokine receptor 5 9 -44511786 NM_007551 159

G protein-coupled receptor activity

plasma membrane

chemotaxis

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

external side of plasma membrane

membrane

C-C chemokine receptor activity

C-X-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

leukocyte chemotaxis

positive regulation of cytokinesis

B cell activation

lymph node development

cell chemotaxis

04060

04062

1448733_at Bmi1 Bmi1 polycomb ring finger oncogene 2 18677017 M64279 354

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

ubiquitin ligase complex

heterochromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

skeletal system development

in utero embryonic development

chromatin binding

protein binding

nucleus

cytoplasm

cytosol

DNA methylation

chromatin organization

chromatin organization

humoral immune response

brain development

zinc ion binding

nuclear body

nuclear body

rostrocaudal neural tube patterning

positive regulation of B cell proliferation

PcG protein complex

PcG protein complex

positive regulation of immature T cell proliferation in thymus

PRC1 complex

PRC1 complex

PRC1 complex

sequence-specific DNA binding

metal ion binding

somatic stem cell division

embryonic skeletal system morphogenesis

embryonic skeletal system development

hematopoietic stem cell homeostasis

RING-like zinc finger domain binding

ubiquitin-protein transferase activator activity

apoptotic signaling pathway

promoter-specific chromatin binding

promoter-specific chromatin binding

promoter-specific chromatin binding

regulation of adaxial/abaxial pattern formation

negative regulation of apoptotic signaling pathway

 
1422084_at Bmx BMX non-receptor tyrosine kinase X -164192841 AF012104 37

nucleotide binding

adaptive immune response

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

ATP binding

nucleoplasm

cytoplasm

plasma membrane

plasma membrane

protein phosphorylation

protein phosphorylation

apoptotic process

cell adhesion

signal transduction

kinase activity

phosphorylation

transferase activity

ruffle membrane

intracellular signal transduction

protein autophosphorylation

metal ion binding

B cell receptor signaling pathway

 
1449453_at Bst1 bone marrow stromal cell antigen 1 5 43818892 AI647987 39

uropod

regulation of cell-matrix adhesion

NAD+ nucleosidase activity

NAD+ nucleosidase activity

plasma membrane

plasma membrane

positive regulation of cell population proliferation

membrane

transferase activity

hydrolase activity

phosphorus-oxygen lyase activity

positive regulation of B cell proliferation

regulation of actin cytoskeleton organization

NADP+ nucleosidase activity

regulation of inflammatory response

regulation of peptidyl-tyrosine phosphorylation

regulation of calcium-mediated signaling

NAD+ nucleotidase, cyclic ADP-ribose generating

regulation of neutrophil chemotaxis

side of membrane

00760

01100

04020

04970

04972

1450644_at Zfp36l1 zinc finger protein 36, C3H type-like 1 12 -80107759 M58566 57

MAPK cascade

MAPK cascade

MAPK cascade

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

P-body

vasculogenesis

proepicardium development

DNA binding

RNA binding

mRNA binding

mRNA binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

mRNA processing

mRNA catabolic process

regulation of translation

apoptotic process

multicellular organism development

heart development

cell population proliferation

response to wounding

regulation of gene expression

regulation of keratinocyte proliferation

neural tube development

nuclear-transcribed mRNA catabolic process, deadenylation-independent decay

regulation of mRNA 3'-end processing

cellular response to insulin stimulus

T cell differentiation in thymus

T cell differentiation in thymus

multicellular organism growth

mRNA 3'-UTR AU-rich region binding

mRNA 3'-UTR AU-rich region binding

mRNA 3'-UTR AU-rich region binding

p38MAPK cascade

regulation of mRNA stability

regulation of mRNA stability

regulation of mRNA stability

phosphatidylinositol 3-kinase/protein kinase B signal transduction

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular response to fibroblast growth factor stimulus

regulation of B cell differentiation

positive regulation of fat cell differentiation

regulation of keratinocyte differentiation

negative regulation of erythrocyte differentiation

positive regulation of monocyte differentiation

regulation of myoblast differentiation

metal ion binding

mesendoderm development

embryonic organ development

mRNA transport

chorio-allantoic fusion

spongiotrophoblast layer development

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA destabilization

ERK1 and ERK2 cascade

cellular response to cAMP

cellular response to cAMP

cellular response to tumor necrosis factor

cellular response to epidermal growth factor stimulus

cellular response to peptide hormone stimulus

cellular response to peptide hormone stimulus

cellular response to glucocorticoid stimulus

cellular response to hypoxia

cellular response to salt stress

cellular response to transforming growth factor beta stimulus

14-3-3 protein binding

regulation of stem cell proliferation

cellular response to raffinose

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

negative regulation of mitotic cell cycle phase transition

regulation of keratinocyte apoptotic process

positive regulation of intracellular mRNA localization

ribonucleoprotein complex

ribonucleoprotein complex

ribonucleoprotein complex

 
1451021_a_at Klf5 Kruppel-like transcription factor 5 14 99298690 BI465857 179

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

angiogenesis

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

Golgi apparatus

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of gene expression

skeletal muscle satellite cell differentiation

satellite cell activation involved in skeletal muscle regeneration

myotube differentiation involved in skeletal muscle regeneration

myotube differentiation involved in skeletal muscle regeneration

microvillus assembly

regulation of microvillus assembly

skeletal muscle cell differentiation

intracellular membrane-bounded organelle

skeletal muscle tissue regeneration

MRF binding

sequence-specific DNA binding

positive regulation of fat cell differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

intestinal epithelial cell development

positive regulation of transcription by transcription factor localization

cell-cell signaling via exosome

positive regulation of miRNA transcription

cellular response to leukemia inhibitory factor

sequence-specific double-stranded DNA binding

 
1442018_at Btg1 BTG anti-proliferation factor 1 10 96617000 BE632903 50

nucleus

nucleus

cytoplasm

cytoplasm

protein methylation

cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

enzyme binding

positive regulation of catalytic activity

positive regulation of endothelial cell differentiation

positive regulation of myoblast differentiation

positive regulation of angiogenesis

negative regulation of mitotic cell cycle

positive regulation of fibroblast apoptotic process

03018

1438948_x_at Tspo translocator protein 15 83563572 AV101079 142

androgen binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

cytosol

steroid biosynthetic process

monoatomic ion transport

chloride transport

lipid transport

glial cell migration

benzodiazepine receptor activity

negative regulation of mitochondrion organization

cholesterol binding

membrane

negative regulation of protein ubiquitination

negative regulation of tumor necrosis factor production

cholesterol homeostasis

positive regulation of apoptotic process

intracellular membrane-bounded organelle

transmembrane transporter binding

negative regulation of nitric oxide biosynthetic process

behavioral response to pain

regulation of steroid biosynthetic process

positive regulation of mitochondrial depolarization

positive regulation of calcium ion transport

contact inhibition

positive regulation of glial cell proliferation

negative regulation of glial cell proliferation

positive regulation of programmed necrotic cell death

establishment of protein localization to mitochondrion

maintenance of protein location in mitochondrion

negative regulation of mitophagy

negative regulation of ATP metabolic process

response to acetylcholine

positive regulation of reactive oxygen species metabolic process

positive regulation of reactive oxygen species metabolic process

negative regulation of corticosterone secretion

04080

1416625_at Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 -84765359 NM_009776 43

complement binding

negative regulation of complement activation, lectin pathway

immune system process

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

complement activation, classical pathway

blood coagulation

hemostasis

negative regulation of peptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

fibrinolysis

innate immune response

collagen-containing extracellular matrix

04610

1449401_at C1qc complement component 1, q subcomponent, C chain 4 -136889801 NM_007574 34

immune system process

extracellular region

extracellular region

collagen trimer

complement component C1 complex

extracellular space

complement activation, classical pathway

complement activation, classical pathway

negative regulation of granulocyte differentiation

innate immune response

synapse

synapse

synapse

negative regulation of macrophage differentiation

complement component C1q complex

postsynapse

synapse pruning

04610

05020

05142

05150

05322

1421211_a_at Ciita class II transactivator 16 10480071, 10489780, 10488177 AF042158 187

negative regulation of transcription by RNA polymerase II

nucleotide binding

transcription cis-regulatory region binding

protein serine/threonine kinase activity

protein binding

ATP binding

GTP binding

nucleus

nucleoplasm

cytosol

regulation of DNA-templated transcription

cell surface

kinase activity

phosphorylation

PML body

transferase activity

acyltransferase activity

response to type II interferon

response to type II interferon

protein-containing complex binding

positive regulation of MHC class I biosynthetic process

positive regulation of MHC class I biosynthetic process

positive regulation of MHC class II biosynthetic process

positive regulation of MHC class II biosynthetic process

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of viral entry into host cell

response to antibiotic

DNA-binding transcription factor binding

04612

05145

05340

1423954_at C3 complement component 3 17 -57203966 K02782 681

positive regulation of type IIa hypersensitivity

positive regulation of protein phosphorylation

positive regulation of activation of membrane attack complex

immune system process

complement receptor mediated signaling pathway

endopeptidase inhibitor activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

lipid metabolic process

fatty acid metabolic process

inflammatory response

complement activation

complement activation

complement activation

complement activation

complement activation, alternative pathway

complement activation, classical pathway

lipid binding

response to bacterium

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of glucose transmembrane transport

regulation of triglyceride biosynthetic process

positive regulation of lipid storage

neuron remodeling

C5L2 anaphylatoxin chemotactic receptor binding

protein-containing complex

oviduct epithelium development

vascular associated smooth muscle cell differentiation

innate immune response

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of angiogenesis

positive regulation of receptor-mediated endocytosis

positive regulation of receptor-mediated endocytosis

positive regulation of developmental growth

positive regulation of phagocytosis

retina development in camera-type eye

positive regulation of phagocytosis, engulfment

positive regulation of phagocytosis, engulfment

positive regulation of ERK1 and ERK2 cascade

amyloid-beta clearance

amyloid-beta clearance

complement-dependent cytotoxicity

complement-mediated synapse pruning

vertebrate eye-specific patterning

positive regulation of apoptotic cell clearance

04145

04610

05140

05142

05150

05322

1439902_at C5ar1 complement component 5a receptor 1 7 -16246742, -16246744 BB552085 290

microglial cell activation

complement component C5a binding

complement receptor mediated signaling pathway

complement receptor activity

complement component C5a receptor activity

complement component C5a receptor activity

complement component C5a receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

chemotaxis

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

cell surface

positive regulation of vascular endothelial growth factor production

positive regulation of macrophage chemotaxis

membrane

basolateral plasma membrane

cell proliferation in hindbrain

neutrophil chemotaxis

cytoplasmic vesicle

response to peptidoglycan

complement component C5a signaling pathway

mRNA transcription by RNA polymerase II

negative regulation of neuron apoptotic process

apical part of cell

positive regulation of angiogenesis

astrocyte activation

positive regulation of epithelial cell proliferation

defense response to Gram-positive bacterium

cognition

positive regulation of ERK1 and ERK2 cascade

positive regulation of neutrophil chemotaxis

amyloid-beta clearance

presynapse organization

regulation of tau-protein kinase activity

04080

04610

05150

1419091_a_at Anxa2 annexin A2 9 69453682 NM_007585 171

angiogenesis

cornified envelope

stress fiber

ruffle

phosphatidylserine binding

positive regulation of receptor recycling

positive regulation of protein phosphorylation

protease binding

phospholipase inhibitor activity

serine-type endopeptidase inhibitor activity

calcium ion binding

protein binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

phosphatidylinositol-4,5-bisphosphate binding

extracellular region

basement membrane

extracellular space

cytoplasm

cytoplasm

cytoplasm

lysosomal membrane

endosome

early endosome

lipid droplet

cytosol

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

cell cortex

cell adhesion

cell-matrix adhesion

body fluid secretion

cytoskeletal protein binding

cell surface

cell surface

response to activity

membrane

membrane

basolateral plasma membrane

nuclear matrix

phospholipase A2 inhibitor activity

cell junction

collagen fibril organization

lung development

midbody

small GTPase binding

late endosome membrane

vesicle

negative regulation of low-density lipoprotein particle receptor catabolic process

protein-containing complex

myelin sheath adaxonal region

sarcolemma

fibrinolysis

mRNA transcription by RNA polymerase II

identical protein binding

Schmidt-Lanterman incisure

macropinosome

S100 protein binding

bone sialoprotein binding

membrane raft

positive regulation of exocytosis

positive regulation of transcription by RNA polymerase II

positive regulation of fibroblast proliferation

calcium-dependent protein binding

perinuclear region of cytoplasm

regulation of neurogenesis

positive regulation of binding

collagen-containing extracellular matrix

extracellular exosome

cellular response to acid chemical

protein localization to plasma membrane

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

plasma membrane protein complex

plasma membrane protein complex

plasma membrane protein complex

epithelial cell apoptotic process

positive regulation of low-density lipoprotein particle clearance

positive regulation of low-density lipoprotein particle receptor binding

positive regulation of low-density lipoprotein receptor activity

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

positive regulation of receptor-mediated endocytosis involved in cholesterol transport

positive regulation of plasma membrane repair

AnxA2-p11 complex

PCSK9-AnxA2 complex

 
1423097_s_at Capn7 calpain 7 14 31336637 BQ257745 23

endopeptidase activity

cysteine-type endopeptidase activity

calcium-dependent cysteine-type endopeptidase activity

nucleus

centrosome

cytosol

proteolysis

proteolysis

peptidase activity

cysteine-type peptidase activity

positive regulation of epithelial cell migration

hydrolase activity

MIT domain binding

self proteolysis

 
1449434_at Car3 carbonic anhydrase 3 3 14863537 NM_007606 68

carbonate dehydratase activity

carbonate dehydratase activity

cytoplasm

cytoplasm

cytosol

cytosol

cytosol

one-carbon metabolic process

response to oxidative stress

zinc ion binding

response to bacterium

nickel cation binding

phosphatase activity

lyase activity

metal ion binding

00910

1448949_at Car4 carbonic anhydrase 4 11 84957753 NM_007607 66

carbonate dehydratase activity

carbonate dehydratase activity

carbonate dehydratase activity

protein binding

rough endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

Golgi apparatus

trans-Golgi network

plasma membrane

plasma membrane

plasma membrane

one-carbon metabolic process

regulation of pH

zinc ion binding

external side of plasma membrane

cell surface

carbon dioxide transport

bicarbonate transport

membrane

apical plasma membrane

sarcoplasmic reticulum

lyase activity

transport vesicle membrane

secretory granule membrane

brush border membrane

sarcolemma

metal ion binding

perinuclear region of cytoplasm

extracellular exosome

side of membrane

00910

1449265_at Casp1 caspase 1 9 5298516 BC008152 965

response to hypoxia

response to hypoxia

microglial cell activation

positive regulation of cytokine production

positive regulation of cytokine production

pattern recognition receptor signaling pathway

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

protein binding

extracellular region

cytoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

cytosol

cytosol

microtubule

plasma membrane

proteolysis

apoptotic process

osmosensory signaling pathway

myoblast fusion

memory

peptidase activity

cysteine-type peptidase activity

response to xenobiotic stimulus

response to bacterium

regulation of autophagy

macrophage cytokine production

response to organic cyclic compound

membrane

protein processing

protein processing

protein autoprocessing

protein autoprocessing

hydrolase activity

kinase binding

response to lipopolysaccharide

response to lipopolysaccharide

interleukin-1 alpha production

interleukin-1 beta production

interleukin-1 beta production

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-18 production

protein-containing complex

response to ATP

defense response to bacterium

identical protein binding

regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

positive regulation of circadian sleep/wake cycle, non-REM sleep

CARD domain binding

regulation of inflammatory response

regulation of inflammatory response

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of inflammatory response

defense response to Gram-negative bacterium

protein maturation

protein maturation

defense response to virus

mitochondrial depolarization

membrane hyperpolarization

positive regulation of macrophage cytokine production

canonical inflammasome complex

pyroptosis

pyroptosis

pyroptosis

pyroptosis

cellular response to lipopolysaccharide

cellular response to organic substance

cellular response to type II interferon

IPAF inflammasome complex

IPAF inflammasome complex

NLRP1 inflammasome complex

NLRP1 inflammasome complex

NLRP3 inflammasome complex

NLRP3 inflammasome complex

caspase binding

scaffold protein binding

AIM2 inflammasome complex

AIM2 inflammasome complex

protease inhibitor complex

programmed necrotic cell death

cytokine precursor processing

signaling receptor ligand precursor processing

AIM2 inflammasome complex assembly

AIM2 inflammasome complex assembly

positive regulation of tumor necrosis factor-mediated signaling pathway

04621

04623

05014

1449591_at Casp4 caspase 4, apoptosis-related cysteine peptidase 9 5308848, 5308859 NM_007609 281

lipopolysaccharide binding

lipopolysaccharide binding

immune system process

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

protein binding

extracellular region

cytoplasm

cytoplasm

mitochondrion

endoplasmic reticulum

cytosol

cytosol

plasma membrane

proteolysis

inflammatory response

actin filament organization

peptidase activity

cysteine-type peptidase activity

lipid binding

macrophage cytokine production

programmed cell death

membrane

protein autoprocessing

protein autoprocessing

hydrolase activity

detection of lipopolysaccharide

interleukin-1 beta production

positive regulation of interleukin-1 beta production

protein-containing complex

ectopic germ cell programmed cell death

ectopic germ cell programmed cell death

defense response to bacterium

defense response to bacterium

regulation of apoptotic process

neuronal cell body

positive regulation of neuron apoptotic process

innate immune response

CARD domain binding

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of inflammatory response

defense response to Gram-positive bacterium

protein maturation

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

canonical inflammasome complex

pyroptosis

pyroptosis

NLRP1 inflammasome complex

NLRP1 inflammasome complex

scaffold protein binding

non-canonical inflammasome complex

non-canonical inflammasome complex

non-canonical inflammasome complex assembly

non-canonical inflammasome complex assembly

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of interleukin-18-mediated signaling pathway

 
1433718_a_at Cbx1 chromobox 1 11 96789134, 96789134 BB224832 107

negative regulation of transcription by RNA polymerase II

chromosome, centromeric region

chromosome, telomeric region

chromatin

chromatin

female pronucleus

male pronucleus

DNA binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

pericentric heterochromatin

pericentric heterochromatin

spindle

chromatin organization

DNA damage response

chromocenter

nuclear body

enzyme binding

methylated histone binding

identical protein binding

intracellular membrane-bounded organelle

negative regulation of DNA-templated transcription

molecular adaptor activity

site of DNA damage

histone methyltransferase binding

 
1419583_at Cbx4 chromobox 4 11 -119077570 NM_007625 48

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

chromatin binding

single-stranded RNA binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

chromatin organization

nuclear body

nuclear body

transferase activity

protein sumoylation

protein sumoylation

SUMO transferase activity

SUMO transferase activity

enzyme binding

PcG protein complex

SUMO binding

SUMO binding

SUMO binding

methylated histone binding

PRC1 complex

PRC1 complex

negative regulation of DNA-templated transcription

phosphoprotein binding

SUMO ligase activity

SUMO ligase activity

 
1425837_a_at Noct nocturnin 3 51224446 AF199491 49

3'-5'-RNA exonuclease activity

deadenylation-dependent decapping of nuclear-transcribed mRNA

P-body

RNA binding

mRNA binding

catalytic activity

poly(A)-specific ribonuclease activity

poly(A)-specific ribonuclease activity

protein binding

nucleus

cytoplasm

mitochondrion

NADP metabolic process

circadian rhythm

response to extracellular stimulus

negative regulation of gene expression

hydrolase activity

NADP phosphatase activity

response to lipopolysaccharide

circadian regulation of gene expression

P-body assembly

regulation of circadian rhythm

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

regulation of embryonic development

metal ion binding

mRNA stabilization

perinuclear region of cytoplasm

rhythmic process

NADPH phosphatase activity

 
1450357_a_at Ccr6 C-C motif chemokine receptor 6 17 8243806, 8236042, 8245057, 8242525 NM_009835 182

leukocyte migration involved in inflammatory response

G protein-coupled receptor activity

chemokine receptor activity

protein binding

plasma membrane

chemotaxis

chemotaxis

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

positive regulation of epithelial cell migration

membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

calcium-mediated signaling

C-C chemokine binding

C-C chemokine binding

C-C chemokine binding

sperm flagellum

sperm flagellum

isotype switching to IgA isotypes

cell chemotaxis

cell chemotaxis

positive regulation of flagellated sperm motility involved in capacitation

positive regulation of flagellated sperm motility involved in capacitation

lymphocyte migration

T cell migration

thymocyte migration

thymocyte migration

sperm midpiece

sperm principal piece

sperm principal piece

sperm plasma membrane

sperm plasma membrane

DN2 thymocyte differentiation

DN3 thymocyte differentiation

regulation of T cell migration

positive regulation of dendritic cell chemotaxis

positive regulation of dendritic cell chemotaxis

04060

04062

1417268_at Cd14 CD14 antigen 18 -36725063 NM_009841 285

lipopolysaccharide binding

lipopolysaccharide binding

positive regulation of cytokine production

positive regulation of cytokine production

lipopolysaccharide immune receptor activity

response to molecule of bacterial origin

immune system process

cell surface pattern recognition receptor signaling pathway

extracellular region

extracellular space

Golgi apparatus

plasma membrane

receptor-mediated endocytosis

inflammatory response

response to bacterium

response to bacterium

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

positive regulation of lipopolysaccharide-mediated signaling pathway

positive regulation of type I interferon production

positive regulation of type II interferon production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

positive regulation of toll-like receptor 4 signaling pathway

response to tumor necrosis factor

innate immune response

membrane raft

membrane raft

membrane raft

positive regulation of endocytosis

lipopolysaccharide receptor complex

lipopolysaccharide receptor complex

lipoteichoic acid binding

cellular response to molecule of bacterial origin

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipoteichoic acid

cellular response to diacyl bacterial lipopeptide

cellular response to triacyl bacterial lipopeptide

side of membrane

04010

04145

04620

04640

04810

05146

1450570_a_at Cd19 CD19 antigen 7 -126408447 NM_009844 836

B-1 B cell differentiation

adaptive immune response

B cell proliferation involved in immune response

immune system process

plasma membrane

plasma membrane

plasma membrane

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

membrane

immunoglobulin mediated immune response

B cell mediated immunity

protein-containing complex

antigen receptor-mediated signaling pathway

B cell receptor signaling pathway

B cell receptor signaling pathway

B cell receptor signaling pathway

regulation of B cell receptor signaling pathway

regulation of B cell receptor signaling pathway

regulation of B cell activation

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

04640

04662

05340

1418770_at Cd2 CD2 antigen 3 -101275907 NM_013486 72

signaling receptor binding

signaling receptor binding

protein binding

extracellular region

nucleoplasm

Golgi apparatus

plasma membrane

plasma membrane

cell-cell junction

cell adhesion

external side of plasma membrane

external side of plasma membrane

cytoplasmic side of plasma membrane

cell surface

membrane

protein kinase binding

natural killer cell activation

receptor tyrosine kinase binding

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

protein-containing complex

heterotypic cell-cell adhesion

natural killer cell mediated cytotoxicity

identical protein binding

identical protein binding

protein self-association

cell-cell adhesion

cell-cell adhesion

04514

04640

1450912_at Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 19 -11249678 BB236617 50

store-operated calcium entry

epidermal growth factor receptor binding

nucleoplasm

plasma membrane

plasma membrane

cell surface receptor signaling pathway

response to bacterium

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

immunoglobulin binding

B cell differentiation

B cell activation

identical protein binding

plasma membrane raft

B cell receptor signaling pathway

protein tetramerization

calcium ion import into cytosol

positive regulation of calcium ion import across plasma membrane

04640

1419768_at Cd22 CD22 antigen 7 -30865403, -30865403 AF102134 145

negative regulation of immunoglobulin production

protein binding

early endosome

early endosome

plasma membrane

cell adhesion

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

coreceptor activity

membrane

protein phosphatase binding

protein phosphatase binding

regulation of endocytosis

carbohydrate binding

regulation of B cell proliferation

regulation of B cell proliferation

neuronal cell body membrane

sialic acid binding

sialic acid binding

B cell activation

B cell activation

CD4 receptor binding

CD4 receptor binding

regulation of immune response

negative regulation of calcium-mediated signaling

negative regulation of B cell receptor signaling pathway

negative regulation of B cell receptor signaling pathway

recycling endosome

recycling endosome

04514

04640

04662

1437025_at Cd28 CD28 antigen 1 60746387 AV313615 529

immunological synapse

protease binding

positive regulation of inflammatory response to antigenic stimulus

plasma membrane

transcription by RNA polymerase II

immune response

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

positive regulation of gene expression

negative regulation of gene expression

membrane

protein kinase binding

T cell costimulation

T cell costimulation

T cell costimulation

T cell costimulation

T cell costimulation

interleukin-2 production

positive regulation of interleukin-10 production

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

positive regulation of interleukin-4 production

CD4-positive, alpha-beta T cell proliferation

CD4-positive, alpha-beta T cell proliferation

T cell proliferation

T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

T cell activation

T cell activation

regulation of T cell proliferation

identical protein binding

phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative thymic T cell selection

regulatory T cell differentiation

regulation of regulatory T cell differentiation

positive regulation of mitotic nuclear division

positive regulation of transcription by RNA polymerase II

positive regulation of isotype switching to IgG isotypes

T cell receptor signaling pathway

T cell receptor signaling pathway

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

apoptotic signaling pathway

protein complex involved in cell adhesion

positive regulation of CD4-positive, alpha-beta T cell proliferation

positive regulation of CD4-positive, alpha-beta T cell proliferation

04514

04660

04672

04940

05320

05322

05323

05330

05332

05416

1450513_at Cd33 CD33 molecule 7 -43527455 NM_021293 27

nucleoplasm

peroxisome

Golgi apparatus

cytosol

plasma membrane

plasma membrane

cell adhesion

cell adhesion

external side of plasma membrane

cell surface

membrane

protein phosphatase binding

carbohydrate binding

sialic acid binding

sialic acid binding

04640

1419206_at Cd37 CD37 antigen 7 -45233631, -45233631 BC019402 35

immunological synapse

immunoglobulin production

positive regulation of immunoglobulin production

regulation of humoral immune response

membrane

negative regulation of myeloid dendritic cell activation

T cell proliferation

negative regulation of T cell proliferation

defense response to protozoan

regulation of defense response to virus

04640

1450136_at Cd38 CD38 antigen 5 43868808 NM_007646 222

response to hypoxia

NAD+ nucleosidase activity

NAD+ nucleosidase activity

plasma membrane

plasma membrane

positive regulation of cytosolic calcium ion concentration

positive regulation of cell population proliferation

response to xenobiotic stimulus

response to hormone

cell surface

negative regulation of neuron projection development

artery smooth muscle contraction

membrane

basolateral plasma membrane

transferase activity

hydrolase activity

hydrolase activity, acting on glycosyl bonds

phosphorus-oxygen lyase activity

phosphorus-oxygen lyase activity

positive regulation of cell growth

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of insulin secretion

response to hydroperoxide

B cell proliferation

identical protein binding

negative regulation of apoptotic process

negative regulation of bone resorption

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of vasoconstriction

NADP+ nucleosidase activity

B cell receptor signaling pathway

long-term synaptic depression

NAD+ nucleotidase, cyclic ADP-ribose generating

00760

01100

04020

04640

04970

04972

1417384_at Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 12 -84373875, -84373875 NM_007647 30

GDP phosphatase activity

GDP phosphatase activity

GDP phosphatase activity

extracellular region

extracellular space

endoplasmic reticulum

endoplasmic reticulum lumen

UDP-glucose metabolic process

UDP catabolic process

protein N-linked glycosylation

nucleoside diphosphate catabolic process

membrane

hydrolase activity

nucleoside diphosphate phosphatase activity

ribonucleoside triphosphate phosphatase activity

CDP phosphatase activity

ADP phosphatase activity

UDP phosphatase activity

UDP phosphatase activity

UDP phosphatase activity

'de novo' post-translational protein folding

IDP phosphatase activity

00230

00240

1422828_at Cd3d CD3 antigen, delta polypeptide 9 44981785 NM_013487 58

adaptive immune response

immune system process

transmembrane signaling receptor activity

transmembrane signaling receptor activity

protein binding

plasma membrane

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

membrane

T cell receptor complex

T cell receptor complex

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

T cell activation

identical protein binding

positive thymic T cell selection

positive thymic T cell selection

protein-containing complex assembly

04640

04660

05142

05340

1422105_at Cd3e CD3 antigen, epsilon polypeptide 9 -44998742 NM_007648 332

immunological synapse

positive regulation of cell-matrix adhesion

adaptive immune response

immune system process

positive regulation of T cell anergy

T cell anergy

transmembrane signaling receptor activity

transmembrane signaling receptor activity

protein binding

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

cell-cell junction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

smoothened signaling pathway

response to nutrient

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

positive regulation of gene expression

negative regulation of gene expression

membrane

dendrite development

SH3 domain binding

peptidyl-tyrosine phosphorylation

calcium-mediated signaling

cerebellum development

T cell costimulation

type II interferon production

interleukin-4 production

positive regulation of type II interferon production

positive regulation of interleukin-2 production

positive regulation of interleukin-4 production

positive regulation of cell-cell adhesion mediated by integrin

CD4-positive, alpha-beta T cell proliferation

T cell proliferation

T cell receptor complex

positive regulation of T cell proliferation

positive regulation of T cell proliferation

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

T cell activation

identical protein binding

dendritic spine

cell body

positive thymic T cell selection

negative thymic T cell selection

negative regulation of smoothened signaling pathway

lymphocyte activation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of calcium-mediated signaling

T cell receptor signaling pathway

positive regulation of T cell activation

apoptotic signaling pathway

positive regulation of CD4-positive, alpha-beta T cell proliferation

04640

04660

05142

05340

1419178_at Cd3g CD3 antigen, gamma polypeptide 9 -44969571 M58149 65

adaptive immune response

immune system process

transmembrane signaling receptor activity

transmembrane signaling receptor activity

cytosol

plasma membrane

establishment or maintenance of cell polarity

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

protein transport

membrane

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

identical protein binding

positive thymic T cell selection

regulation of lymphocyte apoptotic process

04640

04660

05142

1426396_at Cd247 CD247 antigen 1 165788680, 165788680, 165788680 AK017904 174

adaptive immune response

immune system process

transmembrane signaling receptor activity

protein binding

cytoplasm

Golgi apparatus

plasma membrane

plasma membrane

cell surface receptor signaling pathway

membrane

interleukin-2 production

Fc-gamma receptor III complex

Fc-gamma receptor signaling pathway

T cell receptor complex

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

alpha-beta T cell receptor complex

identical protein binding

protein homodimerization activity

protein heterodimerization activity

T cell receptor signaling pathway

T cell receptor signaling pathway

protein complex oligomerization

protein-containing complex assembly

protein tyrosine kinase binding

positive regulation of protein localization to cell surface

04650

04660

05142

1452483_a_at Cd44 CD44 antigen 2 -102811141 X66083 648

regulation of cell growth

branching involved in ureteric bud morphogenesis

wound healing involved in inflammatory response

positive regulation of adaptive immune response

negative regulation of mature B cell apoptotic process

transmembrane signaling receptor activity

cytokine receptor activity

cytokine receptor activity

cytokine receptor activity

type II transforming growth factor beta receptor binding

epidermal growth factor receptor binding

protein binding

hyaluronic acid binding

hyaluronic acid binding

hyaluronic acid binding

extracellular region

Golgi apparatus

cytosol

plasma membrane

plasma membrane

plasma membrane

microvillus

receptor-mediated endocytosis

receptor-mediated endocytosis

inflammatory response

cell adhesion

cell adhesion

external side of plasma membrane

cell surface

cell surface

positive regulation of gene expression

membrane

Wnt signaling pathway

channel regulator activity

basolateral plasma membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

cell migration

protein kinase binding

cytokine binding

hyaluronan catabolic process

hyaluronan catabolic process

hyaluronan catabolic process

neuron projection development

lamellipodium membrane

protein-containing complex

positive regulation of neutrophil apoptotic process

positive regulation of peptidyl-serine phosphorylation

positive regulation of peptidyl-serine phosphorylation

positive regulation of heterotypic cell-cell adhesion

macrophage fusion

macrophage migration inhibitory factor receptor complex

macrophage migration inhibitory factor receptor complex

macrophage migration inhibitory factor receptor complex

cargo receptor activity

cargo receptor activity

cargo receptor activity

T cell activation

cell projection

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of DNA damage response, signal transduction by p53 class mediator

wound healing, spreading of cells

cellular response to fibroblast growth factor stimulus

membrane raft

negative regulation of regulatory T cell differentiation

negative regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

phosphoprotein binding

branching involved in prostate gland morphogenesis

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

monocyte aggregation

positive regulation of monocyte aggregation

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of lamellipodium morphogenesis

negative regulation of CD4-positive, alpha-beta T cell proliferation

04512

04640

1418353_at Cd5 CD5 antigen 19 -10718142 NM_007650 144

protein binding

plasma membrane

plasma membrane

external side of plasma membrane

cell surface

membrane

T cell costimulation

T cell costimulation

apoptotic signaling pathway

04640

1451910_a_at Cd6 CD6 antigen 19 -10789338 U12434 36

lipopolysaccharide binding

immunological synapse formation

immunological synapse

positive regulation of protein phosphorylation

acute inflammatory response to antigenic stimulus

protein binding

plasma membrane

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

cell surface

membrane

protein kinase binding

lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

T cell receptor complex

positive regulation of T cell proliferation

identical protein binding

lipoteichoic acid binding

positive regulation of cytokine production involved in inflammatory response

04514

1449164_at Cd68 CD68 antigen 11 -69664212 BC021637 109

inflammatory response to antigenic stimulus

negative regulation of dendritic cell antigen processing and presentation

lysosome

lysosomal membrane

lysosomal membrane

endosome

plasma membrane

plasma membrane

plasma membrane

membrane

cellular response to nutrient levels

late endosome membrane

autocrine signaling

cellular response to lipopolysaccharide

cellular response to organic substance

establishment of protein localization to organelle

cellular response to oxidised low-density lipoprotein particle stimulus

04142

1428735_at Cd69 CD69 antigen 6 -129267323 AK017979 117

calcium ion binding

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

carbohydrate binding

protein-containing complex

identical protein binding

cellular response to xenobiotic stimulus

 
1426112_a_at Cd72 CD72 antigen 4 -43447723 BC003824 70

transmembrane signaling receptor activity

plasma membrane

membrane

carbohydrate binding

04662

1418830_at Cd79a CD79A antigen (immunoglobulin-associated alpha) 7 24897496 NM_007655 432

adaptive immune response

immune system process

transmembrane signaling receptor activity

protein binding

multivesicular body

plasma membrane

plasma membrane

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

membrane

B cell receptor complex

B cell receptor complex

B cell differentiation

B cell differentiation

B cell proliferation

B cell activation

identical protein binding

membrane raft

B cell receptor signaling pathway

B cell receptor signaling pathway

IgM B cell receptor complex

04662

05340

1416111_at Cd83 CD83 antigen 13 43785111 NM_009856 66

external side of plasma membrane

response to organic cyclic compound

membrane

interleukin-10 production

interleukin-2 production

interleukin-4 production

negative regulation of interleukin-4 production

positive regulation of interleukin-10 production

positive regulation of interleukin-2 production

CD4-positive, alpha-beta T cell differentiation

positive regulation of CD4-positive, alpha-beta T cell differentiation

 
1451673_at Cd8a CD8 subunit alpha 6 71373426 M12825 623

adaptive immune response

immune system process

T cell mediated immunity

T cell mediated immunity

protein binding

plasma membrane

plasma membrane

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

calcium-mediated signaling

protein kinase binding

MHC class I protein complex binding

T cell activation

identical protein binding

receptor complex

receptor complex

plasma membrane raft

cytotoxic T cell differentiation

cytotoxic T cell differentiation

positive regulation of calcium-mediated signaling

T cell receptor signaling pathway

defense response to virus

04514

04612

04640

04660

05340

1426170_a_at Cd8b1 CD8 subunit beta 1 6 71322787 U34882 115

adaptive immune response

immune system process

protein binding

plasma membrane

plasma membrane

external side of plasma membrane

cell surface

cell surface

coreceptor activity

membrane

MHC class I protein binding

receptor complex

regulation of immune response

04514

04612

04640

04660

05340

1426002_a_at Cdc7 cell division cycle 7 5 106964321, 106964560 AB018574 39

nucleotide binding

double-strand break repair via break-induced replication

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

protein phosphorylation

cell cycle

signal transduction

positive regulation of cell population proliferation

positive regulation of nuclear cell cycle DNA replication

positive regulation of G2/M transition of mitotic cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

cell cycle phase transition

intercellular bridge

metal ion binding

cell division

mitotic spindle

04110

1424638_at Cdkn1a cyclin dependent kinase inhibitor 1A 17 29090978, 29093768 AK007630 1178

regulation of cyclin-dependent protein serine/threonine kinase activity

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

cyclin-dependent protein kinase holoenzyme complex

in utero embryonic development

protein kinase inhibitor activity

protein kinase inhibitor activity

cyclin-dependent protein serine/threonine kinase inhibitor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

protein import into nucleus

DNA damage response

DNA damage response

DNA damage response

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

cell cycle

mitotic G2 DNA damage checkpoint signaling

regulation of mitotic cell cycle

regulation of mitotic cell cycle

heart development

negative regulation of cell population proliferation

negative regulation of cell population proliferation

epidermis development

response to UV

regulation of G2/M transition of mitotic cell cycle

negative regulation of gene expression

nuclear body

protein kinase binding

cyclin-dependent protein kinase activating kinase activity

keratinocyte differentiation

negative regulation of cell growth

cyclin binding

positive regulation of B cell proliferation

ubiquitin protein ligase binding

cellular response to extracellular stimulus

negative regulation of protein binding

protein-containing complex

cellular response to amino acid starvation

cellular response to amino acid starvation

wound healing

tissue regeneration

negative regulation of phosphorylation

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of apoptotic process

positive regulation of programmed cell death

keratinocyte proliferation

protein-containing complex binding

negative regulation of cyclin-dependent protein serine/threonine kinase activity

negative regulation of cyclin-dependent protein serine/threonine kinase activity

positive regulation of protein kinase activity

metal ion binding

fibroblast proliferation

positive regulation of fibroblast proliferation

perinuclear region of cytoplasm

regulation of cell cycle

regulation of cell cycle

regulation of cell cycle

PCNA-p21 complex

cellular response to ionizing radiation

cellular response to gamma radiation

cellular response to UV-B

signal transduction by p53 class mediator

cellular senescence

cellular senescence

oncogene-induced cell senescence

oncogene-induced cell senescence

protein sequestering activity

molecular function activator activity

molecular function inhibitor activity

regulation of cell cycle G1/S phase transition

negative regulation of cyclin-dependent protein kinase activity

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of cardiac muscle tissue regeneration

regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle

negative regulation of G1/S transition of mitotic cell cycle

regulation of DNA biosynthetic process

negative regulation of DNA biosynthetic process

positive regulation of reactive oxygen species metabolic process

04012

04110

04115

05160

05200

05214

05215

05218

05219

05220

1420497_a_at Cebpz CCAAT/enhancer binding protein zeta 17 -78919002 NM_009882 25

transcription coactivator activity

nucleus

nucleus

CCAAT-binding factor complex

positive regulation of transcription by RNA polymerase II

 
1427844_a_at Cebpb CCAAT/enhancer binding protein beta 2 167688914 AB012278 583

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

condensed chromosome, centromeric region

chromatin

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

ovarian follicle development

embryonic placenta development

granuloma formation

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

transcription by RNA polymerase II

positive regulation of gene expression

nuclear matrix

nuclear matrix

kinase binding

cell differentiation

neuron differentiation

chromatin DNA binding

response to lipopolysaccharide

regulation of interleukin-6 production

positive regulation of interleukin-4 production

mammary gland epithelial cell proliferation

response to endoplasmic reticulum stress

histone acetyltransferase binding

nuclear glucocorticoid receptor binding

T-helper 1 cell activation

CHOP-C/EBP complex

negative regulation of T cell proliferation

defense response to bacterium

identical protein binding

protein homodimerization activity

histone deacetylase binding

negative regulation of neuron apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

ubiquitin-like protein ligase binding

fat cell differentiation

fat cell differentiation

regulation of cell differentiation

positive regulation of fat cell differentiation

positive regulation of osteoblast differentiation

regulation of osteoclast differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

positive regulation of inflammatory response

brown fat cell differentiation

mammary gland epithelial cell differentiation

myeloid cell development

RNA polymerase II-specific DNA-binding transcription factor binding

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

positive regulation of biomineral tissue development

cellular response to lipopolysaccharide

cellular response to amino acid stimulus

cellular response to interleukin-1

hepatocyte proliferation

hepatocyte proliferation

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

liver regeneration

positive regulation of cold-induced thermogenesis

DNA-binding transcription factor binding

regulation of odontoblast differentiation

regulation of odontoblast differentiation

C/EBP complex

C/EBP complex

sequence-specific double-stranded DNA binding

positive regulation of sodium-dependent phosphate transport

regulation of dendritic cell differentiation

 
1418066_at Cfl2 cofilin 2, muscle 12 -54858818 AI323758 51

actin binding

nucleus

cytoplasm

cytoplasm

cytoskeleton

actin filament organization

skeletal muscle tissue development

actin cytoskeleton

actin cytoskeleton

Z disc

actin filament depolymerization

actin filament depolymerization

actin filament depolymerization

actin filament fragmentation

actin filament fragmentation

positive regulation of actin filament depolymerization

I band

sarcomere organization

muscle cell cellular homeostasis

actin filament severing

actin filament binding

actin filament binding

04360

04666

04810

1451537_at Chi3l1 chitinase 3 like 1 1 134182403, 134182155 BC005611 98

protein binding

extracellular region

extracellular region

extracellular space

cytoplasm

endoplasmic reticulum

carbohydrate metabolic process

chitin catabolic process

apoptotic process

inflammatory response

activation of NF-kappaB-inducing kinase activity

chitin binding

chitin binding

positive regulation of peptidyl-threonine phosphorylation

lung development

positive regulation of interleukin-8 production

positive regulation of angiogenesis

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of ERK1 and ERK2 cascade

00520

1419764_at Chil3 chitinase-like 3 3 -106147553 NM_009892 67

polysaccharide catabolic process

production of molecular mediator involved in inflammatory response

beta-N-acetylhexosaminidase activity

extracellular region

extracellular region

extracellular space

nucleus

cytoplasm

endoplasmic reticulum

carbohydrate metabolic process

chitin catabolic process

chitin catabolic process

inflammatory response

chitin binding

chitin binding

metabolic process

hydrolase activity

hydrolase activity, acting on glycosyl bonds

kinase binding

carbohydrate binding

cytoplasmic vesicle

positive regulation of chemokine production

N-acetyl-beta-D-galactosaminidase activity

 
1416332_at Cirbp cold inducible RNA binding protein 10 80167838, 80167838, 80167838, 80168170, 80165989 NM_007705 87

nucleic acid binding

RNA binding

RNA binding

mRNA 3'-UTR binding

nucleus

nucleus

nucleoplasm

nucleoplasm

spliceosomal complex

cytoplasm

cytoplasm

poly(U) RNA binding

response to UV

cytoplasmic stress granule

negative regulation of cell growth

translation repressor activity

stress granule assembly

positive regulation of translation

positive regulation of mRNA splicing, via spliceosome

mRNA stabilization

small ribosomal subunit rRNA binding

cellular response to cold

regulation of cell cycle G1/S phase transition

 
1455899_x_at Socs3 suppressor of cytokine signaling 3 11 -117966086 BB241535 471

phosphotyrosine residue binding

regulation of protein phosphorylation

protein binding

cytosol

phosphatidylinositol 3-kinase complex

signal transduction

receptor signaling pathway via JAK-STAT

cytoplasmic side of plasma membrane

negative regulation of signal transduction

cell differentiation

cell differentiation

protein tyrosine kinase inhibitor activity

miRNA binding

miRNA binding

intracellular signal transduction

negative regulation of tyrosine phosphorylation of STAT protein

positive regulation of cell differentiation

positive regulation of cell differentiation

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of insulin receptor signaling pathway

phosphatidylinositol phosphate biosynthetic process

1-phosphatidylinositol-3-kinase regulator activity

negative regulation of inflammatory response

branching involved in labyrinthine layer morphogenesis

placenta blood vessel development

cellular response to interleukin-17

cellular response to leukemia inhibitory factor

04120

04380

04630

04910

04920

04930

05160

1450446_a_at Socs1 suppressor of cytokine signaling 1 16 -10783808 AB000710 327

regulation of cytokine production

regulation of protein phosphorylation

insulin-like growth factor receptor binding

protein binding

nucleus

nucleoplasm

cytosol

phosphatidylinositol 3-kinase complex

receptor signaling pathway via JAK-STAT

negative regulation of signal transduction

regulation of activation of Janus kinase activity

kinase inhibitor activity

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

protein kinase binding

macrophage differentiation

cytoplasmic vesicle

intracellular signal transduction

cytoplasmic ribonucleoprotein granule

regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

positive regulation of CD4-positive, alpha-beta T cell differentiation

negative regulation of CD8-positive, alpha-beta T cell differentiation

fat cell differentiation

positive regulation of regulatory T cell differentiation

regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of receptor signaling pathway via JAK-STAT

negative regulation of insulin receptor signaling pathway

phosphatidylinositol phosphate biosynthetic process

1-phosphatidylinositol-3-kinase regulator activity

cellular response to amino acid stimulus

cellular response to cytokine stimulus

cellular response to organic cyclic compound

negative regulation of hepatic stellate cell proliferation

positive regulation of fibroblast apoptotic process

04120

04380

04630

04910

04930

05145

1426124_a_at Clk1 CDC-like kinase 1 1 -58411987 U21209 43

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleus

protein phosphorylation

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

peptidyl-tyrosine phosphorylation

peptidyl-tyrosine phosphorylation

regulation of RNA splicing

regulation of RNA splicing

protein autophosphorylation

 
1417743_at Clk2 CDC-like kinase 2 3 89164794 BC015080 35

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

protein phosphorylation

protein phosphorylation

response to organic substance

response to ionizing radiation

kinase activity

phosphorylation

nuclear body

transferase activity

peptidyl-tyrosine phosphorylation

peptidyl-tyrosine phosphorylation

response to retinoic acid

identical protein binding

regulation of RNA splicing

regulation of RNA splicing

negative regulation of gluconeogenesis

protein autophosphorylation

 
1422886_a_at Clk4 CDC like kinase 4 11 51263113 NM_007714 24

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

nucleus

protein phosphorylation

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

peptidyl-tyrosine phosphorylation

regulation of RNA splicing

regulation of RNA splicing

protein autophosphorylation

 
1421734_at Cxcr2 C-X-C motif chemokine receptor 2 1 74153993 NM_009909 350

acute inflammatory response to antigenic stimulus

positive regulation of leukocyte chemotaxis

interleukin-8 receptor activity

interleukin-8 receptor activity

G protein-coupled receptor activity

chemokine receptor activity

chemokine receptor activity

protein binding

nucleoplasm

plasma membrane

chemotaxis

chemotaxis

immune response

cellular defense response

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

positive regulation of cell population proliferation

external side of plasma membrane

cell surface

positive regulation of cardiac muscle cell apoptotic process

microtubule cytoskeleton

membrane

C-C chemokine receptor activity

C-X-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

interleukin-8 binding

neutrophil chemotaxis

neutrophil chemotaxis

receptor internalization

negative regulation of neutrophil apoptotic process

interleukin-8-mediated signaling pathway

neutrophil activation

mast cell granule

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of vascular permeability

positive regulation of angiogenesis

metanephric tubule morphogenesis

mitotic spindle

positive regulation of neutrophil chemotaxis

04060

04062

04144

1449925_at Cxcr3 C-X-C motif chemokine receptor 3 X -101731534 NM_009910 339

angiogenesis

negative regulation of endothelial cell proliferation

regulation of leukocyte migration

G protein-coupled receptor activity

chemokine receptor activity

plasma membrane

chemotaxis

inflammatory response

immune response

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

positive regulation of cell population proliferation

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

T cell chemotaxis

membrane

C-C chemokine receptor activity

C-X-C chemokine receptor activity

negative regulation of angiogenesis

calcium-mediated signaling

calcium-mediated signaling

chemokine binding

C-C chemokine binding

C-X-C chemokine binding

regulation of cell adhesion

signaling receptor activity

positive regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

positive regulation of chemotaxis

positive regulation of release of sequestered calcium ion into cytosol

cell chemotaxis

negative regulation of execution phase of apoptosis

positive regulation of execution phase of apoptosis

04060

04062

1448710_at Cxcr4 C-X-C motif chemokine receptor 4 1 -128588198 D87747 672

branching involved in blood vessel morphogenesis

neuron migration

neuron migration

kidney development

positive regulation of protein phosphorylation

epithelial cell development

ventricular septum development

actin binding

G protein-coupled receptor activity

chemokine receptor activity

protein binding

lysosome

endosome

early endosome

late endosome

plasma membrane

plasma membrane

cell-cell junction

chemotaxis

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

germ cell development

nervous system development

brain development

brain development

motor neuron axon guidance

germ cell migration

animal organ morphogenesis

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

response to organic cyclic compound

membrane

cell migration

C-C chemokine receptor activity

calcium-mediated signaling

calcium-mediated signaling

cytokine binding

C-C chemokine binding

C-C chemokine binding

neurogenesis

neurogenesis

telencephalon cell migration

regulation of cell adhesion

regulation of cell migration

regulation of cell migration

positive regulation of cell migration

growth cone

cell leading edge

cytoplasmic vesicle

ubiquitin protein ligase binding

myosin light chain binding

protein-containing complex

positive regulation of vascular wound healing

hematopoietic stem cell migration

aorta development

small molecule binding

C-X-C motif chemokine 12 receptor activity

CXCL12-activated CXCR4 signaling pathway

CXCL12-activated CXCR4 signaling pathway

T cell proliferation

regulation of programmed cell death

ubiquitin binding

myelin maintenance

blood vessel endothelial cell migration

endothelial cell differentiation

generation of neurons

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis

regulation of viral process

regulation of chemotaxis

positive regulation of chemotaxis

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception of pain

regulation of calcium ion transport

cardiac muscle contraction

cell chemotaxis

endothelial tube morphogenesis

neural precursor cell proliferation

anchoring junction

positive regulation of ERK1 and ERK2 cascade

cellular response to cytokine stimulus

cellular response to cytokine stimulus

cellular response to organonitrogen compound

positive regulation of calcium ion import

positive regulation of cold-induced thermogenesis

response to tacrolimus

positive regulation of dendrite extension

positive regulation of vasculature development

positive regulation of mesenchymal stem cell migration

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of neuron migration

04060

04062

04144

04360

04670

04672

1419609_at Ccr1 C-C motif chemokine receptor 1 9 -123962125 AV231648 160

phosphatidylinositol phospholipase C activity

G protein-coupled receptor activity

chemokine receptor activity

protein binding

cytoplasm

plasma membrane

calcium ion transport

intracellular calcium ion homeostasis

exocytosis

chemotaxis

inflammatory response

inflammatory response

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

cell-cell signaling

external side of plasma membrane

external side of plasma membrane

negative regulation of gene expression

membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

myeloid cell differentiation

positive regulation of cell migration

negative regulation of bone mineralization

leukocyte chemotaxis

leukocyte chemotaxis

chemokine (C-C motif) ligand 7 binding

chemokine (C-C motif) ligand 7 binding

neuronal cell body

positive regulation of osteoclast differentiation

negative regulation of innate immune response

positive regulation of calcium ion transport

cell chemotaxis

chemokine-mediated signaling pathway

positive regulation of ERK1 and ERK2 cascade

chemokine (C-C motif) ligand 5 binding

chemokine (C-C motif) ligand 5 binding

positive regulation of monocyte chemotaxis

04060

04062

1427419_x_at Ccr9 C-C motif chemokine receptor 9 9 123767210 AJ131357 95

CD8-positive, gamma-delta intraepithelial T cell differentiation

G protein-coupled receptor activity

chemokine receptor activity

protein binding

plasma membrane

chemotaxis

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

cell surface

membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

cell chemotaxis

04060

04062

04672

1424727_at Ccr5 C-C motif chemokine receptor 5 9 124121542 D83648 379

actin binding

G protein-coupled receptor activity

chemokine receptor activity

cytoplasm

endosome

plasma membrane

calcium ion transport

chemotaxis

defense response

inflammatory response

inflammatory response

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

cell-cell signaling

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

positive regulation of gene expression

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

calcium-mediated signaling

protein kinase binding

C-C chemokine binding

C-C chemokine binding

positive regulation of cell-cell adhesion

regulation of cell migration

negative regulation of axon extension

positive regulation of cell killing

positive regulation of fever generation

positive regulation of interleukin-1 beta production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

identical protein binding

positive regulation of neuron differentiation

cell chemotaxis

response to cholesterol

chemokine (C-C motif) ligand 5 binding

chemokine (C-C motif) ligand 5 binding

negative regulation of macrophage apoptotic process

negative regulation of neural precursor cell proliferation

04060

04062

04144

05145

1423466_at Ccr7 C-C motif chemokine receptor 7 11 -99144198 BB204380 392

establishment of T cell polarity

myeloid dendritic cell chemotaxis

lymphocyte chemotaxis across high endothelial venule

positive regulation of dendritic cell antigen processing and presentation

regulation of tolerance induction to self antigen

positive regulation of hypersensitivity

positive regulation of humoral immune response

G protein-coupled receptor activity

chemokine receptor activity

protein binding

mitochondrion

plasma membrane

plasma membrane

chemotaxis

inflammatory response

inflammatory response

immune response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

positive regulation of macrophage chemotaxis

positive regulation of T cell chemotaxis

membrane

C-C chemokine receptor activity

calcium-mediated signaling

actin cytoskeleton organization

response to lipopolysaccharide

regulation of type II interferon production

regulation of interleukin-1 beta production

negative regulation of interleukin-12 production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-12 production

positive regulation of tumor necrosis factor production

response to prostaglandin E

chemokine (C-C motif) ligand 19 binding

chemokine (C-C motif) ligand 19 binding

chemokine (C-C motif) ligand 21 binding

chemokine (C-C motif) ligand 21 binding

C-C motif chemokine 19 receptor activity

C-C motif chemokine 19 receptor activity

C-C motif chemokine 21 receptor activity

positive regulation of T cell proliferation

positive regulation of JUN kinase activity

positive regulation of GTPase activity

negative thymic T cell selection

positive regulation of T-helper 1 cell differentiation

positive regulation of receptor-mediated endocytosis

lymph node development

homeostasis of number of cells

positive regulation of phagocytosis

positive regulation of T cell receptor signaling pathway

positive regulation of filopodium assembly

cell chemotaxis

cellular response to cytokine stimulus

response to nitric oxide

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil chemotaxis

lymphocyte migration into lymph node

mature conventional dendritic cell differentiation

negative regulation of leukocyte apoptotic process

positive regulation of cell motility

positive regulation of thymocyte migration

positive regulation of dendritic cell chemotaxis

positive regulation of immunological synapse formation

positive regulation of T cell costimulation

positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

regulation of dendritic cell dendrite assembly

04060

04062

1419691_at Camp cathelicidin antimicrobial peptide 9 -109847376 NM_009921 135

lipopolysaccharide binding

response to yeast

positive regulation of protein phosphorylation

innate immune response in mucosa

immune system process

chronic inflammatory response

extracellular region

extracellular space

extracellular space

defense response

positive regulation of cell population proliferation

antibacterial humoral response

antifungal humoral response

cytolysis

positive regulation of interleukin-8 production

modulation of process of another organism

neutrophil activation

specific granule

specific granule

defense response to bacterium

defense response to bacterium

cell projection

innate immune response

innate immune response

innate immune response

positive regulation of angiogenesis

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cytolysis by host of symbiont cells

killing by host of symbiont cells

killing by host of symbiont cells

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

amyloid fibril formation

04970

1416740_at Col5a1 collagen, type V, alpha 1 2 27886424 AW744319 97

blood vessel development

heart morphogenesis

extracellular matrix structural constituent

protein binding

extracellular region

collagen trimer

collagen trimer

collagen type V trimer

collagen type V trimer

collagen type XI trimer

basement membrane

extracellular space

extracellular space

cell adhesion

cell adhesion

heparin binding

heparin binding

cell migration

extracellular matrix structural constituent conferring tensile strength

extracellular matrix structural constituent conferring tensile strength

collagen fibril organization

collagen fibril organization

collagen fibril organization

collagen fibril organization

extracellular matrix

collagen biosynthetic process

wound healing, spreading of epidermal cells

tendon development

tendon development

proteoglycan binding

skin development

skin development

integrin biosynthetic process

platelet-derived growth factor binding

eye morphogenesis

regulation of cellular component organization

collagen-containing extracellular matrix

collagen-containing extracellular matrix

collagen-containing extracellular matrix

collagen-containing extracellular matrix

supramolecular fiber organization

negative regulation of endodermal cell differentiation

04510

04512

04974

05146

1459885_s_at Cox7c cytochrome c oxidase subunit 7C 13 -86044797 AA190297 32

protein binding

mitochondrion

mitochondrial inner membrane

mitochondrial respiratory chain complex IV

mitochondrial respiratory chain complex IV

mitochondrial electron transport, cytochrome c to oxygen

mitochondrial electron transport, cytochrome c to oxygen

membrane

mitochondrial membrane

00190

01100

04260

05010

05012

05016

1455393_at Cp ceruloplasmin 3 19957053, 19957053, 19957053, 19957248 BB009037 105

ferroxidase activity

ferroxidase activity

glutathione peroxidase activity

copper ion binding

copper ion binding

extracellular region

extracellular space

extracellular space

extracellular space

plasma membrane

monoatomic ion transport

copper ion transport

iron ion transport

intracellular copper ion homeostasis

intracellular iron ion homeostasis

cell surface

oxidoreductase activity

oxidoreductase activity

oxidoreductase activity, acting on metal ions, oxygen as acceptor

response to copper ion

metal ion binding

phospholipid-hydroperoxide glutathione peroxidase activity

protein-folding chaperone binding

00860

1448730_at Cpa3 carboxypeptidase A3, mast cell 3 -20215615 NM_007753 65

regulation of angiotensin levels in blood

carboxypeptidase activity

metallocarboxypeptidase activity

metallocarboxypeptidase activity

extracellular space

proteolysis

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

hydrolase activity

cytoplasmic vesicle

metal ion binding

04614

04972

04974

1455009_at Cpd carboxypeptidase D 11 -76777207 AW550842 24

carboxypeptidase activity

metallocarboxypeptidase activity

metallocarboxypeptidase activity

extracellular space

nucleus

trans-Golgi network

plasma membrane

proteolysis

peptide metabolic process

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

protein processing

hydrolase activity

protein-containing complex binding

metal ion binding

perinuclear region of cytoplasm

protein phosphatase 2A binding

 
1425289_a_at Cr2 complement receptor 2 1 -195136811 M35684 184

complement binding

immune system process

T cell mediated immunity

DNA binding

complement receptor activity

protein binding

extracellular space

extracellular space

plasma membrane

plasma membrane

inflammatory response

complement activation, alternative pathway

complement activation, alternative pathway

complement activation, classical pathway

external side of plasma membrane

cell surface

membrane

immunoglobulin mediated immune response

B cell differentiation

immunoglobulin receptor binding

signaling receptor activity

B cell proliferation

protein homodimerization activity

receptor complex

innate immune response

negative regulation of complement activation, classical pathway

cartilage development

bone development

cellular response to lipopolysaccharide

04610

04640

04662

1449037_at Crem cAMP responsive element modulator 18 -3294165, -3266353, -3266353, -3266353, -3266353, -3266353 AI467599 157

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

transcription regulator complex

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

glycosphingolipid metabolic process

spermatogenesis

spermatogenesis

circadian rhythm

circadian regulation of gene expression

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

rhythmic process

response to cAMP

ATF4-CREB1 transcription factor complex

sequence-specific double-stranded DNA binding

 
1416326_at Crip1 cysteine-rich protein 1 12 113152011 NM_007763 34

cytoplasm

cytoplasm

zinc ion binding

zinc ion binding

zinc ion binding

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

response to zinc ion

response to zinc ion

regulation of gene expression

peptide binding

peptide binding

metal ion binding

cellular response to antibiotic

cellular response to antibiotic

cellular response to UV-B

cellular response to UV-B

 
1421946_at Crp C-reactive protein, pentraxin-related 1 172698055 NM_007768 92

complement component C1q complex binding

complement component C1q complex binding

calcium ion binding

extracellular region

extracellular space

extracellular space

acute-phase response

complement activation, classical pathway

positive regulation of gene expression

negative regulation of macrophage derived foam cell differentiation

negative regulation of lipid storage

regulation of low-density lipoprotein particle clearance

cholesterol binding

low-density lipoprotein particle binding

low-density lipoprotein particle binding

filopodium

growth cone

regulation of interleukin-8 production

negative regulation of superoxide anion generation

positive regulation of superoxide anion generation

negative regulation of mononuclear cell proliferation

vasoconstriction

identical protein binding

innate immune response

positive regulation of nitric oxide biosynthetic process

metal ion binding

low-density lipoprotein particle receptor binding

protein polymerization

cellular response to calcium ion

positive regulation of dendrite development

 
1420703_at Csf2ra colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 19 -61224401 BM941868 48

cytokine receptor activity

receptor signaling pathway via JAK-STAT

membrane

granulocyte macrophage colony-stimulating factor receptor complex

granulocyte-macrophage colony-stimulating factor signaling pathway

positive regulation of leukocyte proliferation

04060

04630

04640

05200

1455660_at Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 15 78325799, 78325989 BB769628 153

regulation of cell growth

cytokine receptor activity

cytokine receptor activity

protein binding

plasma membrane

receptor signaling pathway via JAK-STAT

external side of plasma membrane

coreceptor activity

membrane

immunoglobulin mediated immune response

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

granulocyte macrophage colony-stimulating factor receptor complex

interleukin-5-mediated signaling pathway

interleukin-3-mediated signaling pathway

granulocyte-macrophage colony-stimulating factor signaling pathway

positive regulation of leukocyte proliferation

04060

04210

04630

1449360_at Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 15 -78282507 NM_007781 59

cytokine receptor activity

cytokine receptor activity

plasma membrane

plasma membrane

receptor signaling pathway via JAK-STAT

external side of plasma membrane

coreceptor activity

membrane

immunoglobulin mediated immune response

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

granulocyte macrophage colony-stimulating factor receptor complex

interleukin-5-mediated signaling pathway

interleukin-3-mediated signaling pathway

granulocyte-macrophage colony-stimulating factor signaling pathway

positive regulation of leukocyte proliferation

04060

04210

04630

1427256_at Vcan versican 13 -89655309, -89709947 BM251152 224

skeletal system development

ureteric bud development

positive regulation of neuroblast proliferation

calcium ion binding

hyaluronic acid binding

extracellular region

extracellular space

cell adhesion

central nervous system development

heart development

glial cell migration

cell surface

glial cell differentiation

protein phosphatase binding

extracellular matrix structural constituent conferring compression resistance

carbohydrate binding

extracellular matrix

cell projection

regulation of phosphoprotein phosphatase activity

synapse

synapse

collagen-containing extracellular matrix

collagen-containing extracellular matrix

perineuronal net

perineuronal net

04514

1422506_a_at Cstb cystatin B 10 78425669 NM_007793 60

protease binding

endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular space

nucleus

nucleolus

cytoplasm

cytosol

cytosol

adult locomotory behavior

negative regulation of peptidase activity

peptidase inhibitor activity

negative regulation of proteolysis

collagen-containing extracellular matrix

 
1434705_at Ctbp2 C-terminal binding protein 2 7 -132987010, -132987010, -132987010 BG072903 152

transcription coregulator binding

transcription coregulator binding

transcription corepressor binding

chromatin binding

transcription coactivator activity

transcription coactivator activity

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

cytosol

regulation of transcription by RNA polymerase II

synaptic vesicle docking

synaptic vesicle docking

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

transcription repressor complex

protein kinase binding

cell differentiation

positive regulation of chromatin binding

identical protein binding

nuclear retinoic acid receptor binding

protein-containing complex binding

synapse

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of retinoic acid receptor signaling pathway

positive regulation of retinoic acid receptor signaling pathway

white fat cell differentiation

NAD binding

ribbon synapse

photoreceptor ribbon synapse

photoreceptor ribbon synapse

photoreceptor ribbon synapse

presynaptic active zone cytoplasmic component

structural constituent of presynaptic active zone

structural constituent of presynaptic active zone

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

presynaptic cytosol

DNA-binding transcription factor binding

cellular response to leukemia inhibitory factor

04310

04330

05200

05220

1416382_at Ctsc cathepsin C 7 88278084, 88278084 NM_009982 79

T cell mediated cytotoxicity

cysteine-type endopeptidase activity

serine-type endopeptidase activity

extracellular space

nucleoplasm

cytoplasm

lysosome

lysosome

centrosome

proteolysis

proteolysis

peptidase activity

cysteine-type peptidase activity

cysteine-type peptidase activity

dipeptidyl-peptidase activity

response to organic substance

peptidase activator activity involved in apoptotic process

hydrolase activity

phosphatase binding

chloride ion binding

negative regulation of myelination

negative regulation of myelination

identical protein binding

intracellular membrane-bounded organelle

protein self-association

protein-folding chaperone binding

proteolysis involved in protein catabolic process

collagen-containing extracellular matrix

positive regulation of proteolysis involved in protein catabolic process

positive regulation of microglial cell activation

positive regulation of apoptotic signaling pathway

04142

1451310_a_at Ctsl cathepsin L 13 -64361889 J02583 221

fibronectin binding

endopeptidase activity

aminopeptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity

protein binding

collagen binding

extracellular region

extracellular space

extracellular space

extracellular space

nucleus

nucleolus

lysosome

lysosome

lysosome

multivesicular body

Golgi apparatus

plasma membrane

microvillus

proteolysis

proteolysis

thyroid hormone generation

immune response

peptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activator activity involved in apoptotic process

external side of plasma membrane

external side of plasma membrane

negative regulation of keratinocyte proliferation

positive regulation of peptidase activity

membrane

hydrolase activity

cysteine-type carboxypeptidase activity

secretory granule

protein catabolic process

collagen catabolic process

kininogen binding

hair follicle morphogenesis

cytoplasmic vesicle

peptide binding

histone binding

histone binding

catagen

perikaryon

intracellular membrane-bounded organelle

CD4-positive, alpha-beta T cell lineage commitment

proteoglycan binding

keratinocyte proliferation

protein-containing complex binding

apical part of cell

decidualization

antigen processing and presentation of peptide antigen

proteolysis involved in protein catabolic process

proteolysis involved in protein catabolic process

elastin catabolic process

collagen-containing extracellular matrix

serpin family protein binding

positive regulation of apoptotic signaling pathway

04142

04145

04612

05323

1454268_a_at Cyba cytochrome b-245, alpha polypeptide 8 -122424770 AK018713 75

stress fiber

positive regulation of endothelial cell proliferation

negative regulation of glomerular filtration by angiotensin

protein binding

cytoplasm

mitochondrion

endosome

plasma membrane

focal adhesion

superoxide metabolic process

inflammatory response

electron transfer activity

smooth muscle hypertrophy

membrane

superoxide-generating NAD(P)H oxidase activity

apical plasma membrane

oxidoreductase activity

cytochrome complex assembly

SH3 domain binding

heme binding

positive regulation of cell growth

dendrite

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of superoxide anion generation

positive regulation of toll-like receptor 2 signaling pathway

superoxide anion generation

superoxide anion generation

NADPH oxidase complex

NADPH oxidase complex

NADPH oxidase complex

neuronal cell body

innate immune response

innate immune response

respiratory burst

positive regulation of blood pressure

metal ion binding

protein heterodimerization activity

positive regulation of smooth muscle cell proliferation

hydrogen peroxide biosynthetic process

positive regulation of phagocytosis

regulation of release of sequestered calcium ion into cytosol

establishment of localization in cell

mucus secretion

positive regulation of mucus secretion

cellular response to organic substance

reactive oxygen species metabolic process

perinuclear endoplasmic reticulum

positive regulation of defense response to bacterium

positive regulation of reactive oxygen species biosynthetic process

04145

04380

04670

05140

1422978_at Cybb cytochrome b-245, beta polypeptide X -9435253 NM_007807 775

protein binding

nuclear envelope

cytoplasm

mitochondrion

plasma membrane

plasma membrane

plasma membrane

superoxide metabolic process

superoxide metabolic process

monoatomic ion transport

defense response

inflammatory response

electron transfer activity

response to xenobiotic stimulus

membrane

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NAD(P)H oxidase activity

oxidoreductase activity

heme binding

dendrite

positive regulation of tumor necrosis factor production

monoatomic ion transmembrane transport

monoatomic ion channel complex

superoxide anion generation

superoxide anion generation

NADPH oxidase complex

NADPH oxidase complex

NADPH oxidase complex

neuronal cell body

innate immune response

innate immune response

phagocytic vesicle

respiratory burst

positive regulation of angiogenesis

metal ion binding

protein heterodimerization activity

flavin adenine dinucleotide binding

hydrogen peroxide biosynthetic process

perinuclear endoplasmic reticulum

hypoxia-inducible factor-1alpha signaling pathway

04145

04380

04670

1425645_s_at Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 7 25897657 AF128849 63

monooxygenase activity

iron ion binding

cytoplasm

mitochondrial inner membrane

endoplasmic reticulum

xenobiotic metabolic process

xenobiotic metabolic process

steroid metabolic process

testosterone 16-alpha-hydroxylase activity

arachidonic acid epoxygenase activity

steroid hydroxylase activity

response to bacterium

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

epoxygenase P450 pathway

heme binding

heme binding

Hsp70 protein binding

xenobiotic catabolic process

cellular ketone metabolic process

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

metal ion binding

Hsp90 protein binding

testosterone 16-beta-hydroxylase activity

anandamide 8,9 epoxidase activity

anandamide 11,12 epoxidase activity

anandamide 14,15 epoxidase activity

aromatase activity

estrogen 2-hydroxylase activity

00590

00830

00980

00982

01100

1415994_at Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 7 140763818 NM_021282 179

Golgi membrane

long-chain fatty acid metabolic process

lipid hydroxylation

monooxygenase activity

monooxygenase activity

iron ion binding

cytoplasm

mitochondrion

mitochondrial inner membrane

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

fatty acid metabolic process

triglyceride metabolic process

xenobiotic metabolic process

xenobiotic metabolic process

steroid metabolic process

arachidonic acid epoxygenase activity

response to bacterium

membrane

monoterpenoid metabolic process

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

4-nitrophenol 2-monooxygenase activity

4-nitrophenol metabolic process

epoxygenase P450 pathway

enzyme binding

heme binding

heme binding

Hsp70 protein binding

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

heterocycle metabolic process

metal ion binding

Hsp90 protein binding

aromatase activity

long-chain fatty acid omega-1 hydroxylase activity

00590

00591

00980

00982

01100

1416809_at Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 5 -145854606 BC010528 63

lipid hydroxylation

monooxygenase activity

monooxygenase activity

iron ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

steroid metabolic process

steroid metabolic process

estrogen metabolic process

retinoic acid 4-hydroxylase activity

response to bacterium

alkaloid catabolic process

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

heme binding

demethylase activity

xenobiotic catabolic process

retinoic acid metabolic process

intracellular membrane-bounded organelle

metal ion binding

testosterone 6-beta-hydroxylase activity

testosterone 6-beta-hydroxylase activity

aromatase activity

oxidative demethylation

oxidative demethylation

estrogen 16-alpha-hydroxylase activity

00140

00591

00830

00980

00982

00983

01100

1420498_a_at Dab2 disabled 2, mitogen-responsive phosphoprotein 15 6386747, 6299788 NM_023118 128

negative regulation of transcription by RNA polymerase II

cell morphogenesis

fibrillar center

in utero embryonic development

positive regulation of receptor recycling

positive regulation of protein phosphorylation

positive regulation of receptor internalization

integrin binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

cytoplasm

plasma membrane

plasma membrane

clathrin-coated pit

clathrin-coated pit

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

apoptotic process

transforming growth factor beta receptor signaling pathway

multicellular organism development

positive regulation of epithelial to mesenchymal transition

positive regulation of epithelial to mesenchymal transition

positive regulation of epithelial to mesenchymal transition

negative regulation of neuron projection development

protein transport

membrane

Wnt signaling pathway

apical plasma membrane

myeloid cell differentiation

clathrin coat of coated pit

clathrin-coated vesicle

cell differentiation

clathrin binding

negative regulation of cell growth

positive regulation of cell migration

positive regulation of cell migration

clathrin-coated vesicle membrane

cytoplasmic vesicle

negative regulation of protein binding

positive regulation of aldosterone biosynthetic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of transcription elongation by RNA polymerase II

leading edge cell differentiation

phosphatidylinositol binding

AP-2 adaptor complex binding

clathrin adaptor activity

clathrin adaptor activity

clathrin adaptor activity

cargo receptor activity

cargo receptor activity

cargo receptor activity

negative regulation of apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

positive regulation of cell adhesion

positive regulation of cell adhesion

positive regulation of endocytosis

positive regulation of endocytosis

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

SMAD binding

clathrin coat assembly

clathrin coat assembly

perinuclear region of cytoplasm

response to steroid hormone

negative regulation of epithelial cell proliferation

low-density lipoprotein particle receptor binding

positive regulation of SMAD protein signal transduction

negative regulation of androgen receptor signaling pathway

negative regulation of ERK1 and ERK2 cascade

cellular response to epidermal growth factor stimulus

hematopoietic stem cell proliferation

cellular response to transforming growth factor beta stimulus

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

renal protein absorption

extrinsic apoptotic signaling pathway

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

positive regulation of substrate adhesion-dependent cell spreading

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to plasma membrane

positive regulation of Wnt signaling pathway, planar cell polarity pathway

positive regulation of clathrin-dependent endocytosis

positive regulation of clathrin-dependent endocytosis

positive regulation of early endosome to late endosome transport

positive regulation of aldosterone secretion

positive regulation of integrin-mediated signaling pathway

negative regulation of extrinsic apoptotic signaling pathway

04144

1433743_at Dach1 dachshund family transcription factor 1 14 -97786845 BG075820 88

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

suckling behavior

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

transcription regulator complex

cytoplasm

Golgi apparatus

cytosol

regulation of DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

multicellular organism development

respiratory gaseous exchange by respiratory system

negative regulation of transcription by competitive promoter binding

nuclear speck

negative regulation of cell migration

regulation of nuclear cell cycle DNA replication

type B pancreatic cell proliferation

negative regulation of DNA-templated transcription

development of primary female sexual characteristics

negative regulation of fibroblast proliferation

negative regulation of fibroblast proliferation

epithelial cell proliferation

negative regulation of cell proliferation involved in contact inhibition

negative regulation of DNA biosynthetic process

 
1418762_at Cd55 CD55 molecule, decay accelerating factor for complement 1 -130439025 NM_010016 115

virus receptor activity

immune system process

positive regulation of T cell cytokine production

enzyme inhibitor activity

plasma membrane

complement activation, classical pathway

positive regulation of cytosolic calcium ion concentration

lipid binding

external side of plasma membrane

cell surface

membrane

apical plasma membrane

regulation of complement activation

regulation of complement activation, classical pathway

regulation of lipopolysaccharide-mediated signaling pathway

innate immune response

membrane raft

negative regulation of complement activation

side of membrane

regulation of complement-dependent cytotoxicity

positive regulation of CD4-positive, alpha-beta T cell activation

positive regulation of CD4-positive, alpha-beta T cell proliferation

04610

04640

05416

1418578_at Dgka diacylglycerol kinase, alpha 10 -128720135, -128720135, -128720135, -128720135 BC006713 62

nucleotide binding

ATP-dependent diacylglycerol kinase activity

ATP-dependent diacylglycerol kinase activity

ATP-dependent diacylglycerol kinase activity

calcium ion binding

ATP binding

phospholipid binding

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

lipid metabolic process

phosphatidic acid biosynthetic process

signal transduction

protein kinase C-activating G protein-coupled receptor signaling pathway

lipid binding

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

diacylglycerol metabolic process

diacylglycerol metabolic process

glycerolipid metabolic process

lipid phosphorylation

lipid phosphorylation

metal ion binding

00561

00564

01100

04070

1422432_at Dbi diazepam binding inhibitor 1 -120113279, -120113279 NM_007830 78

fatty-acyl-CoA binding

fatty-acyl-CoA binding

behavioral fear response

hair follicle development

extracellular space

mitochondrion

endoplasmic reticulum

Golgi apparatus

fatty acid metabolic process

triglyceride metabolic process

learning or memory

synaptic vesicle

lipid binding

glial cell proliferation

lateral ventricle development

benzodiazepine receptor binding

negative regulation of fatty acid beta-oxidation

regulation of synaptic transmission, GABAergic

protein-lipid complex

long-chain fatty acyl-CoA binding

phosphatidylcholine acyl-chain remodeling

identical protein binding

contractile fiber

skin development

positive regulation of lipid biosynthetic process

positive regulation of release of sequestered calcium ion into cytosol

long-term synaptic potentiation

perinuclear endoplasmic reticulum

negative regulation of protein lipidation

positive regulation of CoA-transferase activity

positive regulation of phospholipid transport

03320

1438211_s_at Dbp D site albumin promoter binding protein 7 45705246 BB550183 83

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

circadian rhythm

positive regulation of transcription by RNA polymerase II

rhythmic process

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

 
1416145_at Dhx15 DEAH-box helicase 15 5 -52150202, -52153323 BC003745 47

nucleotide binding

immune system process

nucleic acid binding

RNA binding

RNA binding

RNA helicase activity

double-stranded RNA binding

helicase activity

helicase activity

protein binding

ATP binding

intracellular anatomical structure

nucleus

spliceosomal complex

U12-type spliceosomal complex

mRNA processing

RNA splicing

nuclear speck

hydrolase activity

defense response to bacterium

positive regulation of canonical NF-kappaB signal transduction

innate immune response

defense response to virus

defense response to virus

defense response to virus

U2-type post-mRNA release spliceosomal complex

antiviral innate immune response

antiviral innate immune response

antiviral innate immune response

03040

1423645_a_at Ddx5 DEAD box helicase 5 11 -106780355, -106780354, -106780354 BC009142 112

negative regulation of transcription by RNA polymerase II

nucleotide binding

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

nuclear-transcribed mRNA catabolic process

epithelial to mesenchymal transition

nucleic acid binding

transcription coregulator activity

RNA binding

RNA helicase activity

RNA helicase activity

mRNA 3'-UTR binding

mRNA 3'-UTR binding

helicase activity

protein binding

calmodulin binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

spliceosomal complex

nucleolus

cytoplasm

cytoplasm

regulation of transcription by RNA polymerase II

mRNA processing

protein import into nucleus

circadian rhythm

RNA splicing

mRNA transcription

nuclear speck

hydrolase activity

enzyme binding

BMP signaling pathway

intracellular estrogen receptor signaling pathway

androgen receptor signaling pathway

primary miRNA processing

MH2 domain binding

pre-mRNA binding

ribonucleoprotein complex binding

ribonucleoprotein complex binding

positive regulation of DNA damage response, signal transduction by p53 class mediator

regulation of viral genome replication

myoblast differentiation

regulation of osteoblast differentiation

positive regulation of DNA-templated transcription

SMAD binding

calcium-dependent protein binding

rhythmic process

nuclear androgen receptor binding

regulation of androgen receptor signaling pathway

miRNA transcription

R-SMAD binding

primary miRNA binding

catalytic step 2 spliceosome

intrinsic apoptotic signaling pathway by p53 class mediator

promoter-specific chromatin binding

ribonucleoprotein complex

ribonucleoprotein complex

regulation of skeletal muscle cell differentiation

03040

1424936_a_at Dnah8 dynein, axonemal, heavy chain 8 17 30626935 AF356522 28

nucleotide binding

microtubule motor activity

ATP binding

cytoplasm

cytoskeleton

microtubule

cilium

axoneme

microtubule-based movement

minus-end-directed microtubule motor activity

minus-end-directed microtubule motor activity

ATP hydrolysis activity

dynein complex

motile cilium

sperm flagellum

sperm flagellum

outer dynein arm

outer dynein arm

outer dynein arm assembly

cell projection

dynein intermediate chain binding

dynein intermediate chain binding

dynein light intermediate chain binding

dynein light intermediate chain binding

cilium movement involved in cell motility

 
1438279_at Dpp4 dipeptidylpeptidase 4 2 -62330072, -62333222 BB532984 226

virus receptor activity

behavioral fear response

response to hypoxia

protease binding

B-1a B cell differentiation

regulation of T cell mediated immunity

positive regulation of natural killer cell mediated immunity

aminopeptidase activity

serine-type endopeptidase activity

signaling receptor binding

collagen binding

extracellular region

plasma membrane

plasma membrane

proteolysis

proteolysis

cell adhesion

peptidase activity

serine-type peptidase activity

dipeptidyl-peptidase activity

dipeptidyl-peptidase activity

positive regulation of cell population proliferation

cell surface

negative regulation of extracellular matrix disassembly

membrane

apical plasma membrane

hydrolase activity

lamellipodium

endocytic vesicle

protein catabolic process

T cell costimulation

regulation of cell-cell adhesion mediated by integrin

locomotory exploration behavior

psychomotor behavior

T cell activation

peptide binding

identical protein binding

protein homodimerization activity

cell projection

endothelial cell migration

chemorepellent activity

intercellular canaliculus

anchoring junction

negative regulation of neutrophil chemotaxis

04974

1437301_a_at Dvl1 dishevelled segment polarity protein 1 4 155847401 BB153808 151

regulation of protein phosphorylation

negative regulation of protein phosphorylation

positive regulation of protein phosphorylation

heart looping

outflow tract morphogenesis

frizzled binding

frizzled binding

protein binding

cytoplasm

cytosol

cytosol

cytosol

microtubule

plasma membrane

neurotransmitter secretion

multicellular organism development

axonogenesis

axon guidance

neuromuscular junction development

beta-catenin binding

positive regulation of neuron projection development

postsynaptic density

postsynaptic density

postsynaptic density

microtubule cytoskeleton

microtubule cytoskeleton

membrane

Wnt signaling pathway

synaptic vesicle exocytosis

lateral plasma membrane

enzyme binding

protein kinase binding

protein kinase binding

convergent extension involved in neural plate elongation

clathrin-coated vesicle

axon

axon

dendrite

growth cone

cytoplasmic microtubule organization

cytoplasmic microtubule organization

small GTPase binding

cytoplasmic vesicle

cytoplasmic vesicle

social behavior

protein localization to microtubule

intracellular signal transduction

identical protein binding

neuron projection

neuronal cell body

receptor clustering

dendritic spine

synapse

collateral sprouting

axon extension

dendrite morphogenesis

synapse organization

synapse organization

protein stabilization

convergent extension involved in organogenesis

convergent extension involved in organogenesis

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

Wnt signaling pathway, planar cell polarity pathway

Wnt signaling pathway, planar cell polarity pathway

Wnt signaling pathway, planar cell polarity pathway

prepulse inhibition

dendritic spine morphogenesis

skeletal muscle acetylcholine-gated channel clustering

cochlea morphogenesis

planar cell polarity pathway involved in neural tube closure

planar cell polarity pathway involved in neural tube closure

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

presynapse

presynapse

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

neuronal dense core vesicle

neuronal dense core vesicle

presynapse assembly

presynapse assembly

postsynapse organization

postsynapse organization

regulation of postsynapse organization

regulation of postsynapse organization

positive regulation of neuron projection arborization

Wnt signalosome

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle exocytosis

positive regulation of excitatory postsynaptic potential

04310

04330

04916

05200

05217

1417444_at E2f5 E2F transcription factor 5 3 14578670 BC003220 59

G1/S transition of mitotic cell cycle

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity

fibrillar center

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nuclear envelope

nucleoplasm

nucleoplasm

transcription regulator complex

nucleolus

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

animal organ morphogenesis

sarcoplasm

cell projection organization

intracellular membrane-bounded organelle

sequence-specific DNA binding

protein dimerization activity

regulation of cell cycle

RNA polymerase II transcription regulator complex

04110

04350

1416301_a_at Ebf1 early B cell factor 1 11 44618099, 44620227 BB125261 257

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

multicellular organism development

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

metal ion binding

C2H2 zinc finger domain binding

 
1423571_at S1pr1 sphingosine-1-phosphate receptor 1 3 -115710432 BB133079 288

angiogenesis

angiogenesis

G protein-coupled receptor binding

blood vessel maturation

cardiac muscle tissue growth involved in heart morphogenesis

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

G protein-coupled receptor activity

nucleoplasm

cytoplasm

endosome

plasma membrane

plasma membrane

chemotaxis

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

brain development

cell population proliferation

positive regulation of cell population proliferation

external side of plasma membrane

membrane

cell migration

regulation of metabolic process

lamellipodium assembly

actin cytoskeleton organization

regulation of cell adhesion

positive regulation of cell migration

regulation of bone mineralization

leukocyte chemotaxis

sphingosine-1-phosphate receptor activity

sphingosine-1-phosphate receptor activity

sphingosine-1-phosphate receptor activity

intracellular membrane-bounded organelle

regulation of bone resorption

positive regulation of transcription by RNA polymerase II

sphingolipid binding

positive regulation of smooth muscle cell proliferation

positive regulation of positive chemotaxis

negative regulation of stress fiber assembly

heart trabecula morphogenesis

T cell migration

04080

1436329_at Egr3 early growth response 3 14 70077316, 70077794 AV346607 110

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

positive regulation of endothelial cell proliferation

cell migration involved in sprouting angiogenesis

DNA binding

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

neuromuscular synaptic transmission

peripheral nervous system development

positive regulation of T cell differentiation in thymus

endothelial cell chemotaxis

cellular response to vascular endothelial growth factor stimulus

negative regulation of apoptotic process

sequence-specific DNA binding

cellular response to fibroblast growth factor stimulus

regulation of gamma-delta T cell differentiation

positive regulation of transcription by RNA polymerase II

metal ion binding

sequence-specific double-stranded DNA binding

 
1448175_at Ehd1 EH-domain containing 1 19 6276895 NM_010119 56

nucleotide binding

calcium ion binding

protein binding

ATP binding

GTP binding

cytoplasm

endosome

early endosome

early endosome

lipid droplet

plasma membrane

plasma membrane

cilium

intracellular protein transport

endocytosis

endocytosis

endocytosis

endosome membrane

positive regulation of cholesterol storage

positive regulation of neuron projection development

protein transport

membrane

endosomal transport

ciliary pocket membrane

cell projection organization

endocytic vesicle

endocytic vesicle

platelet dense tubular network membrane

neuron projection development

small GTPase binding

cytoplasmic vesicle

early endosome membrane

endocytic recycling

endocytic recycling

low-density lipoprotein particle clearance

cholesterol homeostasis

identical protein binding

cell projection

myelin sheath

metal ion binding

perinuclear region of cytoplasm

perinuclear region of cytoplasm

protein homooligomerization

recycling endosome membrane

recycling endosome membrane

cilium assembly

cilium assembly

cilium assembly

protein localization to cilium

protein localization to plasma membrane

positive regulation of myoblast fusion

cellular response to nerve growth factor stimulus

positive regulation of endocytic recycling

04144

1449278_at Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 6 70844514, 70844514 NM_010121 287

nucleotide binding

skeletal system development

ossification

angiogenesis

chondrocyte development

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

translation

regulation of translation

regulation of translational initiation

protein phosphorylation

protein phosphorylation

activation of cysteine-type endopeptidase activity involved in apoptotic process

ER overload response

response to unfolded protein

endoplasmic reticulum organization

lactation

positive regulation of signal transduction

positive regulation of vascular endothelial growth factor production

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

regulation of translational initiation by eIF2 alpha phosphorylation

regulation of translational initiation by eIF2 alpha phosphorylation

membrane

kinase activity

phosphorylation

transferase activity

negative regulation of translation

negative regulation of translation

negative regulation of translation

negative regulation of translation

peptidyl-serine phosphorylation

regulation of fatty acid metabolic process

calcium-mediated signaling

enzyme binding

protein phosphatase binding

bone mineralization

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

pancreas development

endocrine pancreas development

negative regulation of myelination

negative regulation of translation in response to stress

positive regulation of protein binding

SREBP signaling pathway

cellular response to amino acid starvation

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

PERK-mediated unfolded protein response

cellular response to glucose starvation

cellular response to glucose starvation

identical protein binding

identical protein binding

negative regulation of apoptotic process

endoplasmic reticulum quality control compartment

fat cell differentiation

positive regulation of transcription by RNA polymerase I

positive regulation of transcription by RNA polymerase I

protein autophosphorylation

protein autophosphorylation

protein autophosphorylation

insulin-like growth factor receptor signaling pathway

perinuclear region of cytoplasm

Hsp90 protein binding

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to cold

eukaryotic initiation factor eIF2 binding

positive regulation of protein localization to nucleus

negative regulation of translation in response to endoplasmic reticulum stress

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of glutathione biosynthetic process

positive regulation of ERAD pathway

04141

05010

05160

1450934_at Eif4a2 eukaryotic translation initiation factor 4A2 16 23107467 BM240314 48

nucleotide binding

cytoplasmic translational initiation

nucleic acid binding

RNA binding

RNA helicase activity

translation initiation factor activity

translation initiation factor activity

helicase activity

ATP binding

translation

translational initiation

eukaryotic translation initiation factor 4F complex

hydrolase activity

ATP hydrolysis activity

perinuclear region of cytoplasm

negative regulation of RNA-dependent RNA polymerase activity

cellular response to leukemia inhibitory factor

03013

1427162_a_at Elk4 ELK4, member of ETS oncogene family 1 132007619, 132008101, 132008344 AW146130 45

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

chromatin binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

cytosol

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cell differentiation

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

04010

1451161_a_at Adgre1 adhesion G protein-coupled receptor E1 17 57358685 U66888 274

adaptive immune response

immune system process

transmembrane signaling receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

calcium ion binding

plasma membrane

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

external side of plasma membrane

membrane

cell periphery

 
1420965_a_at Enc1 ectodermal-neural cortex 1 13 97241104 BM120053 44

chromatin

actin binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoskeleton

multicellular organism development

proteasomal ubiquitin-independent protein catabolic process

proteasomal ubiquitin-independent protein catabolic process

positive regulation of neuron projection development

nuclear matrix

protein ubiquitination

negative regulation of translation

Cul3-RING ubiquitin ligase complex

Cul3-RING ubiquitin ligase complex

neuronal cell body

 
1417338_at Epb42 erythrocyte membrane protein band 4.2 2 -121017890 U03487 47

cell morphogenesis

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

cytoplasm

cytoskeleton

plasma membrane

regulation of cell shape

membrane

peptide cross-linking

peptide cross-linking

hemoglobin metabolic process

cortical cytoskeleton

erythrocyte maturation

spleen development

monoatomic ion homeostasis

multicellular organismal-level iron ion homeostasis

ankyrin-1 complex

 
1418850_at Epc1 enhancer of polycomb homolog 1 18 -6488891, -6435950, -6435950 NM_007935 39

negative regulation of transcription by RNA polymerase II

double-strand break repair via homologous recombination

nucleosome

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

chromatin organization

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

spermatogenesis

spermatid development

nuclear body

cell differentiation

nuclear membrane

piccolo histone acetyltransferase complex

piccolo histone acetyltransferase complex

sperm DNA condensation

NuA4 histone acetyltransferase complex

site of double-strand break

regulation of apoptotic process

negative regulation of gene expression, epigenetic

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of striated muscle cell differentiation

regulation of cell cycle

chromatin-protein adaptor activity

enzyme-substrate adaptor activity

regulation of chromatin organization

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair

 
1422438_at Ephx1 epoxide hydrolase 1, microsomal 1 -180989555 NM_010145 55

catalytic activity

epoxide hydrolase activity

epoxide hydrolase activity

endoplasmic reticulum

lipid metabolic process

cellular aromatic compound metabolic process

oxysterol binding

response to toxic substance

response to organic cyclic compound

membrane

hydrolase activity

ether hydrolase activity

arachidonic acid metabolic process

arachidonic acid metabolic process

aromatic compound catabolic process

enzyme binding

cis-stilbene-oxide hydrolase activity

diol biosynthetic process

intracellular membrane-bounded organelle

epoxide metabolic process

epoxide metabolic process

00980

04976

1419406_a_at Bcl11a BCL11 transcription factor A 11 24080694, 24078055, 24078055 NM_016707 86

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

transcription regulatory region nucleic acid binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription factor activity

transcription coregulator activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of transcription by RNA polymerase II

gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of neuron projection development

negative regulation of neuron projection development

SWI/SNF complex

SWI/SNF complex

nuclear body

protein sumoylation

protein kinase binding

B cell differentiation

T cell differentiation

paraspeckles

protein homodimerization activity

metal ion binding

protein heterodimerization activity

negative regulation of collateral sprouting

positive regulation of collateral sprouting

regulation of dendrite development

postsynapse

DNA-binding transcription factor binding

negative regulation of dendrite extension

negative regulation of neuron remodeling

negative regulation of dendrite development

negative regulation of dendrite development

negative regulation of branching morphogenesis of a nerve

 
1434920_a_at Evl Ena-vasodilator stimulated phosphoprotein 12 108605765, 108635752, 108554719 AW553781 50

actin binding

protein binding

profilin binding

profilin binding

cytoplasm

cytoskeleton

focal adhesion

axon guidance

actin polymerization or depolymerization

actin polymerization or depolymerization

negative regulation of epithelial cell migration

SH3 domain binding

SH3 domain binding

lamellipodium

actin filament-based movement

platelet activation

positive regulation of actin filament polymerization

positive regulation of actin filament polymerization

cell projection

actin nucleation

phagocytic vesicle

barbed-end actin filament capping

protein homotetramerization

positive regulation of stress fiber assembly

cellular response to type II interferon

negative regulation of ruffle assembly

 
1436884_x_at Ewsr1 Ewing sarcoma breakpoint region 1 11 -5069686, -5080077 BB699868 101

nucleic acid binding

transcription coregulator activity

RNA binding

RNA binding

protein binding

calmodulin binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

plasma membrane

regulation of DNA-templated transcription

Cajal body

membrane

identical protein binding

metal ion binding

 
1417160_s_at Wfdc18 WAP four-disulfide core domain 18 11 83709003 NM_007969 20

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

negative regulation of peptidase activity

antibacterial humoral response

peptidase inhibitor activity

innate immune response

 
1435203_at Man2a2 mannosidase 2, alpha 2 7 -80349096 BB794673 23

Golgi membrane

catalytic activity

alpha-mannosidase activity

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

Golgi apparatus

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

protein deglycosylation

metabolic process

mannosidase activity

membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

metal ion binding

00510

01100

1449305_at F10 coagulation factor X 8 13037307 NM_007972 53

serine-type endopeptidase activity

calcium ion binding

phospholipid binding

extracellular region

extracellular space

proteolysis

blood coagulation

hemostasis

peptidase activity

serine-type peptidase activity

hydrolase activity

positive regulation of TOR signaling

04610

1418897_at F2 coagulation factor II 2 -91625319 NM_010168 97

lipopolysaccharide binding

positive regulation of protein phosphorylation

endopeptidase activity

serine-type endopeptidase activity

serine-type endopeptidase activity

serine-type endopeptidase activity

signaling receptor binding

calcium ion binding

protein binding

extracellular region

extracellular space

extracellular space

proteolysis

acute-phase response

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

blood coagulation

hemostasis

heparin binding

peptidase activity

serine-type peptidase activity

positive regulation of cell population proliferation

regulation of cell shape

response to wounding

external side of plasma membrane

regulation of gene expression

hydrolase activity

platelet activation

platelet activation

platelet activation

positive regulation of blood coagulation

positive regulation of blood coagulation

positive regulation of cell growth

positive regulation of insulin secretion

positive regulation of insulin secretion

positive regulation of collagen biosynthetic process

fibrinolysis

negative regulation of proteolysis

negative regulation of astrocyte differentiation

positive regulation of release of sequestered calcium ion into cytosol

regulation of cytosolic calcium ion concentration

cytolysis by host of symbiont cells

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

antimicrobial humoral immune response mediated by antimicrobial peptide

collagen-containing extracellular matrix

collagen-containing extracellular matrix

collagen-containing extracellular matrix

thrombospondin receptor activity

thrombin-activated receptor signaling pathway

neutrophil-mediated killing of gram-negative bacterium

positive regulation of lipid kinase activity

negative regulation of cytokine production involved in inflammatory response

positive regulation of protein localization to nucleus

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

ligand-gated ion channel signaling pathway

ligand-gated ion channel signaling pathway

positive regulation of reactive oxygen species metabolic process

04080

04610

04810

1448931_at F2rl1 F2R like trypsin receptor 1 13 -95511729 NM_007974 325

proteinase-activated receptor activity

G-protein alpha-subunit binding

protease binding

T cell activation involved in immune response

immune system process

positive regulation of leukocyte chemotaxis

positive regulation of cytokine production involved in immune response

positive regulation of glomerular filtration

G protein-coupled receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

early endosome

plasma membrane

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of cytosolic calcium ion concentration

blood coagulation

negative regulation of tumor necrosis factor-mediated signaling pathway

thrombin-activated receptor activity

membrane

regulation of blood coagulation

positive regulation of cell migration

positive regulation of actin filament depolymerization

pseudopodium

positive regulation of pseudopodium assembly

G-protein beta-subunit binding

negative regulation of chemokine production

positive regulation of chemokine production

positive regulation of chemokine production

positive regulation of type II interferon production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-10 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

heterotrimeric G-protein binding

positive regulation of superoxide anion generation

positive regulation of toll-like receptor 2 signaling pathway

negative regulation of toll-like receptor 3 signaling pathway

positive regulation of toll-like receptor 3 signaling pathway

positive regulation of toll-like receptor 4 signaling pathway

positive regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

positive regulation of Rho protein signal transduction

neutrophil activation

vasodilation

vasodilation

vasodilation

regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of eosinophil degranulation

positive regulation of GTPase activity

innate immune response

cell-cell junction maintenance

positive regulation of transcription by RNA polymerase II

regulation of JNK cascade

negative regulation of JNK cascade

positive regulation of JNK cascade

negative regulation of insulin secretion

negative regulation of insulin secretion

leukocyte migration

positive regulation of chemotaxis

positive regulation of positive chemotaxis

defense response to virus

defense response to virus

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of phagocytosis, engulfment

establishment of endothelial barrier

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

thrombin-activated receptor signaling pathway

leukocyte proliferation

positive regulation of neutrophil mediated killing of gram-negative bacterium

mature conventional dendritic cell differentiation

mature conventional dendritic cell differentiation

potassium channel activating, G protein-coupled receptor signaling pathway

potassium channel activating, G protein-coupled receptor signaling pathway

positive regulation of renin secretion into blood stream

regulation of chemokine (C-X-C motif) ligand 2 production

04080

05143

1454699_at Sesn1 sestrin 1 10 41810573, 41887438 BG076140 40

fibrillar center

protein binding

nucleus

nucleoplasm

cytoplasm

positive regulation of macroautophagy

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor

negative regulation of cell growth

cellular response to amino acid starvation

cellular response to glucose starvation

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

GATOR2 complex

leucine binding

leucine binding

cellular response to amino acid stimulus

cellular response to leucine

reactive oxygen species metabolic process

cellular oxidant detoxification

regulation of response to reactive oxygen species

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

cellular response to leucine starvation

04115

1416514_a_at Fscn1 fascin actin-bundling protein 1 5 142960354 NM_007984 77

stress fiber

ruffle

ruffle

podosome

actin binding

protein binding

cytoplasm

cytoplasm

cytosol

cytoskeleton

microvillus

microvillus

cell-cell junction

actin filament organization

cell-cell junction assembly

establishment or maintenance of cell polarity

positive regulation of lamellipodium assembly

actin cytoskeleton

actin cytoskeleton

cell migration

cell migration

cell migration

lamellipodium

lamellipodium

lamellipodium

microspike assembly

actin cytoskeleton organization

parallel actin filament bundle assembly

filopodium

filopodium

filopodium

dendrite

growth cone

growth cone

growth cone

protein-macromolecule adaptor activity

cell projection membrane

cell projection membrane

regulation of microvillus assembly

regulation of actin cytoskeleton organization

establishment of apical/basal cell polarity

cell projection

myelin sheath

microspike

cell motility

actin filament binding

actin filament binding

actin filament binding

actin filament bundle assembly

actin filament bundle assembly

actin filament bundle assembly

positive regulation of filopodium assembly

positive regulation of filopodium assembly

anchoring junction

positive regulation of podosome assembly

positive regulation of extracellular matrix disassembly

 
1421775_at Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide 1 -173221270 NM_010184 145

positive regulation of type I hypersensitivity

serotonin secretion

serotonin secretion

protein binding

plasma membrane

plasma membrane

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

immunoglobulin mediated immune response

type I hypersensitivity

peptidyl-tyrosine phosphorylation

leukotriene biosynthetic process

calcium-mediated signaling

IgE receptor activity

IgE receptor activity

high-affinity IgE receptor activity

high-affinity IgE receptor activity

IgE binding

IgE binding

IgE binding

IgE binding

granulocyte macrophage colony-stimulating factor production

interleukin-3 production

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of interleukin-3 production

mast cell cytokine production

positive regulation of mast cell cytokine production

type 2 immune response

mast cell degranulation

mast cell degranulation

positive regulation of mast cell degranulation

eosinophil degranulation

positive regulation of MAP kinase activity

positive regulation of JUN kinase activity

membrane raft

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of calcium-mediated signaling

establishment of localization in cell

04664

05310

1443264_at Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 19 -11615520 AV241486 46

endosome

plasma membrane

plasma membrane

immune response

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

protein kinase C-activating G protein-coupled receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

membrane

IgE receptor activity

IgE binding

protein kinase binding

Fc-epsilon receptor I complex

Fc-epsilon receptor I complex

SH2 domain binding

positive regulation of mast cell degranulation

membrane raft

phosphoprotein binding

regulation of release of sequestered calcium ion into cytosol

04664

05310

1418340_at Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 1 -171229571 NM_010185 507

positive regulation of type IIa hypersensitivity

positive regulation of type III hypersensitivity

positive regulation of type I hypersensitivity

neutrophil activation involved in immune response

neutrophil activation involved in immune response

T cell differentiation involved in immune response

T cell differentiation involved in immune response

immune system process

Fc receptor mediated stimulatory signaling pathway

Fc receptor mediated stimulatory signaling pathway

serotonin secretion by platelet

transmembrane signaling receptor activity

protein binding

plasma membrane

plasma membrane

plasma membrane

phagocytosis, engulfment

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

integrin-mediated signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

regulation of platelet activation

regulation of platelet activation

membrane

immunoglobulin mediated immune response

immunoglobulin mediated immune response

IgE receptor activity

IgE receptor activity

IgE receptor activity

IgE binding

IgE binding

IgG binding

IgG binding

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

osteoclast differentiation

neutrophil chemotaxis

neutrophil chemotaxis

receptor internalization

interleukin-2 production

interleukin-6 production

interleukin-6 production

tumor necrosis factor production

tumor necrosis factor production

positive regulation of interleukin-10 production

positive regulation of interleukin-4 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

mast cell cytokine production

mast cell cytokine production

positive regulation of mast cell cytokine production

positive regulation of mast cell cytokine production

Fc-epsilon receptor I complex

Fc-epsilon receptor I complex

Fc-gamma receptor III complex

mast cell apoptotic process

mast cell apoptotic process

negative regulation of mast cell apoptotic process

negative regulation of mast cell apoptotic process

Fc-gamma receptor signaling pathway

Fc-gamma receptor signaling pathway

Fc-epsilon receptor signaling pathway

interleukin-3-mediated signaling pathway

antigen processing and presentation of exogenous peptide antigen via MHC class I

antigen processing and presentation of exogenous peptide antigen via MHC class I

defense response to bacterium

defense response to bacterium

identical protein binding

identical protein binding

protein homodimerization activity

mast cell degranulation

mast cell degranulation

positive regulation of mast cell degranulation

positive regulation of mast cell degranulation

innate immune response

innate immune response

membrane raft

mast cell activation

mast cell activation

metal ion binding

protein heterodimerization activity

positive regulation of phagocytosis

positive regulation of phagocytosis

regulation of immune response

positive regulation of immune response

cellular response to low-density lipoprotein particle stimulus

protein localization to plasma membrane

positive regulation of protein localization to cell surface

positive regulation of protein localization to cell surface

04650

04664

05310

1422122_at Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide 8 -3681736, -3681736, -3681736 M99371 91

B cell antigen processing and presentation

positive regulation of humoral immune response mediated by circulating immunoglobulin

plasma membrane

immune response

external side of plasma membrane

external side of plasma membrane

membrane

low-affinity IgE receptor activity

IgE binding

carbohydrate binding

carbohydrate binding

macrophage activation

biological process involved in interspecies interaction between organisms

metal ion binding

positive regulation of nitric-oxide synthase activity

positive regulation of killing of cells of another organism

positive regulation of nitric-oxide synthase biosynthetic process

Fc receptor-mediated immune complex endocytosis

04640

1417876_at Fcgr1 Fc receptor, IgG, high affinity I 3 -96282908 AF143181 204

antibody-dependent cellular cytotoxicity

antibody-dependent cellular cytotoxicity

positive regulation of type IIa hypersensitivity

positive regulation of type III hypersensitivity

immune system process

plasma membrane

receptor-mediated endocytosis

phagocytosis, recognition

phagocytosis, engulfment

cell surface receptor signaling pathway

cell surface receptor signaling pathway

response to bacterium

external side of plasma membrane

external side of plasma membrane

membrane

IgG receptor activity

IgG receptor activity

high-affinity IgG receptor activity

IgG binding

IgG binding

antigen processing and presentation of exogenous antigen

leukotriene receptor binding

antigen processing and presentation of exogenous peptide antigen via MHC class I

defense response to bacterium

innate immune response

positive regulation of phagocytosis

regulation of immune response

positive regulation of phagocytosis, engulfment

04145

04380

04640

04666

05140

05150

05322

1451941_a_at Fcgr2b Fc receptor, IgG, low affinity IIb 1 -170960558 M14216 504

amyloid-beta binding

antibody-dependent cellular cytotoxicity

negative regulation of type I hypersensitivity

immunoglobulin production

immune complex clearance

negative regulation of immunoglobulin production

negative regulation of inflammatory response to antigenic stimulus

negative regulation of acute inflammatory response to antigenic stimulus

negative regulation of humoral immune response mediated by circulating immunoglobulin

protein binding

extracellular region

cytoplasm

cytoskeleton

plasma membrane

plasma membrane

plasma membrane

receptor-mediated endocytosis

phagocytosis

phagocytosis, engulfment

defense response

cell surface receptor signaling pathway

cell surface receptor signaling pathway

response to bacterium

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

immunoglobulin mediated immune response

dendrite development

IgG receptor activity

low-affinity IgG receptor activity

IgG binding

IgG binding

IgG binding

immunoglobulin binding

antigen processing and presentation of exogenous peptide antigen via MHC class II

cerebellum development

negative regulation of B cell proliferation

endocytic recycling

interleukin-10 production

negative regulation of interleukin-10 production

positive regulation of tumor necrosis factor production

negative regulation of neutrophil apoptotic process

B cell proliferation

dendritic spine

cell body

protein-containing complex binding

positive regulation of JNK cascade

regulation of long-term neuronal synaptic plasticity

negative regulation of phagocytosis

positive regulation of phagocytosis

positive regulation of phagocytosis

negative regulation of immune response

positive regulation of DNA-binding transcription factor activity

establishment of localization in cell

recycling endosome

cellular response to molecule of bacterial origin

Fc receptor-mediated immune complex endocytosis

regulation of dendritic spine maintenance

regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway

regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway

cellular response to amyloid-beta

cellular response to amyloid-beta

positive regulation of response to endoplasmic reticulum stress

positive regulation of response to endoplasmic reticulum stress

04145

04380

04662

04666

05150

05322

1448620_at Fcgr3 Fc receptor, IgG, low affinity III 1 -171051168, -171051168 NM_010188 254

antibody-dependent cellular cytotoxicity

antibody-dependent cellular cytotoxicity

positive regulation of type IIa hypersensitivity

positive regulation of type III hypersensitivity

positive regulation of type I hypersensitivity

positive regulation of type I hypersensitivity

serotonin secretion

plasma membrane

phagocytosis, recognition

phagocytosis, engulfment

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

IgG receptor activity

IgG receptor activity

IgG receptor activity

IgG binding

IgG binding

neutrophil chemotaxis

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

immunoglobulin receptor binding

antigen processing and presentation of exogenous peptide antigen via MHC class I

mast cell activation

mast cell activation

positive regulation of phagocytosis

positive regulation of phagocytosis

regulation of immune response

04145

04380

04650

05140

05150

05322

1418497_at Fgf13 fibroblast growth factor 13 X -59062145, -59062145, -59062145, -59062145 AF020737 65

MAPK cascade

neuron migration

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

cytosol

microtubule

plasma membrane

sodium ion transport

negative regulation of microtubule depolymerization

nervous system development

learning or memory

learning

memory

microtubule binding

growth factor activity

intercalated disc

membrane

lateral plasma membrane

sodium channel regulator activity

sodium channel regulator activity

sodium channel regulator activity

hippocampus development

cerebral cortex cell migration

neurogenesis

filopodium

protein kinase activator activity

axon

dendrite

growth cone

cell projection

neuron projection

transmembrane transporter binding

establishment of neuroblast polarity

microtubule polymerization

beta-tubulin binding

negative regulation of collateral sprouting

branching morphogenesis of a nerve

protein localization to plasma membrane

regulation of cardiac muscle cell action potential involved in regulation of contraction

inhibitory synapse assembly

regulation of voltage-gated sodium channel activity

positive regulation of voltage-gated sodium channel activity

04010

04810

05200

05218

1442804_at Fgr FGR proto-oncogene, Src family tyrosine kinase 4 132974094 BB165085 113

nucleotide binding

phosphotyrosine residue binding

phosphotyrosine residue binding

positive regulation of cytokine production

immune system process

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

signaling receptor binding

protein binding

ATP binding

cytoplasm

mitochondrion

mitochondrial inner membrane

cytoskeleton

plasma membrane

plasma membrane

protein phosphorylation

protein phosphorylation

transmembrane receptor protein tyrosine kinase signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

regulation of cell shape

actin cytoskeleton

membrane

aggresome

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

peptidyl-tyrosine phosphorylation

protein kinase binding

protein kinase binding

cell differentiation

bone mineralization

positive regulation of cell migration

ruffle membrane

negative regulation of natural killer cell activation

regulation of actin cytoskeleton organization

immunoglobulin receptor binding

Fc-gamma receptor I complex binding

cell projection

positive regulation of mast cell degranulation

innate immune response

innate immune response

regulation of innate immune response

regulation of protein kinase activity

protein autophosphorylation

skeletal system morphogenesis

regulation of phagocytosis

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

04062

1424828_a_at Fh1 fumarate hydratase 1 1 -175601377 BC006048 58

urea cycle

regulation of arginine metabolic process

catalytic activity

fumarate hydratase activity

fumarate hydratase activity

fumarate hydratase activity

nucleus

chromosome

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

cytosol

tricarboxylic acid cycle

tricarboxylic acid cycle

tricarboxylic acid cycle

fumarate metabolic process

fumarate metabolic process

fumarate metabolic process

malate metabolic process

malate metabolic process

DNA repair

DNA damage response

lyase activity

site of double-strand break

histone binding

tricarboxylic acid cycle enzyme complex

homeostasis of number of cells within a tissue

positive regulation of cold-induced thermogenesis

positive regulation of double-strand break repair via nonhomologous end joining

00020

01100

05200

05211

1416125_at Fkbp5 FK506 binding protein 5 17 -28398752 U16959 134

protein peptidyl-prolyl isomerization

peptidyl-prolyl cis-trans isomerase activity

peptidyl-prolyl cis-trans isomerase activity

protein binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

response to bacterium

isomerase activity

heat shock protein binding

chaperone-mediated protein folding

chaperone-mediated protein folding

 
1418288_at Lpin1 lipin 1 12 -16535668, -16535668 NM_015763 138

negative regulation of transcription by RNA polymerase II

mitochondrial fission

transcription coactivator activity

transcription coactivator activity

protein binding

nucleus

nucleus

transcription regulator complex

cytoplasm

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

cytosol

lipid metabolic process

triglyceride mobilization

immune response

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

phosphatidate phosphatase activity

fatty acid catabolic process

fatty acid catabolic process

membrane

hydrolase activity

triglyceride biosynthetic process

triglyceride biosynthetic process

triglyceride biosynthetic process

actin cytoskeleton organization

ruffle organization

negative regulation of myelination

nuclear membrane

cellular response to insulin stimulus

cellular response to insulin stimulus

cellular response to insulin stimulus

histone deacetylase binding

peroxisome proliferator activated receptor binding

cellular lipid metabolic process

fat cell differentiation

regulation of fat cell differentiation

positive regulation of DNA replication

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

phosphatidic acid metabolic process

RNA polymerase II-specific DNA-binding transcription factor binding

positive regulation of cold-induced thermogenesis

 
1448559_at Flot1 flotillin 1 17 35823356 NM_008027 66

positive regulation of cytokine production

uropod

positive regulation of protein phosphorylation

protease binding

regulation of receptor internalization

regulation of receptor internalization

regulation of receptor internalization

protein binding

endosome

early endosome

microtubule organizing center

plasma membrane

plasma membrane

plasma membrane

caveola

caveola

cell-cell junction

adherens junction

endocytosis

axonogenesis

axon guidance

COP9 signalosome

external side of plasma membrane

membrane

basolateral plasma membrane

flotillin complex

flotillin complex

flotillin complex

extracellular matrix disassembly

lamellipodium

cortical actin cytoskeleton

cytoplasmic vesicle

cytoplasmic vesicle

positive regulation of protein binding

positive regulation of protein binding

positive regulation of synaptic transmission, dopaminergic

positive regulation of interferon-beta production

dsRNA transport

positive regulation of heterotypic cell-cell adhesion

positive regulation of toll-like receptor 3 signaling pathway

centriolar satellite

response to endoplasmic reticulum stress

regulation of Rho protein signal transduction

ionotropic glutamate receptor binding

sarcolemma

positive regulation of canonical NF-kappaB signal transduction

cell-cell contact zone

plasma membrane raft

plasma membrane raft assembly

plasma membrane raft organization

membrane raft

membrane raft

synapse

positive regulation of endocytosis

positive regulation of endocytosis

positive regulation of endocytosis

positive regulation of skeletal muscle tissue development

positive regulation of skeletal muscle tissue development

presynaptic active zone

protein stabilization

regulation of neurotransmitter uptake

protein kinase C signaling

protein kinase C signaling

protein kinase C signaling

cellular response to exogenous dsRNA

protein localization to plasma membrane

protein localization to plasma membrane

protein localization to plasma membrane

dopaminergic synapse

presynapse

glutamatergic synapse

GABA-ergic synapse

positive regulation of myoblast fusion

positive regulation of myoblast fusion

positive regulation of cell junction assembly

positive regulation of cell junction assembly

positive regulation of cell junction assembly

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell-cell adhesion mediated by cadherin

04910

1438164_x_at Flot2 flotillin 2 11 78037930 BB118974 60

uropod

protease binding

acrosomal membrane

endosome

plasma membrane

plasma membrane

caveola

caveola

adherens junction

cell adhesion

negative regulation of gene expression

membrane

basolateral plasma membrane

flotillin complex

flotillin complex

flotillin complex

lamellipodium

endocytic vesicle

cortical actin cytoskeleton

cytoplasmic vesicle

cytoplasmic vesicle

cytoplasmic vesicle

vesicle

ionotropic glutamate receptor binding

positive regulation of canonical NF-kappaB signal transduction

intracellular membrane-bounded organelle

cell-cell contact zone

protein localization to plasma membrane raft

membrane raft

synapse

regulation of myoblast differentiation

regulation of myoblast differentiation

perinuclear region of cytoplasm

presynaptic active zone membrane

protein stabilization

protein localization to plasma membrane

protein localization to plasma membrane

anterograde dendritic transport

anterograde dendritic transport

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic membrane neurotransmitter receptor levels

regulation of postsynaptic membrane neurotransmitter receptor levels

negative regulation of amyloid precursor protein catabolic process

positive regulation of establishment of T cell polarity

04910

1437247_at Fosl2 fos-like antigen 2 5 32136471 BM245170 72

cell morphogenesis

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

ossification

osteoblast differentiation

response to hypoxia

response to hypoxia

cytokine production

cytokine production

NK T cell differentiation

chondrocyte differentiation

inflammatory response to antigenic stimulus

keratinocyte development

growth plate cartilage development

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

inflammatory response

inflammatory response

response to xenobiotic stimulus

gene expression

gene expression

B cell differentiation

T cell differentiation

neutrophil differentiation

macrophage differentiation

macrophage differentiation

bone mineralization

osteoclast differentiation

lung development

response to estradiol

response to lipopolysaccharide

chemokine production

granulocyte macrophage colony-stimulating factor production

interleukin-2 production

interleukin-4 production

collagen metabolic process

collagen biosynthetic process

multicellular organism growth

T-helper 2 cell cytokine production

response to interleukin-13

chondrocyte proliferation

myofibroblast differentiation

regulation of multicellular organism growth

regulation of multicellular organism growth

B cell proliferation

glucose homeostasis

sequence-specific DNA binding

innate immune response

fat cell differentiation

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of fibroblast proliferation

lung alveolus development

smooth muscle tissue development

tissue remodeling

homeostasis of number of cells

homeostasis of number of cells within a tissue

homeostasis of number of cells within a tissue

T cell receptor signaling pathway

T cell receptor signaling pathway

cartilage development

response to glucocorticoid

bone development

bone development

lung connective tissue development

fat pad development

alveolar secondary septum development

mucus secretion

chemokine (C-C motif) ligand 11 production

RNA polymerase II transcription regulator complex

response to interleukin-7

response to Gram-positive bacterium

insulin metabolic process

fat cell apoptotic process

regulation of myofibroblast differentiation

regulation of myofibroblast differentiation

response to bleomycin

response to leukemia inhibitory factor

04380

1422953_at Fpr2 formyl peptide receptor 2 17 17887823 NM_008039 126

amyloid-beta binding

amyloid-beta binding

positive regulation of protein phosphorylation

complement receptor mediated signaling pathway

immune response-regulating cell surface receptor signaling pathway

complement receptor activity

G protein-coupled receptor activity

N-formyl peptide receptor activity

N-formyl peptide receptor activity

scavenger receptor binding

cytoplasm

plasma membrane

plasma membrane

chemotaxis

inflammatory response

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

membrane

calcium-mediated signaling

positive regulation of superoxide anion generation

signaling receptor activity

signaling receptor activity

defense response to bacterium

positive regulation of innate immune response

negative regulation of inflammatory response

positive regulation of phagocytosis

RAGE receptor binding

positive chemotaxis

positive regulation of ERK1 and ERK2 cascade

positive regulation of monocyte chemotaxis

cellular response to amyloid-beta

cellular response to amyloid-beta

04080

05150

1450808_at Fpr1 formyl peptide receptor 1 17 -17876470 NM_013521 88

G protein-coupled receptor binding

complement receptor mediated signaling pathway

complement receptor activity

G protein-coupled receptor activity

N-formyl peptide receptor activity

N-formyl peptide receptor activity

N-formyl peptide receptor activity

scavenger receptor binding

cytoplasm

plasma membrane

plasma membrane

chemotaxis

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

membrane

RAGE receptor binding

04080

05150

1425822_a_at Dtx1 deltex 1, E3 ubiquitin ligase 5 -120680263 AB015422 44

Notch binding

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

cytosol

Notch signaling pathway

Notch signaling pathway

Notch signaling pathway

zinc ion binding

regulation of Notch signaling pathway

glial cell differentiation

protein ubiquitination

protein ubiquitination

nuclear body

transferase activity

SH3 domain binding

T cell differentiation

ubiquitin protein ligase binding

negative regulation of T cell differentiation

negative regulation of neuron differentiation

metal ion binding

ubiquitin protein ligase activity

cellular response to leukemia inhibitory factor

04330

1448700_at G0s2 G0/G1 switch gene 2 1 -193272159 NM_008059 36

mitochondrion

mitochondrion

apoptotic process

extrinsic apoptotic signaling pathway

positive regulation of cold-induced thermogenesis

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

 
1448354_at G6pdx glucose-6-phosphate dehydrogenase X-linked X -74409482 NM_008062 146

cytokine production

angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure

angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure

glucose-6-phosphate dehydrogenase activity

glucose-6-phosphate dehydrogenase activity

glucose-6-phosphate dehydrogenase activity

glucose-6-phosphate dehydrogenase activity

glucose binding

cytoplasm

cytosol

cytosol

cytosol

carbohydrate metabolic process

glucose metabolic process

glucose metabolic process

pentose-phosphate shunt

cholesterol biosynthetic process

NADP metabolic process

NADPH regeneration

NADP biosynthetic process

NADP biosynthetic process

glutathione metabolic process

glutathione metabolic process

response to oxidative stress

pentose-phosphate shunt, oxidative branch

pentose-phosphate shunt, oxidative branch

pentose-phosphate shunt, oxidative branch

cytoplasmic side of plasma membrane

negative regulation of protein glutathionylation

membrane

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors

pentose biosynthetic process

pentose biosynthetic process

pentose biosynthetic process

carbohydrate binding

interleukin-10 production

interleukin-12 production

centriolar satellite

cellular response to oxidative stress

regulation of multicellular organism growth

identical protein binding

identical protein binding

protein homodimerization activity

intracellular membrane-bounded organelle

erythrocyte maturation

regulation of neuron apoptotic process

response to ethanol

ribose phosphate biosynthetic process

erythrocyte development

NADP binding

glucose 6-phosphate metabolic process

negative regulation of cell growth involved in cardiac muscle cell development

positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

negative regulation of reactive oxygen species metabolic process

00030

00480

01100

1417694_at Gab1 growth factor receptor bound protein 2-associated protein 1 8 -80764433, -80764430 NM_021356 107

MAPK cascade

angiogenesis

protein binding

cytoplasm

cytoplasm

cytosol

cell-cell junction

cell cortex

response to oxidative stress

signal transduction

signal transduction

epidermal growth factor receptor signaling pathway

heart development

epidermis development

regulation of cell migration

signaling adaptor activity

signaling adaptor activity

signaling adaptor activity

response to hepatocyte growth factor

cellular response to vascular endothelial growth factor stimulus

vascular endothelial growth factor signaling pathway

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

positive regulation of MAP kinase activity

positive regulation of MAPK cascade

positive regulation of MAPK cascade

positive regulation of angiogenesis

platelet-derived growth factor receptor signaling pathway

labyrinthine layer development

interleukin-6-mediated signaling pathway

endothelial cell chemotaxis to vascular endothelial growth factor

04012

04722

05100

05211

1418655_at B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 10 127165155, 127165830, 127165830, 127165155 U18975 105

Golgi membrane

ganglioside biosynthetic process

ganglioside biosynthetic process

ganglioside biosynthetic process

ganglioside biosynthetic process

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity

Golgi apparatus

lipid metabolic process

sphingolipid metabolic process

glycosphingolipid metabolic process

glycosphingolipid metabolic process

glycosphingolipid biosynthetic process

vacuole organization

spermatogenesis

determination of adult lifespan

acetylgalactosaminyltransferase activity

acetylgalactosaminyltransferase activity

membrane

transferase activity

glycosyltransferase activity

hexosyltransferase activity

lipid storage

nerve development

lipid glycosylation

limb development

motor behavior

00604

01100

1436222_at Gas5 growth arrest specific 5 1 161035165, 161034600 AW547050 83

molecular_function

cellular_component

response to bacterium

 
1448886_at Gata3 GATA binding protein 3 2 -9857077 NM_008091 602

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

cell morphogenesis

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding

transcription coactivator binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

in utero embryonic development

cell fate determination

neuron migration

cell activation

regulation of cytokine production

positive regulation of cytokine production

kidney development

mesonephros development

lens development in camera-type eye

immune system process

immune system development

pro-T cell differentiation

aortic valve morphogenesis

cardiac right ventricle morphogenesis

ventricular septum development

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

interleukin-2 receptor binding

protein binding

nucleus

nucleus

nucleoplasm

chromatin remodeling

chromatin remodeling

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

inflammatory response

humoral immune response

signal transduction

nervous system development

axon guidance

zinc ion binding

cell population proliferation

negative regulation of cell population proliferation

male gonad development

post-embryonic development

positive regulation of signal transduction

gene expression

positive regulation of endothelial cell migration

positive regulation of gene expression

negative regulation of gene expression

negative regulation of epithelial to mesenchymal transition

regulation of neuron projection development

neuron differentiation

T cell differentiation

T cell differentiation

erythrocyte differentiation

macrophage differentiation

regulation of epithelial cell differentiation

TOR signaling

type II interferon production

interleukin-13 production

interleukin-4 production

interleukin-4 production

interleukin-5 production

negative regulation of type II interferon production

negative regulation of type II interferon production

negative regulation of interleukin-2 production

positive regulation of interleukin-13 production

positive regulation of interleukin-13 production

positive regulation of interleukin-4 production

positive regulation of interleukin-4 production

positive regulation of interleukin-5 production

positive regulation of interleukin-5 production

T cell differentiation in thymus

T cell differentiation in thymus

negative regulation of mammary gland epithelial cell proliferation

embryonic hemopoiesis

embryonic hemopoiesis

ureter maturation

parathyroid hormone secretion

norepinephrine biosynthetic process

inner ear morphogenesis

identical protein binding

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of neuron apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

ear development

thymic T cell selection

T-helper 2 cell differentiation

T-helper 2 cell differentiation

innate immune response

cell fate commitment

positive regulation of T cell differentiation

positive regulation of cell differentiation

regulation of T-helper cell differentiation

negative regulation of cell cycle

negative regulation of cell cycle

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

cell maturation

sympathetic nervous system development

thymus development

embryonic organ development

embryonic organ development

developmental growth

anatomical structure formation involved in morphogenesis

homeostasis of number of cells

negative regulation of inflammatory response

T cell receptor signaling pathway

cartilage development

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

parathyroid gland development

pharyngeal system development

uterus development

mesenchymal to epithelial transition

mast cell differentiation

ureteric bud formation

RNA polymerase II-specific DNA-binding transcription factor binding

E-box binding

cellular response to cytokine stimulus

cellular response to interleukin-4

cellular response to interleukin-4

otic vesicle development

cellular response to BMP stimulus

HMG box domain binding

positive regulation of ureteric bud formation

nephric duct morphogenesis

nephric duct formation

regulation of nephron tubule epithelial cell differentiation

ureter morphogenesis

lymphocyte migration

negative regulation of DNA demethylation

negative regulation of DNA demethylation

positive regulation of miRNA transcription

histone methyltransferase binding

sequence-specific double-stranded DNA binding

regulation of establishment of cell polarity

negative regulation of cell motility

negative regulation of endothelial cell apoptotic process

positive regulation of T-helper 2 cell cytokine production

negative regulation of cell proliferation involved in mesonephros development

positive regulation of thyroid hormone generation

positive regulation of transcription regulatory region DNA binding

positive regulation of transcription regulatory region DNA binding

regulation of cellular response to X-ray

negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation

negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation

 
1420549_at Gbp2b guanylate binding protein 2b 3 142594846 NM_010259 45

Golgi membrane

nucleotide binding

activation of innate immune response

immune system process

actin binding

GTPase activity

GTPase activity

GTPase activity

G protein activity

GDP phosphatase activity

endopeptidase inhibitor activity

protein binding

GTP binding

GTP binding

extracellular region

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

plasma membrane

vesicle membrane

actin cytoskeleton

membrane

hydrolase activity

GMP binding

GDP binding

enzyme binding

cytokine binding

symbiont-containing vacuole membrane

spectrin binding

cytoplasmic vesicle

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

defense response to bacterium

identical protein binding

protein homodimerization activity

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

innate immune response

perinuclear region of cytoplasm

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to virus

cytolysis in another organism

Hsp90 protein binding

cellular response to lipopolysaccharide

cellular response to type II interferon

cellular response to type II interferon

symbiont cell surface

positive regulation of pyroptosis

molecular function inhibitor activity

 
1435906_x_at Gbp2 guanylate binding protein 2 3 142620662 BE197524 65

Golgi membrane

nucleotide binding

activation of innate immune response

immune system process

actin binding

GTPase activity

GTPase activity

GTPase activity

G protein activity

G protein activity

GDP phosphatase activity

endopeptidase inhibitor activity

GTP binding

GTP binding

nucleus

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

protein targeting

response to bacterium

vesicle membrane

actin cytoskeleton

membrane

hydrolase activity

GDP binding

enzyme binding

cytokine binding

symbiont-containing vacuole membrane

spectrin binding

GTPase regulator activity

cytoplasmic vesicle

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

defense response to bacterium

defense response to bacterium

identical protein binding

protein homodimerization activity

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

innate immune response

perinuclear region of cytoplasm

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cytolysis in another organism

cytolysis in another organism

Hsp90 protein binding

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to type II interferon

cellular response to type II interferon

symbiont cell surface

symbiont cell surface

positive regulation of pyroptosis

positive regulation of pyroptosis

molecular function inhibitor activity

positive regulation of AIM2 inflammasome complex assembly

 
1419595_a_at Ggh gamma-glutamyl hydrolase 4 20042051 NM_010281 21

extracellular region

extracellular space

extracellular space

lysosome

vacuole

peptidase activity

omega peptidase activity

response to xenobiotic stimulus

response to zinc ion

hydrolase activity

response to insulin

gamma-glutamyl-peptidase activity

gamma-glutamyl-peptidase activity

response to ethanol

tetrahydrofolylpolyglutamate metabolic process

00790

1448485_at Ggt1 gamma-glutamyltransferase 1 10 75573494, 75568661, 75564131, 75571559 NM_008116 69

peptidyltransferase activity

regulation of immune system process

regulation of immune system process

leukotriene-C(4) hydrolase

extracellular space

endoplasmic reticulum

plasma membrane

plasma membrane

plasma membrane

proteolysis

glutathione metabolic process

glutathione biosynthetic process

glutathione catabolic process

glutathione catabolic process

spermatogenesis

peptidase activity

membrane

transferase activity

acyltransferase activity

aminoacyltransferase activity

hydrolase activity

cysteine biosynthetic process

peptide modification

peptide modification

vesicle

glutathione hydrolase activity

glutathione hydrolase activity

perinuclear region of cytoplasm

regulation of inflammatory response

regulation of inflammatory response

leukotriene C4 gamma-glutamyl transferase activity

00430

00460

00480

00590

01100

1417962_s_at Ghr growth hormone receptor 15 -3327524, -3317754, -3317754 NM_010284 313

cytokine receptor activity

growth hormone receptor activity

growth hormone receptor activity

growth hormone receptor activity

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

nucleus

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

endocytosis

receptor signaling pathway via JAK-STAT

lipid binding

hormone-mediated signaling pathway

external side of plasma membrane

cell surface

membrane

membrane

peptide hormone binding

peptide hormone binding

peptide hormone binding

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

taurine metabolic process

growth factor binding

growth factor binding

protein kinase binding

protein phosphatase binding

cytokine binding

regulation of response to nutrient levels

response to estradiol

cellular response to hormone stimulus

cytoplasmic ribonucleoprotein granule

regulation of multicellular organism growth

positive regulation of multicellular organism growth

SH2 domain binding

hormone metabolic process

identical protein binding

protein homodimerization activity

neuronal cell body

receptor complex

positive regulation of receptor signaling pathway via JAK-STAT

positive regulation of receptor signaling pathway via JAK-STAT

insulin-like growth factor receptor signaling pathway

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

growth hormone receptor signaling pathway

growth hormone receptor signaling pathway

growth hormone receptor signaling pathway

growth hormone receptor complex

growth hormone receptor complex

04060

04080

04630

1426235_a_at Glul glutamate-ammonia ligase 1 153899928 AI391218 247

nucleotide binding

magnesium ion binding

angiogenesis

catalytic activity

glutamine synthetase activity

glutamine synthetase activity

protein binding

ATP binding

cytoplasm

cytoplasm

mitochondrion

mitochondrion

endoplasmic reticulum

cytosol

plasma membrane

glutamate metabolic process

glutamine biosynthetic process

glutamine biosynthetic process

nitrogen compound metabolic process

cell population proliferation

cellular response to starvation

response to glucose

regulation of endothelial cell migration

regulation of endothelial cell migration

membrane

nickel cation binding

glutamate binding

transferase activity

ligase activity

protein palmitoylation

ammonia assimilation cycle

protein-cysteine S-palmitoyltransferase activity

manganese ion binding

positive regulation of insulin secretion

protein-containing complex

ribosome biogenesis

identical protein binding

cell projection

perikaryon

myelin sheath

myelin sheath

intracellular membrane-bounded organelle

axon terminus

cell body

dynein light chain binding

metal ion binding

positive regulation of epithelial cell proliferation

positive regulation of synaptic transmission, glutamatergic

glial cell projection

regulation of sprouting angiogenesis

regulation of sprouting angiogenesis

regulation of protein localization to nucleolus

00250

00330

00910

01100

1421947_at Gng12 guanine nucleotide binding protein (G protein), gamma 12 6 66896396, 66896890 NM_025278 32

heterotrimeric G-protein complex

heterotrimeric G-protein complex

actin filament

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

membrane

PDZ domain binding

G-protein beta-subunit binding

G-protein beta-subunit binding

phosphate ion binding

04010

04062

04810

1428733_at Gngt2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 11 95842667, 95842294, 95843244 AK010554 25

heterotrimeric G-protein complex

heterotrimeric G-protein complex

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

membrane

G-protein beta-subunit binding

G-protein beta-subunit binding

04062

1456887_at Cmklr1 chemerin chemokine-like receptor 1 5 -113612354, -113612354 AW228687 83

complement receptor mediated signaling pathway

complement receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

chemotaxis

chemotaxis

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

positive regulation of macrophage chemotaxis

positive regulation of macrophage chemotaxis

membrane

negative regulation of NF-kappaB transcription factor activity

negative regulation of interleukin-12 production

positive regulation of fat cell differentiation

regulation of calcium-mediated signaling

regulation of calcium-mediated signaling

adipokinetic hormone receptor activity

adipokinetic hormone binding

positive regulation of cold-induced thermogenesis

 
1450081_x_at Gpi1 glucose-6-phosphate isomerase 1 7 -34201326 NM_008155 239

in utero embryonic development

mesoderm formation

positive regulation of immunoglobulin production

glucose-6-phosphate isomerase activity

glucose-6-phosphate isomerase activity

glucose-6-phosphate isomerase activity

glucose-6-phosphate isomerase activity

cytokine activity

protein binding

extracellular region

extracellular space

cytoplasm

cytosol

cytosol

plasma membrane

gluconeogenesis

gluconeogenesis

glycolytic process

glycolytic process

glycolytic process

growth factor activity

positive regulation of endothelial cell migration

isomerase activity

ubiquitin protein ligase binding

erythrocyte homeostasis

glucose homeostasis

myelin sheath

negative regulation of neuron apoptotic process

monosaccharide binding

monosaccharide binding

glucose 6-phosphate metabolic process

glucose 6-phosphate metabolic process

ciliary membrane

glycolytic process through glucose-6-phosphate

canonical glycolysis

carbohydrate derivative binding

carbohydrate derivative metabolic process

00010

00030

00500

00520

01100

1434848_at Gpr27 G protein-coupled receptor 27 6 99692366 BB259283 9

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

 
1421816_at Gsr glutathione reductase 8 33653237 AK019177 83

glutathione-disulfide reductase (NADP) activity

glutathione-disulfide reductase (NADP) activity

glutathione-disulfide reductase (NADP) activity

cytoplasm

mitochondrion

mitochondrion

cytosol

cytosol

glutathione metabolic process

glutathione metabolic process

glutathione metabolic process

spermatogenesis

external side of plasma membrane

oxidoreductase activity

oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

cellular response to oxidative stress

identical protein binding

glutathione binding

cell redox homeostasis

cell redox homeostasis

flavin adenine dinucleotide binding

flavin adenine dinucleotide binding

NADP binding

cellular oxidant detoxification

00480

1448148_at Grn granulin 11 102430506 M86736 257

trophectodermal cell proliferation

blastocyst hatching

astrocyte activation involved in immune response

microglial cell activation involved in immune response

cytokine activity

protein binding

extracellular region

extracellular region

extracellular region

extracellular space

extracellular space

extracellular space

mitochondrion

lysosome

lysosome

lysosomal membrane

endosome

late endosome

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

trans-Golgi network

plasma membrane

lysosome organization

lysosomal transport

lysosomal transport

lysosomal lumen acidification

embryo implantation

positive regulation of cell population proliferation

positive regulation of endothelial cell migration

positive regulation of neuron projection development

membrane

positive regulation of cell migration

vesicle

response to estradiol

locomotory exploration behavior

chondrocyte proliferation

negative regulation of neuron apoptotic process

positive regulation of neuron apoptotic process

synapse

positive regulation of angiogenesis

negative regulation of innate immune response

synaptic vesicle endocytosis

positive regulation of axon regeneration

epithelial cell proliferation

positive regulation of epithelial cell proliferation

positive regulation of epithelial cell proliferation

regulation of inflammatory response

negative regulation of inflammatory response

protein stabilization

protein-folding chaperone binding

negative regulation of hydrolase activity

retina development in camera-type eye

male mating behavior

negative regulation of respiratory burst involved in inflammatory response

positive regulation of dendritic spine development

neural precursor cell proliferation

glutamatergic synapse

maintenance of synapse structure

maintenance of synapse structure

positive regulation of inflammatory response to wounding

cerebellar climbing fiber to Purkinje cell synapse

cerebellar climbing fiber to Purkinje cell synapse

positive regulation of defense response to bacterium

negative regulation of neutrophil activation

positive regulation of protein folding

negative regulation of microglial cell activation

positive regulation of trophectodermal cell proliferation

lysosomal protein catabolic process

positive regulation of aspartic-type peptidase activity

positive regulation of aspartic-type peptidase activity

regulation of lysosome organization

positive regulation of lysosome organization

positive regulation of lysosome organization

 
1423423_at Pdia3 protein disulfide isomerase associated 3 2 121413901 BF319868 128

acrosomal vesicle

adaptive immune response

immune system process

peptide antigen assembly with MHC class I protein complex

protein disulfide isomerase activity

protein disulfide isomerase activity

protein binding

extracellular region

extracellular space

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum lumen

smooth endoplasmic reticulum

protein folding

peptidase activity

cell surface

cell surface

cell surface

protein-disulfide reductase activity

apical plasma membrane

isomerase activity

protein-disulfide reductase (glutathione) activity

response to endoplasmic reticulum stress

MHC class I protein binding

identical protein binding

MHC class I peptide loading complex

TAP complex

myelin sheath

Tapasin-ERp57 complex

platelet aggregation

cellular response to vitamin D

extrinsic apoptotic signaling pathway

cellular response to interleukin-7

positive regulation of protein folding

positive regulation of extrinsic apoptotic signaling pathway

04141

04612

1448330_at Gstm1 glutathione S-transferase, mu 1 3 -108012249, -108012259 NM_010358 48

glutathione transferase activity

glutathione transferase activity

steroid binding

protein binding

extracellular region

cytoplasm

cytosol

lipid metabolic process

glutathione metabolic process

glutathione metabolic process

nickel cation binding

transferase activity

enzyme binding

protein kinase binding

protein-containing complex

xenobiotic catabolic process

identical protein binding

identical protein binding

protein homodimerization activity

myelin sheath

glutathione binding

intercellular bridge

cellular response to xenobiotic stimulus

00480

00980

00982

1417883_at Gstt2 glutathione S-transferase, theta 2 10 -75831844 BC012707 26

glutathione transferase activity

glutathione transferase activity

glutathione peroxidase activity

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

glutathione metabolic process

glutathione metabolic process

transferase activity

cellular response to leukemia inhibitory factor

00480

00980

00982

1425628_a_at Gtf2i general transcription factor II I 5 -134237831, -134237831 AF043220 91

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

transcription by RNA polymerase II

embryo development

negative regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

negative regulation of cytosolic calcium ion concentration

RNA polymerase II-specific DNA-binding transcription factor binding

03022

1452896_at Cfap20 cilia and flagella associated protein 20 8 -95420249 AK011217 22

nucleus

nucleoplasm

cytoplasm

centriole

cytoskeleton

microtubule

axonemal microtubule

cilium

cilium

protein polyglutamylation

motile cilium

ciliary basal body

ciliary basal body

cell projection

cilium assembly

cilium assembly

regulation of cilium beat frequency involved in ciliary motility

regulation of cilium beat frequency involved in ciliary motility

axonemal B tubule inner sheath

positive regulation of cell motility

positive regulation of cell motility

positive regulation of feeding behavior

 
1422703_at Gk glycerol kinase X -85701936 BF683028 50

nucleotide binding

glycerol kinase activity

glycerol kinase activity

glycerol kinase activity

glycerol kinase activity

ATP binding

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

cytosol

cytosol

carbohydrate metabolic process

glycerol metabolic process

glycerol metabolic process

glycerol metabolic process

glycerol-3-phosphate metabolic process

triglyceride metabolic process

triglyceride metabolic process

membrane

kinase activity

phosphorylation

phosphorylation

transferase activity

phosphotransferase activity, alcohol group as acceptor

regulation of fatty acid metabolic process

triglyceride biosynthetic process

histone binding

glucose homeostasis

response to ethanol

glycerol-3-phosphate biosynthetic process

glycerol-3-phosphate biosynthetic process

00561

01100

03320

1425643_at Gypa glycophorin A 8 80494044 M26385 37

nucleoplasm

cytosol

plasma membrane

plasma membrane

external side of plasma membrane

membrane

identical protein binding

identical protein binding

regulation of response to osmotic stress

ankyrin-1 complex

05144

1452431_s_at H2-Aa histocompatibility 2, class II antigen A, alpha 17 -34282743 AF119253 123

adaptive immune response

immune system process

peptide antigen assembly with MHC class II protein complex

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

protein binding

lysosome

lysosomal membrane

plasma membrane

immune response

external side of plasma membrane

membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

late endosome membrane

response to type II interferon

negative regulation of T cell proliferation

peptide antigen binding

peptide antigen binding

MHC class II protein complex

MHC class II protein complex

protein-containing complex binding

positive regulation of T cell differentiation

antigen processing and presentation of peptide antigen

positive regulation of immune response

positive regulation of T cell activation

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

1451721_a_at H2-Ab1 histocompatibility 2, class II antigen A, beta 1 17 34263226 M15848 868

adaptive immune response

B cell affinity maturation

immune system process

peptide antigen assembly with MHC class II protein complex

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

positive regulation of antigen processing and presentation

positive regulation of T-helper 1 type immune response

protein binding

intracellular anatomical structure

lysosomal membrane

early endosome

multivesicular body

Golgi apparatus

plasma membrane

immune response

external side of plasma membrane

cell surface

toxic substance binding

membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

ubiquitin protein ligase binding

late endosome membrane

peptide antigen binding

peptide antigen binding

MHC class II protein complex

MHC class II protein complex

protein-containing complex binding

positive regulation of alpha-beta T cell activation

positive regulation of alpha-beta T cell activation

positive regulation of alpha-beta T cell activation

antigen processing and presentation of peptide antigen

positive regulation of immune response

positive regulation of T cell activation

cellular response to type II interferon

protein antigen binding

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

1417314_at Cfb complement factor B 17 -34856373 NM_008198 182

immune system process

serine-type endopeptidase activity

extracellular region

proteolysis

complement activation

complement activation

complement activation, alternative pathway

complement activation, alternative pathway

complement activation, alternative pathway

peptidase activity

serine-type peptidase activity

response to bacterium

hydrolase activity

B cell proliferation

innate immune response

04610

05150

1417025_at H2-Eb1 histocompatibility 2, class II antigen E beta 17 34305866 NM_010382 84

immunological synapse

adaptive immune response

immune system process

peptide antigen assembly with MHC class II protein complex

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

protein binding

lysosomal membrane

lysosomal membrane

plasma membrane

immune response

external side of plasma membrane

cell surface

membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

polysaccharide binding

late endosome membrane

late endosome membrane

MHC class II receptor activity

response to type II interferon

peptide antigen binding

peptide antigen binding

T cell receptor binding

CD4 receptor binding

MHC class II protein complex

MHC class II protein complex

MHC class II protein complex

positive regulation of immune response

positive regulation of T cell activation

04145

04514

04612

04640

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

1454987_a_at Hsd17b8 hydroxysteroid 17-beta dehydrogenase 8 17 -34026032 AI323545 32

estradiol 17-beta-dehydrogenase [NAD(P)] activity

estradiol 17-beta-dehydrogenase [NAD(P)] activity

estradiol 17-beta-dehydrogenase [NAD(P)] activity

mitochondrion

mitochondrial envelope

mitochondrial matrix

plasma membrane

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

steroid biosynthetic process

estrogen biosynthetic process

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process

membrane

oxidoreductase activity

testosterone dehydrogenase (NAD+) activity

protein heterotetramerization

NADH binding

(3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity

oxidoreductase complex

00140

01100

1419744_at H2-DMb2 histocompatibility 2, class II, locus Mb2 17 34145248, 34143228 NM_010388 24

MHC class II protein complex assembly

peptide antigen assembly with MHC class II protein complex

peptide antigen assembly with MHC class II protein complex

protein binding

lysosome

lysosomal membrane

lysosomal membrane

lysosomal membrane

late endosome

multivesicular body

endosome membrane

membrane

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

MHC class II protein complex binding

late endosome membrane

late endosome membrane

positive regulation of T cell proliferation

peptide antigen binding

MHC class II protein complex

MHC class II protein complex

intracellular membrane-bounded organelle

positive regulation of immune response

positive regulation of T cell activation

chaperone cofactor-dependent protein refolding

positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

1419297_at H2-Oa histocompatibility 2, O region alpha locus 17 34092378 NM_008206 33

peptide antigen assembly with MHC class II protein complex

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

lysosomal membrane

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

MHC class II protein complex binding

late endosome membrane

peptide antigen binding

MHC class II protein complex

MHC class II protein complex

regulation of T cell differentiation

positive regulation of immune response

positive regulation of T cell activation

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

1440837_at H2-Ob histocompatibility 2, O region beta locus 17 34238904 BG144448 48

peptide antigen assembly with MHC class II protein complex

negative regulation of antigen processing and presentation of peptide antigen via MHC class II

intracellular anatomical structure

lysosome

lysosomal membrane

antigen processing and presentation of exogenous peptide antigen via MHC class II

MHC class II protein complex binding

MHC class II protein complex binding

late endosome membrane

peptide antigen binding

MHC class II protein complex

MHC class II protein complex

positive regulation of immune response

positive regulation of T cell activation

04145

04514

04612

04672

04940

05140

05145

05150

05310

05320

05322

05323

05330

05332

05416

1421596_s_at Ifi44l interferon-induced protein 44 like 3 -151758736 NM_031367 11

cytoplasm

immune response

immune response

defense response to virus

 
1457769_at H60a histocompatibility 60a 10   BB822862 35

positive regulation of immune response to tumor cell

plasma membrane

external side of plasma membrane

membrane

positive regulation of type II interferon production

positive regulation of natural killer cell activation

positive regulation of natural killer cell activation

susceptibility to natural killer cell mediated cytotoxicity

positive regulation of macrophage activation

positive regulation of nitric oxide biosynthetic process

natural killer cell lectin-like receptor binding

cellular response to organic cyclic compound

04650

1455972_x_at Hadh hydroxyacyl-Coenzyme A dehydrogenase 3 -131233419 AV018774 48

3-hydroxyacyl-CoA dehydrogenase activity

3-hydroxyacyl-CoA dehydrogenase activity

3-hydroxyacyl-CoA dehydrogenase activity

protein binding

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

lipid metabolic process

fatty acid metabolic process

fatty acid beta-oxidation

fatty acid beta-oxidation

response to xenobiotic stimulus

response to activity

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

identical protein binding

negative regulation of insulin secretion

regulation of insulin secretion

NAD+ binding

positive regulation of cold-induced thermogenesis

00062

00071

00280

00310

00380

00650

01100

1419407_at Hc hemolytic complement 2 -34983328 NM_010406 336

in utero embryonic development

neutrophil homeostasis

kidney development

immune system process

endopeptidase inhibitor activity

extracellular region

membrane attack complex

extracellular space

inflammatory response

complement activation, alternative pathway

complement activation, classical pathway

positive regulation of vascular endothelial growth factor production

negative regulation of macrophage chemotaxis

killing of cells of another organism

positive regulation of chemokine production

glomerulus development

innate immune response

positive regulation of angiogenesis

inflammatory response to wounding

04610

05020

05150

05322

1449455_at Hck hemopoietic cell kinase 2 153108467 NM_010407 132

nucleotide binding

phosphotyrosine residue binding

immune system process

protein kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

signaling receptor binding

protein binding

ATP binding

nucleus

cytoplasm

lysosome

Golgi apparatus

cytosol

cytosol

cytoskeleton

actin filament

plasma membrane

caveola

focal adhesion

protein phosphorylation

protein phosphorylation

exocytosis

phagocytosis

inflammatory response

transmembrane receptor protein tyrosine kinase signaling pathway

positive regulation of cell population proliferation

lipid binding

regulation of cell shape

cytoplasmic side of plasma membrane

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

cell differentiation

cytoplasmic vesicle

regulation of actin cytoskeleton organization

intracellular signal transduction

cell projection

negative regulation of apoptotic process

intracellular membrane-bounded organelle

innate immune response

innate immune response

protein autophosphorylation

regulation of phagocytosis

defense response to Gram-positive bacterium

regulation of DNA-binding transcription factor activity

localization

anchoring junction

regulation of podosome assembly

04062

04666

1454713_s_at Hdc histidine decarboxylase 2 -126593659 BG072171 219

histamine metabolic process

histamine biosynthetic process

histamine biosynthetic process

histamine biosynthetic process

histidine decarboxylase activity

histidine decarboxylase activity

histidine decarboxylase activity

histidine decarboxylase activity

cytoplasm

amino acid metabolic process

histidine metabolic process

histidine catabolic process

histidine catabolic process

histidine catabolic process

histidine catabolic process

amino acid binding

lyase activity

carbon-carbon lyase activity

carboxy-lyase activity

carboxylic acid metabolic process

pyridoxal phosphate binding

dendrite

catecholamine biosynthetic process

identical protein binding

neuronal cell body

00340

01100

1422018_at Hivep2 human immunodeficiency virus type I enhancer binding protein 2 10 13966378, 13966074 NM_010437 45

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

transcription regulator complex

DNA-templated transcription

regulation of transcription by RNA polymerase II

signal transduction

positive regulation of transcription by RNA polymerase II

metal ion binding

 
1455897_x_at Hmgn1 high mobility group nucleosomal binding domain 1 16 -96121587 BF464696 79

pyrimidine dimer repair by nucleotide-excision repair

chromatin

female germ cell nucleus

DNA binding

chromatin binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

transcription-coupled nucleotide-excision repair

chromatin organization

chromatin organization

regulation of transcription by RNA polymerase II

response to UV-B

response to UV-C

nucleosomal DNA binding

regulation of development, heterochronic

post-embryonic camera-type eye morphogenesis

regulation of epithelial cell proliferation

positive regulation of NAD+ ADP-ribosyltransferase activity

 
1436549_a_at Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 15 103240396, 103240396 BE685966 103

alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

DNA binding

single-stranded DNA binding

RNA binding

single-stranded RNA binding

mRNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

mRNA processing

RNA splicing

positive regulation of gene expression

protein domain specific binding

RNA strand annealing activity

miRNA binding

cellular response to potassium ion

pre-mRNA binding

identical protein binding

intracellular non-membrane-bounded organelle

synapse

synapse

positive regulation of action potential

mRNA transport

telomeric repeat-containing RNA binding

catalytic step 2 spliceosome

catalytic step 2 spliceosome

cellular response to organic substance

G-rich strand telomeric DNA binding

molecular condensate scaffold activity

DNA/DNA annealing activity

sequence-specific mRNA binding

nucleoplasmic periphery of the nuclear pore complex

ribonucleoprotein complex

03040

1448881_at Hp haptoglobin 8 -109575127 NM_017370 97

liver development

immune system process

serine-type endopeptidase activity

serine-type endopeptidase activity

extracellular region

extracellular space

extracellular space

extracellular space

proteolysis

acute-phase response

Notch signaling pathway

response to bacterium

antioxidant activity

hemoglobin binding

haptoglobin-hemoglobin complex

spherical high-density lipoprotein particle

defense response to bacterium

identical protein binding

blood microparticle

 
1423944_at Hpx hemopexin 7 -105591610 BC011246 45

positive regulation of immunoglobulin production

positive regulation of humoral immune response mediated by circulating immunoglobulin

extracellular region

extracellular space

extracellular space

intracellular iron ion homeostasis

tyrosine phosphorylation of STAT protein

heme transmembrane transporter activity

heme transport

hemoglobin metabolic process

heme binding

heme metabolic process

heme metabolic process

positive regulation of tyrosine phosphorylation of STAT protein

metal ion binding

regulation of protein metabolic process

positive regulation of response to type II interferon

type II interferon-mediated signaling pathway

positive regulation of type II interferon-mediated signaling pathway

 
1427127_x_at Hspa1b heat shock protein 1B 17 -34956428 M12573 338

G protein-coupled receptor binding

protease binding

zona pellucida receptor complex

signaling receptor binding

protein binding

ATP binding

intracellular anatomical structure

nucleus

nucleus

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrial matrix

centrosome

centriole

cytosol

protein folding

binding of sperm to zona pellucida

response to heat

inclusion body

aggresome

basolateral plasma membrane

apical plasma membrane

nuclear speck

ATP hydrolysis activity

ATP hydrolysis activity

enzyme binding

heat shock protein binding

heat shock protein binding

ubiquitin protein ligase binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

protein-containing complex

protein refolding

histone deacetylase binding

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein folding chaperone

protein folding chaperone

protein folding chaperone

cell body

membrane raft

perinuclear region of cytoplasm

NF-kappaB binding

unfolded protein binding

chaperone cofactor-dependent protein refolding

C3HC4-type RING finger domain binding

ATP-dependent protein disaggregase activity

regulation of mitotic spindle assembly

ribonucleoprotein complex

03040

04010

04141

04144

04612

05145

1424067_at Icam1 intercellular adhesion molecule 1 9 21015939 BC008626 604

immunological synapse

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

acute inflammatory response to antigenic stimulus

T cell antigen processing and presentation

positive regulation of cellular extravasation

integrin binding

integrin binding

extracellular space

cell adhesion

cell adhesion

cell adhesion

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

regulation of cell shape

external side of plasma membrane

cell surface

membrane

positive regulation of actin filament polymerization

cell adhesion mediated by integrin

adhesion of symbiont to host

protein-containing complex binding

membrane raft

positive regulation of nitric oxide biosynthetic process

positive regulation of vasoconstriction

receptor-mediated virion attachment to host cell

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of calcium ion transport

establishment of endothelial barrier

extracellular exosome

positive regulation of ERK1 and ERK2 cascade

cellular response to glucose stimulus

T cell extravasation

establishment of endothelial intestinal barrier

establishment of Sertoli cell barrier

cell-cell adhesion

regulation of ruffle assembly

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

cellular response to amyloid-beta

positive regulation of leukocyte adhesion to vascular endothelial cell

cellular response to leukemia inhibitory factor

negative regulation of endothelial cell apoptotic process

04514

04650

04670

05143

05144

05150

05323

05416

1448862_at Icam2 intercellular adhesion molecule 2 11 -106377655 NM_010494 78

uropod

integrin binding

integrin binding

protein binding

plasma membrane

microvillus

cell adhesion

cell adhesion

membrane

cleavage furrow

cell projection

cell periphery

cell-cell adhesion

04514

04650

1425895_a_at Id1 inhibitor of DNA binding 1, HLH protein 2 152736250 U43884 323

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

endothelial cell morphogenesis

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

apoptotic process

multicellular organism development

heart development

circadian rhythm

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

cell differentiation

BMP signaling pathway

protein destabilization

protein destabilization

positive regulation of actin filament bundle assembly

circadian regulation of gene expression

collagen metabolic process

identical protein binding

negative regulation of apoptotic process

negative regulation of DNA binding

regulation of MAPK cascade

negative regulation of DNA-binding transcription factor activity

protein self-association

negative regulation of endothelial cell differentiation

negative regulation of osteoblast differentiation

regulation of angiogenesis

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

response to antibiotic

protein dimerization activity

rhythmic process

positive regulation of epithelial cell proliferation

negative regulation of dendrite morphogenesis

lung morphogenesis

lung vasculature development

proteasome binding

endothelial cell apoptotic process

negative regulation of cold-induced thermogenesis

transcription regulator activity

transcription regulator inhibitor activity

transcription regulator inhibitor activity

regulation of vasculature development

negative regulation of endothelial cell apoptotic process

04350

1435176_a_at Id2 inhibitor of DNA binding 2 12 -25093798 BF019883 477

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

euchromatin

metanephros development

natural killer cell differentiation

natural killer cell differentiation

thigmotaxis

leukocyte differentiation

membranous septum morphogenesis

bundle of His development

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

regulation of transcription by RNA polymerase II

multicellular organism development

heart development

circadian rhythm

positive regulation of cell population proliferation

adult locomotory behavior

entrainment of circadian clock

regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

oligodendrocyte development

regulation of lipid metabolic process

olfactory bulb development

cell differentiation

B cell differentiation

erythrocyte differentiation

circadian regulation of gene expression

circadian regulation of gene expression

protein-containing complex

mammary gland epithelial cell proliferation

regulation of circadian rhythm

entrainment of circadian clock by photoperiod

enucleate erythrocyte differentiation

negative regulation of DNA binding

negative regulation of DNA-binding transcription factor activity

transmembrane transporter binding

locomotor rhythm

negative regulation of B cell differentiation

positive regulation of fat cell differentiation

positive regulation of erythrocyte differentiation

positive regulation of macrophage differentiation

regulation of neuron differentiation

negative regulation of osteoblast differentiation

positive regulation of blood pressure

positive regulation of cell cycle

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

protein dimerization activity

cell development

cell maturation

rhythmic process

lymph node development

Peyer's patch development

embryonic digestive tract morphogenesis

positive regulation of smooth muscle cell proliferation

neuron fate commitment

cell morphogenesis involved in neuron differentiation

astrocyte differentiation

oligodendrocyte differentiation

positive regulation of astrocyte differentiation

negative regulation of oligodendrocyte differentiation

white fat cell differentiation

negative regulation of muscle cell differentiation

adipose tissue development

mammary gland alveolus development

epithelial cell differentiation involved in mammary gland alveolus development

endodermal digestive tract morphogenesis

RNA polymerase II-specific DNA-binding transcription factor binding

cellular response to lithium ion

dopaminergic neuron differentiation

cellular senescence

transcription regulator activity

transcription regulator inhibitor activity

negative regulation of dopaminergic neuron differentiation

negative regulation of core promoter binding

regulation of G1/S transition of mitotic cell cycle

regulation of neural precursor cell proliferation

04350

1416630_at Id3 inhibitor of DNA binding 3 4 136143821 NM_008321 288

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

metanephros development

protein binding

nucleus

nucleus

cytoplasm

regulation of DNA replication

multicellular organism development

central nervous system development

heart development

muscle organ development

circadian rhythm

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

protein domain specific binding

cell differentiation

epithelial cell differentiation

notochord development

circadian regulation of gene expression

odontogenesis

positive regulation of apoptotic process

bHLH transcription factor binding

negative regulation of DNA-binding transcription factor activity

negative regulation of myoblast differentiation

negative regulation of osteoblast differentiation

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

protein dimerization activity

rhythmic process

cellular response to leptomycin B

transcription regulator activity

transcription regulator inhibitor activity

leptomycin B binding

04350

1419647_a_at Ier3 immediate early response 3 17 35821712 NM_133662 44

response to protozoan

negative regulation of systemic arterial blood pressure

protein binding

nucleus

nucleus

nucleus

glycolytic process

regulation of DNA repair

DNA damage response

DNA damage response

mitotic G2 DNA damage checkpoint signaling

intrinsic apoptotic signaling pathway in response to DNA damage

membrane

negative regulation of apoptotic process

positive regulation of protein catabolic process

negative regulation of glycolytic process

regulation of nucleocytoplasmic transport

negative regulation of inflammatory response

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of reactive oxygen species metabolic process

 
1418825_at Irgm1 immunity-related GTPase family M member 1 11 -48865244 NM_008326 95

autophagosome assembly

autophagosome assembly

Golgi membrane

Golgi membrane

nucleotide binding

autophagosome membrane

positive regulation of protein phosphorylation

immune system process

GTPase activity

GTPase activity

GTPase activity

G protein activity

GTP binding

phosphatidylinositol-3,4,5-trisphosphate binding

mitochondrion

lysosome

lysosomal membrane

endosome

late endosome

autophagosome

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

lipid droplet

cytosol

plasma membrane

autophagy

defense response

defense response

lipid binding

response to bacterium

positive regulation of autophagy

positive regulation of autophagy

positive regulation of autophagy

positive regulation of peptidyl-threonine phosphorylation

membrane

hydrolase activity

protein kinase binding

protein-macromolecule adaptor activity

cytoplasmic vesicle

protein destabilization

mitochondrial membrane

negative regulation of type I interferon production

negative regulation of type I interferon production

negative regulation of type II interferon production

positive regulation of peptidyl-serine phosphorylation

cellular response to interferon-beta

defense response to bacterium

defense response to bacterium

defense response to bacterium

cell projection

positive regulation of macrophage activation

negative regulation of canonical NF-kappaB signal transduction

regulation of protein-containing complex assembly

phosphatidylinositol-3,4-bisphosphate binding

protein serine/threonine kinase activator activity

autolysosome

innate immune response

innate immune response

phagocytic vesicle

negative regulation of defense response to virus

negative regulation of defense response to virus

CARD domain binding

negative regulation of inflammatory response

negative regulation of inflammatory response

protein stabilization

defense response to Gram-negative bacterium

BH3 domain binding

positive regulation of type II interferon-mediated signaling pathway

positive regulation of type II interferon-mediated signaling pathway

regulation of protein complex stability

protein lipidation involved in autophagosome assembly

CAMKK-AMPK signaling cascade

protein-containing complex assembly

nucleotide-binding oligomerization domain containing 2 signaling pathway

protein targeting to vacuole involved in autophagy

cellular response to lipopolysaccharide

cellular response to type II interferon

positive regulation of protein serine/threonine kinase activity

regulation of mitochondrial fission

positive regulation of mitochondrial fission

autophagosome maturation

cellular response to virus

negative regulation of cGAS/STING signaling pathway

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of NLRP3 inflammasome complex assembly

positive regulation of autophagosome maturation

positive regulation of autophagosome maturation

positive regulation of mitophagy

positive regulation of mitophagy

cardiolipin binding

cardiolipin binding

negative regulation of hematopoietic stem cell proliferation

positive regulation of xenophagy

positive regulation of lysosome organization

positive regulation of CD4-positive, alpha-beta T cell proliferation

 
1418930_at Cxcl10 C-X-C motif chemokine ligand 10 5 -92346638 NM_021274 338

positive regulation of leukocyte chemotaxis

cytokine activity

extracellular region

extracellular space

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

inflammatory response

immune response

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

chemokine activity

chemokine activity

heparin binding

positive regulation of cell population proliferation

response to bacterium

external side of plasma membrane

T cell chemotaxis

regulation of T cell chemotaxis

negative regulation of angiogenesis

positive regulation of cell migration

neutrophil chemotaxis

killing of cells of another organism

chemoattractant activity

endothelial cell activation

regulation of cell population proliferation

regulation of apoptotic process

CXCR chemokine receptor binding

negative regulation of myoblast differentiation

CXCR3 chemokine receptor binding

positive regulation of release of sequestered calcium ion into cytosol

defense response to virus

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

positive regulation of monocyte chemotaxis

cellular response to interleukin-17

regulation of endothelial tube morphogenesis

negative regulation of myoblast fusion

positive regulation of T cell migration

04060

04062

04620

04622

04623

1419603_at Ifi204 interferon activated gene 204 1 -173747293 NM_008329 65

negative regulation of transcription by RNA polymerase II

activation of innate immune response

activation of innate immune response

immune system process

DNA binding

double-stranded DNA binding

double-stranded DNA binding

double-stranded DNA binding

transcription coregulator activity

protein binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytosol

cytosol

regulation of transcription by RNA polymerase II

multicellular organism development

transcription factor binding

response to bacterium

nuclear speck

monocyte differentiation

ubiquitin protein ligase binding

positive regulation of interleukin-1 beta production

protein-containing complex

cellular response to interferon-alpha

cellular response to interferon-beta

cellular response to interferon-beta

cellular response to glucose starvation

nuclear inclusion body

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

intracellular membrane-bounded organelle

negative regulation of DNA binding

negative regulation of viral genome replication

innate immune response

positive regulation of osteoblast differentiation

negative regulation of gene expression, epigenetic

negative regulation of innate immune response

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

inner ear development

defense response to virus

cellular response to ionizing radiation

intrinsic apoptotic signaling pathway by p53 class mediator

activation of cysteine-type endopeptidase activity

negative regulation of AIM2 inflammasome complex assembly

negative regulation of cysteine-type endopeptidase activity

 
1417292_at Ifi47 interferon gamma inducible protein 47 11 49087016, 49076586 NM_008330 20

GTPase activity

endoplasmic reticulum

endoplasmic reticulum membrane

defense response

defense response

cellular response to interferon-beta

 
1450783_at Ifit1 interferon-induced protein with tetratricopeptide repeats 1 19 34640888 NM_008331 70

immune system process

RNA binding

RNA binding

protein binding

cytoplasm

cytoplasm

cytosol

cytosol

response to virus

response to bacterium

cellular response to interferon-alpha

cellular response to interferon-beta

innate immune response

defense response to virus

defense response to virus

05160

1418293_at Ifit2 interferon-induced protein with tetratricopeptide repeats 2 19 34551087, 34550693 NM_008332 45

immune system process

RNA binding

cytoplasm

endoplasmic reticulum

cytosol

apoptotic process

response to virus

response to virus

negative regulation of protein binding

cellular response to interferon-alpha

positive regulation of apoptotic process

innate immune response

defense response to virus

defense response to virus

antiviral innate immune response

antiviral innate immune response

 
1449025_at Ifit3 interferon-induced protein with tetratricopeptide repeats 3 19 34583528 NM_010501 38

immune system process

protein binding

cytoplasm

mitochondrion

cytosol

cytosol

negative regulation of cell population proliferation

response to virus

response to bacterium

cellular response to interferon-beta

response to stilbenoid

identical protein binding

negative regulation of apoptotic process

innate immune response

defense response to virus

defense response to virus

antiviral innate immune response

 
1451462_a_at Ifnar2 interferon (alpha and beta) receptor 2 16 91372782, 91372782, 91372782 AF013486 96

type I interferon receptor activity

type I interferon receptor activity

type I interferon receptor activity

extracellular region

extracellular space

extracellular space

extracellular space

plasma membrane

regulation of transcription by RNA polymerase II

receptor signaling pathway via JAK-STAT

membrane

protein kinase binding

cytokine binding

type I interferon binding

immature T cell proliferation in thymus

response to interferon-alpha

response to interferon-beta

cellular response to interferon-beta

interleukin-22 receptor activity

defense response to virus

type I interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

04060

04380

04620

04630

04650

05160

1417640_at Cd79b CD79B antigen 11 -106311340 NM_008339 66

adaptive immune response

immune system process

transmembrane signaling receptor activity

protein binding

plasma membrane

plasma membrane

cell surface receptor signaling pathway

response to bacterium

external side of plasma membrane

external side of plasma membrane

membrane

B cell receptor complex

B cell receptor complex

B cell differentiation

identical protein binding

identical protein binding

B cell receptor signaling pathway

B cell receptor signaling pathway

IgM B cell receptor complex

04662

1423756_s_at Igfbp4 insulin-like growth factor binding protein 4 11 99041243 BC019836 107

MAPK cascade

regulation of cell growth

protein binding

insulin-like growth factor binding

extracellular region

extracellular space

extracellular space

extracellular space

regulation of glucose metabolic process

growth factor binding

insulin-like growth factor I binding

insulin-like growth factor II binding

regulation of growth

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

type B pancreatic cell proliferation

 
1417933_at Igfbp6 insulin-like growth factor binding protein 6 15 102144185 NM_008344 47

fibronectin binding

extracellular matrix structural constituent

insulin-like growth factor binding

extracellular region

extracellular space

extracellular space

extracellular space

cell migration

growth factor binding

insulin-like growth factor I binding

insulin-like growth factor I binding

insulin-like growth factor II binding

insulin-like growth factor II binding

positive regulation of stress-activated MAPK cascade

insulin-like growth factor binary complex

identical protein binding

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

collagen-containing extracellular matrix

 
1427329_a_at Ighm immunoglobulin heavy constant mu 12   AI326478 911

MAPK cascade

adaptive immune response

pre-B cell allelic exclusion

B cell affinity maturation

humoral immune response mediated by circulating immunoglobulin

regulation of immunoglobulin production

single-stranded DNA binding

antigen binding

antigen binding

transmembrane signaling receptor activity

protein binding

extracellular region

extracellular space

extracellular space

cytoplasm

plasma membrane

plasma membrane

complement activation, classical pathway

external side of plasma membrane

cell surface

cell surface

membrane

immunoglobulin mediated immune response

peptidyl-tyrosine phosphorylation

antibacterial humoral response

antibacterial humoral response

B cell receptor complex

antigen processing and presentation

regulation of cell morphogenesis

positive regulation of B cell proliferation

phosphatidylcholine binding

immunoglobulin receptor binding

immunoglobulin receptor binding

immunoglobulin receptor binding

B cell proliferation

B cell activation

immunoglobulin complex, circulating

immunoglobulin complex, circulating

identical protein binding

peptidoglycan binding

positive regulation of MAPK cascade

early endosome to late endosome transport

innate immune response

positive regulation of endocytosis

perinuclear region of cytoplasm

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of immune response

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

B cell receptor signaling pathway

positive regulation of B cell activation

IgM B cell receptor complex

pentameric IgM immunoglobulin complex

hexameric IgM immunoglobulin complex

 
1450424_a_at Il18bp interleukin 18 binding protein 7 -102015073 AF110803 33

extracellular region

extracellular space

extracellular space

interleukin-18 binding

interleukin-18 binding

T-helper 1 type immune response

T-helper 1 type immune response

 
1430523_s_at Iglv1 immunoglobulin lambda variable 1 16   AK008145 57

immunoglobulin production

extracellular space

immune response

 
1425519_a_at Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 18 60803848 BC003476 242

prostaglandin biosynthetic process

amyloid-beta binding

positive regulation of protein phosphorylation

positive regulation of cytokine-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway

positive regulation of cytokine-mediated signaling pathway

adaptive immune response

T cell activation involved in immune response

immune system process

positive regulation of dendritic cell antigen processing and presentation

negative regulation of peptide secretion

positive regulation of adaptive immune response

positive regulation of type 2 immune response

positive regulation of type 2 immune response

negative regulation of mature B cell apoptotic process

cytokine receptor activity

cytokine receptor activity

cytokine receptor activity

protein binding

extracellular region

extracellular space

nucleus

cytoplasm

cytoplasm

lysosome

endosome

late endosome

multivesicular body

vacuole

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

plasma membrane

intracellular protein transport

intracellular protein transport

defense response

immune response

external side of plasma membrane

cell surface

cell surface

positive regulation of gene expression

membrane

immunoglobulin mediated immune response

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation

antigen processing and presentation of exogenous peptide antigen via MHC class II

cytokine binding

cytokine binding

MHC class II protein complex binding

negative regulation of cell migration

positive regulation of B cell proliferation

positive regulation of prostaglandin biosynthetic process

positive regulation of chemokine production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

protein-containing complex

positive regulation of kinase activity

positive regulation of kinase activity

response to type II interferon

response to type II interferon

macrophage migration inhibitory factor signaling pathway

macrophage migration inhibitory factor receptor complex

macrophage migration inhibitory factor receptor complex

NOS2-CD74 complex

macrophage migration inhibitory factor binding

macrophage migration inhibitory factor binding

MHC class II protein binding

MHC class II protein binding

CD4 receptor binding

MHC class II protein complex

MHC class II protein binding, via antigen binding groove

negative regulation of apoptotic process

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of DNA damage response, signal transduction by p53 class mediator

protein folding chaperone

positive thymic T cell selection

negative thymic T cell selection

positive regulation of innate immune response

negative regulation of T cell differentiation

positive regulation of T cell differentiation

positive regulation of monocyte differentiation

positive regulation of DNA-templated transcription

negative regulation of viral entry into host cell

positive regulation of viral entry into host cell

positive regulation of fibroblast proliferation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of peptidyl-tyrosine phosphorylation

protein stabilization

nitric-oxide synthase binding

chaperone cofactor-dependent protein refolding

chaperone cofactor-dependent protein refolding

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

protein-containing complex assembly

protein trimerization

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

positive regulation of neutrophil chemotaxis

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of macrophage migration inhibitory factor signaling pathway

04612

1426207_at Ikbkb inhibitor of kappaB kinase beta 8 -22659204 AF088910 508

nucleotide binding

B cell homeostasis

protein kinase activity

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

protein phosphorylation

canonical NF-kappaB signal transduction

canonical NF-kappaB signal transduction

I-kappaB phosphorylation

positive regulation of cell population proliferation

IkappaB kinase activity

IkappaB kinase activity

IkappaB kinase activity

IkappaB kinase complex

IkappaB kinase complex

IkappaB kinase complex

cytoplasmic side of plasma membrane

positive regulation of sodium ion transport

positive regulation of neuron projection development

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

protein kinase binding

protein phosphatase binding

cortical actin cytoskeleton organization

neuron projection development

tumor necrosis factor-mediated signaling pathway

tumor necrosis factor-mediated signaling pathway

tumor necrosis factor-mediated signaling pathway

tumor necrosis factor-mediated signaling pathway

negative regulation of myosin-light-chain-phosphatase activity

CD40 receptor complex

regulation of phosphorylation

identical protein binding

protein homodimerization activity

positive regulation of canonical NF-kappaB signal transduction

protein-containing complex binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

protein maturation

response to cholecystokinin

interleukin-1-mediated signaling pathway

cellular response to tumor necrosis factor

protein localization to plasma membrane

scaffold protein binding

regulation of establishment of endothelial barrier

negative regulation of bicellular tight junction assembly

transferrin receptor binding

positive regulation of cation channel activity

04010

04062

04210

04380

04620

04621

04622

04623

04660

04662

04722

04910

04920

04930

05142

05145

05160

05200

05212

05215

05220

05221

05222

1425454_a_at Il12a interleukin 12a 3 68691423, 68690643 AF128210 485

positive regulation of T cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

cytokine activity

cytokine activity

interleukin-12 receptor binding

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

cytoplasm

endoplasmic reticulum lumen

Golgi lumen

immune response

growth factor activity

cell population proliferation

cell population proliferation

cell surface

response to UV-B

cell migration

endosome lumen

response to lipopolysaccharide

type II interferon production

type II interferon production

negative regulation of interleukin-17 production

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of natural killer cell activation

positive regulation of mononuclear cell proliferation

positive regulation of smooth muscle cell apoptotic process

T-helper 1 cell activation

interleukin-12-mediated signaling pathway

T-helper 1 cell cytokine production

T cell proliferation

positive regulation of T cell proliferation

interleukin-12 beta subunit binding

interleukin-12 beta subunit binding

positive regulation of tyrosine phosphorylation of STAT protein

defense response to protozoan

defense response to protozoan

interleukin-12 complex

interleukin-12 complex

interleukin-12 complex

interleukin-27 binding

positive regulation of T cell differentiation

positive regulation of cell adhesion

positive regulation of natural killer cell mediated cytotoxicity

protein heterodimerization activity

negative regulation of smooth muscle cell proliferation

positive regulation of lymphocyte proliferation

negative regulation of protein secretion

positive regulation of NK T cell activation

cellular response to lipopolysaccharide

extrinsic apoptotic signaling pathway

cellular response to virus

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

positive regulation of dendritic cell chemotaxis

04060

04620

04622

04630

04940

05140

05142

05143

05144

05145

05146

05330

1427164_at Il13ra1 interleukin 13 receptor, alpha 1 X 36112107 BB730912 69

cytokine receptor activity

cytokine receptor activity

positive regulation of cell population proliferation

external side of plasma membrane

membrane

interleukin-13 receptor activity

cytokine-mediated signaling pathway

cytokine binding

receptor complex

04060

04630

1448681_at Il15ra interleukin 15 receptor, alpha chain 2 11705711, 11705292 NM_133836 160

natural killer cell differentiation

extracellular region

nucleus

plasma membrane

receptor signaling pathway via JAK-STAT

cell surface

negative regulation of neuron projection development

membrane

protein kinase binding

cytoplasmic vesicle

positive regulation of natural killer cell differentiation

interleukin-15-mediated signaling pathway

interleukin-15-mediated signaling pathway

interleukin-15 receptor activity

interleukin-15 receptor activity

positive regulation of phagocytosis

04060

04630

04672

1417391_a_at Il16 interleukin 16 7 -83642818, -83642818, -83642818 BC026894 47

cytokine activity

cytokine activity

protein binding

extracellular region

extracellular space

intracellular anatomical structure

nucleus

cytoplasm

cytosol

plasma membrane

focal adhesion

chemotaxis

signal transduction

positive regulation of gene expression

nuclear speck

cytokine-mediated signaling pathway

leukocyte chemotaxis

leukocyte chemotaxis

positive regulation of chemokine production

positive regulation of interleukin-1 alpha production

positive regulation of interleukin-12 production

positive regulation of interleukin-6 production

CD4 receptor binding

CD4 receptor binding

positive regulation of inflammatory response

induction of positive chemotaxis

induction of positive chemotaxis

regulation of calcium ion transport

collagen-containing extracellular matrix

Flemming body

positive regulation of neutrophil activation

 
1417932_at Il18 interleukin 18 9 50554699 NM_008360 644

angiogenesis

angiogenesis

response to hypoxia

cytokine activity

cytokine activity

cytokine activity

extracellular region

extracellular space

extracellular space

cytoplasm

inflammatory response

immune response

cell population proliferation

cell population proliferation

extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of gene expression

positive regulation of macrophage derived foam cell differentiation

positive regulation of smooth muscle cell migration

apical plasma membrane

natural killer cell activation

regulation of cell adhesion

regulation of cell adhesion

sleep

sleep

type II interferon production

interleukin-6 production

positive regulation of chemokine production

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of interleukin-13 production

positive regulation of interleukin-17 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of natural killer cell proliferation

positive regulation of superoxide anion generation

positive regulation of collagen biosynthetic process

negative regulation of neutrophil apoptotic process

interleukin-18-mediated signaling pathway

interleukin-18-mediated signaling pathway

T-helper 1 cell cytokine production

T-helper 1 cell cytokine production

T-helper 1 type immune response

T-helper 1 type immune response

positive regulation of activated T cell proliferation

positive regulation of activated T cell proliferation

neutrophil activation

natural killer cell mediated cytotoxicity

positive regulation of tyrosine phosphorylation of STAT protein

cholesterol homeostasis

positive regulation of apoptotic process

positive regulation of vascular permeability

positive regulation of neuron apoptotic process

interleukin-18 receptor binding

positive regulation of T-helper 2 cell differentiation

negative regulation of myoblast differentiation

positive regulation of transcription by RNA polymerase II

receptor ligand activity

positive regulation of smooth muscle cell proliferation

positive regulation of inflammatory response

negative regulation of peptidyl-tyrosine phosphorylation

defense response to Gram-positive bacterium

detection of mechanical stimulus involved in sensory perception of pain

positive regulation of NF-kappaB transcription factor activity

positive regulation of NK T cell proliferation

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

establishment of skin barrier

triglyceride homeostasis

cellular response to peptide hormone stimulus

positive regulation of cold-induced thermogenesis

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of male germ cell proliferation

positive regulation of hepatocyte proliferation

positive regulation of blood vessel remodeling

positive regulation of T-helper 1 cell cytokine production

04060

04621

04623

05143

05144

05323

1421291_at Il18rap interleukin 18 receptor accessory protein 1 40515361 NM_010553 17

interleukin-1 receptor activity

plasma membrane

inflammatory response

signal transduction

cell population proliferation

coreceptor activity

membrane

hydrolase activity

type II interferon production

interleukin-6 production

interleukin-18-mediated signaling pathway

interleukin-18-mediated signaling pathway

interleukin-18-mediated signaling pathway

T-helper 1 cell cytokine production

interleukin-18 receptor activity

interleukin-18 receptor activity

neutrophil activation

interleukin-18 receptor complex

positive regulation of natural killer cell mediated cytotoxicity

NADP+ nucleosidase activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

NAD+ nucleotidase, cyclic ADP-ribose generating

cellular response to interleukin-18

04060

1419532_at Il1r2 interleukin 1 receptor, type II 1 40084713, 40086092 NM_010555 56

interleukin-1 receptor activity

interleukin-1 receptor activity

interleukin-1, type II, blocking receptor activity

extracellular region

cytoplasm

plasma membrane

negative regulation of protein processing

membrane

protein processing

interleukin-1 binding

interleukin-1 binding

negative regulation of interleukin-1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of interleukin-1-mediated signaling pathway

04010

04060

04640

05146

1421844_at Il1rap interleukin 1 receptor accessory protein 16 26581704, 26581704, 26581704, 26581704 BE285634 54

interleukin-33 receptor activity

immune system process

interleukin-1 receptor activity

interleukin-1 receptor activity

interleukin-1 receptor binding

interleukin-1 receptor binding

protein binding

extracellular region

plasma membrane

inflammatory response

signal transduction

coreceptor activity

membrane

hydrolase activity

cytokine-mediated signaling pathway

interleukin-2 production

positive regulation of interleukin-13 production

positive regulation of interleukin-4 production

positive regulation of interleukin-5 production

positive regulation of interleukin-6 production

protein-containing complex

interleukin-33-mediated signaling pathway

interleukin-33-mediated signaling pathway

innate immune response

synapse

synapse

NADP+ nucleosidase activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of synapse assembly

NAD+ nucleotidase, cyclic ADP-ribose generating

interleukin-1-mediated signaling pathway

glutamatergic synapse

glutamatergic synapse

regulation of postsynaptic density assembly

regulation of postsynaptic density assembly

trans-synaptic signaling by trans-synaptic complex

trans-synaptic signaling by trans-synaptic complex

synaptic membrane adhesion

synaptic membrane adhesion

regulation of presynapse assembly

regulation of presynapse assembly

04060

04210

1451798_at Il1rn interleukin 1 receptor antagonist 2 24345370, 24345290, 24336859 M57525 200

fever generation

inflammatory response to antigenic stimulus

cytokine activity

interleukin-1 receptor binding

interleukin-1, type I receptor binding

interleukin-1, type II receptor binding

interleukin-1 receptor antagonist activity

interleukin-1 receptor antagonist activity

extracellular region

extracellular space

extracellular space

nucleoplasm

cytoplasm

centrosome

cytosol

lipid metabolic process

acute-phase response

inflammatory response

immune response

memory

negative regulation of glutamate secretion

insulin secretion

negative regulation of cell migration

vesicle

negative regulation of heterotypic cell-cell adhesion

negative regulation of apoptotic process

interleukin-1 type I receptor antagonist activity

interleukin-1 type II receptor antagonist activity

negative regulation of membrane potential

response to glucocorticoid

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

 
1416295_a_at Il2rg interleukin 2 receptor, gamma chain X -101264384 L20048 822

mature B cell differentiation

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

cytokine receptor activity

cytokine receptor activity

nucleoplasm

endoplasmic reticulum

plasma membrane

plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

gene expression

regulation of gene expression

positive regulation of gene expression

coreceptor activity

membrane

cytokine-mediated signaling pathway

cytokine binding

interleukin-2 binding

lymphocyte differentiation

B cell differentiation

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

T cell differentiation in thymus

positive regulation of T cell differentiation in thymus

interleukin-15-mediated signaling pathway

interleukin-2-mediated signaling pathway

interleukin-9-mediated signaling pathway

interleukin-15 receptor activity

receptor complex

positive regulation of B cell differentiation

positive regulation of phagocytosis

04060

04144

04630

05340

1452843_at Il6st interleukin 6 signal transducer 13 112464069 AK017211 319

cytokine receptor activity

cytokine receptor activity

ciliary neurotrophic factor receptor activity

interleukin-6 receptor activity

interleukin-6 receptor activity

interleukin-11 receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

ciliary neurotrophic factor receptor binding

interleukin-6 receptor binding

protein binding

extracellular space

plasma membrane

interleukin-6 receptor complex

oncostatin-M receptor complex

glycogen metabolic process

triglyceride mobilization

signal transduction

positive regulation of cell population proliferation

positive regulation of cell population proliferation

regulation of Notch signaling pathway

external side of plasma membrane

external side of plasma membrane

positive regulation of smooth muscle cell migration

coreceptor activity

membrane

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

growth factor binding

cytokine binding

interleukin-11 binding

interleukin-6 binding

interleukin-6 binding

protein tyrosine kinase activator activity

dendrite

neuronal cell body membrane

response to cytokine

interleukin-11-mediated signaling pathway

oncostatin-M-mediated signaling pathway

positive regulation of T cell proliferation

positive regulation of tyrosine phosphorylation of STAT protein

identical protein binding

neuronal cell body

receptor complex

negative regulation of neuron apoptotic process

cell body

membrane raft

positive regulation of osteoblast differentiation

positive regulation of Notch signaling pathway

positive regulation of Notch signaling pathway

positive regulation of astrocyte differentiation

leukemia inhibitory factor signaling pathway

negative regulation of cytosolic calcium ion concentration

intestinal epithelial cell development

intestinal epithelial cell development

interleukin-6-mediated signaling pathway

interleukin-6-mediated signaling pathway

negative regulation of interleukin-6-mediated signaling pathway

interleukin-27-mediated signaling pathway

ciliary neurotrophic factor receptor complex

ciliary neurotrophic factor-mediated signaling pathway

scaffold protein binding

04060

04630

1448575_at Il7r interleukin 7 receptor 15 -9506158 AI573431 391

cell morphogenesis

B cell homeostasis

T cell mediated cytotoxicity

negative regulation of T cell mediated cytotoxicity

immunoglobulin production

cytokine receptor activity

cytokine receptor activity

nucleoplasm

cytosol

plasma membrane

plasma membrane

positive regulation of cell population proliferation

regulation of cell size

regulation of cell size

external side of plasma membrane

external side of plasma membrane

gene expression

positive regulation of gene expression

membrane

cytokine-mediated signaling pathway

hemopoiesis

T cell differentiation

T cell differentiation

T cell differentiation in thymus

positive regulation of T cell differentiation in thymus

B cell proliferation

B cell proliferation

T cell homeostasis

positive regulation of receptor signaling pathway via JAK-STAT

lymph node development

defense response to Gram-positive bacterium

negative regulation of T cell apoptotic process

positive regulation of receptor signaling pathway via STAT

04060

04630

04640

05340

1460669_at Ilf3 interleukin enhancer binding factor 3 9 21367870, 21368531, 21367870 NM_010561 75

virus receptor activity

DNA binding

DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

mitochondrion

protein phosphorylation

protein phosphorylation

protein methylation

negative regulation of translation

enzyme binding

mRNA 3'-UTR AU-rich region binding

negative regulation of viral genome replication

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

defense response to virus

ribonucleoprotein complex

 
1449988_at Gimap1 GTPase, IMAP family member 1 6 48739046 NM_008376 23

nucleotide binding

GTP binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

membrane

B cell differentiation

CD4-positive, alpha-beta T cell differentiation

CD8-positive, alpha-beta T cell differentiation

 
1460432_a_at Eif3e eukaryotic translation initiation factor 3, subunit E 15 -43250039 AK002576 49

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

translation initiation factor activity

translation initiation factor activity

nucleus

nucleus

cytoplasm

cytosol

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex

translation

translational initiation

translational initiation

translational initiation

intracellular calcium ion homeostasis

postsynaptic density

postsynaptic density

PML body

transmembrane transporter binding

positive regulation of translation

positive regulation of intracellular protein transport

positive regulation of mRNA binding

03013

05160

1448436_a_at Irf1 interferon regulatory factor 1 11 53770013, 53770013, 53770472 NM_008390 333

chromatin

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

immune system process

immune system process

regulation of adaptive immune response

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleus

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

apoptotic process

canonical NF-kappaB signal transduction

regulation of gene expression

positive regulation of type I interferon production

positive regulation of interferon-beta production

positive regulation of interleukin-12 production

positive regulation of interleukin-12 production

positive regulation of natural killer cell differentiation

regulation of MyD88-dependent toll-like receptor signaling pathway

toll-like receptor 3 signaling pathway

cellular response to interferon-beta

negative regulation of tyrosine phosphorylation of STAT protein

positive regulation of apoptotic process

CD8-positive, alpha-beta T cell differentiation

sequence-specific DNA binding

sequence-specific DNA binding

innate immune response

regulation of innate immune response

negative regulation of regulatory T cell differentiation

positive regulation of T-helper 1 cell differentiation

negative regulation of T-helper 2 cell differentiation

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

defense response to virus

defense response to virus

regulation of cell cycle

type II interferon-mediated signaling pathway

response to growth hormone

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to peptide hormone stimulus

regulation of CD8-positive, alpha-beta T cell proliferation

05160

1421173_at Irf4 interferon regulatory factor 4 13 30749232 U34307 301

nucleosome

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

immune system process

DNA binding

DNA-binding transcription factor activity

transcription coactivator activity

protein binding

nucleus

nucleus

nucleoplasm

cytosol

chromatin remodeling

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

positive regulation of interleukin-10 production

positive regulation of interleukin-13 production

positive regulation of interleukin-2 production

positive regulation of interleukin-4 production

negative regulation of toll-like receptor signaling pathway

defense response to protozoan

myeloid dendritic cell differentiation

positive regulation of DNA binding

sequence-specific DNA binding

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

T-helper 17 cell lineage commitment

positive regulation of cold-induced thermogenesis

sequence-specific double-stranded DNA binding

 
1427381_at Acod1 aconitate decarboxylase 1 14 103047011 L38281 73

immune system process

positive regulation of antimicrobial humoral response

positive regulation of antimicrobial humoral response

mitochondrion

mitochondrion

defense response

defense response

defense response

inflammatory response

embryo implantation

response to bacterium

lyase activity

negative regulation of NF-kappaB transcription factor activity

negative regulation of type I interferon production

response to lipopolysaccharide

negative regulation of toll-like receptor 2 signaling pathway

negative regulation of toll-like receptor 4 signaling pathway

cellular response to interferon-beta

protein homodimerization activity

protein homodimerization activity

innate immune response

negative regulation of innate immune response

aconitate decarboxylase activity

aconitate decarboxylase activity

aconitate decarboxylase activity

aconitate decarboxylase activity

negative regulation of inflammatory response

defense response to virus

cellular response to molecule of bacterial origin

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to type II interferon

cellular response to interleukin-1

cellular response to tumor necrosis factor

cellular response to progesterone stimulus

tolerance induction to lipopolysaccharide

tolerance induction to lipopolysaccharide

positive regulation of reactive oxygen species metabolic process

 
1422046_at Itgam integrin alpha M 7 128062639 NM_008401 576

microglial cell activation

neutrophil apoptotic process

opsonin binding

opsonin binding

complement component C3b binding

complement receptor mediated signaling pathway

leukocyte migration involved in inflammatory response

integrin binding

protein binding

extracellular space

nucleus

plasma membrane

plasma membrane

receptor-mediated endocytosis

phagocytosis

phagocytosis, engulfment

cell adhesion

cell adhesion

leukocyte cell-cell adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

heparin binding

integrin complex

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

microglia development

membrane

neutrophil chemotaxis

forebrain development

heat shock protein binding

positive regulation of superoxide anion generation

positive regulation of superoxide anion generation

positive regulation of superoxide anion generation

cell adhesion mediated by integrin

integrin alphaM-beta2 complex

cargo receptor activity

cargo receptor activity

positive regulation of neutrophil degranulation

heparan sulfate proteoglycan binding

plasma membrane raft

cellular extravasation

negative regulation of dopamine metabolic process

activated T cell proliferation

positive regulation of mast cell differentiation

leukocyte adhesion to vascular endothelial cell

positive regulation of protein targeting to membrane

amyloid-beta clearance

amyloid-beta clearance

cell-cell adhesion

cell-cell adhesion

complement-mediated synapse pruning

vertebrate eye-specific patterning

positive regulation of microglial cell mediated cytotoxicity

positive regulation of prostaglandin-E synthase activity

04145

04514

04640

04670

04810

05140

05146

05150

1449829_at Itgb2l integrin beta 2-like 16 -96422297 NM_008405 19

amyloid-beta binding

leukocyte migration involved in inflammatory response

integrin binding

plasma membrane

focal adhesion

inflammatory response

cell adhesion

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

cell-matrix adhesion

cell-matrix adhesion

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin complex

cell surface

cell surface

membrane

protein kinase binding

protein kinase binding

secretory granule

ICAM-3 receptor activity

neutrophil chemotaxis

neutrophil chemotaxis

heat shock protein binding

positive regulation of superoxide anion generation

cell adhesion mediated by integrin

heterotypic cell-cell adhesion

integrin alphaL-beta2 complex

receptor clustering

positive regulation of neutrophil degranulation

endothelial cell migration

plasma membrane raft

protein-containing complex binding

cellular extravasation

positive regulation of nitric oxide biosynthetic process

positive regulation of angiogenesis

regulation of peptidyl-tyrosine phosphorylation

cell adhesion molecule binding

cell-cell adhesion

neutrophil migration

04145

04514

04650

04670

04810

05140

05144

05146

05150

05323

05416

1431808_a_at Itih4 inter alpha-trypsin inhibitor, heavy chain 4 14 30886475 AK004893 30

serine-type endopeptidase inhibitor activity

protein binding

extracellular region

extracellular space

cytoplasm

plasma membrane

acute-phase response

negative regulation of peptidase activity

hyaluronan metabolic process

peptidase inhibitor activity

collagen-containing extracellular matrix

 
1417171_at Itk IL2 inducible T cell kinase 11 -46325147, -46344477 NM_010583 153

nucleotide binding

positive regulation of cytokine production

NK T cell differentiation

NK T cell differentiation

NK T cell differentiation

adaptive immune response

adaptive immune response

immune system process

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein binding

ATP binding

nucleus

cytoplasm

cytosol

cytosol

plasma membrane

cell-cell junction

protein phosphorylation

protein phosphorylation

activation of phospholipase C activity

kinase activity

phosphorylation

transferase activity

type II interferon production

type II interferon production

interleukin-4 production

interleukin-4 production

intracellular signal transduction

gamma-delta T cell activation

metal ion binding

T cell receptor signaling pathway

T cell receptor signaling pathway

B cell receptor signaling pathway

04062

04660

04670

1423608_at Itm2a integral membrane protein 2A X -107397194 BI966443 31

amyloid-beta binding

plasma cell differentiation

immunoglobulin production

Golgi apparatus

plasma membrane

membrane

negative regulation of amyloid precursor protein biosynthetic process

 
1460203_at Itpr1 inositol 1,4,5-trisphosphate receptor 1 6 108213095 NM_010585 306

cell morphogenesis

response to hypoxia

response to hypoxia

monoatomic ion channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

calcium channel activity

calcium ion binding

protein binding

nuclear envelope

nuclear envelope

nuclear inner membrane

nucleolus

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

plasma membrane

calcineurin complex

monoatomic ion transport

calcium ion transport

apoptotic process

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

post-embryonic development

positive regulation of neuron projection development

postsynaptic density

calcium-release channel activity

membrane

sarcoplasmic reticulum

sarcoplasmic reticulum

sarcoplasmic reticulum

calcium-mediated signaling

calcium channel inhibitor activity

protein phosphatase binding

protein domain specific binding

dendrite

secretory granule membrane

smooth endoplasmic reticulum membrane

platelet dense granule membrane

platelet dense tubular network

cytoplasmic vesicle

positive regulation of insulin secretion

positive regulation of insulin secretion

endoplasmic reticulum calcium ion homeostasis

protein-containing complex

protein-containing complex

monoatomic ion transmembrane transport

phosphatidylinositol binding

phosphatidylinositol binding

epithelial fluid transport

identical protein binding

neuronal cell body

positive regulation of apoptotic process

negative regulation of apoptotic process

transmembrane transporter binding

protein-containing complex binding

synapse

perinuclear region of cytoplasm

negative regulation of calcium-mediated signaling

voluntary musculoskeletal movement

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport

transmembrane transport

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

calcium ion transmembrane transport

inositol 1,4,5 trisphosphate binding

inositol 1,4,5 trisphosphate binding

cellular response to cAMP

synaptic membrane

liver regeneration

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels

presynapse

postsynapse

GABA-ergic synapse

ion channel modulating, G protein-coupled receptor signaling pathway

ion channel modulating, G protein-coupled receptor signaling pathway

regulation of postsynaptic cytosolic calcium ion concentration

ligand-gated ion channel signaling pathway

ligand-gated ion channel signaling pathway

positive regulation of hepatocyte proliferation

04020

04070

04114

04270

04540

04720

04730

04912

04970

04971

04972

05010

05016

1417297_at Itpr3 inositol 1,4,5-triphosphate receptor 3 17 27057303 NM_080553 192

inositol hexakisphosphate binding

monoatomic ion channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity

calcium channel activity

calcium ion binding

calcium ion binding

protein binding

nucleus

nuclear envelope

nuclear outer membrane

nucleoplasm

nucleolus

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

plasma membrane

plasma membrane

brush border

monoatomic ion transport

calcium ion transport

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

memory

calcium-release channel activity

membrane

apical plasma membrane

sarcoplasmic reticulum

dendrite

secretory granule membrane

monoatomic ion transmembrane transport

phosphatidylinositol binding

phosphatidylinositol binding

identical protein binding

neuronal cell body

receptor complex

inositol 1,3,4,5 tetrakisphosphate binding

protein-containing complex binding

apical part of cell

perinuclear region of cytoplasm

sensory perception of bitter taste

sensory perception of sweet taste

sensory perception of umami taste

release of sequestered calcium ion into cytosol

response to calcium ion

calcium ion homeostasis

transmembrane transport

long-term synaptic potentiation

calcium ion transmembrane transport

inositol 1,4,5 trisphosphate binding

inositol 1,4,5 trisphosphate binding

cellular response to cAMP

cytoplasmic side of endoplasmic reticulum membrane

presynapse

04020

04070

04114

04270

04540

04720

04730

04742

04912

04970

04971

04972

05010

1417409_at Jun jun proto-oncogene 4 -95049035 NM_010591 764

negative regulation of transcription by RNA polymerase II

chromatin

euchromatin

transcription cis-regulatory region binding

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

angiogenesis

angiogenesis

microglial cell activation

release of cytochrome c from mitochondria

liver development

positive regulation of endothelial cell proliferation

outflow tract morphogenesis

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

GTPase activator activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

transcription regulator complex

cytosol

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

apoptotic process

transforming growth factor beta receptor signaling pathway

learning

transcription factor binding

cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

response to xenobiotic stimulus

positive regulation of epithelial cell migration

transcription repressor complex

release from viral latency

enzyme binding

monocyte differentiation

axon regeneration

ubiquitin protein ligase binding

negative regulation of protein autophosphorylation

protein-containing complex

cellular response to reactive oxygen species

response to endoplasmic reticulum stress

leading edge cell differentiation

cAMP response element binding

transcription factor AP-1 complex

transcription factor AP-1 complex

response to muscle stretch

regulation of cell population proliferation

identical protein binding

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of DNA binding

negative regulation of neuron apoptotic process

positive regulation of neuron apoptotic process

sequence-specific DNA binding

negative regulation by host of viral transcription

positive regulation by host of viral transcription

ubiquitin-like protein ligase binding

protein-containing complex binding

positive regulation of monocyte differentiation

positive regulation of DNA replication

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of fibroblast proliferation

positive regulation of fibroblast proliferation

positive regulation of smooth muscle cell proliferation

cellular response to potassium ion starvation

regulation of cell cycle

regulation of cell cycle

membrane depolarization

SMAD protein signal transduction

eyelid development in camera-type eye

RNA polymerase II-specific DNA-binding transcription factor binding

positive regulation of ERK1 and ERK2 cascade

R-SMAD binding

cellular response to cadmium ion

cellular response to calcium ion

HMG box domain binding

cellular response to anisomycin

RNA polymerase II transcription regulator complex

general transcription initiation factor binding

positive regulation of miRNA transcription

positive regulation of vascular associated smooth muscle cell proliferation

sequence-specific double-stranded DNA binding

positive regulation of DNA-templated transcription initiation

04010

04012

04310

04380

04510

04620

04660

04662

04722

04912

05140

05142

05200

05210

05211

05323

1435772_at Kif21b kinesin family member 21B 1 136131389 AV122249 37

nucleotide binding

microtubule motor activity

microtubule motor activity

ATP binding

cytoplasm

cytoskeleton

kinesin complex

microtubule

microtubule

microtubule-based movement

microtubule-based movement

brain development

microtubule binding

microtubule binding

ATP hydrolysis activity

corpus callosum development

cytoplasmic vesicle

cell projection

 
1416021_a_at Fabp5 fatty acid binding protein 5, epidermal 3 10012584 BC002008 150

retinoic acid binding

long-chain fatty acid transporter activity

fatty acid binding

fatty acid binding

extracellular region

extracellular space

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

glucose metabolic process

lipid metabolic process

phosphatidylcholine biosynthetic process

lipid transport

lipid binding

negative regulation of glucose transmembrane transport

postsynaptic density

fatty acid transport

regulation of prostaglandin biosynthetic process

positive regulation of peroxisome proliferator activated receptor signaling pathway

glucose homeostasis

identical protein binding

synapse

regulation of sensory perception of pain

regulation of retrograde trans-synaptic signaling by endocanabinoid

positive regulation of cold-induced thermogenesis

03320

1456341_a_at Klf9 Kruppel-like transcription factor 9 19 23141225 AV354744 96

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

cytosol

plasma membrane

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

embryo implantation

negative regulation of keratinocyte proliferation

positive regulation of transcription by RNA polymerase II

metal ion binding

rhythmic process

progesterone receptor signaling pathway

cellular response to cortisol stimulus

 
1421304_at Klra2 killer cell lectin-like receptor, subfamily A, member 2 6 -131219234 NM_008462 25

plasma membrane

cell adhesion

membrane

carbohydrate binding

 
1458802_at Hivep3 human immunodeficiency virus type I enhancer binding protein 3 4 119814677 BB164127 46

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

cytoplasm

cytosol

regulation of transcription by RNA polymerase II

skeletal muscle cell differentiation

positive regulation of DNA-templated transcription

metal ion binding

 
1451716_at Mafb MAF bZIP transcription factor B 2 -160363676 AW412521 292

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

segment specification

respiratory gaseous exchange by respiratory system

gene expression

protein processing

rhombomere 5 development

rhombomere 6 development

abducens nerve formation

keratinocyte differentiation

T cell differentiation in thymus

brain segmentation

inner ear morphogenesis

identical protein binding

sequence-specific DNA binding

protein-containing complex binding

regulation of myeloid cell differentiation

negative regulation of erythrocyte differentiation

negative regulation of osteoclast differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

thymus development

RNA polymerase II transcription regulator complex

cornified envelope assembly

sequence-specific double-stranded DNA binding

 
1455434_a_at Ktn1 kinectin 1 14 47663755, 47649310 BF162017 36

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

microtubule-based movement

protein transport

membrane

kinesin binding

 
1433939_at Aff3 AF4/FMR2 family, member 3 1 -38175990 BQ177036 39

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

cytosol

DNA-templated transcription

regulation of DNA-templated transcription

regulation of DNA-templated transcription

regulation of gene expression

regulation of gene expression

nuclear body

super elongation complex

response to tumor necrosis factor

embryonic hindlimb morphogenesis

embryonic hindlimb morphogenesis

 
1428094_at Lamp2 lysosomal-associated membrane protein 2 X -38405048, -38419502, -38399646 BB390704 183

autophagosome membrane

protein binding

extracellular space

lysosome

lysosome

lysosomal membrane

lysosomal membrane

lysosomal membrane

endosome

late endosome

late endosome

trans-Golgi network

plasma membrane

plasma membrane

protein targeting

autophagy

lysosomal lumen acidification

ion channel inhibitor activity

cellular response to starvation

cellular response to starvation

membrane

enzyme binding

protein domain specific binding

protein catabolic process

phagocytic vesicle membrane

platelet dense granule membrane

negative regulation of protein-containing complex assembly

cytoplasmic vesicle

regulation of protein stability

late endosome membrane

late endosome membrane

late endosome membrane

signaling adaptor activity

intracellular membrane-bounded organelle

autolysosome

membrane raft

muscle cell cellular homeostasis

perinuclear region of cytoplasm

protein stabilization

chaperone-mediated autophagy

chaperone-mediated autophagy

chaperone-mediated autophagy

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to lysosome involved in chaperone-mediated autophagy

protein targeting to lysosome involved in chaperone-mediated autophagy

chaperone-mediated autophagy translocation complex

extracellular exosome

autophagosome maturation

autophagosome maturation

negative regulation of NLRP3 inflammasome complex assembly

lysosomal protein catabolic process

lysosomal matrix

04142

04145

1460651_at Lat linker for activation of T cells 7 -126363827 AF036907 158

immunological synapse

immunological synapse

immunological synapse

adaptive immune response

lymphocyte homeostasis

immune system process

protein binding

Golgi apparatus

plasma membrane

plasma membrane

cell-cell junction

inflammatory response

inflammatory response

immune response

immune response

cellular defense response

signal transduction

transmembrane receptor protein tyrosine kinase signaling pathway

integrin-mediated signaling pathway

Ras protein signal transduction

COP9 signalosome

gene expression

membrane

calcium-mediated signaling

protein kinase binding

protein kinase binding

signaling receptor complex adaptor activity

intracellular signal transduction

intracellular signal transduction

mast cell degranulation

positive regulation of protein kinase activity

homeostasis of number of cells

T cell receptor signaling pathway

regulation of T cell activation

regulation of T cell activation

04650

04660

04664

04666

1421164_a_at Arhgef1 Rho guanine nucleotide exchange factor 1 7 24902985, 24904345 NM_008488 62

G protein-coupled receptor binding

G protein-coupled receptor binding

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

GTPase activator activity

protein binding

cytoplasm

cytoplasm

cytosol

plasma membrane

microtubule depolymerization

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

membrane

04270

04810

1448550_at Lbp lipopolysaccharide binding protein 2 158306492 NM_008489 65

lipopolysaccharide binding

lipopolysaccharide binding

lipopolysaccharide binding

leukocyte chemotaxis involved in inflammatory response

macrophage activation involved in immune response

macrophage activation involved in immune response

macrophage activation involved in immune response

immune system process

cell surface pattern recognition receptor signaling pathway

signaling receptor binding

extracellular region

extracellular space

extracellular space

extracellular space

lipid transport

acute-phase response

acute-phase response

lipid binding

cell surface

cell surface

coreceptor activity

lipopolysaccharide transport

membrane

neutrophil chemotaxis

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

detection of molecule of bacterial origin

response to lipopolysaccharide

response to lipopolysaccharide

tumor necrosis factor production

negative regulation of tumor necrosis factor production

positive regulation of chemokine production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of toll-like receptor 4 signaling pathway

defense response to bacterium

positive regulation of macrophage activation

positive regulation of macrophage activation

innate immune response

innate immune response

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

positive regulation of phagocytosis, engulfment

positive regulation of respiratory burst involved in inflammatory response

lipoteichoic acid binding

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipoteichoic acid

lipopeptide binding

positive regulation of neutrophil chemotaxis

regulation of membrane permeability

04620

1425396_a_at Lck lymphocyte protein tyrosine kinase 4 -129548343, -129548343 BC011474 302

nucleotide binding

pericentriolar material

immunological synapse

phosphotyrosine residue binding

antigen binding

protein kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein serine/threonine phosphatase activity

signaling receptor binding

protein binding

ATP binding

cytoplasm

cytosol

plasma membrane

plasma membrane

cell-cell junction

protein phosphorylation

protein phosphorylation

protein phosphorylation

activation of cysteine-type endopeptidase activity involved in apoptotic process

cell surface receptor signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway

response to xenobiotic stimulus

response to mechanical stimulus

response to metal ion

positive regulation of gene expression

phospholipase activator activity

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-tyrosine phosphorylation

peptidyl-tyrosine phosphorylation

protein kinase binding

protein phosphatase binding

protein phosphatase binding

endocytic vesicle

T cell differentiation

T cell differentiation

positive regulation of heterotypic cell-cell adhesion

intracellular signal transduction

peptidyl-tyrosine autophosphorylation

Fc-gamma receptor signaling pathway

SH2 domain binding

gamma-delta T cell differentiation

positive regulation of tyrosine phosphorylation of STAT protein

response to hydrogen peroxide

T cell receptor binding

CD4 receptor binding

CD4 receptor binding

CD8 receptor binding

identical protein binding

phospholipase binding

phosphatidylinositol 3-kinase binding

protein-containing complex binding

innate immune response

membrane raft

positive regulation of gamma-delta T cell differentiation

regulation of regulatory T cell differentiation

protein autophosphorylation

B cell receptor signaling pathway

B cell receptor signaling pathway

regulation of T cell receptor signaling pathway

positive regulation of T cell activation

ATPase binding

release of sequestered calcium ion into cytosol

positive regulation of uterine smooth muscle contraction

glutamatergic synapse

postsynaptic specialization, intracellular component

positive regulation of leukocyte cell-cell adhesion

protein antigen binding

positive regulation of intrinsic apoptotic signaling pathway

04380

04650

04660

05340

1427747_a_at Lcn2 lipocalin 2 2 -32384636 X14607 375

protease binding

immune system process

iron ion binding

iron ion binding

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

cytosol

monoatomic ion transport

iron ion transport

apoptotic process

short-term memory

long-term memory

response to xenobiotic stimulus

response to virus

response to bacterium

response to herbicide

positive regulation of endothelial cell migration

positive regulation of gene expression

siderophore transport

siderophore transport

positive regulation of cell projection organization

cytoplasmic vesicle

small molecule binding

defense response to bacterium

identical protein binding

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

innate immune response

cellular response to hydrogen peroxide

extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of hippocampal neuron apoptotic process

negative regulation of hippocampal neuron apoptotic process

positive regulation of cold-induced thermogenesis

iron ion sequestering activity

positive regulation of reactive oxygen species biosynthetic process

enterobactin binding

positive regulation of iron ion import across plasma membrane

positive regulation of endothelial tube morphogenesis

positive regulation of reactive oxygen species metabolic process

 
1452024_a_at Ldb1 LIM domain binding 1 19 -46032589, -46032589, -46032589 AF030333 137

negative regulation of transcription by RNA polymerase II

chromatin

transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery

gastrulation with mouth forming second

hair follicle development

DNA binding

chromatin binding

transcription coactivator activity

protein binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

transcription regulator complex

transcription regulator complex

transcription by RNA polymerase II

cell adhesion

multicellular organism development

nervous system development

anterior/posterior axis specification

epithelial structure maintenance

Wnt signaling pathway

enzyme binding

enzyme binding

cerebellum development

cerebellar Purkinje cell differentiation

cellular component assembly

neuron differentiation

LIM domain binding

LIM domain binding

LIM domain binding

LIM domain binding

regulation of cell migration

cell leading edge

positive regulation of transcription elongation by RNA polymerase II

protein-containing complex

protein-containing complex

somatic stem cell population maintenance

identical protein binding

protein homodimerization activity

regulation of kinase activity

protein self-association

negative regulation of erythrocyte differentiation

positive regulation of cell adhesion

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of hemoglobin biosynthetic process

regulation of focal adhesion assembly

primitive erythrocyte differentiation

head development

RNA polymerase II-specific DNA-binding transcription factor binding

RNA polymerase II transcription regulator complex

DNA-binding transcription factor binding

DNA-binding transcription factor binding

beta-catenin-TCF complex

 
1434499_a_at Ldhb lactate dehydrogenase B 6 -142490248 AV219418 77

catalytic activity

lactate dehydrogenase activity

L-lactate dehydrogenase activity

L-lactate dehydrogenase activity

L-lactate dehydrogenase activity

cytoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

cytosol

cytosol

lactate metabolic process

lactate metabolic process

pyruvate metabolic process

pyruvate metabolic process

membrane

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

lactate biosynthetic process from pyruvate

NAD metabolic process

carboxylic acid metabolic process

kinase binding

identical protein binding

myelin sheath

membrane raft

NAD binding

oxidoreductase complex

00010

00270

00620

00640

01100

1454734_at Lef1 lymphoid enhancer binding factor 1 3 131110296, 131112790, 131156293, 131110322, 131112790 AV156352 676

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

transcription corepressor binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

branching involved in blood vessel morphogenesis

somitogenesis

somitogenesis

epithelial to mesenchymal transition

vasculature development

sprouting angiogenesis

nucleic acid binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

transcription regulator complex

cytoplasm

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

beta-catenin binding

transcription factor binding

DNA binding, bending

DNA binding, bending

positive regulation of gene expression

positive regulation of epithelial to mesenchymal transition

Wnt signaling pathway

dentate gyrus development

hippocampus development

forebrain radial glial cell differentiation

forebrain neuroblast division

formation of radial glial scaffolds

regulation of cell-cell adhesion

regulation of Wnt signaling pathway

positive regulation of Wnt signaling pathway

neutrophil differentiation

embryonic limb morphogenesis

nuclear estrogen receptor binding

positive regulation of cell migration

BMP signaling pathway

positive regulation of granulocyte differentiation

mammary gland development

negative regulation of interleukin-13 production

negative regulation of interleukin-4 production

negative regulation of interleukin-5 production

protein-DNA complex

T cell receptor V(D)J recombination

B cell proliferation

histone binding

odontogenesis of dentin-containing tooth

odontogenesis of dentin-containing tooth

histone deacetylase binding

negative regulation of apoptotic process

negative regulation of DNA binding

sequence-specific DNA binding

sequence-specific DNA binding

tongue development

positive regulation by host of viral transcription

T-helper 1 cell differentiation

gamma-catenin binding

positive regulation of gamma-delta T cell differentiation

positive regulation of cell differentiation

negative regulation of striated muscle tissue development

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

alpha-beta T cell differentiation

paraxial mesoderm formation

cell development

regulation of neurogenesis

sensory perception of taste

anatomical structure regression

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

face morphogenesis

cell chemotaxis

apoptotic process involved in morphogenesis

chorio-allantoic fusion

trachea gland development

secondary palate development

armadillo repeat domain binding

C2H2 zinc finger domain binding

protein localization to chromatin

cellular response to cytokine stimulus

cellular response to interleukin-4

positive regulation of cell proliferation in bone marrow

negative regulation of apoptotic process in bone marrow cell

odontoblast differentiation

positive regulation of cell cycle process

RNA polymerase II transcription regulator complex

transcription regulator inhibitor activity

positive regulation of odontoblast differentiation

apoptotic process involved in blood vessel morphogenesis

positive regulation of chondrocyte proliferation

epithelial cell apoptotic process

sequence-specific double-stranded DNA binding

beta-catenin-TCF complex

beta-catenin-TCF complex

beta-catenin-TCF complex

04310

04520

04916

05200

05210

05213

05215

05216

05217

05221

05412

1426808_at Lgals3 lectin, galactose binding, soluble 3 14 47373859 X16834 428

skeletal system development

cornified envelope

immunological synapse

immunological synapse

immunological synapse

immune system process

monocyte chemotaxis

monocyte chemotaxis

protein binding

extracellular region

extracellular region

extracellular space

extracellular space

extracellular space

nucleus

nucleus

nucleus

nucleoplasm

spliceosomal complex

cytoplasm

cytoplasm

cytoplasm

mitochondrial inner membrane

cytosol

mRNA processing

positive regulation of cell population proliferation

RNA splicing

external side of plasma membrane

cell surface

cell surface

positive regulation of serotonin secretion

IgE binding

IgE binding

protein phosphatase binding

cell differentiation

extracellular matrix organization

carbohydrate binding

neutrophil chemotaxis

neutrophil chemotaxis

extracellular matrix

positive regulation of protein-containing complex assembly

killing of cells of another organism

Fc-gamma receptor I complex binding

chemoattractant activity

regulation of T cell proliferation

negative regulation of apoptotic process

laminin binding

laminin binding

innate immune response

positive regulation of angiogenesis

negative regulation of endocytosis

negative regulation of endocytosis

negative regulation of endocytosis

monosaccharide binding

disaccharide binding

disaccharide binding

eosinophil chemotaxis

eosinophil chemotaxis

macrophage chemotaxis

macrophage chemotaxis

advanced glycation end-product receptor activity

negative regulation of T cell receptor signaling pathway

positive chemotaxis

positive chemotaxis

antimicrobial humoral immune response mediated by antimicrobial peptide

collagen-containing extracellular matrix

regulation of T cell apoptotic process

oligosaccharide binding

mononuclear cell migration

positive regulation of mononuclear cell migration

positive regulation of calcium ion import

positive regulation of calcium ion import

glial cell projection

molecular condensate scaffold activity

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of protein localization to plasma membrane

negative regulation of cell proliferation in bone marrow

negative regulation of immunological synapse formation

negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

negative regulation of extrinsic apoptotic signaling pathway

negative regulation of extrinsic apoptotic signaling pathway

 
1421217_a_at Lgals9 lectin, galactose binding, soluble 9 11 -78962978 NM_010708 121

positive regulation of cytokine production

immune system process

signaling receptor binding

protein binding

extracellular region

extracellular region

extracellular space

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

chemotaxis

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

transforming growth factor beta receptor signaling pathway

female pregnancy

positive regulation of gene expression

negative regulation of gene expression

galactoside binding

galactoside binding

galactoside binding

enzyme binding

enzyme binding

carbohydrate binding

carbohydrate binding

carbohydrate binding

carbohydrate binding

response to lipopolysaccharide

negative regulation of type II interferon production

negative regulation of type II interferon production

negative regulation of type II interferon production

positive regulation of chemokine production

positive regulation of interleukin-1 production

positive regulation of interleukin-10 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

negative regulation of natural killer cell activation

regulation of natural killer cell differentiation

positive regulation of macrophage activation

receptor clustering

negative regulation of natural killer cell degranulation

protein serine/threonine kinase activator activity

positive regulation of innate immune response

maintenance of protein location

positive regulation of regulatory T cell differentiation

disaccharide binding

negative regulation of inflammatory response

positive regulation of oxidoreductase activity

positive regulation of SMAD protein signal transduction

collagen-containing extracellular matrix

cellular response to virus

positive regulation of defense response to bacterium

positive regulation of T cell migration

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell proliferation

 
1454984_at Lifr LIF receptor alpha 15 7129571, 7140541, 7129571 AV246615 116

cytokine receptor activity

cytokine receptor activity

ciliary neurotrophic factor receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

oncostatin-M receptor activity

ciliary neurotrophic factor receptor binding

ciliary neurotrophic factor receptor binding

protein binding

extracellular region

plasma membrane

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

external side of plasma membrane

negative regulation of muscle cell apoptotic process

membrane

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

growth factor binding

cytokine binding

cytokine binding

animal organ regeneration

response to cytokine

oncostatin-M-mediated signaling pathway

receptor complex

receptor complex

neuron projection morphogenesis

leukemia inhibitory factor signaling pathway

ciliary neurotrophic factor-mediated signaling pathway

04060

04630

1421262_at Lipg lipase, endothelial 18 -74939321 BC020991 61

lipoprotein lipase activity

lipoprotein lipase activity

phospholipase activity

phospholipase activity

triglyceride lipase activity

extracellular region

extracellular space

extracellular space

early endosome

Golgi apparatus

lipid metabolic process

fatty acid biosynthetic process

heparin binding

phospholipase A1 activity

phospholipase A1 activity

cell surface

positive regulation of high-density lipoprotein particle clearance

lipid catabolic process

lipase activity

hydrolase activity

triglyceride catabolic process

positive regulation of cholesterol transport

high-density lipoprotein particle remodeling

high-density lipoprotein particle remodeling

cholesterol homeostasis

cholesterol homeostasis

reverse cholesterol transport

regulation of lipoprotein metabolic process

carboxylic ester hydrolase activity

phosphatidylserine 1-acylhydrolase activity

1-acyl-2-lysophosphatidylserine acylhydrolase activity

phospholipid homeostasis

00561

01100

1423520_at Lmnb1 lamin B1 18 56707812 AA270173 164

double-stranded DNA binding

structural constituent of cytoskeleton

structural constituent of cytoskeleton

nucleus

nucleus

nuclear envelope

nuclear envelope

nuclear envelope

nuclear envelope

nuclear inner membrane

lamin filament

nuclear lamina

nuclear lamina

nuclear lamina

nucleoplasm

nucleoplasm

intermediate filament

nuclear envelope organization

nuclear envelope organization

nuclear migration

JUN kinase binding

positive regulation of G2/M transition of mitotic cell cycle

nuclear matrix

nuclear matrix

heterochromatin formation

nuclear membrane

nuclear periphery

phospholipase binding

positive regulation of JNK cascade

nuclear pore localization

protein localization to nuclear envelope

cellular response to L-glutamate

sequence-specific double-stranded DNA binding

 
1460194_at Phyh phytanoyl-CoA hydroxylase 2 4918995 NM_010726 29

fatty acid alpha-oxidation

fatty acid alpha-oxidation

fatty acid alpha-oxidation

catalytic activity

protein binding

mitochondrion

peroxisome

peroxisome

peroxisomal matrix

2-oxoglutarate metabolic process

isoprenoid metabolic process

ferrous iron binding

oxidoreductase activity

2-oxobutyrate catabolic process

carboxylic acid binding

L-ascorbic acid binding

metal ion binding

phytanoyl-CoA dioxygenase activity

phytanoyl-CoA dioxygenase activity

dioxygenase activity

methyl-branched fatty acid metabolic process

9+0 non-motile cilium

04146

1448213_at Anxa1 annexin A1 19 -20373433 NM_010730 251

cornified envelope

cornified envelope

neutrophil homeostasis

neutrophil homeostasis

phosphatidylserine binding

adaptive immune response

immune system process

monocyte chemotaxis

regulation of leukocyte migration

single-stranded DNA binding

single-stranded RNA binding

phospholipase inhibitor activity

calcium ion binding

protein binding

phospholipid binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

extracellular region

extracellular space

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

endosome

cytosol

cytosol

actin filament

plasma membrane

plasma membrane

plasma membrane

cilium

phagocytosis

phagocytosis

inflammatory response

signal transduction

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

lipid binding

regulation of cell shape

cell surface

myoblast migration involved in skeletal muscle regeneration

membrane

apical plasma membrane

lateral plasma membrane

peptide cross-linking

phospholipase A2 inhibitor activity

actin cytoskeleton organization

insulin secretion

keratinocyte differentiation

positive regulation of vesicle fusion

positive regulation of prostaglandin biosynthetic process

cytoplasmic vesicle

motile cilium

mitochondrial membrane

DNA duplex unwinding

regulation of interleukin-1 production

negative regulation of interleukin-8 production

positive regulation of interleukin-2 production

protein-containing complex

positive regulation of neutrophil apoptotic process

cellular response to vascular endothelial growth factor stimulus

double-stranded DNA helicase activity

positive regulation of T cell proliferation

neutrophil activation

regulation of cell population proliferation

sarcolemma

mast cell granule

identical protein binding

cell projection

positive regulation of apoptotic process

innate immune response

positive regulation of T-helper 1 cell differentiation

negative regulation of T-helper 2 cell differentiation

negative regulation of exocytosis

alpha-beta T cell differentiation

metal ion binding

regulation of hormone secretion

calcium-dependent protein binding

arachidonic acid secretion

negative regulation of protein secretion

regulation of inflammatory response

localization

collagen-containing extracellular matrix

extracellular exosome

cellular response to hydrogen peroxide

prolactin secretion

cellular response to glucocorticoid stimulus

cellular response to glucocorticoid stimulus

cellular response to glucocorticoid stimulus

granulocyte chemotaxis

positive regulation of cell migration involved in sprouting angiogenesis

positive regulation of wound healing

synaptic membrane

neutrophil clearance

positive regulation of G1/S transition of mitotic cell cycle

DNA/DNA annealing activity

 
1448655_at Lrp1 low density lipoprotein receptor-related protein 1 10 -127538157 NM_008512 382

protease binding

astrocyte activation involved in immune response

cardiac septum development

signaling receptor binding

calcium ion binding

protein binding

nucleus

cytoplasm

endosome

early endosome

Golgi apparatus

cytoskeleton

plasma membrane

plasma membrane

clathrin-coated pit

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

phagocytosis

phagocytosis

lysosomal transport

enzyme-linked receptor protein signaling pathway

positive regulation of cytosolic calcium ion concentration

protein kinase C-activating G protein-coupled receptor signaling pathway

multicellular organism development

cholesterol metabolic process

external side of plasma membrane

negative regulation of gene expression

negative regulation of cell-substrate adhesion

positive regulation of cholesterol efflux

positive regulation of neuron projection development

negative regulation of neuron projection development

negative regulation of smooth muscle cell migration

coreceptor activity

membrane

basolateral plasma membrane

alpha-2 macroglobulin receptor activity

clathrin-coated vesicle

negative regulation of Wnt signaling pathway

dendrite

negative regulation of transforming growth factor beta receptor signaling pathway

clathrin heavy chain binding

positive regulation of protein binding

positive regulation of lipid transport

regulation of cholesterol transport

regulation of phospholipase A2 activity

insulin-responsive compartment

regulation of actin cytoskeleton organization

apolipoprotein binding

apolipoprotein binding

positive regulation of insulin secretion involved in cellular response to glucose stimulus

aorta morphogenesis

cargo receptor activity

cargo receptor activity

cargo receptor activity

neuronal cell body

negative regulation of apoptotic process

receptor complex

apoptotic cell clearance

negative regulation of neuron apoptotic process

cellular lipid catabolic process

axonal growth cone

protein-containing complex binding

apical part of cell

positive regulation of axon extension

positive regulation of endocytosis

metal ion binding

perinuclear region of cytoplasm

positive regulation of axon extension involved in regeneration

positive regulation of collateral sprouting of injured axon

positive regulation of phagocytosis

positive regulation of protein transport

negative regulation of cytosolic calcium ion concentration

negative regulation of focal adhesion assembly

negative regulation of SMAD protein signal transduction

coronary vasculature development

chemoattraction of axon

positive regulation of ERK1 and ERK2 cascade

amyloid-beta clearance

amyloid-beta clearance by transcytosis

amyloid-beta clearance by transcytosis

amyloid-beta clearance by transcytosis

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

amyloid-beta clearance by cellular catabolic process

transport across blood-brain barrier

positive regulation of Schwann cell migration

positive regulation of amyloid-beta clearance

positive regulation of protein localization to plasma membrane

positive regulation of cholesterol import

positive regulation of transcytosis

cellular response to amyloid-beta

positive regulation of vascular associated smooth muscle cell migration

regulation of pulmonary blood vessel remodeling

positive regulation of lysosomal protein catabolic process

positive regulation of chemokine (C-X-C motif) ligand 2 production

negative regulation of platelet-derived growth factor receptor-beta signaling pathway

05010

05144

1419135_at Ltb lymphotoxin B 17 35194506 NM_008518 169

cytokine activity

tumor necrosis factor receptor binding

extracellular space

plasma membrane

immune response

gene expression

membrane

positive regulation of interleukin-12 production

positive regulation of canonical NF-kappaB signal transduction

skin development

lymph node development

positive regulation of extrinsic apoptotic signaling pathway

04060

05323

1420407_at Ltb4r1 leukotriene B4 receptor 1 14 55765961 NM_008519 143

leukotriene B4 receptor activity

leukotriene B4 receptor activity

G protein-coupled receptor activity

leukotriene receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

G protein-coupled peptide receptor activity

membrane

04080

1416435_at Ltbr lymphotoxin B receptor 6 -125306570 NM_010736 231

protein binding

Golgi apparatus

plasma membrane

apoptotic process

immune response

membrane

ubiquitin protein ligase binding

ubiquitin protein ligase binding

identical protein binding

myeloid dendritic cell differentiation

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of JNK cascade

hematopoietic or lymphoid organ development

lymph node development

positive regulation of extrinsic apoptotic signaling pathway

04060

04672

1450009_at Ltf lactotransferrin 9 111019291 NM_008522 112

ossification

lipopolysaccharide binding

regulation of cytokine production

innate immune response in mucosa

immune system process

serine-type endopeptidase activity

cysteine-type endopeptidase inhibitor activity

iron ion binding

extracellular region

extracellular space

extracellular space

cytoplasm

cytoplasm

early endosome

plasma membrane

proteolysis

monoatomic ion transport

iron ion transport

iron ion transport

heparin binding

peptidase activity

serine-type peptidase activity

cell surface

hydrolase activity

antibacterial humoral response

antibacterial humoral response

antifungal humoral response

secretory granule

killing of cells of another organism

negative regulation of lipopolysaccharide-mediated signaling pathway

regulation of tumor necrosis factor production

negative regulation of ATP-dependent activity

protein-containing complex

positive regulation of osteoblast proliferation

positive regulation of toll-like receptor 4 signaling pathway

specific granule

positive regulation of canonical NF-kappaB signal transduction

protein serine/threonine kinase activator activity

negative regulation by host of viral process

negative regulation of viral genome replication

innate immune response

positive regulation of osteoblast differentiation

negative regulation of membrane potential

metal ion binding

negative regulation of viral process

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

positive regulation of NF-kappaB transcription factor activity

cytolysis by host of symbiont cells

recycling endosome

bone morphogenesis

antimicrobial humoral immune response mediated by antimicrobial peptide

positive regulation of protein serine/threonine kinase activity

membrane destabilizing activity

negative regulation of single-species biofilm formation in or on host organism

positive regulation of chondrocyte proliferation

negative regulation of cysteine-type endopeptidase activity

 
1451780_at Blnk B cell linker 19 -40928926 AF068182 110

protein binding

cytoplasm

cytoplasm

cytosol

plasma membrane

transmembrane receptor protein tyrosine kinase signaling pathway

lipid binding

positive regulation of gene expression

membrane

enzyme binding

protein kinase binding

intracellular signal transduction

intracellular signal transduction

signaling adaptor activity

B cell activation

SH2 domain binding

intracellular membrane-bounded organelle

phospholipase binding

B cell receptor signaling pathway

protein tyrosine kinase binding

04380

04662

05340

1416359_at Snx18 sorting nexin 18 13 -113592178 AV344473 23

mitotic cell cycle

mitotic cytokinesis

protein binding

phosphatidylinositol-4,5-bisphosphate binding

endosome

plasma membrane

plasma membrane

endocytosis

endocytosis

cell cycle

lipid binding

cytoplasmic side of plasma membrane

protein transport

membrane

endosomal transport

endosomal transport

clathrin-coated vesicle

growth cone

cytoplasmic vesicle

cytoplasmic vesicle

phosphatidylinositol binding

phosphatidylinositol binding

cleavage furrow formation

cleavage furrow formation

neuronal cell body

positive regulation of GTPase activity

cell division

recycling endosome membrane

extracellular exosome

plasma membrane tubulation

positive regulation of autophagosome assembly

 
1416930_at Ly6d lymphocyte antigen 6 family member D 15 -74762055 NM_010742 32

plasma membrane

cell surface

cell surface

membrane

lymphocyte differentiation

lymphocyte differentiation

response to stilbenoid

side of membrane

 
1422041_at Pilrb1 paired immunoglobin-like type 2 receptor beta 1 5 -137852146 NM_133209 12

myeloid dendritic cell activation

protein binding

plasma membrane

membrane

MHC class I protein binding

MHC class I protein binding

negative regulation of osteoclast differentiation

 
1426218_at Glcci1 glucocorticoid induced transcript 1 6 8520057, 8509599 AA152997 34

cytoplasm

cytoplasm

 
1454775_at Hdac10 histone deacetylase 10 15 -89123302 AW548891 28

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

histone deacetylase activity

nucleus

nucleoplasm

cytoplasm

cytosol

DNA repair

DNA recombination

chromatin organization

chromatin remodeling

regulation of DNA-templated transcription

autophagy

DNA damage response

macroautophagy

hydrolase activity

deacetylase activity

deacetylase activity

enzyme binding

positive regulation of mismatch repair

peptidyl-lysine deacetylation

homologous recombination

histone deacetylase binding

intracellular membrane-bounded organelle

negative regulation of DNA-templated transcription

metal ion binding

acetylputrescine deacetylase activity

acetylspermidine deacetylase activity

polyamine deacetylation

spermidine deacetylation

 
1438398_at Rbm39 RNA binding motif protein 39 2 -156147240, -156147240 BB203348 50

nucleic acid binding

RNA binding

protein binding

nucleus

nucleoplasm

mRNA processing

RNA splicing

microtubule cytoskeleton

nuclear speck

protein-containing complex

centriolar satellite

regulation of mRNA splicing, via spliceosome

RS domain binding

U1 snRNP binding

 
1449874_at Ly96 lymphocyte antigen 96 1 16688455 NM_016923 127

lipopolysaccharide binding

lipopolysaccharide immune receptor activity

lipopolysaccharide immune receptor activity

toll-like receptor signaling pathway

immune system process

protein binding

extracellular region

plasma membrane

inflammatory response

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

positive regulation of lipopolysaccharide-mediated signaling pathway

positive regulation of lipopolysaccharide-mediated signaling pathway

positive regulation of lipopolysaccharide-mediated signaling pathway

positive regulation of lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

detection of lipopolysaccharide

detection of lipopolysaccharide

positive regulation of tumor necrosis factor production

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

Toll-like receptor 4 binding

receptor complex

innate immune response

lipopolysaccharide receptor complex

lipopolysaccharide receptor complex

lipopolysaccharide receptor complex

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

04620

05145

1439200_x_at Erdr1x erythroid differentiation regulator 1 x X, Y 90785441 BE686792 31

molecular_function

cellular_component

negative regulation of cell population proliferation

negative regulation of cell migration

somatic stem cell population maintenance

 
1437540_at Mcoln3 mucolipin 3 3 146121790 AV313762 55

monoatomic cation channel activity

cytoplasm

lysosomal membrane

endosome

plasma membrane

plasma membrane

monoatomic ion transport

sensory perception of sound

locomotory behavior

lipid binding

membrane

cytoplasmic vesicle

monoatomic ion transmembrane transport

inner ear auditory receptor cell differentiation

cell projection

NAADP-sensitive calcium-release channel activity

 
1434678_at Mbnl3 muscleblind like splicing factor 3 X -51113493 AV306759 31

RNA binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytosol

mRNA processing

multicellular organism development

RNA splicing

regulation of RNA splicing

regulation of RNA splicing

negative regulation of myoblast differentiation

metal ion binding

 
1455104_at Mxd1 MAX dimerization protein 1 6 -86647044 AV228517 49

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

protein binding

nucleus

nucleoplasm

mitochondrion

cytosol

regulation of transcription by RNA polymerase II

protein dimerization activity

Mad-Max complex

 
1440162_x_at Edaradd EDAR associated via death domain 13 -12471208 BB446560 53

hair follicle development

death receptor binding

protein binding

cytoplasm

signal transduction

canonical NF-kappaB signal transduction

multicellular organism development

cell differentiation

odontogenesis of dentin-containing tooth

trachea gland development

positive regulation of non-canonical NF-kappaB signal transduction

 
1422486_a_at Smad4 SMAD family member 4 18 -73634790 AK004804 546

negative regulation of transcription by RNA polymerase II

chromatin

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription corepressor binding

transcription coactivator binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

ovarian follicle development

ovarian follicle development

osteoblast differentiation

branching involved in ureteric bud morphogenesis

response to hypoxia

in utero embryonic development

gastrulation with mouth forming second

kidney development

epithelial to mesenchymal transition

outflow tract septum morphogenesis

atrioventricular valve formation

epithelial to mesenchymal transition involved in endocardial cushion formation

left ventricular cardiac muscle tissue morphogenesis

positive regulation of cell proliferation involved in heart valve morphogenesis

cardiac septum development

brainstem development

DNA binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

collagen binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

cytoplasm

centrosome

cytosol

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

intracellular iron ion homeostasis

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

spermatogenesis

single fertilization

gastrulation

axon guidance

endoderm development

mesoderm development

cell population proliferation

cell population proliferation

negative regulation of cell population proliferation

male gonad development

female gonad development

anatomical structure morphogenesis

anatomical structure morphogenesis

anterior/posterior pattern specification

negative regulation of cardiac muscle hypertrophy

positive regulation of gene expression

epithelial cell migration

positive regulation of cardiac muscle cell apoptotic process

positive regulation of epithelial to mesenchymal transition

neural crest cell differentiation

cardiac muscle hypertrophy in response to stress

regulation of transforming growth factor beta receptor signaling pathway

cell differentiation

cell differentiation

negative regulation of cell growth

BMP signaling pathway

BMP signaling pathway

BMP signaling pathway

positive regulation of transforming growth factor beta receptor signaling pathway

filamin binding

activin responsive factor complex

somite rostral/caudal axis specification

regulation of transforming growth factor beta2 production

activin receptor signaling pathway

protein-containing complex

positive regulation of luteinizing hormone secretion

positive regulation of luteinizing hormone secretion

intracellular signal transduction

atrioventricular canal development

endothelial cell activation

regulation of cell population proliferation

regulation of cell population proliferation

negative regulation of protein catabolic process

embryonic digit morphogenesis

identical protein binding

identical protein binding

protein homodimerization activity

sulfate binding

sequence-specific DNA binding

protein-containing complex binding

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

SMAD binding

metal ion binding

positive regulation of follicle-stimulating hormone secretion

positive regulation of follicle-stimulating hormone secretion

mesendoderm development

developmental growth

neuron fate commitment

neuron fate specification

tissue morphogenesis

sebaceous gland development

formation of anatomical boundary

regulation of binding

regulation of hair follicle development

uterus development

positive regulation of SMAD protein signal transduction

SMAD protein signal transduction

SMAD protein signal transduction

SMAD protein signal transduction

ventricular septum morphogenesis

endocardial cell differentiation

female gonad morphogenesis

RNA polymerase II-specific DNA-binding transcription factor binding

secondary palate development

interleukin-6-mediated signaling pathway

ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

I-SMAD binding

I-SMAD binding

R-SMAD binding

SMAD protein complex

heteromeric SMAD protein complex

heteromeric SMAD protein complex

heteromeric SMAD protein complex

cellular response to glucose stimulus

response to transforming growth factor beta

cellular response to transforming growth factor beta stimulus

metanephric mesenchyme morphogenesis

nephrogenic mesenchyme morphogenesis

seminiferous tubule development

negative regulation of canonical Wnt signaling pathway

RNA polymerase II transcription regulator complex

extrinsic apoptotic signaling pathway

positive regulation of extracellular matrix assembly

positive regulation of miRNA transcription

negative regulation of cardiac myofibril assembly

04110

04310

04350

04520

05200

05210

05212

05220

1443771_x_at Smad7 SMAD family member 7 18 75367364 BB241324 269

negative regulation of transcription by RNA polymerase II

fibrillar center

ureteric bud development

negative regulation of T cell cytokine production

transcription corepressor activity

protein binding

collagen binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

centrosome

cytosol

cytosol

plasma membrane

adherens junction

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

beta-catenin binding

anatomical structure morphogenesis

regulation of epithelial to mesenchymal transition

negative regulation of peptidyl-threonine phosphorylation

negative regulation of peptidyl-threonine phosphorylation

negative regulation of transcription by competitive promoter binding

regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell-cell adhesion

positive regulation of cell-cell adhesion

cell differentiation

negative regulation of ossification

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

negative regulation of BMP signaling pathway

negative regulation of protein ubiquitination

protein-containing complex localization

ubiquitin protein ligase binding

negative regulation of activin receptor signaling pathway

protein-containing complex

protein-containing complex

negative regulation of peptidyl-serine phosphorylation

negative regulation of peptidyl-serine phosphorylation

adherens junction assembly

type I transforming growth factor beta receptor binding

intracellular signal transduction

metal ion binding

artery morphogenesis

protein stabilization

negative regulation of ubiquitin-protein transferase activity

ventricular cardiac muscle tissue morphogenesis

regulation of cardiac muscle contraction

regulation of ventricular cardiac muscle cell membrane depolarization

negative regulation of SMAD protein signal transduction

negative regulation of SMAD protein signal transduction

SMAD protein signal transduction

ventricular septum morphogenesis

I-SMAD binding

I-SMAD binding

activin receptor binding

heteromeric SMAD protein complex

cellular response to transforming growth factor beta stimulus

cellular response to transforming growth factor beta stimulus

transcription regulator inhibitor activity

transcription regulator inhibitor activity

negative regulation of chondrocyte proliferation

positive regulation of chondrocyte hypertrophy

ubiquitin ligase-substrate adaptor activity

cellular response to leukemia inhibitory factor

negative regulation of T-helper 17 type immune response

negative regulation of T-helper 17 cell differentiation

04144

04350

1456060_at Maf MAF bZIP transcription factor 8 -115703252 AV284857 208

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

cytokine production

lens development in camera-type eye

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

positive regulation of gene expression

megakaryocyte differentiation

regulation of chondrocyte differentiation

identical protein binding

sequence-specific DNA binding

protein-containing complex binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

cell development

inner ear development

lens fiber cell differentiation

lens fiber cell differentiation

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

 
1448647_at Man2a1 mannosidase 2, alpha 1 17 64601648 NM_008549 42

Golgi membrane

Golgi membrane

Golgi membrane

in utero embryonic development

liver development

catalytic activity

alpha-mannosidase activity

alpha-mannosidase activity

mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity

extracellular space

Golgi apparatus

Golgi medial cisterna

cis-Golgi network

carbohydrate metabolic process

mannose metabolic process

N-glycan processing

N-glycan processing

N-glycan processing

protein deglycosylation

mitochondrion organization

vacuole organization

respiratory gaseous exchange by respiratory system

metabolic process

mannosidase activity

membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds

carbohydrate binding

identical protein binding

protein homodimerization activity

metal ion binding

lung alveolus development

positive regulation of neurogenesis

retina morphogenesis in camera-type eye

00510

01100

1456439_x_at Mical1 microtubule associated monooxygenase, calponin and LIM domain containing 1 10 41476313, 41478009 BB209438 31

negative regulation of protein phosphorylation

actin binding

actin binding

monooxygenase activity

monooxygenase activity

protein binding

cytoplasm

endosome

cytosol

cytoskeleton

actin filament

endosome membrane

membrane

NAD(P)H oxidase H2O2-forming activity

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

SH3 domain binding

sulfur oxidation

protein kinase binding

actin filament depolymerization

actin filament depolymerization

midbody

small GTPase binding

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

intercellular bridge

metal ion binding

FAD binding

FAD binding

regulation of regulated secretory pathway

hippocampal mossy fiber expansion

 
1449498_at Marco macrophage receptor with collagenous structure 1 -120474537 NM_010766 77

amyloid-beta binding

G protein-coupled receptor binding

immune system process

collagen trimer

extracellular space

cytoplasm

plasma membrane

plasma membrane

endocytosis

receptor-mediated endocytosis

phagocytosis, engulfment

membrane

extracellular matrix

cargo receptor activity

apoptotic cell clearance

innate immune response

amyloid-beta clearance

04145

1434888_a_at Matr3 matrin 3 18 35562157 BM219545 73

blastocyst formation

activation of innate immune response

immune system process

heart valve development

ventricular septum development

nucleic acid binding

RNA binding

RNA binding

nucleus

nucleus

zinc ion binding

post-transcriptional regulation of gene expression

nuclear matrix

miRNA binding

identical protein binding

innate immune response

metal ion binding

 
1416881_at Mcl1 myeloid cell leukemia sequence 1 3 95658720 BC003839 275

release of cytochrome c from mitochondria

protein binding

nucleus

nucleus

cytoplasm

mitochondrion

mitochondrion

mitochondrial outer membrane

cytosol

apoptotic process

DNA damage response

multicellular organism development

mitochondrial fusion

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

negative regulation of autophagy

channel activity

membrane

membrane

cell differentiation

response to cytokine

protein homodimerization activity

regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

protein-containing complex binding

protein heterodimerization activity

protein heterodimerization activity

protein dimerization activity

BH domain binding

BH3 domain binding

BH3 domain binding

Bcl-2 family protein complex

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway in absence of ligand

extrinsic apoptotic signaling pathway in absence of ligand

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

negative regulation of anoikis

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

 
1449965_at Mcpt8 mast cell protease 8 14 -56082163 NM_008572 57

serine-type endopeptidase activity

extracellular region

extracellular space

cytoplasm

proteolysis

peptidase activity

serine-type peptidase activity

hydrolase activity

intracellular membrane-bounded organelle

 
1460542_s_at Mdm4 transformed mouse 3T3 cell double minute 4 1 -132986104, -132986104 BQ173933 142

negative regulation of transcription by RNA polymerase II

regulation of heart rate

heart valve development

atrioventricular valve morphogenesis

endocardial cushion morphogenesis

ventricular septum development

atrial septum development

ubiquitin-protein transferase activity

protein binding

nucleus

nucleoplasm

positive regulation of cell population proliferation

protein ubiquitination

transcription repressor complex

enzyme binding

negative regulation of protein catabolic process

negative regulation of apoptotic process

negative regulation of DNA-templated transcription

metal ion binding

regulation of cell cycle

protein-containing complex assembly

negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

04115

1424852_at Mef2c myocyte enhancer factor 2C 13 83504033, 83573606, 83524742, 83523655 BB280300 457

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

MAPK cascade

MAPK cascade

MAPK cascade

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

blood vessel development

osteoblast differentiation

osteoblast differentiation

neuron migration

B cell homeostasis

heart looping

endochondral ossification

endochondral ossification

blood vessel remodeling

chondrocyte differentiation

germinal center formation

regulation of germinal center formation

response to ischemia

primary heart field specification

secondary heart field specification

outflow tract morphogenesis

sinoatrial valve morphogenesis

cardiac ventricle formation

cardiac ventricle formation

DNA binding

DNA binding

minor groove of adenine-thymine-rich DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

regulation of DNA-templated transcription

regulation of DNA-templated transcription

apoptotic process

humoral immune response

multicellular organism development

nervous system development

axon guidance

heart development

heart development

skeletal muscle tissue development

muscle cell fate determination

learning or memory

gene expression

positive regulation of cardiac muscle hypertrophy

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

negative regulation of gene expression

positive regulation of alkaline phosphatase activity

neural crest cell differentiation

cardiac muscle hypertrophy in response to stress

nuclear speck

sarcomere

cell differentiation

cell differentiation

neuron differentiation

platelet formation

monocyte differentiation

negative regulation of ossification

melanocyte differentiation

positive regulation of bone mineralization

positive regulation of B cell proliferation

protein-containing complex

embryonic heart tube development

embryonic heart tube development

skeletal muscle cell differentiation

skeletal muscle cell differentiation

cellular response to trichostatin A

B cell proliferation

histone deacetylase binding

histone deacetylase binding

intracellular membrane-bounded organelle

positive regulation of MAPK cascade

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

cell fate commitment

regulation of megakaryocyte differentiation

positive regulation of myoblast differentiation

positive regulation of neuron differentiation

positive regulation of osteoblast differentiation

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of neurotransmitter secretion

protein heterodimerization activity

protein dimerization activity

regulation of synaptic plasticity

positive regulation of skeletal muscle tissue development

neuron development

cell morphogenesis involved in neuron differentiation

embryonic viscerocranium morphogenesis

embryonic skeletal system morphogenesis

negative regulation of epithelial cell proliferation

B cell receptor signaling pathway

smooth muscle cell differentiation

regulation of synapse assembly

regulation of synaptic transmission, glutamatergic

cardiac muscle cell differentiation

cardiac muscle cell differentiation

ventricular cardiac muscle cell differentiation

roof of mouth development

regulation of synaptic activity

positive regulation of cardiac muscle cell proliferation

excitatory postsynaptic potential

transdifferentiation

regulation of sarcomere organization

cartilage morphogenesis

regulation of dendritic spine development

renal tubule morphogenesis

RNA polymerase II-specific DNA-binding transcription factor binding

cellular response to lipopolysaccharide

cellular response to calcium ion

cellular response to retinoic acid

cellular response to growth factor stimulus

cellular response to parathyroid hormone stimulus

cellular response to xenobiotic stimulus

cellular response to fluid shear stress

cellular response to transforming growth factor beta stimulus

HMG box domain binding

cell proliferation in bone marrow

positive regulation of cell proliferation in bone marrow

glomerulus morphogenesis

nephron tubule epithelial cell differentiation

sympathetic neuron axon guidance

DNA-binding transcription factor binding

semaphorin-plexin signaling pathway involved in axon guidance

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of vascular associated smooth muscle cell migration

negative regulation of vascular endothelial cell proliferation

sequence-specific double-stranded DNA binding

positive regulation of macrophage apoptotic process

regulation of NMDA receptor activity

regulation of AMPA receptor activity

positive regulation of cardiac muscle cell differentiation

positive regulation of cardiac muscle cell differentiation

positive regulation of behavioral fear response

epithelial cell proliferation involved in renal tubule morphogenesis

positive regulation of skeletal muscle cell differentiation

04010

1434487_at Mef2d myocyte enhancer factor 2D 3 88142371 AV334508 130

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

osteoblast differentiation

endochondral ossification

chondrocyte differentiation

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

regulation of DNA-templated transcription

apoptotic process

multicellular organism development

nervous system development

enzyme binding

cell differentiation

cell differentiation

skeletal muscle cell differentiation

protein homodimerization activity

histone deacetylase binding

histone deacetylase binding

intracellular membrane-bounded organelle

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

protein dimerization activity

RNA polymerase II-specific DNA-binding transcription factor binding

DNA-binding transcription factor binding

positive regulation of vascular associated smooth muscle cell proliferation

sequence-specific double-stranded DNA binding

 
1422869_at Mertk MER proto-oncogene tyrosine kinase 2 128698914 NM_008587 238

nucleotide binding

photoreceptor outer segment

natural killer cell differentiation

negative regulation of cytokine production

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

ATP binding

extracellular space

cytoplasm

plasma membrane

protein phosphorylation

phagocytosis

phagocytosis

transmembrane receptor protein tyrosine kinase signaling pathway

multicellular organism development

spermatogenesis

nervous system development

membrane

kinase activity

phosphorylation

cell migration

transferase activity

platelet activation

secretion by cell

positive regulation of kinase activity

substrate adhesion-dependent cell spreading

receptor complex

apoptotic cell clearance

apoptotic cell clearance

apoptotic cell clearance

lymphocyte activation

positive regulation of phagocytosis

negative regulation of lymphocyte activation

establishment of localization in cell

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

retina development in camera-type eye

vagina development

neutrophil clearance

negative regulation of leukocyte apoptotic process

 
1434447_at Met met proto-oncogene 6 17463956 BG060788 431

negative regulation of transcription by RNA polymerase II

nucleotide binding

neuron migration

endothelial cell morphogenesis

liver development

liver development

placenta development

protein kinase activity

protein tyrosine kinase activity

transmembrane receptor protein tyrosine kinase activity

hepatocyte growth factor receptor activity

hepatocyte growth factor receptor activity

hepatocyte growth factor receptor activity

protein binding

ATP binding

extracellular space

protein phosphorylation

phagocytosis

transmembrane receptor protein tyrosine kinase signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway

chemical synaptic transmission

multicellular organism development

nervous system development

brain development

muscle organ development

muscle organ development

skeletal muscle tissue development

beta-catenin binding

basal plasma membrane

basal plasma membrane

positive regulation of gene expression

negative regulation of gene expression

positive regulation of peptidyl-threonine phosphorylation

negative regulation of peptidyl-threonine phosphorylation

positive regulation of glucose transmembrane transport

positive regulation of neuron projection development

muscle cell migration

myotube differentiation

membrane

kinase activity

phosphorylation

cell migration

transferase activity

semaphorin receptor activity

protein phosphatase binding

neuron differentiation

flagellated sperm motility

dendrite

adult behavior

pancreas development

positive regulation of microtubule polymerization

regulation of interleukin-6 production

positive regulation of peptidyl-serine phosphorylation

positive regulation of kinase activity

negative regulation of Rho protein signal transduction

sperm flagellum

glucose homeostasis

identical protein binding

neuronal cell body

receptor complex

phospholipase binding

positive regulation of MAPK cascade

phosphatidylinositol 3-kinase binding

protein-containing complex binding

postsynaptic membrane

positive regulation of DNA replication

positive regulation of mitotic nuclear division

positive regulation of transcription by RNA polymerase II

protein autophosphorylation

hepatocyte growth factor receptor signaling pathway

branching morphogenesis of an epithelial tube

positive regulation of dendrite morphogenesis

modulation of chemical synaptic transmission

positive chemotaxis

positive chemotaxis

myoblast proliferation

negative regulation of stress fiber assembly

establishment of localization in cell

cardiac muscle cell development

cardiac muscle contraction

excitatory synapse

excitatory postsynaptic potential

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

establishment of skin barrier

negative regulation of thrombin-activated receptor signaling pathway

semaphorin-plexin signaling pathway

semaphorin-plexin signaling pathway

negative regulation of transforming growth factor beta production

reactive oxygen species metabolic process

molecular function activator activity

regulation of cellular response to oxidative stress

positive regulation of p38MAPK cascade

negative regulation of hydrogen peroxide-mediated programmed cell death

glucose transmembrane transport

negative regulation of guanyl-nucleotide exchange factor activity

positive regulation of endothelial cell chemotaxis

04060

04144

04360

04510

04520

05100

05144

05200

05211

05218

1418652_at Cxcl9 C-X-C motif chemokine ligand 9 5 -92321330 NM_008599 136

cytokine activity

extracellular region

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

inflammatory response

immune response

adenylate cyclase-activating G protein-coupled receptor signaling pathway

chemokine activity

chemokine activity

response to bacterium

external side of plasma membrane

neutrophil chemotaxis

killing of cells of another organism

regulation of cell population proliferation

CXCR chemokine receptor binding

positive regulation of myoblast differentiation

CXCR3 chemokine receptor binding

positive regulation of release of sequestered calcium ion into cytosol

defense response to virus

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

positive regulation of myoblast fusion

04060

04062

04620

1455214_at Mitf melanogenesis associated transcription factor 6 97991782, 97929816, 97807057 BB763517 528

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleus

cytoplasm

lysosome

lysosomal membrane

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

multicellular organism development

regulation of gene expression

positive regulation of gene expression

membrane

Wnt signaling pathway

cell differentiation

osteoclast differentiation

melanocyte differentiation

melanocyte differentiation

melanocyte differentiation

negative regulation of cell migration

protein-containing complex

regulation of cell population proliferation

camera-type eye development

negative regulation of apoptotic process

pigmentation

pigmentation

sequence-specific DNA binding

cell fate commitment

regulation of osteoclast differentiation

regulation of osteoclast differentiation

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

bone remodeling

protein dimerization activity

protein-containing complex assembly

E-box binding

E-box binding

melanocyte apoptotic process

positive regulation of DNA-templated transcription initiation

regulation of RNA biosynthetic process

04380

04916

05200

05218

1428725_at Pias2 protein inhibitor of activated STAT 2 18 77065679, 77065679, 77065207, 77065207 AK018146 71

DNA binding

transcription coregulator activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

zinc ion binding

PML body

transferase activity

protein sumoylation

protein sumoylation

protein sumoylation

SUMO transferase activity

SUMO transferase activity

SUMO transferase activity

protein domain specific binding

nuclear estrogen receptor binding

androgen receptor signaling pathway

ubiquitin protein ligase binding

nuclear glucocorticoid receptor binding

negative regulation of DNA-binding transcription factor activity

positive regulation of DNA-templated transcription

metal ion binding

nuclear androgen receptor binding

positive regulation of dendrite morphogenesis

regulation of androgen receptor signaling pathway

negative regulation of androgen receptor signaling pathway

RNA polymerase II-specific DNA-binding transcription factor binding

RNA polymerase II-specific DNA-binding transcription factor binding

SUMO ligase activity

SUMO ligase activity

04120

04630

05160

05200

05222

1437226_x_at Marcksl1 MARCKS-like 1 4 129513580 AV110584 52

actin binding

calmodulin binding

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

plasma membrane

actin filament organization

central nervous system development

synaptic vesicle

cell population proliferation

positive regulation of cell population proliferation

membrane

presynaptic membrane

actin filament binding

regulation of presynaptic cytosolic calcium ion concentration

presynaptic cytosol

04666

05140

1448383_at Mmp14 matrix metallopeptidase 14 (membrane-inserted) 14 54431597 NM_008608 234

skeletal system development

ossification

endochondral ossification

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

integrin binding

extracellular space

extracellular space

nucleus

cytoplasm

cytosol

plasma membrane

plasma membrane

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

response to hormone

positive regulation of myotube differentiation

positive regulation of protein processing

membrane

cell migration

hydrolase activity

extracellular matrix organization

positive regulation of cell growth

lung development

positive regulation of cell migration

collagen catabolic process

collagen catabolic process

extracellular matrix

cytoplasmic vesicle

zymogen activation

zymogen activation

zymogen activation

chondrocyte proliferation

macropinosome

intermediate filament cytoskeleton

positive regulation of B cell differentiation

negative regulation of Notch signaling pathway

metal ion binding

embryonic cranial skeleton morphogenesis

branching morphogenesis of an epithelial tube

tissue remodeling

negative regulation of focal adhesion assembly

head development

bone development

metalloaminopeptidase activity

craniofacial suture morphogenesis

regulation of protein localization to plasma membrane

positive regulation of macrophage migration

04912

1449366_at Mmp8 matrix metallopeptidase 8 9 7558428 NM_008611 102

endopeptidase activity

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular space

extracellular space

extracellular space

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

hydrolase activity

protein catabolic process

extracellular matrix organization

collagen catabolic process

collagen catabolic process

extracellular matrix

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

tumor necrosis factor binding

metal ion binding

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

positive regulation of neuroinflammatory response

positive regulation of neuroinflammatory response

positive regulation of tumor necrosis factor-mediated signaling pathway

positive regulation of microglial cell activation

 
1448291_at Mmp9 matrix metallopeptidase 9 2 164948218 NM_013599 1127

skeletal system development

skeletal system development

positive regulation of protein phosphorylation

fibronectin binding

positive regulation of leukocyte migration

endopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

serine-type endopeptidase activity

extracellular region

extracellular space

extracellular space

proteolysis

apoptotic process

response to oxidative stress

heart development

embryo implantation

peptidase activity

peptidase activity

metallopeptidase activity

zinc ion binding

response to xenobiotic stimulus

cell migration

hydrolase activity

protein catabolic process

extracellular matrix organization

extracellular matrix organization

extracellular matrix organization

collagen catabolic process

collagen catabolic process

collagen catabolic process

extracellular matrix

positive regulation of synaptic plasticity

protein-containing complex

cellular response to reactive oxygen species

identical protein binding

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of DNA binding

protein-containing complex binding

positive regulation of epidermal growth factor receptor signaling pathway

positive regulation of angiogenesis

metal ion binding

negative regulation of fibroblast proliferation

macrophage chemotaxis

tissue remodeling

positive regulation of keratinocyte migration

collagen-containing extracellular matrix

cellular response to cadmium ion

cellular response to cell-matrix adhesion

cellular response to UV-A

positive regulation of release of cytochrome c from mitochondria

positive regulation of receptor binding

response to amyloid-beta

positive regulation of vascular associated smooth muscle cell proliferation

negative regulation of epithelial cell differentiation involved in kidney development

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cation channel activity

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

04670

05200

05219

1448788_at Cd200 CD200 molecule 16 -45382134 AF004023 116

protein binding

plasma membrane

negative regulation of cell population proliferation

cell surface

cell surface

cell surface

membrane

axon

axon

negative regulation of NF-kappaB transcription factor activity

negative regulation of interleukin-6 production

positive regulation of CREB transcription factor activity

heterotypic cell-cell adhesion

heterotypic cell-cell adhesion

neuron projection

neuronal cell body

neuronal cell body

negative regulation of macrophage activation

cell body

regulation of immune response

positive regulation of transforming growth factor beta production

protein binding involved in heterotypic cell-cell adhesion

cell-cell adhesion

cell-cell adhesion mediator activity

cell-cell adhesion mediator activity

positive regulation of arginase activity

positive regulation of protein-glutamine gamma-glutamyltransferase activity

regulation of neuroinflammatory response

negative regulation of neuroinflammatory response

negative regulation of neuroinflammatory response

negative regulation of neuroinflammatory response

negative regulation of matrix metallopeptidase secretion

negative regulation of macrophage migration

negative regulation of T cell migration

 
1416915_at Msh6 mutS homolog 6 17 87975049 U42190 81

nucleotide binding

magnesium ion binding

four-way junction DNA binding

chromatin

DNA binding

DNA binding

chromatin binding

damaged DNA binding

damaged DNA binding

double-stranded DNA binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

Golgi apparatus

cytosol

DNA repair

mismatch repair

mismatch repair

mismatch repair

mismatch repair

DNA damage response

ATP-dependent activity, acting on DNA

determination of adult lifespan

intrinsic apoptotic signaling pathway in response to DNA damage

response to UV

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments

enzyme binding

mismatched DNA binding

mismatched DNA binding

guanine/thymine mispair binding

guanine/thymine mispair binding

single guanine insertion binding

single thymine insertion binding

MutSalpha complex

MutSalpha complex

MutSalpha complex

oxidized purine DNA binding

MutLalpha complex binding

methylated histone binding

intracellular membrane-bounded organelle

ADP binding

isotype switching

isotype switching

negative regulation of DNA recombination

negative regulation of DNA recombination

positive regulation of helicase activity

intrinsic apoptotic signaling pathway

ATP-dependent DNA damage sensor activity

03430

05200

05210

1422557_s_at Mt1 metallothionein 1 8 94179088 NM_013602 343

copper ion binding

nucleus

nucleus

cytoplasm

cytoplasm

lysosome

cytosol

cytosol

intracellular zinc ion homeostasis

intracellular zinc ion homeostasis

nitric oxide mediated signal transduction

zinc ion binding

zinc ion binding

detoxification of copper ion

detoxification of copper ion

intracellular monoatomic cation homeostasis

negative regulation of neuron apoptotic process

metal ion binding

metal ion binding

cellular response to chromate

cellular response to cadmium ion

cellular response to copper ion

cellular response to zinc ion

cellular response to zinc ion

 
1428942_at Mt2 metallothionein 2 8 94172617 AA796766 223

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

intracellular zinc ion homeostasis

intracellular zinc ion homeostasis

nitric oxide mediated signal transduction

zinc ion binding

zinc ion binding

response to bacterium

detoxification of copper ion

detoxification of copper ion

cadmium ion binding

metal ion binding

metal ion binding

cellular response to cadmium ion

cellular response to copper ion

cellular response to zinc ion

 
1419254_at Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase 6 -83305703 BG076333 45

magnesium ion binding

catalytic activity

methenyltetrahydrofolate cyclohydrolase activity

methenyltetrahydrofolate cyclohydrolase activity

methenyltetrahydrofolate cyclohydrolase activity

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NAD+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

methylenetetrahydrofolate dehydrogenase (NADP+) activity

mitochondrion

mitochondrion

mitochondrion

one-carbon metabolic process

metabolic process

oxidoreductase activity

hydrolase activity

tetrahydrofolate interconversion

phosphate ion binding

tetrahydrofolate metabolic process

00670

01100

1451905_a_at Mx1 MX dynamin-like GTPase 1 16 -97447036, -97447034 M21039 124

GTPase activity

protein binding

GTP binding

GTP binding

nucleus

nucleus

nuclear pore

cytoplasm

cytosol

response to virus

nuclear membrane

identical protein binding

innate immune response

perinuclear region of cytoplasm

 
1450194_a_at Myb myeloblastosis oncogene 10 -21124929 NM_033597 343

G1/S transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

mitotic cell cycle

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

in utero embryonic development

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

cytosol

cytosol

regulation of DNA-templated transcription

regulation of DNA-templated transcription

calcium ion transport

regulation of gene expression

stem cell division

myeloid cell differentiation

B cell differentiation

erythrocyte differentiation

positive regulation of collagen biosynthetic process

positive regulation of neuron apoptotic process

T-helper 2 cell differentiation

negative regulation of megakaryocyte differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

spleen development

thymus development

embryonic digestive tract development

positive regulation of smooth muscle cell proliferation

homeostasis of number of cells

positive regulation of glial cell proliferation

myeloid cell development

cellular response to interleukin-6

positive regulation of transforming growth factor beta production

WD40-repeat domain binding

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

negative regulation of hematopoietic progenitor cell differentiation

positive regulation of miRNA transcription

positive regulation of hepatic stellate cell proliferation

cellular response to leukemia inhibitory factor

positive regulation of hepatic stellate cell activation

positive regulation of testosterone secretion

 
1419272_at Myd88 myeloid differentiation primary response gene 88 9 -119335933 BC005591 2408

response to molecule of fungal origin

leukocyte activation involved in inflammatory response

neutrophil activation involved in immune response

immune system process

MyD88-dependent toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

signaling receptor binding

Toll binding

interleukin-1 receptor binding

interleukin-1 receptor binding

protein binding

nucleus

cytoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

plasma membrane

chromatin organization

phagocytosis

phagocytosis

apoptotic process

inflammatory response

immune response

signal transduction

cell surface receptor signaling pathway

transmembrane receptor protein serine/threonine kinase signaling pathway

JNK cascade

JNK cascade

Toll signaling pathway

Toll signaling pathway

response to virus

induced systemic resistance

cell surface

gene expression

regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

macrophage cytokine production

macrophage cytokine production

microglia differentiation

immunoglobulin mediated immune response

cytokine-mediated signaling pathway

extrinsic component of plasma membrane

neurogenesis

extrinsic component of cytoplasmic side of plasma membrane

lipopolysaccharide-mediated signaling pathway

positive regulation of type I interferon production

response to peptidoglycan

response to lipopolysaccharide

response to lipopolysaccharide

chemokine production

type I interferon production

interleukin-6 production

tumor necrosis factor production

tumor necrosis factor production

regulation of interleukin-6 production

regulation of tumor necrosis factor production

positive regulation of chemokine production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-17 production

positive regulation of interleukin-23 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

protein-containing complex

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

toll-like receptor 8 signaling pathway

Toll-like receptor binding

Toll-like receptor binding

signaling adaptor activity

signaling adaptor activity

interleukin-33-mediated signaling pathway

regulation of cell population proliferation

defense response to bacterium

identical protein binding

defense response to protozoan

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

skin development

protein self-association

innate immune response

innate immune response

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

positive regulation of smooth muscle cell proliferation

positive regulation of lymphocyte proliferation

regulation of inflammatory response

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

defense response to virus

molecular adaptor activity

type I interferon-mediated signaling pathway

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

interleukin-1-mediated signaling pathway

interleukin-1-mediated signaling pathway

response to interleukin-1

3'-UTR-mediated mRNA stabilization

neutrophil-mediated killing of bacterium

TIR domain binding

cellular response to lipopolysaccharide

cellular response to organic substance

establishment of endothelial intestinal barrier

cellular response to oxidised low-density lipoprotein particle stimulus

ATP-dependent histone chaperone activity

positive regulation of cytokine production involved in inflammatory response

positive regulation of cytokine production involved in inflammatory response

positive regulation of NLRP3 inflammasome complex assembly

regulation of neutrophil migration

regulation of chemokine (C-X-C motif) ligand 1 production

regulation of chemokine (C-X-C motif) ligand 2 production

04210

04620

05140

05142

05143

05144

05145

1422580_at Myl4 myosin, light polypeptide 4 11 104577280, 104550662, 104576984 NM_010858 93

regulation of the force of heart contraction

actin monomer binding

actin monomer binding

calcium ion binding

myosin complex

myosin II complex

A band

A band

positive regulation of ATP-dependent activity

actin filament binding

cardiac muscle contraction

cardiac muscle contraction

 
1449550_at Myo1c myosin IC 11 75656014, 75651508, 75652149, 75650518 NM_008659 86

microfilament motor activity

microfilament motor activity

microfilament motor activity

nucleotide binding

cytoskeletal motor activity

actin binding

signaling receptor binding

protein binding

calmodulin binding

calmodulin binding

ATP binding

phospholipid binding

nucleus

nucleolus

cytoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

plasma membrane

microvillus

microvillus

brush border

chromatin remodeling

protein targeting to membrane

endocytosis

actin filament organization

basal plasma membrane

actin cytoskeleton

membrane

membrane

lateral plasma membrane

myosin complex

nuclear body

actin filament-based movement

vesicle transport along actin filament

positive regulation of cell migration

cytoplasmic vesicle membrane

positive regulation of actin filament polymerization

small GTPase binding

cytoplasmic vesicle

filamentous actin

stereocilium

stereocilium bundle

ruffle membrane

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

cell projection

membrane raft

phagocytic vesicle

positive regulation of transcription by RNA polymerase I

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase III

actin filament binding

actin filament binding

cellular response to type II interferon

positive regulation of protein targeting to membrane

positive regulation of protein targeting to membrane

positive regulation of protein targeting to membrane

B-WICH complex

positive regulation of cellular response to insulin stimulus

positive regulation of cellular response to insulin stimulus

positive regulation of cellular response to insulin stimulus

positive regulation of vascular endothelial growth factor signaling pathway

regulation of bicellular tight junction assembly

 
1460273_a_at Naip2 NLR family, apoptosis inhibitory protein 2 13 -100144062 NM_010872 26

nucleotide binding

immune system process

protein binding

ATP binding

ATP binding

apoptotic process

inflammatory response

inflammatory response

negative regulation of tumor necrosis factor-mediated signaling pathway

detection of bacterium

detection of bacterium

defense response to bacterium

defense response to bacterium

regulation of apoptotic process

neuronal cell body

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

perikaryon

innate immune response

positive regulation of JNK cascade

metal ion binding

pyroptosis

pyroptosis

cellular response to estrogen stimulus

IPAF inflammasome complex

IPAF inflammasome complex

protein serine/threonine kinase binding

04621

1425609_at Ncf1 neutrophil cytosolic factor 1 5 -134220258, -134220052 BE370703 363

response to yeast

leukocyte mediated cytotoxicity

respiratory burst involved in defense response

protein binding

cytoplasm

cytoplasm

cytosol

cytosol

plasma membrane

leukotriene metabolic process

NADP catabolic process

smooth muscle contraction

inflammatory response

cellular defense response

lipid binding

response to bacterium

cytoplasmic side of plasma membrane

membrane

membrane

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NADPH oxidase activator activity

superoxide-generating NADPH oxidase activator activity

superoxide-generating NADPH oxidase activator activity

superoxide-generating NADPH oxidase activator activity

SH3 domain binding

dendrite

phosphatidylinositol binding

superoxide anion generation

superoxide anion generation

defense response to bacterium

NADPH oxidase complex

NADPH oxidase complex

neuronal cell body

phosphatidylinositol-3,4-bisphosphate binding

respiratory burst

respiratory burst

respiratory burst

negative regulation of smooth muscle contraction

hydrogen peroxide biosynthetic process

epithelial cell proliferation

defense response to Gram-positive bacterium

defense response to fungus

regulation of respiratory burst involved in inflammatory response

neutrophil-mediated killing of gram-positive bacterium

neutrophil-mediated killing of fungus

reactive oxygen species biosynthetic process

04062

04145

04380

04666

04670

05140

1418465_at Ncf4 neutrophil cytosolic factor 4 15 78244810 NM_008677 42

protein binding

cytoplasm

cytoplasm

endosome

cytosol

phagocytosis

lipid binding

endosome membrane

membrane

superoxide-generating NADPH oxidase activator activity

superoxide-generating NADPH oxidase activator activity

phosphatidylinositol-3-phosphate binding

phosphatidylinositol binding

superoxide anion generation

superoxide anion generation

NADPH oxidase complex

NADPH oxidase complex

respiratory burst

04145

04380

04670

05140

1428479_at Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 18 -80606204, -80647434, -80647434, -80606204 BB356861 536

G1/S transition of mitotic cell cycle

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription coactivator binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

cytokine production

epithelial to mesenchymal transition

lymphangiogenesis

B-1a B cell differentiation

heart valve development

aortic valve development

pulmonary valve development

heart valve morphogenesis

aortic valve morphogenesis

pulmonary valve morphogenesis

endocardial cushion development

nucleic acid binding

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

transcription by RNA polymerase II

transcription by RNA polymerase II

calcium ion transport

heart development

transcription factor binding

gene expression

positive regulation of gene expression

negative regulation of keratinocyte proliferation

transition between fast and slow fiber

sarcoplasm

nuclear body

osteoclast differentiation

calcineurin-NFAT signaling cascade

calcineurin-NFAT signaling cascade

calcineurin-NFAT signaling cascade

intracellular signal transduction

wound healing

regulation of hair cycle

sequence-specific DNA binding

keratinocyte proliferation

cell quiescence

negative regulation of osteoblast differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

mitogen-activated protein kinase p38 binding

perinuclear region of cytoplasm

ventricular septum morphogenesis

branching involved in lymph vessel morphogenesis

heart trabecula morphogenesis

RNA polymerase II-specific DNA-binding transcription factor binding

cellular response to calcium ion

stem cell proliferation

DNA-binding transcription factor binding

negative regulation of vascular associated smooth muscle cell differentiation

semi-lunar valve development

sequence-specific double-stranded DNA binding

positive regulation of DNA biosynthetic process

negative regulation of stem cell proliferation

04310

04360

04370

04380

04650

04660

04662

1434836_at Nfatc2ip nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein 7 -126382853 AV277440 29

cytokine production

cytokine production

protein binding

nucleus

cytoplasm

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

 
1419976_s_at Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 8 106059589, 106058817 C79787 160

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

branching involved in blood vessel morphogenesis

response to hypoxia

cytokine production

blood vessel remodeling

DNA binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

cytosol

cytosol

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

multicellular organism development

heart development

transcription factor binding

transcription factor binding

cardiac muscle hypertrophy in response to stress

myotube differentiation

myotube cell development

T cell differentiation

calcineurin-NFAT signaling cascade

calcineurin-NFAT signaling cascade

vascular associated smooth muscle cell differentiation

sequence-specific DNA binding

positive thymic T cell selection

cellular respiration

positive regulation of nitric oxide biosynthetic process

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

thymus development

skeletal muscle fiber development

cellular response to calcium ion

cellular response to lithium ion

vascular associated smooth muscle cell development

negative regulation of miRNA transcription

DN4 thymocyte differentiation

negative regulation of vascular associated smooth muscle cell differentiation

positive regulation of artery morphogenesis

sequence-specific double-stranded DNA binding

regulation of store-operated calcium entry

04310

04360

04370

04650

04660

04662

1416543_at Nfe2l2 nuclear factor, erythroid derived 2, like 2 2 -75675512, -75691051 NM_010902 1716

chromatin

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription coregulator binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

centrosome

cytosol

cytosol

cytosol

plasma membrane

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

inflammatory response

response to oxidative stress

transcription factor binding

response to organic substance

proteasomal ubiquitin-independent protein catabolic process

positive regulation of gene expression

positive regulation of gene expression

negative regulation of cardiac muscle cell apoptotic process

positive regulation of neuron projection development

protein ubiquitination

protein domain specific binding

positive regulation of blood coagulation

endoplasmic reticulum unfolded protein response

ubiquitin protein ligase binding

protein-DNA complex

cellular response to oxidative stress

cellular response to oxidative stress

cellular response to oxidative stress

response to endoplasmic reticulum stress

PERK-mediated unfolded protein response

cellular response to glucose starvation

proteasome-mediated ubiquitin-dependent protein catabolic process

positive regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

sequence-specific DNA binding

regulation of innate immune response

cell redox homeostasis

cell redox homeostasis

positive regulation of angiogenesis

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of embryonic development

aflatoxin catabolic process

positive regulation of glucose import

RNA polymerase II-specific DNA-binding transcription factor binding

cellular response to hydrogen peroxide

cellular response to copper ion

cellular response to tumor necrosis factor

cellular response to hypoxia

cellular response to xenobiotic stimulus

cellular response to fluid shear stress

cellular response to laminar fluid shear stress

RNA polymerase II transcription regulator complex

negative regulation of cellular response to hypoxia

regulation of cellular response to oxidative stress

negative regulation of hematopoietic stem cell differentiation

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of glutathione biosynthetic process

cellular response to angiotensin

negative regulation of vascular associated smooth muscle cell migration

regulation of removal of superoxide radicals

negative regulation of endothelial cell apoptotic process

positive regulation of reactive oxygen species metabolic process

04141

1418932_at Nfil3 nuclear factor, interleukin 3, regulated 13 -52967208 AY061760 130

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

natural killer cell differentiation

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

DNA-templated transcription

regulation of DNA-templated transcription

regulation of DNA-templated transcription

transcription by RNA polymerase II

immune response

circadian rhythm

circadian rhythm

positive regulation of gene expression

positive regulation of gene expression

identical protein binding

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

rhythmic process

cellular response to interleukin-4

RNA polymerase II transcription regulator complex

 
1418722_at Ngp neutrophilic granule protein 9 110419807 NM_008694 22

cysteine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular region

extracellular space

extracellular space

defense response

negative regulation of peptidase activity

negative regulation of angiogenesis

peptidase inhibitor activity

cytoplasmic vesicle

negative regulation of lymphangiogenesis

 
1448465_at Nipsnap1 nipsnap homolog 1 11 4873950 BC010837 31

protein binding

protein binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

membrane

sensory perception of pain

sensory perception of pain

synaptic membrane

 
1456573_x_at Nnt nicotinamide nucleotide transhydrogenase 13 -119335526, -119334316 BB205930 75

negative regulation of protein phosphorylation

mitochondrion

mitochondrion

mitochondrial inner membrane

NADPH regeneration

NADPH regeneration

NAD(P)+ transhydrogenase activity

NAD(P)+ transhydrogenase activity

positive regulation of mitochondrial membrane potential

membrane

oxidoreductase activity

intracellular oxygen homeostasis

negative regulation of apoptotic process

cell redox homeostasis

NADP binding

NADP binding

reactive oxygen species metabolic process

cellular oxidant detoxification

proton transmembrane transport

positive regulation of hydrogen peroxide catabolic process

00760

01100

1426851_a_at Ccn3 cellular communication network factor 3 15 54745909 X96585 75

angiogenesis

chondrocyte differentiation

chondrocyte differentiation

Notch binding

integrin binding

integrin binding

extracellular region

extracellular space

extracellular space

cytoplasm

gap junction

cell adhesion

signal transduction

signal transduction

growth factor activity

heparin binding

regulation of gene expression

fibroblast migration

negative regulation of myotube differentiation

smooth muscle cell migration

negative regulation of cell growth

axon

dendrite

extracellular matrix

cell adhesion mediated by integrin

endothelial cell chemotaxis

neuronal cell body

intracellular membrane-bounded organelle

type B pancreatic cell proliferation

positive regulation of cell differentiation

positive regulation of Notch signaling pathway

negative regulation of insulin secretion

smooth muscle cell proliferation

smooth muscle cell proliferation

negative regulation of inflammatory response

cell chemotaxis

negative regulation of SMAD protein signal transduction

hematopoietic stem cell homeostasis

collagen-containing extracellular matrix

anchoring junction

endothelial cell-cell adhesion

negative regulation of monocyte chemotaxis

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of chondrocyte proliferation

negative regulation of sensory perception of pain

bone regeneration

 
1415839_a_at Npm1 nucleophosmin 1 11 -33152497, -33154924 NM_008722 183

ribosomal subunit export from nucleus

ribosomal large subunit export from nucleus

ribosomal large subunit export from nucleus

ribosomal small subunit export from nucleus

ribosomal small subunit export from nucleus

cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

core promoter sequence-specific DNA binding

regulation of cell growth

granular component

p53 binding

nucleic acid binding

DNA binding

chromatin binding

transcription coactivator activity

RNA binding

RNA binding

RNA binding

protein kinase inhibitor activity

protein binding

ATP binding

phosphatidylinositol-3,4,5-trisphosphate binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

nucleolus

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

centrosome

centrosome

centrosome

cytosol

cytoskeleton

DNA repair

nucleosome assembly

chromatin remodeling

cell volume homeostasis

cell volume homeostasis

nucleocytoplasmic transport

nucleocytoplasmic transport

centrosome cycle

protein localization

protein localization

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

rRNA transcription

post-transcriptional regulation of gene expression

negative regulation of gene expression

negative regulation of cardiac muscle cell apoptotic process

regulation of centrosome duplication

regulation of centrosome duplication

positive regulation of centrosome duplication

negative regulation of centrosome duplication

large ribosomal subunit

small ribosomal subunit

nuclear matrix

nuclear speck

rRNA binding

rRNA binding

enzyme binding

protein kinase binding

Tat protein binding

positive regulation of cellular biosynthetic process

positive regulation of cellular biosynthetic process

positive regulation of protein ubiquitination

spindle pole centrosome

regulation of protein stability

protein destabilization

regulation of endodeoxyribonuclease activity

protein-containing complex

protein-DNA complex

cellular response to UV

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

ribosomal small subunit biogenesis

histone binding

histone binding

identical protein binding

identical protein binding

protein homodimerization activity

ribosomal large subunit binding

ribosomal small subunit binding

negative regulation of apoptotic process

negative regulation of apoptotic process

protein kinase B binding

regulation of DNA damage response, signal transduction by p53 class mediator

regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of protein kinase activity by regulation of protein phosphorylation

positive regulation of translation

positive regulation of DNA replication

positive regulation of protein kinase activity

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of centriole replication

negative regulation of mRNA splicing, via spliceosome

negative regulation of epithelial cell proliferation

protein stabilization

protein stabilization

positive regulation of DNA metabolic process

NF-kappaB binding

unfolded protein binding

positive regulation of NF-kappaB transcription factor activity

regulation of cell cycle

regulation of endoribonuclease activity

regulation of eIF2 alpha phosphorylation by dsRNA

cellular senescence

DNA-binding transcription factor binding

molecular condensate scaffold activity

regulation of mRNA stability involved in cellular response to UV

positive regulation of cell cycle G2/M phase transition

positive regulation of protein localization to nucleolus

positive regulation of protein localization to nucleolus

ribonucleoprotein complex

ribonucleoprotein complex

 
1420361_at Slc11a1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 1 74375202 NM_013612 249

negative regulation of cytokine production

positive regulation of cytokine production

T cell proliferation involved in immune response

T cell cytokine production

positive regulation of dendritic cell antigen processing and presentation

positive regulation of T-helper 1 type immune response

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

iron ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

manganese ion transmembrane transporter activity

lysosome

lysosomal membrane

lysosomal membrane

endosome

late endosome

late endosome

plasma membrane

plasma membrane

monoatomic ion transport

iron ion transport

iron ion transport

manganese ion transport

manganese ion transport

manganese ion transport

manganese ion transport

intracellular iron ion homeostasis

intracellular iron ion homeostasis

phagocytosis

inflammatory response

vacuolar acidification

response to bacterium

response to bacterium

endosome membrane

endosome membrane

positive regulation of gene expression

cadmium ion transmembrane transporter activity

nitrite transport

membrane

metal ion transport

phagocytic vesicle membrane

phagocytic vesicle membrane

phagocytic vesicle membrane

phagocytic vesicle membrane

late endosome membrane

activation of protein kinase activity

response to lipopolysaccharide

response to lipopolysaccharide

response to lipopolysaccharide

type II interferon production

interleukin-2 production

interleukin-3 production

positive regulation of type II interferon production

response to type II interferon

iron ion transmembrane transport

wound healing

macrophage activation

macrophage activation

defense response to bacterium

protein homodimerization activity

defense response to protozoan

MHC class II biosynthetic process

respiratory burst

positive regulation of transcription by RNA polymerase II

metal ion transmembrane transporter activity

transition metal ion transmembrane transporter activity

antigen processing and presentation of peptide antigen

mRNA stabilization

positive regulation of phagocytosis

defense response to Gram-negative bacterium

metal cation:proton antiporter activity

metal cation:proton antiporter activity

metal cation:proton antiporter activity

establishment of localization in cell

multicellular organismal-level iron ion homeostasis

cadmium ion transmembrane transport

tertiary granule membrane

cellular detoxification of cadmium ion

L-arginine transmembrane transport

04142

1435088_at Nsd1 nuclear receptor-binding SET-domain protein 1 13 55209781 BM945177 58

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

gastrulation with mouth forming second

chromatin binding

transcription coregulator activity

transcription coregulator activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

chromosome

chromatin organization

regulation of DNA-templated transcription

regulation of DNA-templated transcription

multicellular organism development

methyltransferase activity

zinc ion binding

transferase activity

nuclear estrogen receptor binding

methylation

regulation of peptidyl-serine phosphorylation

histone methyltransferase complex

histone methyltransferase activity

histone H4K20 methyltransferase activity

nuclear retinoic acid receptor binding

positive regulation of DNA-templated transcription

metal ion binding

nuclear retinoid X receptor binding

nuclear thyroid hormone receptor binding

histone H3K36 methyltransferase activity

histone H3K36 methyltransferase activity

histone H3K36 methyltransferase activity

nuclear androgen receptor binding

histone H3K36 dimethyltransferase activity

regulation of RNA polymerase II regulatory region sequence-specific DNA binding

00310

1416107_at Nsg2 neuron specific gene family member 2 11 32001276, 32000699, 32000418, 32000418 NM_008741 25

lysosome

endosome

endosome

early endosome

late endosome

Golgi apparatus

dopamine receptor signaling pathway

membrane

endosomal transport

dendrite

cytoplasmic vesicle membrane

cytoplasmic vesicle

clathrin light chain binding

clathrin light chain binding

multivesicular body membrane

trans-Golgi network membrane

cell projection

lysosomal lumen

clathrin coat assembly

clathrin coat assembly

Golgi cis cisterna membrane

 
1451054_at Orm1 orosomucoid 1 4 63344555 BE628912 62

regulation of immune system process

extracellular region

extracellular space

extracellular space

acute-phase response

small molecule binding

 
1420967_at Slc25a15 solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 8 -22375549, -22375549 AW541300 20

L-ornithine transmembrane transporter activity

L-ornithine transmembrane transporter activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

L-lysine transmembrane transporter activity

antiporter activity

membrane

L-arginine transmembrane transporter activity

L-lysine transmembrane transport

L-arginine transmembrane transport

mitochondrial L-ornithine transmembrane transport

 
1421456_at P2ry1 purinergic receptor P2Y, G-protein coupled 1 3 61002784 NM_008772 124

nucleotide binding

G protein-coupled ADP receptor activity

G protein-coupled ADP receptor activity

positive regulation of protein phosphorylation

G protein-coupled adenosine receptor signaling pathway

G protein-coupled receptor activity

ATP binding

ATP binding

plasma membrane

plasma membrane

plasma membrane

cilium

monoatomic ion transport

monoatomic ion transport

signal transduction

G protein-coupled receptor signaling pathway

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

glial cell migration

regulation of cell shape

response to mechanical stimulus

negative regulation of norepinephrine secretion

postsynaptic density

membrane

basolateral plasma membrane

apical plasma membrane

signal transduction involved in regulation of gene expression

platelet activation

dendrite

A1 adenosine receptor binding

A1 adenosine receptor binding

positive regulation of inositol trisphosphate biosynthetic process

G protein-coupled purinergic nucleotide receptor signaling pathway

eating behavior

positive regulation of monoatomic ion transport

positive regulation of monoatomic ion transport

ADP binding

cell body

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled ATP receptor activity

G protein-coupled ATP receptor activity

postsynaptic membrane

positive regulation of transcription by RNA polymerase II

positive regulation of hormone secretion

protein heterodimerization activity

presynaptic active zone membrane

establishment of localization in cell

establishment of localization in cell

positive regulation of penile erection

positive regulation of ERK1 and ERK2 cascade

cellular response to organic cyclic compound

cellular response to purine-containing compound

protein localization to plasma membrane

relaxation of muscle

scaffold protein binding

blood vessel diameter maintenance

glutamatergic synapse

regulation of presynaptic cytosolic calcium ion concentration

regulation of synaptic vesicle exocytosis

04080

1416410_at Pafah1b3 platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 7 -25295048, -25295048 NM_008776 37

1-alkyl-2-acetylglycerophosphocholine esterase activity

protein binding

cytoplasm

cytoplasm

lipid metabolic process

spermatogenesis

spermatogenesis

1-alkyl-2-acetylglycerophosphocholine esterase complex

lipid catabolic process

hydrolase activity

identical protein binding

protein homodimerization activity

protein-containing complex binding

protein heterodimerization activity

platelet-activating factor acetyltransferase activity

platelet-activating factor acetyltransferase activity

00565

01100

1454638_a_at Pah phenylalanine hydroxylase 10 87521794 AW106920 125

catalytic activity

monooxygenase activity

phenylalanine 4-monooxygenase activity

phenylalanine 4-monooxygenase activity

phenylalanine 4-monooxygenase activity

iron ion binding

L-phenylalanine metabolic process

L-phenylalanine catabolic process

tyrosine biosynthetic process

tyrosine biosynthetic process

metabolic process

aromatic amino acid metabolic process

oxidoreductase activity

amino acid binding

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

tyrosine biosynthetic process, by oxidation of phenylalanine

tyrosine biosynthetic process, by oxidation of phenylalanine

identical protein binding

metal ion binding

00360

00400

01100

1420979_at Pak1 p21 (RAC1) activated kinase 1 7 97842938, 97788540 BF456404 224

nucleotide binding

response to hypoxia

ruffle

positive regulation of protein phosphorylation

catalytic activity

protein kinase activity

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

collagen binding

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

cytoplasm

cytoplasm

cytosol

cytoskeleton

actin filament

plasma membrane

cell-cell junction

focal adhesion

chromatin remodeling

protein phosphorylation

protein phosphorylation

exocytosis

apoptotic process

DNA damage response

neuromuscular junction development

metabolic process

positive regulation of cell population proliferation

response to organic substance

regulation of gene expression

positive regulation of fibroblast migration

postsynaptic density

postsynaptic density

intercalated disc

membrane

kinase activity

phosphorylation

dendrite development

cell migration

transferase activity

transmission of nerve impulse

protein kinase binding

amygdala development

establishment of cell polarity

Z disc

lamellipodium

actin cytoskeleton organization

positive regulation of cell migration

axon

axon

dendrite

dendrite

growth cone

positive regulation of microtubule polymerization

small GTPase binding

nuclear membrane

cellular response to insulin stimulus

regulation of actin cytoskeleton organization

regulation of actin cytoskeleton organization

protein-containing complex

positive regulation of peptidyl-serine phosphorylation

positive regulation of intracellular estrogen receptor signaling pathway

intracellular signal transduction

wound healing

identical protein binding

cell projection

gamma-tubulin binding

receptor clustering

regulation of MAPK cascade

regulation of MAPK cascade

positive regulation of JUN kinase activity

positive regulation of axon extension

positive regulation of insulin receptor signaling pathway

protein autophosphorylation

hepatocyte growth factor receptor signaling pathway

branching morphogenesis of an epithelial tube

neuron projection morphogenesis

regulation of axonogenesis

localization

positive regulation of stress fiber assembly

negative regulation of cell proliferation involved in contact inhibition

dendritic spine development

negative regulation of cell growth involved in cardiac muscle cell development

gamma-aminobutyric acid secretion, neurotransmission

glutamate secretion, neurotransmission

anchoring junction

cellular response to organic cyclic compound

positive regulation of microtubule nucleation

positive regulation of protein targeting to membrane

observational learning

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

GABA-ergic synapse

GABA-ergic synapse

GABA-ergic synapse

regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

regulation of long-term synaptic potentiation

protein localization to cytoplasmic stress granule

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of vascular associated smooth muscle cell migration

04010

04012

04062

04360

04510

04650

04660

04666

04810

05211

1458978_at Pax5 paired box 5 4 -44524750 BG144033 229

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

transcription regulator complex

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

multicellular organism development

spermatogenesis

nervous system development

animal organ morphogenesis

lateral ventricle development

cerebral cortex development

cell differentiation

adult behavior

skeletal muscle cell differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

embryonic cranial skeleton morphogenesis

anatomical structure development

dopaminergic neuron differentiation

 
1418840_at Pdcd4 programmed cell death 4 19 53903350, 53892230 NM_011050 101

RNA binding

protein binding

nucleus

nucleus

cytoplasm

cytosol

cytosol

apoptotic process

BMP signaling pathway

positive regulation of smooth muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of DNA-templated transcription

positive regulation of inflammatory response

regulation of protein metabolic process

epithelial to mesenchymal transition involved in cardiac fibroblast development

cellular response to lipopolysaccharide

negative regulation of cytokine production involved in inflammatory response

positive regulation of non-canonical NF-kappaB signal transduction

negative regulation of vascular associated smooth muscle cell proliferation

negative regulation of myofibroblast differentiation

negative regulation of vascular associated smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell apoptotic process

positive regulation of endothelial cell apoptotic process

 
1422474_at Pde4b phosphodiesterase 4B, cAMP specific 4 102589842, 102254938, 102254741, 102570059, 102587557, 102421554 BM246564 79

gamma-tubulin complex

neutrophil homeostasis

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

calcium channel regulator activity

protein binding

nucleus

centrosome

cytosol

cytosol

voltage-gated calcium channel complex

synaptic vesicle

postsynaptic density

membrane

cAMP-mediated signaling

Z disc

cAMP binding

neutrophil chemotaxis

positive regulation of type II interferon production

positive regulation of interleukin-2 production

gamma-tubulin binding

dendritic spine

transmembrane transporter binding

transmembrane transporter binding

3',5'-cyclic-GMP phosphodiesterase activity

perinuclear region of cytoplasm

perinuclear region of cytoplasm

T cell receptor signaling pathway

leukocyte migration

excitatory synapse

cellular response to lipopolysaccharide

cellular response to xenobiotic stimulus

cellular response to epinephrine stimulus

negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

cell periphery

regulation of cardiac muscle cell contraction

negative regulation of relaxation of cardiac muscle

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

00230

1458218_s_at Pde7a phosphodiesterase 7A 3 -19223108, -19223108 AU015378 30

cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-nucleotide phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

3',5'-cyclic-AMP phosphodiesterase activity

nucleus

cytoplasm

cytosol

signal transduction

phosphoric diester hydrolase activity

hydrolase activity

cAMP-mediated signaling

cAMP-mediated signaling

cAMP-mediated signaling

metal ion binding

3',5'-cyclic-GMP phosphodiesterase activity

perinuclear region of cytoplasm

00230

1422760_at Padi4 peptidyl arginine deiminase, type IV 4 -140745507 NM_011061 120

immune system process

protein-arginine deiminase activity

protein-arginine deiminase activity

protein-arginine deiminase activity

calcium ion binding

nucleus

nucleus

cytoplasm

cytoplasm

chromatin organization

nucleosome assembly

chromatin remodeling

chromatin remodeling

hydrolase activity

stem cell population maintenance

protein-containing complex

identical protein binding

post-translational protein modification

innate immune response

metal ion binding

histone arginine deiminase activity

histone arginine deiminase activity

histone H3R2 arginine deiminase activity

histone H3R8 arginine deiminase activity

histone H3R17 arginine deiminase activity

histone H3R26 arginine deiminase activity

 
1419276_at Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 10 -24637913 AF339910 147

cell morphogenesis

cell morphogenesis

ossification

vasculogenesis

osteoblast differentiation

osteoblast differentiation

kidney development

B-1 B cell homeostasis

endochondral ossification

morphogenesis of an epithelium

response to dietary excess

leukocyte activation involved in inflammatory response

plasma cell differentiation

immunoglobulin production involved in immunoglobulin-mediated immune response

inflammatory response to antigenic stimulus

nucleic acid binding

exonuclease activity

phosphodiesterase I activity

phosphodiesterase I activity

phosphodiesterase I activity

phosphodiesterase I activity

dinucleotide phosphatase activity

dinucleotide phosphatase activity

dinucleotide phosphatase activity

scavenger receptor activity

insulin receptor binding

calcium ion binding

ATP binding

extracellular region

extracellular region

extracellular space

extracellular space

extracellular space

plasma membrane

plasma membrane

generation of precursor metabolites and energy

glycolytic process

fatty acid metabolic process

phosphate-containing compound metabolic process

nitrogen compound metabolic process

immune response

mitochondrion organization

smoothened signaling pathway

heart development

sensory perception of sound

adult walking behavior

phosphoric diester hydrolase activity

zinc ion binding

cell population proliferation

cell population proliferation

determination of adult lifespan

adult locomotory behavior

fibroblast growth factor receptor signaling pathway

nucleoside triphosphate catabolic process

nucleoside triphosphate catabolic process

response to wounding

cell surface

cell surface

cell surface

response to inorganic substance

gene expression

gene expression

gene expression

gene expression

coenzyme A diphosphatase activity

magnesium ion homeostasis

microglia differentiation

coenzyme A catabolic process

coenzyme A catabolic process

membrane

Wnt signaling pathway

pyrophosphatase activity

hydrolase activity

phosphatase activity

phosphatase activity

phosphatase activity

organic phosphonate metabolic process

cellular homeostasis

cellular homeostasis

spinal cord development

central nervous system myelination

T cell differentiation

macrophage differentiation

polysaccharide binding

negative regulation of ossification

bone mineralization

bone mineralization

bone mineralization

bone mineralization

negative regulation of cell growth

osteoclast differentiation

melanocyte differentiation

regulation of bone mineralization

negative regulation of bone mineralization

inorganic diphosphate transport

inorganic diphosphate transport

inorganic diphosphate transport

inorganic diphosphate transport

inorganic diphosphate transport

intracellular phosphate ion homeostasis

sequestering of triglyceride

axon regeneration

biomineral tissue development

negative regulation of protein autophosphorylation

response to magnesium ion

response to magnesium ion

type II interferon production

response to insulin

cellular response to insulin stimulus

response to ATP

tooth mineralization

response to vitamin B6

post-embryonic forelimb morphogenesis

multicellular organism growth

bone mineralization involved in bone maturation

aorta development

ligamentous ossification

response to platelet-derived growth factor

collagen-activated signaling pathway

hormone metabolic process

middle ear morphogenesis

odontogenesis

glucose homeostasis

mRNA transcription by RNA polymerase II

identical protein binding

protein homodimerization activity

protein homodimerization activity

defense response to protozoan

cell projection

neuronal cell body

skin development

cell body

fat cell differentiation

bone resorption

negative regulation of fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of glycogen biosynthetic process

ATP metabolic process

ATP metabolic process

ATP metabolic process

glucose import

negative regulation of glucose import

negative regulation of insulin receptor signaling pathway

muscle cell cellular homeostasis

bone remodeling

metal ion binding

nucleoside triphosphate diphosphatase activity

nucleoside triphosphate diphosphatase activity

3'-phosphoadenosine 5'-phosphosulfate metabolic process

sensory perception of temperature stimulus

sensory perception of mechanical stimulus

cartilage development

neuron apoptotic process

establishment of localization in cell

phosphate ion homeostasis

phosphate ion homeostasis

phosphate ion homeostasis

phosphate ion homeostasis

calcium ion homeostasis

calcium ion homeostasis

long-term synaptic potentiation

bone trabecula formation

bone development

endochondral bone morphogenesis

adipose tissue development

fat pad development

artery development

articular cartilage development

protein poly-ADP-ribosylation

mucus secretion

vitamin D3 metabolic process

diphosphate metabolic process

diphosphate metabolic process

cementum mineralization

cementum mineralization

cementum mineralization

nucleic acid metabolic process

hematopoietic stem cell migration to bone marrow

oligodendrocyte apoptotic process

apical dendrite

basal dendrite

bone growth

cyclic-GMP-AMP hydrolase activity

cyclic-GMP-AMP hydrolase activity

cyclic-GMP-AMP hydrolase activity

response to Gram-positive bacterium

inhibition of non-skeletal tissue mineralization

inhibition of non-skeletal tissue mineralization

inhibition of non-skeletal tissue mineralization

inhibition of non-skeletal tissue mineralization

apoptotic process involved in development

microglial cell migration

response to sodium phosphate

response to sodium phosphate

cellular response to sodium phosphate

vascular associated smooth muscle cell migration

negative regulation of hh target transcription factor activity

vascular associated smooth muscle cell proliferation

00230

00500

00740

00760

00770

01100

1452279_at Cfp complement factor properdin X -20925453 BB800282 53

immune system process

extracellular region

extracellular space

complement activation

complement activation, alternative pathway

secretory granule

innate immune response

positive regulation of immune response

cytoplasmic side of Golgi membrane

cytoplasmic side of Golgi membrane

positive regulation of opsonization

 
1418209_a_at Pfn2 profilin 2 3 -57841894 NM_019410 64

actin binding

actin binding

actin monomer binding

protein binding

phosphatidylinositol-4,5-bisphosphate binding

cytoplasm

cytoplasm

cytosol

cytoskeleton

negative regulation of epithelial cell migration

negative regulation of epithelial cell migration

ATP hydrolysis activity

actin cytoskeleton organization

regulation of actin filament polymerization

regulation of actin filament polymerization

negative regulation of actin filament polymerization

positive regulation of actin filament polymerization

positive regulation of actin filament polymerization

positive regulation of actin filament bundle assembly

positive regulation of actin filament bundle assembly

positive regulation of ATP-dependent activity

positive regulation of peptidyl-serine phosphorylation

positive regulation of peptidyl-serine phosphorylation

modulation of chemical synaptic transmission

modulation of chemical synaptic transmission

protein stabilization

positive regulation of stress fiber assembly

positive regulation of stress fiber assembly

Schaffer collateral - CA1 synapse

presynapse

postsynapse

modification of postsynaptic actin cytoskeleton

modification of postsynaptic actin cytoskeleton

glutamatergic synapse

glutamatergic synapse

presynaptic modulation of chemical synaptic transmission

presynaptic modulation of chemical synaptic transmission

negative regulation of ruffle assembly

negative regulation of ruffle assembly

regulation of synaptic vesicle exocytosis

04810

1426554_a_at Pgam1 phosphoglycerate mutase 1 19 41911870 BI407347 60

catalytic activity

bisphosphoglycerate mutase activity

phosphoglycerate mutase activity

phosphoglycerate mutase activity

cytoplasm

cytosol

cytosol

gluconeogenesis

glycolytic process

hydrolase activity

isomerase activity

intramolecular phosphotransferase activity

protein kinase binding

myelin sheath

glyceraldehyde-3-phosphate biosynthetic process

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity

sperm principal piece

00010

01100

1438640_x_at Pgk1 phosphoglycerate kinase 1 X 106187099 AV305101 202

nucleotide binding

phosphoglycerate kinase activity

phosphoglycerate kinase activity

phosphoglycerate kinase activity

protein binding

ATP binding

ATP binding

extracellular space

cytoplasm

cytosol

cytosol

gluconeogenesis

gluconeogenesis

glycolytic process

glycolytic process

glycolytic process

kinase activity

phosphorylation

negative regulation of angiogenesis

transferase activity

plasminogen activation

ADP binding

ADP binding

membrane raft

glyceraldehyde-3-phosphate biosynthetic process

protein-disulfide reductase (NAD(P)) activity

canonical glycolysis

cellular response to hypoxia

00010

01100

1424302_at Pirb paired Ig-like receptor B 7 -3712504, -3712506 U96693 87

amyloid-beta binding

amyloid-beta binding

B cell homeostasis

adaptive immune response

immune system process

protein binding

extracellular space

cytoplasm

plasma membrane

plasma membrane

learning or memory

protein phosphatase 1 binding

external side of plasma membrane

cell surface

membrane

cytokine-mediated signaling pathway

cytokine-mediated signaling pathway

B cell mediated immunity

MHC class Ib protein complex binding

MHC class Ib protein binding

HLA-A specific inhibitory MHC class I receptor activity

HLA-B specific inhibitory MHC class I receptor activity

MHC class I receptor activity

MHC class Ib receptor activity

inhibitory MHC class I receptor activity

inhibitory MHC class I receptor activity

positive regulation of protein dephosphorylation

SH2 domain binding

MHC class I protein binding

protein homodimerization activity

protein homodimerization activity

myeloid dendritic cell differentiation

protein-containing complex binding

protein-containing complex binding

negative regulation of osteoclast differentiation

cell adhesion molecule binding

negative regulation of protein metabolic process

regulation of long-term synaptic potentiation

positive regulation of long-term synaptic depression

04380

04662

1420611_at Prkacb protein kinase, cAMP dependent, catalytic, beta 3 -146729578, -146729578, -146729578, -146729578 AV024339 72

nucleotide binding

magnesium ion binding

magnesium ion binding

neural tube closure

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

AMP-activated protein kinase activity

cAMP-dependent protein kinase activity

cAMP-dependent protein kinase activity

cAMP-dependent protein kinase activity

ATP binding

ATP binding

nucleus

nucleus

cytoplasm

centrosome

cytosol

cytosol

plasma membrane

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase complex

cAMP-dependent protein kinase complex

protein phosphorylation

protein phosphorylation

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

protein kinase A signaling

membrane

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

ubiquitin protein ligase binding

negative regulation of smoothened signaling pathway

perinuclear region of cytoplasm

negative regulation of meiotic cell cycle

regulation of protein processing

ciliary base

negative regulation of TORC1 signaling

04010

04020

04062

04114

04210

04270

04310

04340

04540

04720

04740

04742

04910

04912

04914

04916

04962

04970

04971

04976

05020

05146

05414

1460419_a_at Prkcb protein kinase C, beta 7 122289124 X59274 236

nucleotide binding

adaptive immune response

immune system process

chromatin binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

diacylglycerol-dependent serine/threonine kinase activity

diacylglycerol-dependent serine/threonine kinase activity

protein kinase C binding

calcium channel regulator activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

centrosome

cytosol

plasma membrane

plasma membrane

chromatin organization

regulation of transcription by RNA polymerase II

protein phosphorylation

calcium ion transport

intracellular calcium ion homeostasis

apoptotic process

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

spectrin

zinc ion binding

response to xenobiotic stimulus

regulation of glucose transmembrane transport

negative regulation of glucose transmembrane transport

regulation of dopamine secretion

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

nuclear receptor coactivator activity

positive regulation of vascular endothelial growth factor receptor signaling pathway

brush border membrane

positive regulation of insulin secretion

histone H3T6 kinase activity

intracellular signal transduction

regulation of growth

B cell activation

histone binding

positive regulation of canonical NF-kappaB signal transduction

post-translational protein modification

calyx of Held

calyx of Held

positive regulation of angiogenesis

negative regulation of insulin receptor signaling pathway

metal ion binding

nuclear androgen receptor binding

B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

cellular response to carbohydrate stimulus

presynapse

presynaptic modulation of chemical synaptic transmission

presynaptic modulation of chemical synaptic transmission

presynaptic cytosol

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle exocytosis

04010

04012

04020

04062

04070

04270

04310

04370

04510

04530

04540

04650

04662

04664

04666

04670

04720

04730

04912

04916

04960

04970

04971

04972

04973

05140

05143

05146

05200

05214

05223

1450172_at Pknox1 Pbx/knotted 1 homeobox 17 31564772 AA409923 99

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

angiogenesis

angiogenesis

DNA binding

chromatin binding

protein binding

nucleus

nucleoplasm

transcription regulator complex

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

hemopoiesis

T cell differentiation

erythrocyte differentiation

camera-type eye development

sequence-specific DNA binding

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
1452521_a_at Plaur plasminogen activator, urokinase receptor 7 24462482 X62701 202

positive regulation of protein phosphorylation

signaling receptor binding

protein binding

extracellular region

plasma membrane

plasma membrane

plasma membrane

external side of plasma membrane

cell surface

regulation of plasminogen activation

membrane

enzyme binding

protein domain specific binding

regulation of cell adhesion

positive regulation of homotypic cell-cell adhesion

urokinase plasminogen activator signaling pathway

negative regulation of apoptotic process

positive regulation of DNA binding

positive regulation of epidermal growth factor receptor signaling pathway

mesenchymal cell differentiation

regulation of fibrinolysis

epithelial cell differentiation involved in prostate gland development

positive regulation of release of cytochrome c from mitochondria

side of membrane

protein complex involved in cell-matrix adhesion

serine-type endopeptidase complex

serine-type endopeptidase complex

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

04610

1435043_at Plcb1 phospholipase C, beta 1 2 134786163 BB794831 121

G2/M transition of mitotic cell cycle

G2/M transition of mitotic cell cycle

chromatin

oocyte maturation

phosphatidylinositol phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphatidylinositol phospholipase C activity

GTPase activator activity

calcium ion binding

protein binding

calmodulin binding

calmodulin binding

lamin binding

phosphatidylinositol-4,5-bisphosphate binding

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

plasma membrane

plasma membrane

mRNA processing

lipid metabolic process

cell adhesion

signal transduction

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

glutamate receptor signaling pathway

brain development

memory

memory

phosphoric diester hydrolase activity

regulation of G protein-coupled receptor signaling pathway

insulin receptor signaling pathway

membrane

lipid catabolic process

nuclear speck

nuclear speck

nuclear speck

hydrolase activity

enzyme binding

cerebral cortex development

erythrocyte differentiation

macrophage differentiation

phosphatidylinositol catabolic process

positive regulation of insulin secretion

positive regulation of insulin secretion

positive regulation of sodium:proton antiporter activity

positive regulation of interleukin-12 production

inositol trisphosphate metabolic process

protein-containing complex

response to monosaccharide

intracellular signal transduction

interleukin-12-mediated signaling pathway

interleukin-15-mediated signaling pathway

positive regulation of embryonic development

identical protein binding

myelin sheath

response to peptide hormone

fat cell differentiation

positive regulation of myoblast differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of JNK cascade

phosphatidylinositol metabolic process

phosphatidylinositol metabolic process

insulin-like growth factor receptor signaling pathway

phosphatidylinositol-mediated signaling

positive regulation of developmental growth

release of sequestered calcium ion into cytosol

activation of meiosis involved in egg activation

interleukin-1-mediated signaling pathway

regulation of fertilization

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

GABA-ergic synapse

ion channel modulating, G protein-coupled receptor signaling pathway

postsynaptic modulation of chemical synaptic transmission

postsynaptic modulation of chemical synaptic transmission

postsynaptic modulation of chemical synaptic transmission

regulation of retrograde trans-synaptic signaling by endocanabinoid

regulation of retrograde trans-synaptic signaling by endocanabinoid

postsynaptic cytosol

postsynaptic cytosol

positive regulation of G1/S transition of mitotic cell cycle

cellular response to fluoride

regulation of establishment of endothelial barrier

cellular response to vasopressin

cellular response to ionomycin

cellular response to glyceraldehyde

ligand-gated ion channel signaling pathway

positive regulation of acrosome reaction

negative regulation of monocyte extravasation

positive regulation of CD24 production

00562

01100

04020

04062

04070

04270

04310

04540

04720

04730

04912

04916

04970

04971

04972

05010

05016

05142

05143

05146

1435149_at Plcg1 phospholipase C, gamma 1 2 160731309 BM121087 204

in utero embryonic development

ruffle

phosphatidylinositol phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphatidylinositol phospholipase C activity

phospholipase C activity

phospholipase C activity

guanyl-nucleotide exchange factor activity

insulin receptor binding

neurotrophin TRKA receptor binding

calcium ion binding

protein binding

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

cell-cell junction

lipid metabolic process

calcium ion transport

signal transduction

epidermal growth factor receptor signaling pathway

phosphoric diester hydrolase activity

COP9 signalosome

phospholipid catabolic process

response to organonitrogen compound

positive regulation of epithelial cell migration

positive regulation of epithelial cell migration

lipid catabolic process

cell migration

hydrolase activity

calcium-mediated signaling

protein kinase binding

lamellipodium

clathrin-coated vesicle

receptor tyrosine kinase binding

phosphatidylinositol catabolic process

ruffle membrane

ruffle membrane

inositol trisphosphate metabolic process

inositol trisphosphate biosynthetic process

glutamate receptor binding

intracellular signal transduction

cell projection

positive regulation of blood vessel endothelial cell migration

positive regulation of angiogenesis

phosphatidylinositol metabolic process

phosphatidylinositol metabolic process

metal ion binding

phosphatidylinositol-mediated signaling

calcium-dependent phospholipase C activity

modulation of chemical synaptic transmission

modulation of chemical synaptic transmission

T cell receptor signaling pathway

release of sequestered calcium ion into cytosol

phosphoprotein binding

positive regulation of release of sequestered calcium ion into cytosol

cellular response to epidermal growth factor stimulus

Schaffer collateral - CA1 synapse

Schaffer collateral - CA1 synapse

glutamatergic synapse

glutamatergic synapse

response to curcumin

positive regulation of vascular endothelial cell proliferation

positive regulation of endothelial cell apoptotic process

00562

01100

04012

04020

04070

04370

04650

04660

04664

04666

04670

04722

05200

05214

05223

1437113_s_at Pld1 phospholipase D1 3 27984170, 27938679 BM228590 126

catalytic activity

phospholipase D activity

phospholipase D activity

phospholipase D activity

protein binding

cytoplasm

endosome

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

lipid metabolic process

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

phospholipid catabolic process

phospholipid catabolic process

membrane

lipid catabolic process

apical plasma membrane

hydrolase activity

lamellipodium

endocytic vesicle

positive regulation of cell migration

cellular response to nutrient

vesicle

Golgi cisterna

regulation of microvillus assembly

regulation of microvillus assembly

phosphatidylinositol binding

intracellular membrane-bounded organelle

response to peptide hormone

synapse

positive regulation of translation

defense response to Gram-positive bacterium

regulation of vesicle-mediated transport

N-acylphosphatidylethanolamine-specific phospholipase D activity

plasma membrane region

regulation of synaptic vesicle cycle

cholinergic synapse

00564

00565

01100

04144

04666

04912

05212

1416289_at Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 4 -147909752 NM_011122 43

iron ion binding

protein binding

endoplasmic reticulum

endoplasmic reticulum

ferrous iron binding

procollagen-lysine 5-dioxygenase activity

procollagen-lysine 5-dioxygenase activity

epidermis development

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

peptidyl-lysine hydroxylation

peptidyl-lysine hydroxylation

L-ascorbic acid binding

peptide binding

metal ion binding

dioxygenase activity

collagen-containing extracellular matrix

catalytic complex

00310

1456103_at Pml promyelocytic leukemia 9 -58217179 BB667149 209

chromosome, telomeric region

heterochromatin

response to hypoxia

response to hypoxia

positive regulation of defense response to virus by host

immune system process

DNA binding

transcription coactivator activity

transcription coactivator activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

endosome

endoplasmic reticulum

cytosol

regulation of DNA-templated transcription

protein targeting

protein import into nucleus

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

transforming growth factor beta receptor signaling pathway

zinc ion binding

negative regulation of cell population proliferation

negative regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to DNA damage

intrinsic apoptotic signaling pathway in response to oxidative stress

response to UV

response to gamma radiation

regulation of calcium ion transport into cytosol

fibroblast migration

membrane

nuclear matrix

nuclear matrix

negative regulation of angiogenesis

negative regulation of angiogenesis

PML body

PML body

PML body

PML body

SUMO transferase activity

SUMO transferase activity

myeloid cell differentiation

regulation of cell adhesion

negative regulation of cell growth

PML body organization

PML body organization

protein-containing complex localization

ubiquitin protein ligase binding

nuclear membrane

SUMO binding

positive regulation of telomere maintenance

negative regulation of telomere maintenance via telomerase

endoplasmic reticulum calcium ion homeostasis

negative regulation of interleukin-1 beta production

negative regulation of interleukin-1 production

circadian regulation of gene expression

negative regulation of translation in response to oxidative stress

response to cytokine

regulation of circadian rhythm

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

protein homodimerization activity

entrainment of circadian clock by photoperiod

proteasome-mediated ubiquitin-dependent protein catabolic process

suppression of viral release by host

suppression of viral release by host

suppression of viral release by host

innate immune response

innate immune response

innate immune response

cell fate commitment

negative regulation of DNA-templated transcription

negative regulation of mitotic cell cycle

SMAD binding

metal ion binding

protein heterodimerization activity

positive regulation of fibroblast proliferation

retinoic acid receptor signaling pathway

rhythmic process

protein stabilization

cobalt ion binding

maintenance of protein location in nucleus

defense response to virus

regulation of cell cycle

negative regulation of telomerase activity

positive regulation of apoptotic process involved in mammary gland involution

molecular adaptor activity

SMAD protein signal transduction

branching involved in mammary gland duct morphogenesis

ubiquitin-like protein ligase activity

protein-containing complex assembly

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

cellular response to interleukin-4

intrinsic apoptotic signaling pathway by p53 class mediator

cellular senescence

oncogene-induced cell senescence

extrinsic apoptotic signaling pathway

sumo-dependent protein binding

positive regulation of signal transduction by p53 class mediator

positive regulation of protein localization to chromosome, telomeric region

cellular response to leukemia inhibitory factor

negative regulation of ubiquitin-dependent protein catabolic process

positive regulation of peptidyl-lysine acetylation

regulation of double-strand break repair

positive regulation of apoptotic signaling pathway

positive regulation of apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

04120

04144

05200

05221

1416530_a_at Pnp purine-nucleoside phosphorylase 14 50944302 BC003788 89

allantoin metabolic process

allantoin metabolic process

allantoin metabolic process

nucleoside binding

positive regulation of T cell mediated cytotoxicity

purine nucleobase binding

catalytic activity

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

purine-nucleoside phosphorylase activity

extracellular region

cytoplasm

cytoplasm

cytosol

cytosol

nucleobase-containing compound metabolic process

inosine catabolic process

inosine catabolic process

inosine catabolic process

deoxyinosine catabolic process

deoxyinosine catabolic process

adenosine catabolic process

adenosine catabolic process

deoxyadenosine catabolic process

deoxyadenosine catabolic process

deoxyguanosine catabolic process

purine ribonucleoside salvage

GTP biosynthetic process

AMP catabolic process

AMP catabolic process

GMP catabolic process to guanine

IMP catabolic process

IMP catabolic process

DNA repair

nicotinamide riboside catabolic process

immune response

intrinsic apoptotic signaling pathway in response to DNA damage

apoptotic mitochondrial changes

nucleoside metabolic process

nucleotide biosynthetic process

response to xenobiotic stimulus

response to gamma radiation

transferase activity

glycosyltransferase activity

pentosyltransferase activity

B cell differentiation

GMP salvage

IMP salvage

positive regulation of interleukin-2 production

urate biosynthetic process

urate biosynthetic process

T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

purine nucleoside metabolic process

purine nucleoside metabolic process

purine nucleoside metabolic process

phosphate ion binding

identical protein binding

purine-containing compound salvage

amide catabolic process

amide catabolic process

amide catabolic process

AMP salvage

positive regulation of B cell differentiation

positive regulation of DNA repair

GMP catabolic process

dGMP catabolic process

dGMP catabolic process

dAMP catabolic process

dAMP catabolic process

dGTP metabolic process

guanosine catabolic process

alpha-beta T cell differentiation

positive regulation of alpha-beta T cell differentiation

positive regulation of alpha-beta T cell differentiation

guanosine phosphorylase activity

T cell apoptotic process

negative regulation of T cell apoptotic process

00230

00240

00760

01100

1423272_at Polg polymerase (DNA directed), gamma 7 -79446230, -79446230 BM934958 128

protease binding

DNA binding

chromatin binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

exonuclease activity

protein binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial matrix

gamma DNA polymerase complex

DNA replication

DNA-templated DNA replication

mitochondrial DNA replication

mitochondrial DNA replication

mitochondrial DNA replication

single-stranded DNA 3'-5' DNA exonuclease activity

determination of adult lifespan

3'-5' exonuclease activity

3'-5' exonuclease activity

transferase activity

nucleotidyltransferase activity

protein-containing complex

mitochondrial nucleoid

terminal bouton

intracellular membrane-bounded organelle

DNA replication proofreading

5'-deoxyribose-5-phosphate lyase activity

01100

1418190_at Pon1 paraoxonase 1 6 -5168089 NM_011134 101

aryldialkylphosphatase activity

aryldialkylphosphatase activity

arylesterase activity

arylesterase activity

arylesterase activity

calcium ion binding

phospholipid binding

extracellular region

extracellular space

extracellular space

blood circulation

high-density lipoprotein particle binding

cholesterol metabolic process

cholesterol metabolic process

response to toxic substance

response to toxic substance

positive regulation of cholesterol efflux

hydrolase activity

aromatic compound catabolic process

positive regulation of transporter activity

high-density lipoprotein particle

spherical high-density lipoprotein particle

protein homodimerization activity

carboxylic acid catabolic process

organophosphate catabolic process

phosphatidylcholine metabolic process

metal ion binding

positive regulation of binding

acyl-L-homoserine-lactone lactonohydrolase activity

response to fluoride

01100

1416957_at Pou2af1 POU domain, class 2, associating factor 1 9 51213689 NM_011136 83

germinal center B cell differentiation

DNA binding

transcription coactivator activity

transcription coactivator activity

transcription coactivator activity

protein binding

nucleus

positive regulation of interleukin-6 production

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

POU domain binding

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

cellular response to virus

 
1449937_at Endou endonuclease, polyU-specific 15 -97711018, -97711018 AI528824 17

RNA binding

nuclease activity

endonuclease activity

RNA endonuclease activity

RNA endonuclease activity

scavenger receptor activity

extracellular region

cytoplasm

proteolysis

immune response

post-transcriptional gene silencing

hydrolase activity

lyase activity

polysaccharide binding

metal ion binding

negative regulation of lipid catabolic process

 
1448380_at Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 11 -118392746 NM_011150 41

scavenger receptor activity

scavenger receptor activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

cell adhesion

membrane

 
1420743_a_at Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform 14 -70222978, -70217864 NM_008915 40

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

calcium-dependent protein serine/threonine phosphatase activity

calcium-dependent protein serine/threonine phosphatase activity

calcium-dependent protein serine/threonine phosphatase activity

protein binding

calmodulin binding

calmodulin binding

cytoplasm

cytoplasm

mitochondrion

cytosol

calcineurin complex

calcineurin complex

calcineurin complex

calcineurin complex

protein dephosphorylation

penetration of zona pellucida

protein serine/threonine phosphatase complex

hydrolase activity

myosin phosphatase activity

calcineurin-NFAT signaling cascade

calmodulin-dependent protein phosphatase activity

calmodulin-dependent protein phosphatase activity

sperm flagellum

metal ion binding

positive regulation of calcineurin-NFAT signaling cascade

sperm midpiece

sperm mitochondrial sheath

calcineurin-mediated signaling

calcineurin-mediated signaling

presynapse

glutamatergic synapse

glutamatergic synapse

presynaptic cytosol

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

positive regulation of calcium ion import across plasma membrane

negative regulation of calcium ion import across plasma membrane

04010

04020

04114

04210

04310

04360

04370

04380

04650

04660

04662

04720

05010

05014

1421926_at Mapk11 mitogen-activated protein kinase 11 15 -89142483 AV329330 82

MAPK cascade

nucleotide binding

osteoblast differentiation

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

MAP kinase activity

MAP kinase activity

MAP kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

protein phosphorylation

positive regulation of gene expression

kinase activity

phosphorylation

transferase activity

stress-activated protein kinase signaling cascade

positive regulation of interleukin-12 production

intracellular signal transduction

p38MAPK cascade

stress-activated MAPK cascade

stress-activated MAPK cascade

cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation

negative regulation of cardiac muscle cell proliferation

bone development

cellular response to interleukin-1

cellular response to UV-B

cellular response to virus

04010

04370

04380

04620

04621

04622

04660

04664

04670

04722

04912

04914

05014

05140

05142

05145

05160

1440866_at Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 17 -78852549 AV328340 234

nucleotide binding

positive regulation of cytokine production

immune system process

RNA binding

double-stranded RNA binding

double-stranded RNA binding

protein kinase activity

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

eukaryotic translation initiation factor 2alpha kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

translation

protein phosphorylation

protein phosphorylation

response to virus

response to toxic substance

kinase activity

phosphorylation

transferase activity

negative regulation of translation

endoplasmic reticulum unfolded protein response

response to lipopolysaccharide

positive regulation of chemokine production

positive regulation of stress-activated MAPK cascade

response to vitamin E

negative regulation of osteoblast proliferation

cellular response to amino acid starvation

response to interferon-alpha

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

identical protein binding

positive regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of MAPK cascade

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

protein autophosphorylation

protein autophosphorylation

perinuclear region of cytoplasm

positive regulation of NF-kappaB transcription factor activity

defense response to virus

antiviral innate immune response

regulation of NLRP3 inflammasome complex assembly

positive regulation of non-canonical NF-kappaB signal transduction

regulation of hematopoietic progenitor cell differentiation

regulation of hematopoietic stem cell proliferation

regulation of hematopoietic stem cell differentiation

04141

05160

1455696_a_at Prpf4b pre-mRNA processing factor 4B 13 34875528 BB344827 28

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

spliceosomal complex

chromosome

mRNA processing

protein phosphorylation

protein phosphorylation

RNA splicing

kinase activity

phosphorylation

nuclear speck

transferase activity

mRNA cis splicing, via spliceosome

catalytic step 2 spliceosome

 
1419669_at Prtn3 proteinase 3 10 79879666 U97073 39

serine-type endopeptidase activity

serine-type endopeptidase activity

signaling receptor binding

protein binding

extracellular region

extracellular space

lysosome

cytosol

plasma membrane

proteolysis

proteolysis

membrane protein ectodomain proteolysis

peptidase activity

serine-type peptidase activity

membrane

hydrolase activity

enzyme binding

collagen catabolic process

azurophil granule lumen

intracellular membrane-bounded organelle

positive regulation of GTPase activity

plasma membrane raft

cell-cell junction maintenance

negative regulation of phagocytosis

neutrophil extravasation

mature conventional dendritic cell differentiation

 
1417385_at Npepps aminopeptidase puromycin sensitive 11 -97205841 AK010446 45

aminopeptidase activity

extracellular space

nucleus

cytoplasm

cytoplasm

cytosol

proteolysis

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

zinc ion binding

membrane

hydrolase activity

peptide binding

peptide catabolic process

metal ion binding

metalloaminopeptidase activity

cellular response to hypoxia

 
1418183_a_at Cyth1 cytohesin 1 11 -118164169, -118164169, -118181100, -118164169, -118181100 AB013464 34

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

cytosol

plasma membrane

plasma membrane

bicellular tight junction

lipid binding

cytoplasmic side of plasma membrane

membrane

neuromuscular junction

regulation of ARF protein signal transduction

anchoring junction

establishment of epithelial cell polarity

extrinsic component of presynaptic membrane

presynaptic modulation of chemical synaptic transmission

 
1421410_a_at Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 18 77794549 BC002123 43

actin binding

protein binding

cytoplasm

cytoplasm

cytosol

cytoskeleton

actin filament

plasma membrane

cytoskeleton organization

membrane

actin filament polymerization

actin filament binding

 
1428853_at Ptch1 patched 1 13 -63508327, -63508327 BG071079 1421

negative regulation of transcription by RNA polymerase II

branching involved in ureteric bud morphogenesis

in utero embryonic development

cell fate determination

neural tube formation

neural tube closure

heart morphogenesis

patched binding

smoothened binding

smoothened binding

protein binding

extracellular region

Golgi apparatus

plasma membrane

plasma membrane

plasma membrane

plasma membrane

caveola

cilium

signal transduction

regulation of mitotic cell cycle

pattern specification process

brain development

hedgehog receptor activity

hedgehog receptor activity

heparin binding

zinc ion binding

negative regulation of cell population proliferation

epidermis development

animal organ morphogenesis

dorsal/ventral pattern formation

epidermal cell fate specification

response to chlorate

negative regulation of keratinocyte proliferation

positive regulation of cholesterol efflux

cholesterol binding

cholesterol binding

membrane

protein processing

spinal cord motor neuron differentiation

neural tube patterning

dorsal/ventral neural tube patterning

neural plate axis specification

embryonic limb morphogenesis

embryonic limb morphogenesis

cyclin binding

cyclin binding

midbody

mammary gland development

regulation of protein localization

regulation of protein localization

limb morphogenesis

hindlimb morphogenesis

regulation of growth

negative regulation of multicellular organism growth

regulation of cell population proliferation

glucose homeostasis

intracellular membrane-bounded organelle

negative regulation of DNA-binding transcription factor activity

keratinocyte proliferation

dendritic growth cone

axonal growth cone

protein-containing complex binding

apical part of cell

positive regulation of epidermal cell differentiation

negative regulation of osteoblast differentiation

negative regulation of smoothened signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of smoothened signaling pathway

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

perinuclear region of cytoplasm

embryonic organ development

epithelial cell proliferation

negative regulation of epithelial cell proliferation

negative regulation of cell division

pharyngeal system development

mammary gland duct morphogenesis

mammary gland epithelial cell differentiation

cell differentiation involved in kidney development

somite development

somite development

cellular response to cholesterol

cellular response to cholesterol

commissural neuron axon guidance

stem cell proliferation

cell proliferation involved in metanephros development

protein localization to plasma membrane

hedgehog family protein binding

hedgehog family protein binding

negative regulation of stem cell proliferation

04340

05200

05217

1416249_at Nadk NAD kinase 4 155563814, 155562380 AW538068 26

nucleotide binding

NAD+ kinase activity

NAD+ kinase activity

NAD+ kinase activity

ATP binding

cytosol

NADP biosynthetic process

NADP biosynthetic process

kinase activity

phosphorylation

transferase activity

NAD metabolic process

positive regulation of insulin secretion involved in cellular response to glucose stimulus

metal ion binding

00760

01100

1450071_at Ash1l ASH1 like histone lysine methyltransferase 3 88965811 BG694892 45

MAPK cascade

skeletal system development

negative regulation of acute inflammatory response

DNA binding

chromatin binding

nucleus

nucleoplasm

nucleoplasm

chromosome

Golgi apparatus

bicellular tight junction

chromatin organization

regulation of DNA-templated transcription

transcription by RNA polymerase II

inflammatory response

single fertilization

methyltransferase activity

post-embryonic development

regulation of gene expression

macrophage cytokine production

transferase activity

flagellated sperm motility

methylation

interleukin-6 production

histone methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 methyltransferase activity

negative regulation of MAPK cascade

positive regulation of transcription by RNA polymerase II

decidualization

metal ion binding

histone H3K9 methyltransferase activity

histone H3K36 methyltransferase activity

sebaceous gland development

negative regulation of inflammatory response

uterus morphogenesis

anchoring junction

histone H3K9 monomethyltransferase activity

histone H3K36 trimethyltransferase activity

tarsal gland development

uterine gland development

00310

04530

1436766_at Luc7l2 LUC7-like 2 (S. cerevisiae) 6 38555722, 38551333, 38551333 BB475271 30

mRNA binding

mRNA binding

nucleus

U1 snRNP

U1 snRNP

mRNA splice site recognition

mRNA splice site recognition

nuclear speck

enzyme binding

U2-type prespliceosome

 
1436448_a_at Ptgs1 prostaglandin-endoperoxide synthase 1 2 36230425 AA833146 318

prostaglandin biosynthetic process

prostaglandin biosynthetic process

photoreceptor outer segment

peroxidase activity

prostaglandin-endoperoxide synthase activity

prostaglandin-endoperoxide synthase activity

nuclear envelope

cytoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

prostaglandin metabolic process

response to oxidative stress

learning

memory

regulation of blood pressure

negative regulation of norepinephrine secretion

membrane

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

cyclooxygenase pathway

cyclooxygenase pathway

heme binding

keratinocyte differentiation

negative regulation of epinephrine secretion

maintenance of blood-brain barrier

regulation of cell population proliferation

neuron projection

intracellular membrane-bounded organelle

positive regulation of vasoconstriction

positive regulation of smooth muscle contraction

metal ion binding

dioxygenase activity

00590

01100

1419657_a_at Slc25a36 solute carrier family 25, member 36 9 -97077010 BB503267 23

mitochondrial genome maintenance

mitochondrial genome maintenance

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

pyrimidine nucleotide transport

mitochondrion organization

pyrimidine nucleotide transmembrane transporter activity

pyrimidine nucleotide transmembrane transporter activity

membrane

regulation of mitochondrial membrane potential

transmembrane transport

pyrimidine nucleotide import into mitochondrion

 
1417219_s_at Tmsb10 thymosin beta 10 6 -72957346, -72957346, -72957346 NM_025284 36

actin monomer binding

actin monomer binding

cytoplasm

cytoplasm

actin cytoskeleton organization

regulation of cell migration

sequestering of actin monomers

 
1448830_at Dusp1 dual specificity phosphatase 1 17 -26505590 NM_013642 233

endoderm formation

phosphoprotein phosphatase activity

protein serine/threonine phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleus

cytoplasm

cytoplasm

protein dephosphorylation

cell cycle

negative regulation of cell adhesion

protein tyrosine/serine/threonine phosphatase activity

negative regulation of cell population proliferation

protein tyrosine/threonine phosphatase activity

protein tyrosine/threonine phosphatase activity

dephosphorylation

hydrolase activity

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

myosin phosphatase activity

growth factor binding

MAP kinase tyrosine phosphatase activity

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

peptidyl-tyrosine dephosphorylation

intracellular signal transduction

peptidyl-threonine dephosphorylation

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of MAP kinase activity

negative regulation of MAPK cascade

mitogen-activated protein kinase binding

mitogen-activated protein kinase binding

peptidyl-serine dephosphorylation

negative regulation of ERK1 and ERK2 cascade

negative regulation of monocyte chemotaxis

negative regulation of p38MAPK cascade

negative regulation of p38MAPK cascade

cellular response to chemokine

negative regulation of DNA biosynthetic process

04010

1448511_at Ptprcap protein tyrosine phosphatase receptor type C polypeptide-associated protein 19 4154645 NM_016933 30

plasma membrane

plasma membrane

membrane

 
1418539_a_at Ptpre protein tyrosine phosphatase receptor type E 7 135651898, 135593480, 135537823, 135605827 U35368 54

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

protein tyrosine phosphatase activity

nucleus

cytoplasm

cytoplasm

plasma membrane

plasma membrane

protein dephosphorylation

protein dephosphorylation

transmembrane receptor protein tyrosine phosphatase signaling pathway

membrane

dephosphorylation

hydrolase activity

phosphatase activity

regulation of mast cell activation

identical protein binding

negative regulation of insulin receptor signaling pathway

negative regulation of insulin receptor signaling pathway

 
1438828_at Rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 11 54596145, 54596145, 54522844 BM243959 25

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

centrosome

cytosol

plasma membrane

plasma membrane

Ras protein signal transduction

apical plasma membrane

apical plasma membrane

microvillus assembly

endocytic vesicle

endocytic vesicle

GTP-dependent protein binding

small GTPase binding

positive regulation of GTPase activity

positive regulation of GTPase activity

phosphatidic acid binding

protein localization to plasma membrane

 
1416082_at Rab1a RAB1A, member RAS oncogene family 11 20201411 AW108405 92

autophagosome assembly

autophagosome assembly

Golgi membrane

nucleotide binding

GTPase activity

GTPase activity

G protein activity

protein binding

GTP binding

cytoplasm

endosome

early endosome

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

intracellular protein transport

intracellular protein transport

endoplasmic reticulum to Golgi vesicle-mediated transport

endocytosis

autophagy

Golgi organization

endomembrane system

protein transport

membrane

vesicle-mediated transport

cell migration

cell migration

hydrolase activity

virion assembly

growth hormone secretion

melanosome transport

positive regulation of interleukin-8 production

substrate adhesion-dependent cell spreading

melanosome

defense response to bacterium

neuronal cell body

synapse

vesicle transport along microtubule

COPII-coated vesicle cargo loading

presynapse

positive regulation of glycoprotein metabolic process

 
1438097_at Rab20 RAB20, member RAS oncogene family 8 -11453389 BG066967 33

nucleotide binding

GTPase activity

GTPase activity

GTP binding

Golgi apparatus

intracellular protein transport

endomembrane system

protein transport

membrane

cytoplasmic vesicle

intracellular membrane-bounded organelle

phagocytic vesicle

phagocytic vesicle

cellular response to type II interferon

phagosome acidification

phagosome-lysosome fusion

 
1418890_a_at Rab3d RAB3D, member RAS oncogene family 9 -21907491 BB349707 61

nucleotide binding

GTPase activity

GTPase activity

protein binding

GTP binding

mitochondrion

endosome

cytoplasmic microtubule

plasma membrane

plasma membrane

exocytosis

vesicle docking involved in exocytosis

synaptic vesicle

protein secretion

protein transport

membrane

regulation of exocytosis

regulation of exocytosis

peptidyl-cysteine methylation

GTP-dependent protein binding

myosin V binding

myosin V binding

zymogen granule

bone resorption

protein localization to plasma membrane

secretory vesicle

positive regulation of regulated secretory pathway

04972

1440208_at Rac2 Rac family small GTPase 2 15 -78559168 BE691393 153

nucleotide binding

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

nuclear envelope

cytoplasm

cytosol

actin filament

plasma membrane

chemotaxis

chemotaxis

actin filament organization

actin filament organization

signal transduction

G protein-coupled receptor signaling pathway

small GTPase-mediated signal transduction

cell population proliferation

cell population proliferation

positive regulation of lamellipodium assembly

positive regulation of lamellipodium assembly

positive regulation of lamellipodium assembly

regulation of cell-substrate adhesion

membrane

protein kinase regulator activity

lamellipodium

cell projection assembly

actin cytoskeleton organization

actin cytoskeleton organization

regulation of cell migration

regulation of T cell proliferation

erythrocyte enucleation

regulation of mast cell degranulation

bone resorption

regulation of respiratory burst

regulation of mast cell chemotaxis

mast cell proliferation

mast cell proliferation

positive regulation of mast cell proliferation

positive regulation of mast cell proliferation

lymphocyte aggregation

positive regulation of neutrophil chemotaxis

positive regulation of neutrophil chemotaxis

regulation of neutrophil migration

04010

04062

04310

04360

04370

04510

04520

04650

04662

04664

04666

04670

04810

05200

05210

05212

05416

1434295_at Rasgrp1 RAS guanyl releasing protein 1 2 -117279983 BE691356 85

positive regulation of protein phosphorylation

inflammatory response to antigenic stimulus

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

calcium ion binding

cytoplasm

endoplasmic reticulum

Golgi apparatus

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

small GTPase-mediated signal transduction

Ras protein signal transduction

zinc ion binding

membrane

diacylglycerol binding

natural killer cell activation

cell differentiation

phosphatidylcholine binding

secretory granule localization

positive regulation of granulocyte macrophage colony-stimulating factor production

positive regulation of type II interferon production

positive regulation of tumor necrosis factor production

mast cell cytokine production

positive regulation of natural killer cell activation

positive regulation of natural killer cell differentiation

positive regulation of T cell differentiation in thymus

T cell proliferation

B cell proliferation

T cell activation

B cell activation

identical protein binding

mast cell degranulation

positive regulation of MAP kinase activity

positive regulation of GTPase activity

positive regulation of GTPase activity

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of JNK cascade

positive regulation of Ras protein signal transduction

metal ion binding

vesicle transport along microtubule

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

activation of GTPase activity

activation of GTPase activity

04010

04660

1426863_at Rbmx RNA binding motif protein, X chromosome X -57383347, -57386029 BM123721 36

regulation of alternative mRNA splicing, via spliceosome

euchromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

nucleic acid binding

chromatin binding

RNA binding

RNA binding

single-stranded RNA binding

mRNA binding

nucleus

spliceosomal complex

spliceosomal complex

transcription by RNA polymerase II

mRNA splice site recognition

mRNA processing

membrane protein ectodomain proteolysis

RNA splicing

postsynaptic density

protein domain specific binding

protein-containing complex

identical protein binding

supraspliceosomal complex

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of mRNA splicing, via spliceosome

extracellular exosome

catalytic step 2 spliceosome

cellular response to interleukin-1

glutamatergic synapse

regulation of postsynapse organization

ribonucleoprotein complex

03040

1436196_at Rel reticuloendotheliosis oncogene 11 -23736849 BE691546 259

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

cytokine production

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

regulation of DNA-templated transcription

inflammatory response

canonical NF-kappaB signal transduction

negative regulation of gene expression

negative regulation of interferon-beta production

positive regulation of interleukin-12 production

cellular response to stress

response to cytokine

non-canonical NF-kappaB signal transduction

sequence-specific DNA binding

innate immune response

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

 
1424632_a_at Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit 10 39732159 AB031049 59

nucleotide binding

double-strand break repair via homologous recombination

nucleic acid binding

DNA binding

DNA-directed DNA polymerase activity

DNA-directed DNA polymerase activity

nucleus

nucleus

nucleolus

DNA replication

DNA repair

DNA damage response

zeta DNA polymerase complex

zeta DNA polymerase complex

transferase activity

nucleotidyltransferase activity

translesion synthesis

error-prone translesion synthesis

error-prone translesion synthesis

metal ion binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

01100

1448101_s_at Trim27 tripartite motif-containing 27 13 21179930 NM_009054 59

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

fibrillar center

negative regulation of adaptive immune response

DNA binding

transcription coactivator activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

endosome

negative regulation of protein kinase activity

zinc ion binding

negative regulation of autophagy

transferase activity

SUMO transferase activity

retromer complex

nuclear membrane

negative regulation of type I interferon production

negative regulation of interleukin-2 production

negative regulation of tumor necrosis factor production

positive regulation of type II interferon production

negative regulation of viral transcription

negative regulation of viral transcription

negative regulation of viral transcription

Arp2/3 complex-mediated actin nucleation

retrograde transport, endosome to Golgi

identical protein binding

suppression of viral release by host

innate immune response

innate immune response

innate immune response

negative regulation of gene expression, epigenetic

metal ion binding

positive regulation of DNA-binding transcription factor activity

positive regulation of actin nucleation

ubiquitin protein ligase activity

ubiquitin protein ligase activity

protein K63-linked ubiquitination

protein K63-linked ubiquitination

negative regulation of calcium ion import

 
1437375_at Rfx3 regulatory factor X, 3 (influences HLA class II expression) 19 -27761720, -27761720 BB745175 61

chromatin

chromatin

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

transcription regulator complex

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

multicellular organism development

determination of left/right symmetry

cell differentiation

endocrine pancreas development

sequence-specific DNA binding

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

cell maturation

regulation of insulin secretion

cilium assembly

cilium-dependent cell motility

epithelial cilium movement involved in determination of left/right asymmetry

type B pancreatic cell maturation

sequence-specific double-stranded DNA binding

positive regulation of type B pancreatic cell development

 
1448948_at Slc50a1 solute carrier family 50 (sugar transporter), member 1 3 -89268245 NM_009057 20

Golgi apparatus

plasma membrane

carbohydrate transport

carbohydrate transport

endomembrane system

membrane

glucoside transmembrane transporter activity

sugar transmembrane transporter activity

sugar transmembrane transporter activity

 
1450688_at Rgl2 ral guanine nucleotide dissociation stimulator-like 2 17 33929893 NM_009059 24

guanyl-nucleotide exchange factor activity

signal transduction

small GTPase-mediated signal transduction

negative regulation of cardiac muscle cell apoptotic process

regulation of Ral protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

 
1448852_at Rgn regucalcin X 20549817 NM_009060 83

negative regulation of protein phosphorylation

gluconolactonase activity

gluconolactonase activity

gluconolactonase activity

gluconolactonase activity

calcium ion binding

calcium ion binding

nucleus

cytoplasm

intracellular calcium ion homeostasis

spermatogenesis

zinc ion binding

positive regulation of triglyceride biosynthetic process

positive regulation of glucose metabolic process

hydrolase activity

L-ascorbic acid biosynthetic process

L-ascorbic acid biosynthetic process

L-ascorbic acid biosynthetic process

enzyme regulator activity

negative regulation of apoptotic process

negative regulation of nitric oxide biosynthetic process

positive regulation of fatty acid biosynthetic process

metal ion binding

negative regulation of epithelial cell proliferation

regulation of calcium-mediated signaling

negative regulation of flagellated sperm motility

negative regulation of RNA biosynthetic process

negative regulation of bone development

positive regulation of proteolysis involved in protein catabolic process

negative regulation of DNA catabolic process

negative regulation of DNA biosynthetic process

 
1419273_at Uri1 URI1, prefoldin-like chaperone 7 -37959991 AV278756 36

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II complex binding

regulation of cell growth

chromatin binding

chromatin binding

transcription corepressor activity

transcription corepressor activity

protein phosphatase inhibitor activity

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

regulation of transcription by RNA polymerase II

response to virus

negative regulation of phosphatase activity

negative regulation of phosphatase activity

phosphatase inhibitor activity

cell projection

phosphoprotein binding

cellular response to growth factor stimulus

cellular response to steroid hormone stimulus

RPAP3/R2TP/prefoldin-like complex

negative regulation of intrinsic apoptotic signaling pathway

 
1419311_at Trim10 tripartite motif-containing 10 17 36869573 NM_011280 20

protein binding

cytoplasm

cytoplasm

zinc ion binding

protein ubiquitination

erythrocyte differentiation

innate immune response

innate immune response

negative regulation of viral entry into host cell

metal ion binding

ubiquitin protein ligase activity

 
1419586_at Rp2 retinitis pigmentosa 2 homolog X 20364480, 20364480 BF168611 27

nucleotide binding

magnesium ion binding

GTPase activator activity

GTPase activator activity

GTP binding

nucleoplasm

cytoplasm

Golgi apparatus

centriole

plasma membrane

plasma membrane

cilium

cilium

post-Golgi vesicle-mediated transport

post-Golgi vesicle-mediated transport

protein transport

membrane

nuclear body

cytoplasmic vesicle

ciliary basal body

ciliary basal body

cell projection

periciliary membrane compartment

periciliary membrane compartment

 
1436699_x_at Rpl18 ribosomal protein L18 7 45718070 BB422726 42

cytoplasmic translation

cytoplasmic translation

RNA binding

structural constituent of ribosome

structural constituent of ribosome

structural constituent of ribosome

nucleolus

cytoplasm

endoplasmic reticulum

cytosol

cytosol

ribosome

translation

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic ribosome

synapse

ribonucleoprotein complex

03010

1448398_s_at Rpl22 ribosomal protein L22 4 152324435, 152325725 NM_009079 248

cytoplasmic translation

RNA binding

RNA binding

structural constituent of ribosome

structural constituent of ribosome

structural constituent of ribosome

nucleus

cytoplasm

cytosol

ribosome

ribosome

ribosome

ribosome

ribosome

translation

heparin binding

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic ribosome

identical protein binding

synapse

synapse

alpha-beta T cell differentiation

presynapse

presynapse

postsynapse

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

translation at presynapse

translation at presynapse

translation at presynapse

translation at postsynapse

ribonucleoprotein complex

03010

1455195_at Rps24 ribosomal protein S24 14 24490752, 24490677 BM119287 39

cytoplasmic translation

structural constituent of ribosome

structural constituent of ribosome

nucleus

cytoplasm

endoplasmic reticulum

cytosol

cytosol

ribosome

rRNA processing

translation

small ribosomal subunit

cytosolic ribosome

cytosolic small ribosomal subunit

cytosolic small ribosomal subunit

cytosolic small ribosomal subunit

translation initiation factor binding

small-subunit processome

erythrocyte homeostasis

ribosomal small subunit biogenesis

synapse

synapse

synapse

presynapse

postsynapse

translation at presynapse

translation at postsynapse

ribonucleoprotein complex

03010

1417542_at Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 17 7170114 BB737182 61

nucleotide binding

magnesium ion binding

oocyte maturation

brain renin-angiotensin system

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ribosomal protein S6 kinase activity

ribosomal protein S6 kinase activity

protein serine/threonine/tyrosine kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

spindle

protein phosphorylation

heart development

negative regulation of cell population proliferation

positive regulation of gene expression

cardiac muscle cell apoptotic process

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-serine phosphorylation

intracellular signal transduction

positive regulation of apoptotic process

negative regulation of cell cycle

negative regulation of meiotic nuclear division

heart contraction

regulation of protein processing

cellular response to carbohydrate stimulus

meiotic spindle

04010

04114

04150

04720

04722

04914

1451860_a_at Trim30a tripartite motif-containing 30A 7 -104409025, -104409025 AF220015 39

protein polyubiquitination

P-body

activation of innate immune response

DNA binding

transcription coactivator activity

ubiquitin-protein transferase activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

autophagy

zinc ion binding

response to bacterium

positive regulation of autophagy

protein kinase binding

protein kinase binding

protein-macromolecule adaptor activity

regulation of lipopolysaccharide-mediated signaling pathway

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

regulation of protein localization

regulation of protein localization

negative regulation of toll-like receptor signaling pathway

pattern recognition receptor activity

identical protein binding

protein homodimerization activity

protein homodimerization activity

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade

suppression of viral release by host

innate immune response

innate immune response

positive regulation of protein catabolic process

regulation of viral entry into host cell

negative regulation of viral entry into host cell

positive regulation of viral entry into host cell

metal ion binding

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

protein autoubiquitination

ubiquitin protein ligase activity

protein K63-linked ubiquitination

negative regulation of NLRP3 inflammasome complex assembly

omegasome

negative regulation of reactive oxygen species metabolic process

 
1434437_x_at Rrm2 ribonucleotide reductase M2 12 24708253 AV301324 81

blastocyst development

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

protein binding

nucleus

nuclear envelope

cytoplasm

cytosol

cytosol

ribonucleoside-diphosphate reductase complex

ribonucleoside-diphosphate reductase complex

ribonucleoside-diphosphate reductase complex

ferric iron binding

ribonucleoside diphosphate metabolic process

ribonucleoside diphosphate metabolic process

deoxyribonucleotide metabolic process

deoxyribonucleotide biosynthetic process

deoxyribonucleotide biosynthetic process

2'-deoxyribonucleotide biosynthetic process

2'-deoxyribonucleotide biosynthetic process

oxidoreductase activity

identical protein binding

protein homodimerization activity

metal ion binding

protein heterotetramerization

positive regulation of G1/S transition of mitotic cell cycle

00230

00240

00480

01100

04115

1460351_at S100a11 S100 calcium binding protein A11 3 93520495 BC021916 43

ruffle

calcium ion binding

calcium ion binding

extracellular space

nucleus

cytoplasm

cytoplasm

cytoplasm

positive regulation of smooth muscle cell migration

regulation of cell population proliferation

protein homodimerization activity

S100 protein binding

S100 protein binding

metal ion binding

calcium-dependent protein binding

calcium-dependent protein binding

collagen-containing extracellular matrix

 
1421375_a_at S100a6 S100 calcium binding protein A6 (calcyclin) 3 90612893 NM_011313 93

ruffle

calcium ion binding

calcium ion binding

calcium ion binding

protein binding

tropomyosin binding

nucleus

nucleus

nuclear envelope

cytoplasm

cytosol

plasma membrane

zinc ion binding

cytoplasmic side of plasma membrane

monoatomic ion transmembrane transporter activity

membrane

protein homodimerization activity

S100 protein binding

S100 protein binding

metal ion binding

calcium-dependent protein binding

calcium-dependent protein binding

perinuclear region of cytoplasm

perinuclear region of cytoplasm

collagen-containing extracellular matrix

 
1419394_s_at S100a8 S100 calcium binding protein A8 (calgranulin A) 3 90669070 NM_013650 177

immune system process

leukocyte migration involved in inflammatory response

leukocyte migration involved in inflammatory response

peptide secretion

peptide secretion

positive regulation of peptide secretion

positive regulation of peptide secretion

calcium ion binding

calcium ion binding

extracellular region

extracellular space

cytoplasm

cytosol

cytoskeleton

plasma membrane

autophagy

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

chemotaxis

inflammatory response

astrocyte development

membrane

antioxidant activity

peptidyl-cysteine S-nitrosylation

neutrophil chemotaxis

neutrophil chemotaxis

response to lipopolysaccharide

regulation of toll-like receptor signaling pathway

autocrine signaling

innate immune response

intermediate filament cytoskeleton

metal ion binding

calcium-dependent protein binding

positive regulation of inflammatory response

neutrophil aggregation

neutrophil aggregation

calprotectin complex

positive regulation of intrinsic apoptotic signaling pathway

 
1448756_at S100a9 S100 calcium binding protein A9 (calgranulin B) 3 -90692629 NM_009114 253

cornified envelope

immune system process

leukocyte migration involved in inflammatory response

leukocyte migration involved in inflammatory response

chronic inflammatory response

peptide secretion

peptide secretion

positive regulation of peptide secretion

positive regulation of peptide secretion

calcium ion binding

calcium ion binding

extracellular region

extracellular space

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

regulation of translation

autophagy

apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

chemotaxis

inflammatory response

positive regulation of neuron projection development

astrocyte development

astrocyte development

membrane

antioxidant activity

peptidyl-cysteine S-nitrosylation

peptidyl-cysteine S-nitrosylation

actin cytoskeleton organization

positive regulation of blood coagulation

neutrophil chemotaxis

neutrophil chemotaxis

leukocyte chemotaxis

response to lipopolysaccharide

regulation of toll-like receptor signaling pathway

autocrine signaling

autocrine signaling

peptidyl-cysteine S-trans-nitrosylation

modulation of process of another organism

endothelial cell migration

innate immune response

regulation of integrin biosynthetic process

regulation of integrin biosynthetic process

metal ion binding

calcium-dependent protein binding

positive regulation of inflammatory response

regulation of respiratory burst involved in inflammatory response

antimicrobial humoral immune response mediated by antimicrobial peptide

antimicrobial humoral immune response mediated by antimicrobial peptide

neutrophil aggregation

neutrophil aggregation

calprotectin complex

S100A9 complex

positive regulation of intrinsic apoptotic signaling pathway

 
1450788_at Saa1 serum amyloid A 1 7 -46740496 NM_009117 104

G protein-coupled receptor binding

protein binding

extracellular region

extracellular space

cytoplasmic microtubule

acute-phase response

heparin binding

cholesterol metabolic process

response to bacterium

high-density lipoprotein particle

 
1450826_a_at Saa3 serum amyloid A 3 7 -46711997 NM_011315 86

extracellular region

extracellular space

acute-phase response

I-kappaB phosphorylation

response to bacterium

high-density lipoprotein particle

response to stilbenoid

Toll-like receptor 4 binding

chemoattractant activity

cell chemotaxis

cellular response to interleukin-1

 
1437389_x_at Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 4 -129703168, -129713814 AV117555 112

negative regulation of transcription by RNA polymerase II

regulation of alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

RNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

mRNA processing

cell cycle

cell surface receptor signaling pathway

cell surface receptor signaling pathway

poly(A) binding

poly(A) binding

poly(U) RNA binding

membrane

SH3 domain binding

protein domain specific binding

protein-containing complex

signaling adaptor activity

signaling adaptor activity

SH2 domain binding

identical protein binding

identical protein binding

protein-containing complex binding

positive regulation of translational initiation

regulation of RNA export from nucleus

positive regulation of RNA export from nucleus

regulation of mRNA splicing, via spliceosome

T cell receptor signaling pathway

Grb2-Sos complex

protein tyrosine kinase binding

protein tyrosine kinase binding

 
1419059_at Apcs amyloid P component, serum 1 -172893960 NM_011318 82

complement component C1q complex binding

complement component C1q complex binding

calcium ion binding

extracellular region

extracellular space

extracellular space

carbohydrate binding

protein-containing complex

identical protein binding

negative regulation by host of viral exo-alpha-sialidase activity

negative regulation by host of viral glycoprotein metabolic process

innate immune response

innate immune response

negative regulation of monocyte differentiation

negative regulation of viral entry into host cell

virion binding

metal ion binding

negative regulation of viral process

protein-containing complex assembly

negative regulation of exo-alpha-sialidase activity

negative regulation of glycoprotein metabolic process

 
1416008_at Satb1 special AT-rich sequence binding protein 1 17 -51736186, -51736186, -51736186, -51736186, -51736186 AV172776 111

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

heterochromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

chromatin binding

DNA-binding transcription factor activity

nucleus

nucleoplasm

chromatin organization

chromatin remodeling

chromatin remodeling

regulation of DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

epidermis development

nuclear matrix

nuclear body

PML body

T cell activation

CD4-positive, alpha-beta T cell differentiation

CD8-positive, alpha-beta T cell differentiation

sequence-specific DNA binding

activated T cell proliferation

reflex

DNA-binding transcription factor binding

 
1415964_at Scd1 stearoyl-Coenzyme A desaturase 1 19 -44394449 NM_009127 287

stearoyl-CoA 9-desaturase activity

stearoyl-CoA 9-desaturase activity

stearoyl-CoA 9-desaturase activity

stearoyl-CoA 9-desaturase activity

iron ion binding

iron ion binding

nucleolus

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid biosynthetic process

unsaturated fatty acid biosynthetic process

triglyceride metabolic process

lipid biosynthetic process

response to bacterium

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

palmitoyl-CoA 9-desaturase activity

palmitoyl-CoA 9-desaturase activity

palmitoyl-CoA 9-desaturase activity

cholesterol homeostasis

intracellular membrane-bounded organelle

metal ion binding

sebaceous gland development

defense response to Gram-positive bacterium

white fat cell differentiation

brown fat cell differentiation

lipid homeostasis

sterol homeostasis

response to fatty acid

response to fatty acid

positive regulation of cold-induced thermogenesis

tarsal gland development

monounsaturated fatty acid biosynthetic process

monounsaturated fatty acid biosynthetic process

monounsaturated fatty acid biosynthetic process

monounsaturated fatty acid biosynthetic process

01040

03320

1415822_at Scd2 stearoyl-Coenzyme A desaturase 2 19 44293675 BG060909 57

stearoyl-CoA 9-desaturase activity

stearoyl-CoA 9-desaturase activity

stearoyl-CoA 9-desaturase activity

stearoyl-CoA 9-desaturase activity

iron ion binding

iron ion binding

nucleolus

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid metabolic process

fatty acid metabolic process

fatty acid biosynthetic process

unsaturated fatty acid biosynthetic process

unsaturated fatty acid biosynthetic process

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

palmitoyl-CoA 9-desaturase activity

palmitoyl-CoA 9-desaturase activity

palmitoyl-CoA 9-desaturase activity

intracellular membrane-bounded organelle

metal ion binding

response to fatty acid

response to fatty acid

monounsaturated fatty acid biosynthetic process

monounsaturated fatty acid biosynthetic process

01040

03320

1420764_at Scrg1 scrapie responsive gene 1 8 57455922 NM_009136 23

extracellular region

cytoplasm

Golgi apparatus

Golgi apparatus

neuron projection terminus

neuron projection terminus

 
1448061_at Msr1 macrophage scavenger receptor 1 8 -39581699, -39603451 AA183642 264

amyloid-beta binding

amyloid-beta binding

scavenger receptor activity

collagen trimer

plasma membrane

plasma membrane

endocytosis

receptor-mediated endocytosis

phagocytosis, engulfment

negative regulation of gene expression

positive regulation of macrophage derived foam cell differentiation

positive regulation of cholesterol storage

positive regulation of cholesterol storage

membrane

low-density lipoprotein particle binding

low-density lipoprotein particle binding

cholesterol transport

low-density lipoprotein particle

plasma lipoprotein particle clearance

plasma lipoprotein particle clearance

cargo receptor activity

lipoprotein transport

establishment of localization in cell

amyloid-beta clearance

amyloid-beta clearance

amyloid-beta clearance

04145

1449984_at Cxcl2 C-X-C motif chemokine ligand 2 5 90903898 NM_009140 178

response to molecule of bacterial origin

cytokine activity

extracellular region

extracellular space

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

inflammatory response

immune response

positive regulation of cytosolic calcium ion concentration

chemokine activity

chemokine activity

neutrophil chemotaxis

neutrophil chemotaxis

leukocyte chemotaxis

CXCR chemokine receptor binding

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

04060

04062

04621

1440173_x_at Selp selectin, platelet 1 164115263 BB224329 395

lipopolysaccharide binding

positive regulation of leukocyte migration

positive regulation of leukocyte migration

regulation of cellular extravasation

calcium ion binding

protein binding

extracellular space

extracellular space

plasma membrane

inflammatory response

cell adhesion

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

heparin binding

external side of plasma membrane

external side of plasma membrane

external side of plasma membrane

positive regulation of platelet activation

membrane

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

carbohydrate binding

platelet alpha granule membrane

regulation of integrin activation

sialic acid binding

sialic acid binding

sialic acid binding

response to cytokine

calcium-mediated signaling using intracellular calcium source

fucose binding

positive regulation of cell adhesion

metal ion binding

calcium-dependent protein binding

leukocyte migration

leukocyte migration

leukocyte migration

leukocyte tethering or rolling

leukocyte tethering or rolling

leukocyte tethering or rolling

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

oligosaccharide binding

oligosaccharide binding

cellular response to interleukin-6

cell-cell adhesion

positive regulation of leukocyte tethering or rolling

04514

05144

05150

1439768_x_at Sema4f sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain 6 -82911884 BB271145 33

neural crest cell migration

protein binding

endoplasmic reticulum

plasma membrane

plasma membrane

multicellular organism development

nervous system development

axon guidance

axon guidance

membrane

cell differentiation

semaphorin receptor binding

semaphorin receptor binding

positive regulation of cell migration

negative regulation of axon extension

retinal ganglion cell axon guidance

cell projection

synapse

postsynaptic membrane

chemorepellent activity

axon extension

negative regulation of axon extension involved in axon guidance

negative chemotaxis

semaphorin-plexin signaling pathway

postsynaptic density membrane

glutamatergic synapse

04360

1418747_at Spi1 Spi-1 proto-oncogene 2 91096677, 91096699, 91082404 NM_011355 445

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

chromatin

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity

DNA-binding transcription repressor activity

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

vasculature development

germinal center B cell differentiation

follicular B cell differentiation

lymphoid progenitor cell differentiation

immature B cell differentiation

defense response to tumor cell

pro-T cell differentiation

myeloid leukocyte differentiation

myeloid leukocyte differentiation

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

RNA binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

regulation of DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transforming growth factor beta receptor signaling pathway

multicellular organism development

positive regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

lymphocyte differentiation

cell differentiation

erythrocyte differentiation

macrophage differentiation

granulocyte differentiation

lipopolysaccharide-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

somatic stem cell population maintenance

TRAIL-activated apoptotic signaling pathway

histone deacetylase binding

myeloid dendritic cell differentiation

negative regulation of neutrophil degranulation

sequence-specific DNA binding

sequence-specific DNA binding

negative regulation of MHC class II biosynthetic process

positive regulation of B cell differentiation

regulation of erythrocyte differentiation

transcription initiation-coupled chromatin remodeling

transcription initiation-coupled chromatin remodeling

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of DNA-binding transcription factor activity

NFAT protein binding

anatomical structure regression

molecular adaptor activity

RNA polymerase II-specific DNA-binding transcription factor binding

RNA polymerase II-specific DNA-binding transcription factor binding

interleukin-6-mediated signaling pathway

oncogene-induced cell senescence

STAT family protein binding

endothelial to hematopoietic transition

negative regulation of protein localization to chromatin

DNA-binding transcription factor binding

DNA-binding transcription factor binding

protein sequestering activity

positive regulation of p38MAPK cascade

negative regulation of non-canonical NF-kappaB signal transduction

apoptotic process involved in blood vessel morphogenesis

positive regulation of miRNA transcription

positive regulation of miRNA transcription

positive regulation of microglial cell mediated cytotoxicity

negative regulation of adipose tissue development

pericyte cell differentiation

positive regulation of antifungal innate immune response

regulation of myeloid progenitor cell differentiation

positive regulation of myeloid dendritic cell chemotaxis

04380

05200

05221

1423130_a_at Srsf5 serine and arginine-rich splicing factor 5 12 80945498 AW212917 43

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

cytosol

mRNA processing

RNA splicing

response to wounding

nuclear speck

nuclear speck

response to insulin

positive regulation of RNA splicing

protein kinase B binding

RS domain binding

03040

1423150_at Scg5 secretogranin V 2 -113776312 AK019337 54

enzyme inhibitor activity

extracellular region

nucleus

intracellular protein transport

neuropeptide signaling pathway

peptide hormone processing

secretory granule

enzyme regulator activity

regulation of hormone secretion

regulation of hormone secretion

unfolded protein binding

 
1449393_at Sh2d1a SH2 domain containing 1A X 42502564, 42505321 NM_011364 141

adaptive immune response

immune system process

protein binding

cytoplasm

humoral immune response

cellular defense response

cell-cell signaling

natural killer cell mediated cytotoxicity

natural killer cell mediated cytotoxicity

innate immune response

positive regulation of natural killer cell mediated cytotoxicity

positive regulation of natural killer cell mediated cytotoxicity

regulation of immune response

negative regulation of T cell receptor signaling pathway

04650

1452246_at Ostf1 osteoclast stimulating factor 1 19 -18580363 U58888 34

cytoplasm

signal transduction

SH3 domain binding

 
1416329_at Cyfip1 cytoplasmic FMR1 interacting protein 1 7 55842070 NM_011370 73

RNA 7-methylguanosine cap binding

RNA 7-methylguanosine cap binding

cell morphogenesis

actin binding

protein binding

profilin binding

cytoplasm

regulation of translation

regulation of translation

multicellular organism development

nervous system development

axon guidance

regulation of cell shape

positive regulation of lamellipodium assembly

Rac protein signal transduction

lamellipodium

lamellipodium assembly

lamellipodium assembly

cell differentiation

regulation of actin filament polymerization

neuron projection development

SCAR complex

SCAR complex

small GTPase binding

regulation of myelination

filopodium tip

cellular response to insulin stimulus

cell projection

neuron projection

neuron projection

neuronal cell body

terminal bouton

dendritic spine

dendritic growth cone

axonal growth cone

synapse

synapse

positive regulation of axon extension

perinuclear region of cytoplasm

axon extension

positive regulation of axonogenesis

cognition

positive regulation of neurotrophin TRK receptor signaling pathway

response to electrical stimulus

excitatory synapse

central region of growth cone

peripheral region of growth cone

dendrite extension

postsynapse

modification of synaptic structure

modification of synaptic structure

regulation of translation at postsynapse, modulating synaptic transmission

regulation of translation at postsynapse, modulating synaptic transmission

regulation of translation at postsynapse, modulating synaptic transmission

regulation of translation at postsynapse, modulating synaptic transmission

regulation of translation at postsynapse, modulating synaptic transmission

positive regulation of dendrite development

positive regulation of ruffle assembly

negative regulation of synaptic vesicle recycling

regulation of modification of postsynaptic actin cytoskeleton

regulation of modification of postsynaptic actin cytoskeleton

positive regulation of Arp2/3 complex-mediated actin nucleation

04810

1420928_at St6gal1 beta galactoside alpha 2,6 sialyltransferase 1 16 23226020, 23290469, 23224739 BG075800 87

Golgi trans cisterna

Golgi membrane

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

beta-galactoside alpha-2,6-sialyltransferase activity

extracellular region

Golgi apparatus

Golgi apparatus

Golgi medial cisterna

N-acetylneuraminate metabolic process

protein glycosylation

sialyltransferase activity

sialyltransferase activity

membrane

transferase activity

glycosyltransferase activity

protein N-linked glycosylation via asparagine

protein N-linked glycosylation via asparagine

protein N-linked glycosylation via asparagine

positive regulation of mononuclear cell proliferation

protein homodimerization activity

negative regulation of chemotaxis

sialylation

sialylation

regulation of substrate adhesion-dependent cell spreading

negative regulation of macrophage apoptotic process

00510

00514

01100

1425668_a_at St3gal4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 9 -35046575 AB061305 50

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Golgi apparatus

protein glycosylation

protein glycosylation

protein glycosylation

lipid metabolic process

N-acetyllactosaminide alpha-2,3-sialyltransferase activity

N-acetyllactosaminide alpha-2,3-sialyltransferase activity

sialyltransferase activity

glycoprotein biosynthetic process

glycolipid biosynthetic process

glycolipid biosynthetic process

oligosaccharide biosynthetic process

membrane

transferase activity

glycosyltransferase activity

positive regulation of blood coagulation

lipid glycosylation

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase

cognition

sialylation

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte tethering or rolling

protein sialylation

00601

01100

1455695_at St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 6 -142821540 BI736113 76

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Golgi apparatus

protein glycosylation

protein glycosylation

N-glycan processing

lipid metabolic process

sphingolipid metabolic process

cell population proliferation

sialyltransferase activity

oligosaccharide metabolic process

membrane

transferase activity

glycosyltransferase activity

cellular response to heat

epithelial cell proliferation

positive regulation of epithelial cell proliferation

00601

00603

00604

01100

1419186_a_at St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 1 -95587681, -95627242 NM_009183 66

ganglioside biosynthetic process

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Golgi apparatus

protein glycosylation

protein glycosylation

N-glycan processing

N-glycan processing

sialyltransferase activity

oligosaccharide metabolic process

oligosaccharide metabolic process

membrane

transferase activity

glycosyltransferase activity

sialylation

sialylation

 
1416206_at Sipa1 signal-induced proliferation associated gene 1 19 -5651184 D11374 35

epithelial cell morphogenesis

GTPase activator activity

GTPase activator activity

nucleus

cytoplasm

cytoplasm

Golgi apparatus

plasma membrane

membrane

protein-containing complex

cellular response to water deprivation

regulation of small GTPase mediated signal transduction

regulation of cell cycle

establishment of epithelial cell polarity

04670

1418257_at Slc12a7 solute carrier family 12, member 7 13 73763696, 73763659 BB732135 40

plasma membrane

monoatomic ion transport

potassium ion transport

cell volume homeostasis

cell volume homeostasis

chemical synaptic transmission

ammonium transmembrane transporter activity

symporter activity

potassium:chloride symporter activity

potassium:chloride symporter activity

membrane

protein kinase binding

transmembrane transporter activity

protein-containing complex

chloride ion homeostasis

potassium ion homeostasis

transmembrane transport

cellular response to glucose stimulus

potassium ion transmembrane transport

ammonium import across plasma membrane

chloride transmembrane transport

potassium ion import across plasma membrane

04966

1426599_a_at Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 4 119108744 BM209618 408

Golgi membrane

female germ cell nucleus

photoreceptor inner segment

female pronucleus

long-chain fatty acid transporter activity

glucose transmembrane transporter activity

glucose transmembrane transporter activity

protein binding

intracellular anatomical structure

cytoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

caveola

cell-cell junction

central nervous system development

carbohydrate transport

intercalated disc

long-chain fatty acid import across plasma membrane

membrane

membrane

basolateral plasma membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

apical plasma membrane

kinase binding

transmembrane transporter activity

Z disc

midbody

cortical actin cytoskeleton

vesicle

response to insulin

dehydroascorbic acid transmembrane transporter activity

dehydroascorbic acid transmembrane transporter activity

cellular response to glucose starvation

sarcolemma

identical protein binding

xenobiotic transport

xenobiotic transmembrane transporter activity

protein self-association

membrane raft

synapse

glucose import

glucose import

D-glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

transmembrane transport

protein-containing complex assembly

dehydroascorbic acid transport

dehydroascorbic acid transport

dehydroascorbic acid transport

glucose import across plasma membrane

presynapse

transport across blood-brain barrier

glucose transmembrane transport

glucose transmembrane transport

glucose transporter complex

04920

04976

05200

05211

1455285_at Slc31a1 solute carrier family 31, member 1 4 62360700 BB771765 64

angiogenesis

angiogenesis

copper ion transmembrane transporter activity

copper ion transmembrane transporter activity

copper ion transmembrane transporter activity

copper ion binding

protein binding

endosome

late endosome

plasma membrane

plasma membrane

monoatomic ion transport

copper ion transport

intracellular copper ion homeostasis

intercalated disc

silver ion transmembrane transporter activity

silver ion transmembrane transporter activity

copper ion import

copper ion import

copper ion import

plasma membrane copper ion transport

membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

early endosome membrane

copper ion transmembrane transport

vascular endothelial growth factor receptor-2 signaling pathway

identical protein binding

xenobiotic transport

xenobiotic transport

xenobiotic transmembrane transporter activity

neuronal cell body

protein complex oligomerization

establishment of localization in cell

recycling endosome

recycling endosome membrane

transmembrane transport

cellular response to cisplatin

copper ion import across plasma membrane

silver ion transmembrane transport

silver ion transmembrane transport

 
1416654_at Slc31a2 solute carrier family 31, member 2 4 62291546, 62286428 NM_025286 25

protein binding

lysosome

lysosomal membrane

endosome

late endosome

plasma membrane

monoatomic ion transport

intracellular copper ion homeostasis

intracellular copper ion homeostasis

copper ion import

membrane

cytoplasmic vesicle

late endosome membrane

recycling endosome

regulation of copper ion transmembrane transport

 
1417392_a_at Slc7a7 solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 14 -54369441, -54369441, -54369441, -54369441, -54369441 NM_011405 30

regulation of arginine metabolic process

regulation of arginine metabolic process

amino acid transmembrane transport

plasma membrane

amino acid transport

basic amino acid transmembrane transporter activity

basic amino acid transmembrane transporter activity

L-amino acid transmembrane transporter activity

leucine transport

membrane

basolateral plasma membrane

transmembrane transporter activity

transmembrane transport

L-arginine transmembrane transport

basic amino acid transmembrane transport

04974

1418612_at Slfn1 schlafen 1 11 83116819 NM_011407 22

negative regulation of transcription by RNA polymerase II

negative regulation of protein phosphorylation

adaptive immune response

immune system process

RNA nuclease activity

protein binding

nucleus

nucleus

cytoplasm

cytosol

negative regulation of cell population proliferation

T cell proliferation

negative regulation of T cell proliferation

ribosome binding

regulation of cell cycle

negative regulation of G1/S transition of mitotic cell cycle

negative regulation of G1/S transition of mitotic cell cycle

 
1427102_at Slfn4 schlafen 4 11 83175185 AF099975 23

molecular_function

RNA nuclease activity

cellular_component

nucleus

cytosol

response to bacterium

ribosome binding

 
1448377_at Slpi secretory leukocyte peptidase inhibitor 2 -164354069 NM_011414 66

immune system process

DNA binding

mRNA binding

endopeptidase inhibitor activity

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

Golgi apparatus

immune response

negative regulation of peptidase activity

antibacterial humoral response

antibacterial humoral response

antibacterial humoral response

enzyme binding

peptidase inhibitor activity

negative regulation of protein binding

response to lipopolysaccharide

modulation of process of another organism

defense response to bacterium

negative regulation of viral genome replication

innate immune response

innate immune response

 
1421052_a_at Sms spermine synthase X -157443850, -157443850 NM_009214 33

polyamine biosynthetic process

spermine biosynthetic process

spermine biosynthetic process

spermine metabolic process

S-adenosylmethionine-dependent methyltransferase activity

transferase activity

spermine synthase activity

spermine synthase activity

00270

00330

00410

00480

01100

1429009_at Snrnp70 small nuclear ribonucleoprotein 70 (U1) 7 -45376453 BI689977 49

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

mRNA binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

U1 snRNP

U1 snRNP

nuclear speck

U1 snRNA binding

U1 snRNA binding

regulation of RNA splicing

positive regulation of mRNA splicing, via spliceosome

U2-type prespliceosome

U1 snRNP binding

ribonucleoprotein complex

03040

1420952_at Son Son DNA binding protein 16 91647823, 91647823 BB701473 38

microtubule cytoskeleton organization

mitotic cytokinesis

nucleic acid binding

DNA binding

RNA binding

RNA binding

protein binding

nucleus

mRNA processing

cell cycle

RNA splicing

nuclear speck

negative regulation of apoptotic process

regulation of RNA splicing

regulation of mRNA splicing, via spliceosome

regulation of mRNA splicing, via spliceosome

RS domain binding

regulation of cell cycle

 
1453003_at Sorl1 sortilin-related receptor, LDLR class A repeats-containing 9 -41964708, -41964708 AK013519 87

amyloid-beta binding

diet induced thermogenesis

transmembrane signaling receptor activity

protein binding

extracellular region

extracellular space

extracellular space

nuclear envelope lumen

nuclear envelope lumen

endosome

early endosome

multivesicular body

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

trans-Golgi network

plasma membrane

protein targeting

protein targeting

protein targeting to lysosome

protein targeting to lysosome

post-Golgi vesicle-mediated transport

post-Golgi vesicle-mediated transport

endocytosis

receptor-mediated endocytosis

neuropeptide signaling pathway

multicellular organism development

cell surface

negative regulation of triglyceride catabolic process

regulation of smooth muscle cell migration

membrane

membrane

cell migration

aspartic-type endopeptidase inhibitor activity

aspartic-type endopeptidase inhibitor activity

low-density lipoprotein particle binding

negative regulation of BMP signaling pathway

small GTPase binding

negative regulation of protein-containing complex assembly

cytoplasmic vesicle

Golgi cisterna

protein localization to Golgi apparatus

insulin receptor recycling

insulin receptor recycling

neuropeptide binding

neuronal cell body

protein retention in Golgi apparatus

protein retention in Golgi apparatus

protein retention in Golgi apparatus

positive regulation of protein catabolic process

positive regulation of insulin receptor signaling pathway

positive regulation of insulin receptor signaling pathway

perinuclear region of cytoplasm

negative regulation of neurogenesis

protein maturation

recycling endosome

positive regulation of protein exit from endoplasmic reticulum

perinucleolar compartment

endosome to plasma membrane protein transport

positive regulation of glial cell-derived neurotrophic factor production

positive regulation of glial cell-derived neurotrophic factor production

negative regulation of amyloid-beta formation

negative regulation of amyloid-beta formation

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of early endosome to recycling endosome transport

positive regulation of protein localization to early endosome

negative regulation of amyloid precursor protein catabolic process

negative regulation of amyloid precursor protein catabolic process

negative regulation of neurofibrillary tangle assembly

positive regulation of adipose tissue development

positive regulation of adipose tissue development

adaptive thermogenesis

positive regulation of endocytic recycling

 
1433575_at Sox4 SRY (sex determining region Y)-box 4 13 -28948919 BG083485 201

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

pro-B cell differentiation

mitral valve morphogenesis

cardiac right ventricle morphogenesis

atrial septum primum morphogenesis

noradrenergic neuron differentiation

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

cytoplasm

cytoplasm

mitochondrion

regulation of DNA-templated transcription

regulation of DNA-templated transcription

nervous system development

brain development

heart development

positive regulation of cell population proliferation

negative regulation of cell population proliferation

gene expression

glial cell proliferation

spinal cord development

glial cell development

neuron differentiation

T cell differentiation

endocrine pancreas development

negative regulation of protein ubiquitination

regulation of protein stability

positive regulation of insulin secretion

somatic stem cell population maintenance

miRNA binding

ascending aorta morphogenesis

glucose homeostasis

positive regulation of apoptotic process

regulation of DNA damage response, signal transduction by p53 class mediator

positive regulation of gamma-delta T cell differentiation

negative regulation of myoblast differentiation

positive regulation of myoblast differentiation

positive regulation of myoblast differentiation

positive regulation of translation

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

sympathetic nervous system development

camera-type eye morphogenesis

protein stabilization

protein stabilization

ventricular septum morphogenesis

mesenchyme development

neuroepithelial cell differentiation

kidney morphogenesis

hematopoietic stem cell homeostasis

cellular response to glucose stimulus

positive regulation of canonical Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

sequence-specific double-stranded DNA binding

positive regulation of N-terminal peptidyl-lysine acetylation

 
1424923_at Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G 12 104236146, 104214453 BC002065 30

adaptive immune response

immune system process

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular space

extracellular space

nucleus

cytoplasm

apoptotic process

negative regulation of peptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

response to cytokine

response to peptide hormone

 
1456615_a_at Bptf bromodomain PHD finger transcription factor 11 -107033080 AA867746 58

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

embryonic placenta development

nucleus

nucleus

nucleoplasm

chromatin remodeling

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

brain development

brain development

endoderm development

ATP-dependent activity, acting on DNA

transcription factor binding

anterior/posterior pattern specification

NURF complex

NURF complex

dendrite

methylated histone binding

sequence-specific DNA binding

cell body

positive regulation of transcription by RNA polymerase II

perinuclear region of cytoplasm

ATPase complex

 
1422601_at Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 13 33004540 NM_009256 41

T cell mediated cytotoxicity

protease binding

acute inflammatory response to antigenic stimulus

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

protein binding

extracellular space

extracellular space

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

cytosol

immune response

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

protection from natural killer cell mediated cytotoxicity

defense response to bacterium

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

collagen-containing extracellular matrix

negative regulation of T cell apoptotic process

05146

1434260_at Fchsd2 FCH and double SH3 domains 2 7 101108774 BB461848 20

protein binding

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

plasma membrane

clathrin-coated pit

endocytosis

neuromuscular synaptic transmission

lipid binding

protein transport

membrane

regulation of actin filament polymerization

positive regulation of actin filament polymerization

neuromuscular junction

cell projection

phosphatidylinositol-3,4-bisphosphate binding

recycling endosome

membrane organization

anchoring junction

clathrin-dependent endocytosis

stereocilium shaft

positive regulation of Arp2/3 complex-mediated actin nucleation

 
1415794_a_at Spin1 spindlin 1 13 51134317, 51100879, 51101546 BM228780 40

DNA binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

spindle

cytosol

cytosol

cytoskeleton

chromatin organization

regulation of DNA-templated transcription

cell cycle

female meiotic nuclear division

multicellular organism development

gamete generation

rRNA transcription

Wnt signaling pathway

positive regulation of Wnt signaling pathway

nuclear membrane

methylated histone binding

methylated histone binding

positive regulation of DNA-templated transcription

meiotic cell cycle

 
1438968_x_at Spint2 serine protease inhibitor, Kunitz type 2 7 -29256329 AV058358 44

neural tube closure

neural tube closure

serine-type endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

cytoplasm

plasma membrane

establishment or maintenance of cell polarity

negative regulation of peptidase activity

membrane

negative regulation of cell-cell adhesion

peptidase inhibitor activity

epithelial cell morphogenesis involved in placental branching

epithelial cell morphogenesis involved in placental branching

basement membrane organization

negative regulation of cell motility

negative regulation of neural precursor cell proliferation

 
1426411_a_at Strbp spermatid perinuclear RNA binding protein 2 -37569867, -37569867, -37569867, -37569867 AK006314 32

manchette

RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

nucleus

cytoplasm

cytoskeleton

multicellular organism development

spermatogenesis

spermatid development

mechanosensory behavior

microtubule binding

microtubule cytoskeleton

tubulin binding

cell differentiation

cell motility

 
1449254_at Spp1 secreted phosphoprotein 1 5 104435110, 104436191 NM_009263 938

ossification

osteoblast differentiation

osteoblast differentiation

cytokine activity

integrin binding

integrin binding

extracellular region

extracellular space

extracellular space

cytoplasm

Golgi apparatus

androgen catabolic process

intracellular calcium ion homeostasis

intracellular sodium ion homeostasis

cell adhesion

cell adhesion

response to organic substance

positive regulation of cell-substrate adhesion

bone mineralization

bone mineralization

neutrophil chemotaxis

neutrophil chemotaxis

intracellular phosphate ion homeostasis

intracellular chloride ion homeostasis

biomineral tissue development

vesicle

response to vitamin D

urate biosynthetic process

small molecule binding

cell projection

negative regulation of apoptotic process

ion binding

apical part of cell

positive regulation of bone resorption

positive regulation of bone resorption

positive regulation of DNA-templated transcription

perinuclear region of cytoplasm

response to steroid hormone

extracellular matrix binding

extracellular matrix binding

calcium ion homeostasis

cellular response to testosterone stimulus

cellular response to fluid shear stress

collecting duct development

cellular response to leukemia inhibitory factor

positive regulation of estradiol secretion

04510

04512

04620

1437378_x_at Scarb1 scavenger receptor class B, member 1 5 -125277086, -125283319 BB224405 393

lipopolysaccharide binding

amyloid-beta binding

phosphatidylserine binding

lipopolysaccharide immune receptor activity

endothelial cell proliferation

scavenger receptor activity

cytoplasm

cytoplasm

lysosome

plasma membrane

plasma membrane

plasma membrane

plasma membrane

caveola

caveola

androgen biosynthetic process

cholesterol catabolic process

cholesterol catabolic process

lipid transport

phagocytosis, recognition

high-density lipoprotein particle binding

lipid binding

cell surface

cell surface

positive regulation of triglyceride biosynthetic process

positive regulation of cholesterol storage

positive regulation of cholesterol storage

regulation of phosphatidylcholine catabolic process

phospholipid transport

lipopolysaccharide transport

membrane

low-density lipoprotein particle binding

low-density lipoprotein particle binding

low-density lipoprotein particle binding

cholesterol transport

cholesterol transport

microvillus membrane

detection of lipopolysaccharide

cholesterol efflux

cholesterol efflux

cholesterol efflux

cholesterol efflux

apolipoprotein binding

apolipoprotein binding

apolipoprotein A-I binding

high-density lipoprotein particle remodeling

plasma lipoprotein particle clearance

low-density lipoprotein particle clearance

high-density lipoprotein particle clearance

high-density lipoprotein particle clearance

vitamin transmembrane transport

cholesterol homeostasis

identical protein binding

intracellular membrane-bounded organelle

blood vessel endothelial cell migration

recognition of apoptotic cell

recognition of apoptotic cell

recognition of apoptotic cell

reverse cholesterol transport

adhesion of symbiont to host

carotenoid transport

regulation of phagocytosis

positive regulation of nitric-oxide synthase activity

triglyceride homeostasis

high-density lipoprotein particle receptor activity

high-density lipoprotein particle receptor activity

cholesterol import

cholesterol import

cholesterol import

cholesterol import

intestinal lipid absorption

04145

04975

04976

04977

05160

1428681_at Usf3 upstream transcription factor family member 3 16 44173396 AK017426 16

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial to mesenchymal transition

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

 
1456500_at Aph1b aph1 homolog B, gamma secretase subunit 9 -66775486 AV232784 35

Golgi membrane

synaptic transmission, dopaminergic

endoplasmic reticulum

endoplasmic reticulum

plasma membrane

membrane protein ectodomain proteolysis

Notch signaling pathway

Notch signaling pathway

Notch receptor processing

Notch receptor processing

Notch receptor processing

short-term memory

locomotory behavior

positive regulation of endopeptidase activity

membrane

protein processing

protein processing

transport vesicle

protein-macromolecule adaptor activity

protein-macromolecule adaptor activity

amyloid-beta formation

amyloid-beta formation

synaptic transmission, glutamatergic

amyloid precursor protein catabolic process

positive regulation of catalytic activity

prepulse inhibition

endopeptidase activator activity

gamma-secretase complex

gamma-secretase complex

gamma-secretase complex

gamma-secretase complex

04330

05010

1455107_at Srpk1 serine/arginine-rich protein specific kinase 1 17 -28589587 BQ176926 38

nucleotide binding

spliceosomal complex assembly

magnesium ion binding

magnesium ion binding

chromatin

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

chromosome

cytoplasm

cytoplasm

endoplasmic reticulum

cytosol

plasma membrane

mRNA processing

protein phosphorylation

protein phosphorylation

chromosome segregation

RNA splicing

kinase activity

phosphorylation

nuclear speck

transferase activity

peptidyl-serine phosphorylation

cell differentiation

intracellular signal transduction

intracellular signal transduction

intracellular signal transduction

intracellular membrane-bounded organelle

positive regulation of viral genome replication

negative regulation of viral genome replication

regulation of mRNA processing

regulation of mRNA processing

regulation of mRNA processing

protein serine kinase activity

 
1455656_at Btla B and T lymphocyte associated 16 45224336 BM240873 80

adaptive immune response

immune system process

immune response-regulating cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway

protein binding

plasma membrane

plasma membrane

cell surface receptor signaling pathway

external side of plasma membrane

membrane

negative regulation of B cell proliferation

signaling receptor activity

signaling receptor activity

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

 
1450033_a_at Stat1 signal transducer and activator of transcription 1 1 52119437, 52119621 AW214029 996

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription corepressor binding

transcription coactivator binding

negative regulation of endothelial cell proliferation

positive regulation of defense response to virus by host

DNA binding

double-stranded DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

tumor necrosis factor receptor binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytoplasm

cytosol

cytosol

DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

activation of cysteine-type endopeptidase activity involved in apoptotic process

defense response

signal transduction

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

cell population proliferation

response to bacterium

macrophage derived foam cell differentiation

negative regulation of angiogenesis

nuclear receptor binding

cytokine-mediated signaling pathway

enzyme binding

axon

dendrite

lipopolysaccharide-mediated signaling pathway

CCR5 chemokine receptor binding

response to lipopolysaccharide

positive regulation of interferon-alpha production

protein-containing complex

tumor necrosis factor-mediated signaling pathway

negative regulation of macrophage fusion

response to type I interferon

response to type II interferon

response to type II interferon

histone acetyltransferase binding

response to interferon-beta

cellular response to interferon-beta

interleukin-9-mediated signaling pathway

regulation of cell population proliferation

histone binding

identical protein binding

protein homodimerization activity

negative regulation of canonical NF-kappaB signal transduction

response to exogenous dsRNA

response to peptide hormone

sequence-specific DNA binding

ubiquitin-like protein ligase binding

positive regulation of erythrocyte differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

negative regulation by virus of viral protein levels in host cell

perinuclear region of cytoplasm

defense response to virus

defense response to virus

protein phosphatase 2A binding

type II interferon-mediated signaling pathway

type II interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

renal tubule development

interleukin-27-mediated signaling pathway

ISGF3 complex

cellular response to lipopolysaccharide

cellular response to cytokine stimulus

cellular response to type II interferon

cellular response to organic cyclic compound

RNA polymerase II transcription regulator complex

promoter-specific chromatin binding

04062

04380

04620

04630

05140

05145

05160

05200

05212

1450403_at Stat2 signal transducer and activator of transcription 2 10 128270497 AF088862 139

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

regulation of protein phosphorylation

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

cytoplasm

cytosol

plasma membrane

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

defense response

signal transduction

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

regulation of cell population proliferation

identical protein binding

response to peptide hormone

ubiquitin-like protein ligase binding

positive regulation of transcription by RNA polymerase II

defense response to virus

type I interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

ISGF3 complex

regulation of mitochondrial fission

04062

04380

04630

05160

1442083_at Rsrc2 arginine/serine-rich coiled-coil 2 5 -123728425 BB036922 22

molecular_function

cellular_component

biological_process

 
1419709_at Stfa3 stefin A3 16 -36450536 NM_025288 16

cornified envelope

protease binding

cysteine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular space

nucleoplasm

cytoplasm

cytosol

cytosol

negative regulation of peptidase activity

peptide cross-linking

keratinocyte differentiation

negative regulation of proteolysis

cell-cell adhesion

peptidase inhibitor complex

 
1427983_at Zfp280c zinc finger protein 280C X -48541625, -48541625 AI504060 18

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

regulation of DNA-templated transcription

metal ion binding

 
1437390_x_at Stx1a syntaxin 1A (brain) 5 135023481 AV339210 209

SNARE binding

SNARE binding

SNARE binding

acrosomal vesicle

positive regulation of neurotransmitter secretion

positive regulation of neurotransmitter secretion

SNAP receptor activity

SNAP receptor activity

protein binding

plasma membrane

plasma membrane

plasma membrane

plasma membrane

neurotransmitter transport

intracellular protein transport

intracellular protein transport

exocytosis

exocytosis

synaptic vesicle

synaptic vesicle

voltage-gated potassium channel complex

response to gravity

positive regulation of norepinephrine secretion

regulation of synaptic vesicle priming

endomembrane system

postsynaptic density

membrane

synaptic vesicle exocytosis

synaptic vesicle exocytosis

synaptic vesicle exocytosis

vesicle-mediated transport

protein sumoylation

myosin binding

calcium-ion regulated exocytosis

regulation of exocytosis

calcium channel inhibitor activity

chloride channel inhibitor activity

kinase binding

insulin secretion

secretory granule

axon

synaptic vesicle membrane

synaptic vesicle membrane

protein-macromolecule adaptor activity

SNARE complex

SNARE complex

cytoplasmic vesicle

synaptic vesicle fusion to presynaptic active zone membrane

synaptic vesicle fusion to presynaptic active zone membrane

nuclear membrane

myosin head/neck binding

secretion by cell

protein-containing complex

positive regulation of catecholamine secretion

SNARE complex assembly

actomyosin

presynaptic membrane

identical protein binding

neuron projection

neuron projection

ATP-dependent protein binding

transmembrane transporter binding

protein-containing complex binding

regulated exocytosis

synapse

positive regulation of exocytosis

positive regulation of calcium ion-dependent exocytosis

hormone secretion

vesicle docking

vesicle docking

calcium-dependent protein binding

synaptic vesicle endocytosis

presynaptic active zone membrane

presynaptic active zone membrane

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

synaptobrevin 2-SNAP-25-syntaxin-1a complex

synaptobrevin 2-SNAP-25-syntaxin-1a complex

protein localization to membrane

Schaffer collateral - CA1 synapse

presynapse

modulation of excitatory postsynaptic potential

postsynaptic density membrane

glutamatergic synapse

positive regulation of excitatory postsynaptic potential

04130

1456479_at Snx30 sorting nexin family member 30 4 59805649 BB359719 16

phagophore assembly site

autophagy of mitochondrion

cytoplasm

endosome

early endosome

early endosome

protein transport

protein transport

membrane

endocytic recycling

piecemeal microautophagy of the nucleus

phosphatidylinositol binding

reticulophagy

positive regulation of autophagosome assembly

 
1439825_at Dtx3l deltex 3-like, E3 ubiquitin ligase 16 -35926514 BB705351 19

DNA damage checkpoint signaling

positive regulation of defense response to virus by host

immune system process

ubiquitin-protein transferase activity

enzyme inhibitor activity

nucleus

nucleoplasm

cytoplasm

lysosome

endosome

early endosome

cytosol

DNA repair

double-strand break repair

chromatin organization

ubiquitin-dependent protein catabolic process

DNA damage response

Notch signaling pathway

endosome to lysosome transport

protein transport

membrane

protein ubiquitination

transferase activity

enzyme binding

positive regulation of protein binding

protein-containing complex

positive regulation of chromatin binding

histone binding

ubiquitin-like protein ligase binding

innate immune response

positive regulation of DNA-templated transcription

metal ion binding

negative regulation of ubiquitin-protein transferase activity

defense response to virus

protein autoubiquitination

protein K48-linked ubiquitination

STAT family protein binding

protein ADP-ribosyltransferase-substrate adaptor activity

histone ubiquitin ligase activity

DNA repair-dependent chromatin remodeling

histone H4K91 ubiquitin ligase activity

positive regulation of protein localization to nucleus

positive regulation of protein localization to early endosome

positive regulation of receptor catabolic process

04330

1435665_at Trim30d tripartite motif-containing 30D 7 -104470013 BM241342 13

protein polyubiquitination

P-body

activation of innate immune response

transcription coactivator activity

ubiquitin-protein transferase activity

nucleoplasm

cytoplasm

cytoplasm

cytosol

autophagy

positive regulation of autophagy

protein kinase binding

protein kinase binding

protein-macromolecule adaptor activity

regulation of lipopolysaccharide-mediated signaling pathway

regulation of protein localization

regulation of protein localization

pattern recognition receptor activity

identical protein binding

protein homodimerization activity

protein homodimerization activity

positive regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade

suppression of viral release by host

innate immune response

innate immune response

regulation of viral entry into host cell

negative regulation of viral entry into host cell

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

ubiquitin protein ligase activity

protein K63-linked ubiquitination

omegasome

 
1423543_at Swap70 SWA-70 protein 7 110221702 AK019882 65

DNA binding

protein binding

ATP binding

nucleus

nucleus

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

positive regulation of cytosolic calcium ion concentration

regulation of actin polymerization or depolymerization

actin cytoskeleton

membrane

somatic cell DNA recombination

negative regulation of actin filament depolymerization

positive regulation of actin filament bundle assembly

regulation of protein localization

negative regulation of cell-cell adhesion mediated by integrin

cell projection

isotype switching

actin filament bundle assembly

positive regulation of mast cell chemotaxis

negative regulation of peptidyl-serine dephosphorylation

 
1424356_a_at Metrnl meteorin, glial cell differentiation regulator-like 11 121702426 BC024445 41

hormone activity

hormone activity

extracellular region

extracellular space

extracellular space

extracellular space

response to cold

response to muscle activity

fat cell differentiation

negative regulation of inflammatory response

brown fat cell differentiation

positive regulation of brown fat cell differentiation

positive regulation of brown fat cell differentiation

energy homeostasis

energy homeostasis

 
1435343_at Dock10 dedicator of cytokinesis 10 1 -80501067, -80501067 BF715043 32

B cell homeostasis

marginal zone B cell differentiation

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

nucleus

nucleoplasm

cytoplasm

cytosol

small GTPase-mediated signal transduction

regulation of cell migration

regulation of cell migration

small GTPase binding

cell projection

dendritic spine

positive regulation of GTPase activity

positive regulation of GTPase activity

synapse

dendritic spine morphogenesis

dendritic spine morphogenesis

postsynapse

postsynapse

glutamatergic synapse

glutamatergic synapse

 
1436423_at Themis thymocyte selection associated 10 28668359, 28668359, 28668394 BE628523 42

adaptive immune response

immune system process

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cell-cell junction

multicellular organism development

COP9 signalosome

positive T cell selection

negative T cell selection

T cell receptor signaling pathway

T cell receptor signaling pathway

 
1435545_at Bicral BRD4 interacting chromatin remodeling complex associated protein like 17 -46798115 BB242234 21

chromatin

chromatin remodeling

regulation of transcription by RNA polymerase II

positive regulation of cell population proliferation

SWI/SNF complex

SWI/SNF complex

SWI/SNF complex

negative regulation of cell differentiation

positive regulation of DNA-templated transcription

GBAF complex

positive regulation of stem cell population maintenance

 
1442135_at Ado 2-aminoethanethiol dioxygenase 10 -67544510 AA839814 20

iron ion binding

iron ion binding

iron ion binding

protein binding

mitochondrion

oxidoreductase activity

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

metal ion binding

cysteamine dioxygenase activity

cysteamine dioxygenase activity

dioxygenase activity

cellular response to hypoxia

00430

01100

1437253_at Dennd6a DENN domain containing 6A 14 26573857, 26579549, 26579549 BB235551 18

guanyl-nucleotide exchange factor activity

cytoplasm

endosome

intracellular membrane-bounded organelle

recycling endosome

recycling endosome

positive regulation of cell-cell adhesion mediated by cadherin

 
1451234_at Fam193b family with sequence similarity 193, member B 13 -55539315 BC021381 18

molecular_function

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytoplasm

cytoplasm

biological_process

nuclear speck

 
1436397_at Tifab TRAF-interacting protein with forkhead-associated domain, family member B 13 -56173702 BB040051 14

toll-like receptor signaling pathway

hematopoietic progenitor cell differentiation

canonical NF-kappaB signal transduction

thorax and anterior abdomen determination

regulation of gene expression

trigeminal nerve development

vestibulocochlear nerve formation

myeloid cell differentiation

myeloid cell differentiation

peristalsis

auditory behavior

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

genitalia morphogenesis

deubiquitinase activator activity

inner ear morphogenesis

regulation of muscle organ development

genitalia development

inner ear development

neuromuscular process controlling balance

mastication

cochlea development

cochlea morphogenesis

craniofacial suture morphogenesis

learned vocalization behavior

negative regulation of relaxation of muscle

regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

negative regulation of saliva secretion

hard palate morphogenesis

 
1440865_at Ifitm6 interferon induced transmembrane protein 6 7 -141015811 BB193024 19

molecular_function

plasma membrane

response to type II interferon

response to interferon-alpha

response to interferon-beta

negative regulation of viral genome replication

negative regulation of viral entry into host cell

defense response to virus

type I interferon-mediated signaling pathway

 
1455110_at Gabpb2 GA repeat binding protein, beta 2 3 -95181765 AW536205 28

transcription cis-regulatory region binding

transcription cis-regulatory region binding

nucleus

nucleus

identical protein binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

 
1447792_x_at Gpr174 G protein-coupled receptor 174 X 107255877, 107284345 BB241847 22

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

centriolar satellite

positive regulation of Rho protein signal transduction

T cell homeostasis

intracellular membrane-bounded organelle

bioactive lipid receptor activity

 
1455042_at Tbl1x transducin (beta)-like 1 X-linked X 77511226 BF682509 41

histone deacetylase complex

histone deacetylase complex

transcription cis-regulatory region binding

transcription cis-regulatory region binding

DNA binding

chromatin binding

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription repressor complex

histone binding

identical protein binding

proteasome-mediated ubiquitin-dependent protein catabolic process

response to estrogen

fat cell differentiation

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

response to steroid hormone

protein stabilization

mitotic spindle

04310

1427670_a_at Tcf12 transcription factor 12 9 -71844251, -71844251, -71844251 M97636 137

chromatin

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleoplasm

transcription regulator complex

transcription regulator complex

cytoplasm

regulation of transcription by RNA polymerase II

multicellular organism development

nervous system development

gene expression

positive regulation of gene expression

nuclear speck

cell differentiation

cAMP response element binding

intracellular membrane-bounded organelle

bHLH transcription factor binding

positive regulation of neuron differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

SMAD binding

protein heterodimerization activity

protein dimerization activity

E-box binding

HMG box domain binding

RNA polymerase II transcription regulator complex

response to gonadotropin-releasing hormone

DNA-binding transcription factor binding

sequence-specific double-stranded DNA binding

 
1434148_at Tcf4 transcription factor 4 18 69345720, 69344491, 69346159 BB364520 241

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

TFIIB-class transcription factor binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

transcription corepressor activity

protein binding

nucleus

nucleus

transcription regulator complex

transcription regulator complex

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

multicellular organism development

nervous system development

beta-catenin binding

negative regulation of gene expression

negative regulation of angiogenesis

cell differentiation

endothelial cell activation

identical protein binding

bHLH transcription factor binding

protein self-association

positive regulation of neuron differentiation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

protein dimerization activity

protein-DNA complex assembly

beta-catenin-TCF7L2 complex

E-box binding

regulation of vascular endothelial growth factor signaling pathway

sequence-specific double-stranded DNA binding

beta-catenin-TCF complex

 
1433471_at Tcf7 transcription factor 7, T cell specific 11 -52252282, -52252282 AI323642 282

negative regulation of transcription by RNA polymerase II

euchromatin

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

beta-catenin binding

Wnt signaling pathway

nuclear body

neural tube development

embryonic genitalia morphogenesis

T cell receptor V(D)J recombination

regulation of cell population proliferation

gamma-delta T cell differentiation

negative regulation of apoptotic process

canonical Wnt signaling pathway involved in negative regulation of apoptotic process

regulation of gamma-delta T cell differentiation

alpha-beta T cell differentiation

embryonic digestive tract morphogenesis

embryonic hindgut morphogenesis

canonical Wnt signaling pathway

canonical Wnt signaling pathway

cellular response to interleukin-4

sequence-specific double-stranded DNA binding

beta-catenin-TCF complex

04310

04520

04916

05200

05210

05213

05215

05216

05217

05221

05412

1429428_at Tcf7l2 transcription factor 7 like 2, T cell specific, HMG box 19 55741809, 55895320 BB175494 286

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

blood vessel development

intracellular glucose homeostasis

in utero embryonic development

DNA binding

chromatin binding

chromatin binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

cytosol

glycogen metabolic process

glucose metabolic process

regulation of gluconeogenesis

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

beta-catenin binding

beta-catenin binding

beta-catenin binding

fibroblast growth factor receptor signaling pathway

cellular response to starvation

response to glucose

post-embryonic development

positive regulation of epithelial to mesenchymal transition

positive regulation of triglyceride biosynthetic process

positive regulation of heparan sulfate proteoglycan biosynthetic process

oligodendrocyte development

Wnt signaling pathway

nuclear receptor binding

protein kinase binding

neural tube development

pituitary gland development

bone mineralization

BMP signaling pathway

negative regulation of BMP signaling pathway

embryonic genitalia morphogenesis

regulation of myelination

positive regulation of insulin secretion

positive regulation of insulin secretion

positive regulation of protein binding

secretory granule localization

regulation of hormone metabolic process

protein-DNA complex

somatic stem cell population maintenance

somatic stem cell population maintenance

multicellular organism growth

organ growth

negative regulation of fibroblast growth factor receptor signaling pathway

odontogenesis of dentin-containing tooth

glucose homeostasis

glucose homeostasis

positive regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

sequence-specific DNA binding

sequence-specific DNA binding

maintenance of DNA repeat elements

skin development

gamma-catenin binding

fat cell differentiation

negative regulation of fat cell differentiation

negative regulation of gluconeogenesis

positive regulation of gluconeogenesis

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of organ growth

positive regulation of lipid biosynthetic process

embryonic digestive tract morphogenesis

embryonic hindgut morphogenesis

myoblast fate commitment

myoblast fate commitment

regulation of skeletal muscle tissue development

regulation of smooth muscle cell proliferation

regulation of oligodendrocyte differentiation

epithelial cell proliferation

positive regulation of epithelial cell proliferation

positive regulation of epithelial cell proliferation

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

canonical Wnt signaling pathway

face morphogenesis

regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus

RNA polymerase II-specific DNA-binding transcription factor binding

armadillo repeat domain binding

beta-catenin-TCF7L2 complex

catenin-TCF7L2 complex

catenin-TCF7L2 complex

negative regulation of canonical Wnt signaling pathway

positive regulation of protein localization to nucleus

insulin metabolic process

promoter-specific chromatin binding

beta-catenin-TCF complex

negative regulation of type B pancreatic cell apoptotic process

negative regulation of extrinsic apoptotic signaling pathway

04310

04520

04916

05200

05210

05213

05215

05216

05217

05221

05412

1452377_at Kmt2a lysine (K)-specific methyltransferase 2A 9 -44803354 AK017541 226

DNA binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

cytosol

DNA methylation

chromatin organization

regulation of DNA-templated transcription

methyltransferase activity

zinc ion binding

visual learning

response to light stimulus

post-embryonic development

anterior/posterior pattern specification

anterior/posterior pattern specification

regulation of gene expression

positive regulation of gene expression

transferase activity

peptidyl-lysine monomethylation

methylation

circadian regulation of gene expression

histone methyltransferase complex

histone methyltransferase complex

embryonic hemopoiesis

exploration behavior

protein modification process

histone H3K4 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 methyltransferase activity

histone H3K4 methyltransferase activity

identical protein binding

protein homodimerization activity

T-helper 2 cell differentiation

unmethylated CpG binding

transcription initiation-coupled chromatin remodeling

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

fibroblast proliferation

negative regulation of fibroblast proliferation

regulation of short-term neuronal synaptic plasticity

rhythmic process

spleen development

homeostasis of number of cells within a tissue

cognition

definitive hemopoiesis

protein-containing complex assembly

lysine-acetylated histone binding

MLL1 complex

cellular response to transforming growth factor beta stimulus

negative regulation of DNA methylation-dependent heterochromatin formation

protein-cysteine methyltransferase activity

DNA-binding transcription factor binding

histone H3K4 monomethyltransferase activity

histone H3K4 trimethyltransferase activity

 
1426297_at Tcf3 transcription factor 3 10 -80409540 AF352579 346

negative regulation of transcription by RNA polymerase II

chromatin

nucleosome

euchromatin

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

natural killer cell differentiation

B cell lineage commitment

DNA binding

chromatin binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

transcription regulator complex

transcription regulator complex

transcription regulator complex

cytoplasm

cytosol

chromatin remodeling

regulation of DNA-templated transcription

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

gastrulation

nervous system development

response to xenobiotic stimulus

gene expression

positive regulation of gene expression

positive regulation of gene expression

lymphocyte differentiation

cell differentiation

PDZ domain binding

erythrocyte differentiation

positive regulation of B cell proliferation

mitogen-activated protein kinase kinase kinase binding

response to lipopolysaccharide

protein-containing complex

T cell differentiation in thymus

immunoglobulin V(D)J recombination

immunoglobulin V(D)J recombination

immunoglobulin V(D)J recombination

identical protein binding

protein homodimerization activity

bHLH transcription factor binding

bHLH transcription factor binding

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of neuron differentiation

positive regulation of cell cycle

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

protein heterodimerization activity

protein dimerization activity

cell development

Peyer's patch development

protein stabilization

positive regulation of DNA-binding transcription factor activity

RNA polymerase II-specific DNA-binding transcription factor binding

RNA polymerase II-specific DNA-binding transcription factor binding

vitamin D response element binding

E-box binding

E-box binding

E-box binding

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

DNA-binding transcription factor binding

regulation of G1/S transition of mitotic cell cycle

 
1419537_at Tfec transcription factor EC 6 -16833380 NM_031198 34

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

nucleoplasm

cytosol

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

cellular response to heat

positive regulation of transcription by RNA polymerase II

protein dimerization activity

sequence-specific double-stranded DNA binding

 
1434339_at Fnbp1l formin binding protein 1-like 3 -122538718 AW548221 30

cytoplasm

cytosol

cytoskeleton

plasma membrane

endocytosis

vesicle budding from membrane

autophagy

signal transduction

lipid binding

membrane invagination

membrane

vesicle organization

vesicle transport along actin filament

cytoplasmic vesicle

GTPase binding

positive regulation of filopodium assembly

cilium assembly

clathrin-dependent endocytosis

plasma membrane tubulation

 
1457825_x_at Tcn2 transcobalamin 2 11 -3917079, -3917077, -3917079 BB515151 40

extracellular region

extracellular space

extracellular space

extracellular space

extracellular space

monoatomic ion transport

cobalt ion transport

external side of plasma membrane

cobalamin transport

cobalamin transport

cobalamin transport

cobalamin binding

cobalamin binding

cobalamin binding

metal ion binding

molecular carrier activity

cargo receptor ligand activity

cargo receptor ligand activity

04977

1444003_at Neurl3 neuralized E3 ubiquitin protein ligase 3 1 -36264601 AW610818 18

immune system process

cytoplasm

early endosome

protein ubiquitination

transferase activity

innate immune response

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin-dependent endocytosis

 
1437105_at Kdm5a lysine demethylase 5A 6 120364098 BM246184 59

negative regulation of transcription by RNA polymerase II

chromatin

transcription cis-regulatory region binding

DNA binding

chromatin binding

transcription coactivator activity

enzyme inhibitor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

chromatin organization

chromatin remodeling

regulation of DNA-templated transcription

multicellular organism development

zinc ion binding

oxidoreductase activity

chromatin DNA binding

histone H3K4 demethylase activity

circadian regulation of gene expression

protein-DNA complex

histone H3K4me/H3K4me2/H3K4me3 demethylase activity

histone H3K4me/H3K4me2/H3K4me3 demethylase activity

methylated histone binding

histone binding

positive regulation of DNA-templated transcription

metal ion binding

rhythmic process

regulation of DNA-binding transcription factor activity

dioxygenase activity

facultative heterochromatin formation

 
1452099_at Utp25 UTP25 small subunit processome component 1 -193104399, -193104402, -193104402, -193115655 BG070043 24

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nucleus

nucleolus

nucleolus

rRNA processing

multicellular organism development

rRNA binding

protein catabolic process

protein destabilization

small-subunit processome

U3 snoRNA binding

U3 snoRNA binding

positive regulation of embryonic development

embryonic organ development

protein localization to nucleolus

 
1434573_at Traf3ip3 TRAF3 interacting protein 3 1 -193175503 BE986588 27

Golgi membrane

cytoplasmic pattern recognition receptor signaling pathway

mitochondrion

mitochondrial outer membrane

lysosome

endoplasmic reticulum membrane

Golgi apparatus

plasma membrane

membrane

mitochondrial membrane

positive regulation of type I interferon production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

cellular response to interferon-alpha

cellular response to interferon-beta

regulation of protein homodimerization activity

zf-TRAF domain binding

molecular adaptor activity

antiviral innate immune response

 
1425958_at Il36g interleukin 36G 2 24186475 AY071843 46

cytokine production

positive regulation of cytokine production

immune system process

inflammatory response to antigenic stimulus

cytokine activity

cytokine activity

extracellular region

extracellular space

extracellular space

nucleoplasm

cytoplasm

cytosol

plasma membrane

inflammatory response

immune response

positive regulation of gene expression

cytokine-mediated signaling pathway

interleukin-6 production

positive regulation of interleukin-6 production

innate immune response

negative regulation of myoblast differentiation

cellular response to lipopolysaccharide

negative regulation of myoblast fusion

 
1451243_at Rnpep arginyl aminopeptidase (aminopeptidase B) 1 -135262698 BC019200 22

aminopeptidase activity

copper ion binding

extracellular region

extracellular space

extracellular space

plasma membrane

proteolysis

proteolysis

peptidase activity

metallopeptidase activity

zinc ion binding

external side of plasma membrane

protein processing

hydrolase activity

secretory granule

peptide binding

negative regulation of blood pressure

metal ion binding

cobalt ion binding

metalloaminopeptidase activity

metalloaminopeptidase activity

 
1434404_at Miga1 mitoguardin 1 3 -152273459 BB375245 23

mitochondrion

mitochondrial outer membrane

plasma membrane

mitochondrial fusion

mitochondrial fusion

mitochondrial fusion

membrane

protein homodimerization activity

protein heterodimerization activity

 
1426159_x_at Tcrb-J T cell receptor beta, joining region 6   U46841 50    
1454658_at Ilvbl ilvB (bacterial acetolactate synthase)-like 10 78574512, 78574499, 78574990, 78574990 BI408416 19

magnesium ion binding

fatty acid alpha-oxidation

catalytic activity

acetolactate synthase activity

endoplasmic reticulum

endoplasmic reticulum membrane

acetolactate synthase complex

lipid metabolic process

fatty acid metabolic process

isoleucine biosynthetic process

valine biosynthetic process

membrane

lyase activity

thiamine pyrophosphate binding

metal ion binding

flavin adenine dinucleotide binding

 
1437377_a_at Polrmt polymerase (RNA) mitochondrial (DNA directed) 10 -79736124 BB739221 29

3'-5'-RNA exonuclease activity

DNA-directed RNA polymerase complex

mitochondrial promoter sequence-specific DNA binding

DNA binding

DNA primase activity

DNA-directed 5'-3' RNA polymerase activity

DNA-directed 5'-3' RNA polymerase activity

protein binding

mitochondrion

mitochondrion

mitochondrial matrix

DNA-templated transcription

mitochondrial transcription

mitochondrial transcription

transcription initiation at mitochondrial promoter

transferase activity

nucleotidyltransferase activity

protein-containing complex

protein-containing complex

mitochondrial DNA-directed RNA polymerase complex

mitochondrial nucleoid

sequence-specific DNA binding

sequence-specific DNA binding

 
1455019_x_at Ckap4 cytoskeleton-associated protein 4 10 -84526304 BB818012 39

molecular_function

protein binding

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

rough endoplasmic reticulum

rough endoplasmic reticulum

lipid droplet

cytoskeleton

plasma membrane

biological_process

cell surface

membrane

04141

1434306_at Rab3ip RAB3A interacting protein 10 -116905779 BF319015 30

guanyl-nucleotide exchange factor activity

protein binding

nucleus

cytoplasm

centrosome

cytosol

cytoskeleton

protein targeting to membrane

exocytosis

protein transport

small GTPase binding

small GTPase binding

protein localization to organelle

identical protein binding

identical protein binding

cell projection

perinuclear region of cytoplasm

GTPase binding

negative regulation of filopodium assembly

cilium assembly

Golgi to plasma membrane transport vesicle

proximal dendrite

 
1428332_at Pik3ip1 phosphoinositide-3-kinase interacting protein 1 11 3330730 AW556858 28

endopeptidase activity

signaling receptor binding

extracellular space

plasma membrane

membrane

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

phosphatidylinositol 3-kinase inhibitor activity

phosphatidylinositol 3-kinase inhibitor activity

 
1416542_at Phf1 PHD finger protein 1 17 26933126 NM_009343 36

transcription corepressor binding

DNA binding

chromatin binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

centrosome

cytosol

cytoskeleton

chromatin organization

chromatin organization

regulation of DNA-templated transcription

DNA damage response

methylated histone binding

methylated histone binding

methylated histone binding

ESC/E(Z) complex

ESC/E(Z) complex

site of double-strand break

identical protein binding

metal ion binding

DNA repair-dependent chromatin remodeling

histone methyltransferase binding

 
1434648_a_at Ccm2 cerebral cavernous malformation 2 11 6560182, 6546886 BI903794 60

blood vessel development

vasculogenesis

vasculogenesis

vasculogenesis

in utero embryonic development

in utero embryonic development

endothelial cell development

endothelial cell development

vasculature development

vasculature development

endothelium development

protein binding

cytoplasm

mitochondrion

heart development

heart development

heart development

heart development

protein-containing complex

multicellular organism growth

multicellular organism growth

cell-cell junction organization

regulation of angiogenesis

inner ear development

venous blood vessel morphogenesis

venous blood vessel morphogenesis

pericardium development

pericardium development

blood vessel endothelial cell differentiation

endothelial tube morphogenesis

 
1436034_at Cep68 centrosomal protein 68 11 -20227036 AW550283 20

nucleoplasm

cytoplasm

centrosome

cytosol

cytoskeleton

centrosome cycle

centriole-centriole cohesion

protein kinase binding

protein domain specific binding

cell junction

protein localization to organelle

centriolar satellite

 
1427241_at Papolg poly(A) polymerase gamma 11 -23862645 BC019635 16

nucleotide binding

RNA binding

ATP binding

nucleus

nucleus

nucleoplasm

cytosol

mRNA polyadenylation

mRNA processing

nuclear body

transferase activity

nucleotidyltransferase activity

RNA 3'-end processing

metal ion binding

poly(A) RNA polymerase activity

03015

1460204_at Tec tec protein tyrosine kinase 5 -72755717 NM_013689 76

nucleotide binding

adaptive immune response

adaptive immune response

immune system process

protein kinase activity

protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

non-membrane spanning protein tyrosine kinase activity

protein binding

ATP binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

plasma membrane

cell-cell junction

protein phosphorylation

protein phosphorylation

integrin-mediated signaling pathway

lipid binding

regulation of platelet activation

regulation of platelet activation

membrane

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

tissue regeneration

protein self-association

metal ion binding

T cell receptor signaling pathway

B cell receptor signaling pathway

B cell receptor signaling pathway

04380

04660

1428466_at Chd3 chromodomain helicase DNA binding protein 3 11 -69343272 AK011183 37

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

transcription cis-regulatory region binding

DNA binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

centrosome

chromatin organization

chromatin remodeling

chromatin remodeling

spindle organization

centrosome cycle

NuRD complex

NuRD complex

NuRD complex

NuRD complex

PML body

ATP hydrolysis activity

ATP hydrolysis activity

centriolar satellite

histone binding

regulation of cell fate specification

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

ATP-dependent chromatin remodeler activity

ATP-dependent chromatin remodeler activity

regulation of stem cell differentiation

 
1434873_a_at Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 11 -69881566 BB115902 18

molecular_function

GTPase activator activity

cytoplasm

endosome

lipid metabolic process

signal transduction

biological_process

membrane

lipid catabolic process

metal ion binding

04144

1451601_a_at Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate 11 -72451637, -72451637 BC025823 43

B cell homeostasis

lymphocyte homeostasis

regulation of humoral immune response

regulation of humoral immune response

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

sphingosine-1-phosphate receptor signaling pathway

endosome

plasma membrane

sphingolipid metabolic process

lipid transport

lipid transport

sensory perception of sound

membrane

membrane

transmembrane transporter activity

T cell homeostasis

sphingolipid transporter activity

sphingolipid transporter activity

sphingolipid transporter activity

regulation of eye pigmentation

lymph node development

transmembrane transport

bone development

lymphocyte migration

regulation of T cell migration

 
1425025_at Tmem106a transmembrane protein 106A 11 101582241, 101582241, 101582298 BC022145 14

immune system process

molecular_function

plasma membrane

membrane

positive regulation of interleukin-1 beta production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

CD80 biosynthetic process

CD86 biosynthetic process

macrophage activation

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade

innate immune response

positive regulation of MHC class II biosynthetic process

positive regulation of nitric oxide metabolic process

 
1460363_at Tnrc6c trinucleotide repeat containing 6C 11 117654288 BB795102 25

P-body

endoderm formation

molecular_function

nucleic acid binding

RNA binding

nucleoplasm

cytosol

regulation of translation

transforming growth factor beta receptor signaling pathway

endoderm development

regulatory ncRNA-mediated gene silencing

embryonic hemopoiesis

miRNA-mediated post-transcriptional gene silencing

miRNA-mediated post-transcriptional gene silencing

embryonic organ development

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

lung saccule development

regulation of miRNA-mediated gene silencing

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

 
1426640_s_at Trib2 tribbles pseudokinase 2 12 -15791726 BB354684 56

protein kinase activity

protein kinase inhibitor activity

ATP binding

nucleus

cytoplasm

cytoskeleton

protein phosphorylation

mitogen-activated protein kinase kinase binding

ubiquitin protein ligase binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of interleukin-10 production

regulation of MAP kinase activity

negative regulation of DNA-binding transcription factor activity

negative regulation of fat cell differentiation

positive regulation of ubiquitin-protein transferase activity

ubiquitin-protein transferase regulator activity

RNA polymerase II-specific DNA-binding transcription factor binding

 
1448224_at Tfam transcription factor A, mitochondrial 10 -71225476 NM_009360 225

transcription cis-regulatory region binding

mitochondrial promoter sequence-specific DNA binding

mitochondrial promoter sequence-specific DNA binding

transcription coactivator binding

DNA binding

chromatin binding

nucleus

mitochondrion

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial transcription

mitochondrial transcription

transcription initiation at mitochondrial promoter

transcription initiation at mitochondrial promoter

heat shock protein binding

protein-containing complex

mitochondrial respiratory chain complex assembly

mitochondrial transcription factor activity

mitochondrial nucleoid

mitochondrial nucleoid

sequence-specific DNA binding

positive regulation of DNA-templated transcription

05016

1415871_at Tgfbi transforming growth factor, beta induced 13 56609585 NM_009369 91

extracellular matrix structural constituent

collagen binding

extracellular region

basement membrane

extracellular space

extracellular space

extracellular space

extracellular space

trans-Golgi network

cell adhesion

cell adhesion

extracellular matrix organization

extracellular matrix organization

extracellular matrix

extracellular matrix

identical protein binding

cell adhesion molecule binding

extracellular matrix binding

localization

collagen-containing extracellular matrix

 
1426397_at Tgfbr2 transforming growth factor, beta receptor II 9 -116087694 BG793483 626

nucleotide binding

branching involved in blood vessel morphogenesis

vasculogenesis

in utero embryonic development

epithelial to mesenchymal transition

heart looping

positive regulation of mesenchymal cell proliferation

lens development in camera-type eye

positive regulation of tolerance induction to self antigen

positive regulation of B cell tolerance induction

positive regulation of T cell tolerance induction

outflow tract septum morphogenesis

membranous septum morphogenesis

outflow tract morphogenesis

aortic valve morphogenesis

atrioventricular valve morphogenesis

tricuspid valve morphogenesis

cardiac left ventricle morphogenesis

endocardial cushion fusion

growth plate cartilage development

growth plate cartilage chondrocyte growth

protein kinase activity

protein serine/threonine kinase activity

transmembrane receptor protein serine/threonine kinase activity

transforming growth factor beta receptor activity

transforming growth factor beta receptor activity

transforming growth factor beta receptor activity

transforming growth factor beta receptor activity, type II

protein binding

ATP binding

glycosaminoglycan binding

extracellular space

plasma membrane

plasma membrane

plasma membrane

caveola

protein phosphorylation

protein phosphorylation

receptor-mediated endocytosis

apoptotic process

transmembrane receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

Notch signaling pathway

smoothened signaling pathway

gastrulation

brain development

heart development

heart development

negative regulation of cell population proliferation

response to xenobiotic stimulus

animal organ morphogenesis

external side of plasma membrane

external side of plasma membrane

cell surface

regulation of gene expression

positive regulation of epithelial cell migration

positive regulation of epithelial to mesenchymal transition

membrane

kinase activity

phosphorylation

transferase activity

activin receptor activity

kinase activator activity

cell differentiation

lung development

mitogen-activated protein kinase kinase kinase binding

type I transforming growth factor beta receptor binding

type I transforming growth factor beta receptor binding

type III transforming growth factor beta receptor binding

embryonic hemopoiesis

aorta morphogenesis

signaling receptor activity

regulation of cell population proliferation

receptor complex

receptor complex

membrane raft

positive regulation of angiogenesis

SMAD binding

SMAD binding

SMAD binding

metal ion binding

activin binding

positive regulation of smooth muscle cell proliferation

embryonic cranial skeleton morphogenesis

artery morphogenesis

transforming growth factor beta binding

transforming growth factor beta binding

transforming growth factor beta binding

positive regulation of NK T cell differentiation

cartilage development

roof of mouth development

negative regulation of cardiac muscle cell proliferation

molecular adaptor activity

positive regulation of SMAD protein signal transduction

SMAD protein signal transduction

ventricular septum morphogenesis

lung morphogenesis

bronchus development

bronchus morphogenesis

trachea morphogenesis

trachea formation

mammary gland morphogenesis

lung lobe morphogenesis

Langerhans cell differentiation

secondary palate development

transforming growth factor beta ligand-receptor complex

response to cholesterol

response to cholesterol

cellular response to growth factor stimulus

regulation of stem cell proliferation

positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

inferior endocardial cushion morphogenesis

lens fiber cell apoptotic process

miRNA transport

positive regulation of reactive oxygen species metabolic process

positive regulation of CD4-positive, alpha-beta T cell proliferation

regulation of stem cell differentiation

04010

04060

04144

04350

04380

04520

05142

05200

05210

05212

05220

1433795_at Tgfbr3 transforming growth factor, beta receptor III 5 -107106566 BM122301 93

blood vessel development

vasculogenesis

osteoblast differentiation

in utero embryonic development

blastocyst development

epithelial to mesenchymal transition

epithelial to mesenchymal transition

liver development

blood vessel remodeling

muscular septum morphogenesis

outflow tract morphogenesis

ventricular compact myocardium morphogenesis

epicardial cell to mesenchymal cell transition

transmembrane signaling receptor activity

transforming growth factor beta receptor activity

transforming growth factor beta receptor activity

transforming growth factor beta receptor activity

transforming growth factor beta receptor activity

type II transforming growth factor beta receptor binding

type II transforming growth factor beta receptor binding

transforming growth factor beta receptor binding

protein binding

glycosaminoglycan binding

glycosaminoglycan binding

extracellular region

extracellular space

cytoplasm

endoplasmic reticulum

plasma membrane

immune response

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor signaling pathway

transforming growth factor beta receptor complex assembly

heparin binding

cell population proliferation

positive regulation of cell population proliferation

external side of plasma membrane

cell surface

positive regulation of gene expression

negative regulation of gene expression

negative regulation of epithelial cell migration

negative regulation of epithelial to mesenchymal transition

coreceptor activity

membrane

cell migration

regulation of transforming growth factor beta receptor signaling pathway

fibroblast growth factor binding

PDZ domain binding

negative regulation of cell migration

BMP signaling pathway

BMP signaling pathway

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of BMP signaling pathway

response to follicle-stimulating hormone

collagen metabolic process

inhibin-betaglycan-ActRII complex

response to prostaglandin E

response to luteinizing hormone

intracellular signal transduction

BMP binding

negative regulation of canonical NF-kappaB signal transduction

receptor complex

SMAD binding

SMAD binding

activin binding

transforming growth factor beta binding

transforming growth factor beta binding

transforming growth factor beta binding

negative regulation of epithelial cell proliferation

positive regulation of NF-kappaB transcription factor activity

ventricular cardiac muscle tissue morphogenesis

roof of mouth development

cardiac muscle cell proliferation

positive regulation of cardiac muscle cell proliferation

definitive hemopoiesis

cardiac epithelial to mesenchymal transition

definitive erythrocyte differentiation

heart trabecula formation

positive regulation of SMAD protein signal transduction

positive regulation of SMAD protein signal transduction

negative regulation of SMAD protein signal transduction

ventricular septum morphogenesis

apoptotic process involved in morphogenesis

epicardium-derived cardiac fibroblast cell development

coronary vasculature development

coronary vasculature morphogenesis

vasculogenesis involved in coronary vascular morphogenesis

vasculogenesis involved in coronary vascular morphogenesis

visceral serous pericardium development

heart trabecula morphogenesis

secondary palate development

protein-containing complex assembly

transforming growth factor beta receptor activity, type III

positive regulation of cell migration involved in sprouting angiogenesis

blood vessel diameter maintenance

negative regulation of extracellular matrix assembly

negative regulation of apoptotic process involved in morphogenesis

 
1451416_a_at Tgm1 transglutaminase 1, K polypeptide 14 -55700008, -55700008 BC026422 66

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

adherens junction

animal organ morphogenesis

positive regulation of keratinocyte proliferation

membrane

transferase activity

acyltransferase activity

peptide cross-linking

peptide cross-linking

protein metabolic process

keratinocyte differentiation

keratinization

identical protein binding

positive regulation of cell cycle

metal ion binding

 
1433428_x_at Tgm2 transglutaminase 2, C polypeptide 2 -158116404 AW321975 290

nucleotide binding

chromatin

nucleosome

blood vessel remodeling

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

protein-glutamine gamma-glutamyltransferase activity

calcium ion binding

calcium ion binding

GTP binding

GTP binding

extracellular region

nucleus

chromosome

cytoplasm

mitochondrion

mitochondrion

cytosol

cytosol

plasma membrane

proteolysis

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

peptidase activity

transaminase activity

gene expression

dopamine secretion

membrane

transferase activity

acyltransferase activity

hydrolase activity

peptide cross-linking

peptide cross-linking

peptide cross-linking

protein deamination

protein domain specific binding

extracellular matrix

extracellular matrix

negative regulation of endoplasmic reticulum calcium ion concentration

negative regulation of endoplasmic reticulum calcium ion concentration

identical protein binding

regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of canonical NF-kappaB signal transduction

phospholipase binding

apoptotic cell clearance

positive regulation of cell adhesion

metal ion binding

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

protein-glutamine glutaminase activity

positive regulation of neurogenesis

protein homooligomerization

positive regulation of mitochondrial calcium ion concentration

positive regulation of mitochondrial calcium ion concentration

branching involved in salivary gland morphogenesis

salivary gland cavitation

collagen-containing extracellular matrix

cellular response to cocaine

histone serotonyltransferase activity

histone dopaminyltransferase activity

peptide histaminyltransferase activity

cellular response to dopamine

cellular response to serotonin

regulation of apoptotic cell clearance

regulation of apoptotic cell clearance

05016

1424988_at Mylip myosin regulatory light chain interacting protein 13 45389741 BC010206 32

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

cytoplasm

cytoskeleton

plasma membrane

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

nervous system development

cytoskeletal protein binding

negative regulation of neuron projection development

negative regulation of low-density lipoprotein particle clearance

membrane

protein ubiquitination

transferase activity

protein destabilization

regulation of low-density lipoprotein particle receptor catabolic process

cholesterol homeostasis

positive regulation of protein catabolic process

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

cellular response to low-density lipoprotein particle stimulus

 
1433649_at Kdm1b lysine (K)-specific demethylase 1B 13 47043498 BM243793 28

negative regulation of transcription by RNA polymerase II

chromatin

nucleosome

chromatin binding

protein binding

nucleus

nucleoplasm

chromosome

chromatin organization

multicellular organism development

transcription factor binding

zinc ion binding

zinc ion binding

oxidoreductase activity

oxidoreductase activity

histone H3K4 demethylase activity

histone binding

epigenetic programing of female pronucleus

transcription initiation-coupled chromatin remodeling

positive regulation of transcription by RNA polymerase II

metal ion binding

flavin adenine dinucleotide binding

flavin adenine dinucleotide binding

genomic imprinting

FAD binding

FAD-dependent H3K4me/H3K4me3 demethylase activity

FAD-dependent H3K4me/H3K4me3 demethylase activity

 
1460302_at Thbs1 thrombospondin 1 2 118111875 AI385532 363

angiogenesis

phosphatidylserine binding

negative regulation of endothelial cell proliferation

negative regulation of endothelial cell proliferation

negative regulation of cell-matrix adhesion

fibronectin binding

protease binding

sprouting angiogenesis

negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

negative regulation of dendritic cell antigen processing and presentation

outflow tract morphogenesis

endocardial cushion development

growth plate cartilage development

growth plate cartilage development

endopeptidase inhibitor activity

integrin binding

extracellular matrix structural constituent

calcium ion binding

protein binding

extracellular region

fibrinogen complex

extracellular space

extracellular space

extracellular space

endoplasmic reticulum

apoptotic process

inflammatory response

inflammatory response

response to unfolded protein

cell adhesion

heparin binding

positive regulation of cell population proliferation

negative regulation of cell population proliferation

response to mechanical stimulus

response to glucose

external side of plasma membrane

cell surface

positive regulation of endothelial cell migration

negative regulation of endothelial cell migration

negative regulation of long-chain fatty acid import across plasma membrane

negative regulation of nitric oxide mediated signal transduction

negative regulation of cGMP-mediated signaling

negative regulation of plasminogen activation

positive regulation of macrophage chemotaxis

positive regulation of fibroblast migration

positive regulation of cell-substrate adhesion

cell migration

negative regulation of angiogenesis

negative regulation of angiogenesis

negative regulation of angiogenesis

negative regulation of angiogenesis

sarcoplasmic reticulum

fibroblast growth factor binding

peptide cross-linking

secretory granule

low-density lipoprotein particle binding

positive regulation of blood coagulation

positive regulation of cell migration

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transforming growth factor beta receptor signaling pathway

extracellular matrix

platelet alpha granule

response to magnesium ion

negative regulation of interleukin-12 production

positive regulation of tumor necrosis factor production

response to endoplasmic reticulum stress

negative regulation of fibroblast growth factor receptor signaling pathway

positive regulation of phosphorylation

protein homodimerization activity

positive regulation of macrophage activation

negative regulation of apoptotic process

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

laminin binding

positive regulation of MAP kinase activity

positive regulation of blood vessel endothelial cell migration

negative regulation of blood vessel endothelial cell migration

engulfment of apoptotic cell

positive regulation of translation

positive regulation of angiogenesis

behavioral response to pain

blood vessel morphogenesis

positive regulation of smooth muscle cell proliferation

transforming growth factor beta binding

extracellular matrix binding

positive regulation of chemotaxis

response to calcium ion

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of fibrinolysis

collagen-containing extracellular matrix

collagen-containing extracellular matrix

fibrinogen binding

collagen V binding

monocyte aggregation

positive regulation of transforming growth factor beta production

cellular response to nitric oxide

negative regulation of cell migration involved in sprouting angiogenesis

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

negative regulation of sprouting angiogenesis

positive regulation of endothelial cell apoptotic process

positive regulation of reactive oxygen species metabolic process

negative regulation of endothelial cell chemotaxis

04115

04145

04350

04510

04512

05144

05219

1451221_at Ice1 interactor of little elongation complex ELL subunit 1 13 -70588688 BC018507 19

euchromatin

nucleus

nucleoplasm

transcription elongation factor complex

Cajal body

nuclear body

protein-macromolecule adaptor activity

positive regulation of protein-containing complex assembly

histone locus body

snRNA transcription by RNA polymerase II

snRNA transcription by RNA polymerase III

positive regulation of transcription by RNA polymerase III

positive regulation of intracellular protein transport

 
1423135_at Thy1 thymus cell antigen 1, theta 9 44043383 AV028402 303

angiogenesis

regulation of cell-matrix adhesion

positive regulation of cellular extravasation

GTPase activator activity

GTPase activator activity

integrin binding

integrin binding

endoplasmic reticulum

cytosol

plasma membrane

cytoskeleton organization

integrin-mediated signaling pathway

integrin-mediated signaling pathway

integrin-mediated signaling pathway

cell-cell signaling

cell-cell signaling

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

apical plasma membrane

enzyme binding

protein kinase binding

negative regulation of cell migration

dendrite

dendrite

growth cone

axolemma

dendrite membrane

neuronal cell body membrane

heterotypic cell-cell adhesion

GPI anchor binding

receptor clustering

myelin sheath

membrane raft

membrane raft

membrane raft

retinal cone cell development

focal adhesion assembly

negative regulation of axonogenesis

T cell receptor signaling pathway

negative regulation of T cell receptor signaling pathway

positive regulation of T cell activation

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of focal adhesion assembly

positive regulation of focal adhesion assembly

positive regulation of focal adhesion assembly

negative regulation of neuron projection regeneration

negative regulation of neuron projection regeneration

side of membrane

cell-cell adhesion

regulation of Rho-dependent protein serine/threonine kinase activity

04670

1416814_at Tia1 cytotoxic granule-associated RNA binding protein 1 6 86404218 BG518542 77

regulation of alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

negative regulation of cytokine production

nucleic acid binding

RNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

mRNA processing

apoptotic process

RNA splicing

cytoplasmic stress granule

cytoplasmic stress granule

negative regulation of translation

negative regulation of translation

stress granule assembly

mRNA 3'-UTR AU-rich region binding

regulation of mRNA splicing, via spliceosome

nuclear stress granule

nuclear stress granule

protein localization to cytoplasmic stress granule

positive regulation of epithelial cell apoptotic process

ribonucleoprotein complex

 
1452821_at Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 7 -128439776, -128439776 AK020218 55

nucleic acid binding

DNA binding

RNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleoplasm

cytoplasm

lysosome

cytosol

apoptotic process

germ cell development

negative regulation of cell population proliferation

cytoplasmic stress granule

cytoplasmic stress granule

stem cell division

positive regulation of hippo signaling

mRNA 3'-UTR AU-rich region binding

stem cell proliferation

protein-RNA adaptor activity

ribonucleoprotein complex

positive regulation of miRNA-mediated gene silencing

positive regulation of stem cell proliferation

 
1415869_a_at Trim28 tripartite motif-containing 28 7 13024151 NM_011588 205

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

euchromatin

heterochromatin

in utero embryonic development

epithelial to mesenchymal transition

DNA binding

DNA binding

chromatin binding

chromatin binding

transcription coactivator activity

transcription corepressor activity

protein kinase activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

DNA repair

chromatin organization

chromatin organization

protein phosphorylation

embryo implantation

zinc ion binding

transferase activity

protein sumoylation

protein sumoylation

SUMO transferase activity

ubiquitin protein ligase binding

protein-containing complex

Krueppel-associated box domain binding

positive regulation of protein import into nucleus

post-fertilization epigenetic regulation of gene expression

positive regulation of DNA binding

positive regulation of DNA binding

suppression of viral release by host

innate immune response

innate immune response

innate immune response

innate immune response

positive regulation of DNA repair

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

protein autophosphorylation

metal ion binding

convergent extension involved in axis elongation

embryonic placenta morphogenesis

ubiquitin protein ligase activity

chromo shadow domain binding

genomic imprinting

positive regulation of DNA methylation-dependent heterochromatin formation

positive regulation of DNA methylation-dependent heterochromatin formation

RNA polymerase II transcription regulator complex

RNA polymerase II transcription regulator complex

negative regulation of DNA demethylation

promoter-specific chromatin binding

 
1460227_at Timp1 tissue inhibitor of metalloproteinase 1 X 20870165 BC008107 283

protease binding

protease binding

connective tissue replacement involved in inflammatory response wound healing

enzyme inhibitor activity

cytokine activity

extracellular region

basement membrane

basement membrane

extracellular space

extracellular space

extracellular space

growth factor activity

metalloendopeptidase inhibitor activity

metalloendopeptidase inhibitor activity

zinc ion binding

positive regulation of cell population proliferation

response to hormone

negative regulation of peptidase activity

negative regulation of endopeptidase activity

negative regulation of endopeptidase activity

peptidase inhibitor activity

extracellular matrix

extracellular matrix

response to cytokine

negative regulation of apoptotic process

negative regulation of catalytic activity

metal ion binding

negative regulation of membrane protein ectodomain proteolysis

negative regulation of membrane protein ectodomain proteolysis

cellular response to UV-A

negative regulation of trophoblast cell migration

negative regulation of metallopeptidase activity

regulation of integrin-mediated signaling pathway

 
1451253_at Pxk PX domain containing serine/threonine kinase 14 8098210 BC016131 24

actin binding

protein kinase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

early endosome

late endosome

cytosol

plasma membrane

plasma membrane

plasma membrane

protein phosphorylation

protein targeting to lysosome

inflammatory response

endosome to lysosome transport

membrane

negative regulation of ATP-dependent activity

negative regulation of ATP-dependent activity

protein-containing complex

centriolar satellite

phosphatidylinositol binding

phosphatidylinositol binding

negative regulation of monoatomic ion transport

negative regulation of monoatomic ion transport

early endosome to late endosome transport

modulation of chemical synaptic transmission

 
1438673_at Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 14 14703024, 14718783 AW555750 49

solute:inorganic anion antiporter activity

protein binding

cytoplasm

plasma membrane

plasma membrane

plasma membrane

purine nucleotide biosynthetic process

pyrimidine nucleotide biosynthetic process

monoatomic ion transport

sodium ion transport

monoatomic anion transport

visual perception

sensory perception of sound

monoatomic anion transmembrane transporter activity

sodium:bicarbonate symporter activity

sodium:bicarbonate symporter activity

sodium:bicarbonate symporter activity

symporter activity

bicarbonate transport

membrane

basolateral plasma membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

apical plasma membrane

apical plasma membrane

cochlear nucleus development

cytoplasmic vesicle

stereocilium

locomotory exploration behavior

cell projection

retinal cell programmed cell death

regulation of intracellular pH

regulation of intracellular pH

transmembrane transport

auditory receptor cell development

auditory receptor cell development

camera-type eye photoreceptor cell differentiation

retina vasculature morphogenesis in camera-type eye

cellular response to growth factor stimulus

phagosome acidification

 
1437525_a_at Polr3a polymerase (RNA) III (DNA directed) polypeptide A 14 -24448693 BB559175 19

magnesium ion binding

RNA polymerase III activity

chromatin binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

RNA polymerase III complex

RNA polymerase III complex

cytoplasm

zinc ion binding

positive regulation of interferon-beta production

tRNA transcription by RNA polymerase III

innate immune response

DNA/RNA hybrid binding

00230

00240

01100

03020

04623

1418162_at Tlr4 toll-like receptor 4 4 66827550 AF185285 3343

lipopolysaccharide binding

lipopolysaccharide binding

microglial cell activation

lipopolysaccharide immune receptor activity

lipopolysaccharide immune receptor activity

lipopolysaccharide immune receptor activity

phagocytic cup

activation of innate immune response

toll-like receptor signaling pathway

wound healing involved in inflammatory response

B cell proliferation involved in immune response

immune system process

nitric oxide production involved in inflammatory response

regulation of dendritic cell cytokine production

MyD88-dependent toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

innate immune response-activating signaling pathway

transmembrane signaling receptor activity

signaling receptor binding

protein binding

cytoplasm

endosome

plasma membrane

plasma membrane

leukotriene metabolic process

nitric oxide biosynthetic process

phagocytosis

inflammatory response

inflammatory response

immune response

response to oxidative stress

signal transduction

activation of NF-kappaB-inducing kinase activity

I-kappaB phosphorylation

I-kappaB phosphorylation

JNK cascade

JNK cascade

response to bacterium

external side of plasma membrane

cell surface

endosome membrane

gene expression

positive regulation of platelet activation

positive regulation of gene expression

positive regulation of gene expression

positive regulation of gene expression

macrophage cytokine production

macrophage cytokine production

astrocyte development

microglia differentiation

positive regulation of smooth muscle cell migration

membrane

neurogenesis

positive regulation of B cell proliferation

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

lipopolysaccharide-mediated signaling pathway

response to lipopolysaccharide

response to lipopolysaccharide

response to lipopolysaccharide

detection of lipopolysaccharide

detection of lipopolysaccharide

detection of lipopolysaccharide

detection of lipopolysaccharide

interferon-beta production

type II interferon production

interleukin-10 production

interleukin-6 production

interleukin-6 production

tumor necrosis factor production

tumor necrosis factor production

regulation of tumor necrosis factor production

negative regulation of type II interferon production

negative regulation of interleukin-17 production

negative regulation of interleukin-23 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of chemokine production

positive regulation of chemokine production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of type II interferon production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 production

positive regulation of interleukin-1 production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-12 production

positive regulation of interleukin-13 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

toll-like receptor 4 signaling pathway

TRIF-dependent toll-like receptor signaling pathway

cellular response to platelet-derived growth factor stimulus

signaling receptor activity

B cell proliferation

macrophage activation

macrophage activation

macrophage activation

defense response to bacterium

identical protein binding

cell projection

positive regulation of macrophage activation

positive regulation of apoptotic process

positive regulation of canonical NF-kappaB signal transduction

receptor complex

receptor complex

positive regulation of MAP kinase activity

phosphatidylinositol 3-kinase binding

innate immune response

MHC class II biosynthetic process

positive regulation of MHC class II biosynthetic process

positive regulation of nitric oxide biosynthetic process

positive regulation of nitric oxide biosynthetic process

response to ethanol

mast cell activation

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

positive regulation of JNK cascade

lymphocyte proliferation

lipopolysaccharide receptor complex

protein heterodimerization activity

perinuclear region of cytoplasm

positive regulation of smooth muscle cell proliferation

positive regulation of lymphocyte proliferation

regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

defense response to Gram-negative bacterium

defense response to Gram-negative bacterium

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception of pain

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

stress-activated MAPK cascade

positive regulation of nitric-oxide synthase biosynthetic process

intestinal epithelial structure maintenance

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

ERK1 and ERK2 cascade

negative regulation of ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

nucleotide-binding oligomerization domain containing 1 signaling pathway

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway

nucleotide-binding oligomerization domain containing 2 signaling pathway

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

response to fatty acid

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipoteichoic acid

cellular response to type II interferon

negative regulation of cold-induced thermogenesis

cellular response to oxidised low-density lipoprotein particle stimulus

cellular response to oxidised low-density lipoprotein particle stimulus

positive regulation of cytokine production involved in inflammatory response

positive regulation of cytokine production involved in inflammatory response

positive regulation of NLRP3 inflammasome complex assembly

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of reactive oxygen species biosynthetic process

positive regulation of cellular response to macrophage colony-stimulating factor stimulus

positive regulation of matrix metallopeptidase secretion

cellular response to amyloid-beta

positive regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of extrinsic apoptotic signaling pathway

04145

04620

05140

05142

05144

05145

05146

05323

1422754_at Tmod1 tropomodulin 1 4 46039221 NM_021883 65

actin binding

tropomyosin binding

tropomyosin binding

tropomyosin binding

cytoplasm

cytoskeleton

cytoskeleton

striated muscle thin filament

striated muscle thin filament

actin filament

muscle contraction

muscle contraction

actin filament organization

COP9 signalosome

adult locomotory behavior

membrane

myofibril

myofibril

myofibril

sarcomere

sarcomere

myofibril assembly

myofibril assembly

cortical cytoskeleton

pointed-end actin filament capping

lens fiber cell development

 
1438855_x_at Tnfaip2 tumor necrosis factor, alpha-induced protein 2 12 111442660 BB233088 30

exocyst

exocyst

SNARE binding

angiogenesis

exocytosis

exocytosis

multicellular organism development

cell differentiation

exocyst localization

 
1460415_a_at Cd40 CD40 antigen 2 165055635 AI385482 607

positive regulation of protein phosphorylation

immune system process

immunoglobulin production

regulation of immunoglobulin production

immune response-regulating cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway

antigen binding

protein binding

extracellular region

extracellular space

plasma membrane

intracellular calcium ion homeostasis

intracellular calcium ion homeostasis

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

B cell mediated immunity

enzyme binding

protein domain specific binding

CD40 signaling pathway

CD40 signaling pathway

positive regulation of B cell proliferation

positive regulation of B cell proliferation

ubiquitin protein ligase binding

interleukin-12 production

positive regulation of interleukin-12 production

CD40 receptor complex

CD40 receptor complex

signaling receptor activity

B cell proliferation

B cell proliferation

B cell activation

B cell activation

B cell activation

positive regulation of tyrosine phosphorylation of STAT protein

defense response to protozoan

neuronal cell body

varicosity

intracellular membrane-bounded organelle

positive regulation of MAP kinase activity

phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of blood vessel endothelial cell migration

positive regulation of GTPase activity

positive regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

positive regulation of isotype switching to IgG isotypes

regulation of immune response

positive regulation of NF-kappaB transcription factor activity

defense response to virus

positive regulation of protein kinase C signaling

positive regulation of endothelial cell apoptotic process

04060

04514

04620

04672

05144

05145

05310

05320

05322

05330

05340

05416

1452389_at Cd27 CD27 antigen 6 -125232621 L24495 112

positive regulation of immunoglobulin production

transmembrane signaling receptor activity

protein binding

apoptotic process

external side of plasma membrane

external side of plasma membrane

cell surface

membrane

positive regulation of type II interferon production

B cell proliferation

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of B cell differentiation

positive regulation of T cell differentiation

positive regulation of JNK cascade

negative regulation of T cell apoptotic process

extrinsic apoptotic signaling pathway

04060

1449184_at Pglyrp1 peptidoglycan recognition protein 1 7 18884689 NM_009402 41

immune system process

cytokine activity

extracellular region

extracellular space

cytoplasm

apoptotic process

zinc ion binding

N-acetylmuramoyl-L-alanine amidase activity

peptidoglycan catabolic process

response to bacterium

peptidoglycan immune receptor activity

peptidoglycan immune receptor activity

detection of bacterium

detection of bacterium

Hsp70 protein binding

killing of cells of another organism

negative regulation of type II interferon production

negative regulation of natural killer cell differentiation involved in immune response

defense response to bacterium

peptidoglycan binding

peptidoglycan binding

innate immune response

receptor ligand activity

negative regulation of inflammatory response

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

biological process involved in interaction with host

molecular adaptor activity

antimicrobial humoral immune response mediated by antimicrobial peptide

 
1416731_at Top2b topoisomerase (DNA) II beta 14 16365205 BB166592 72

nucleotide binding

resolution of meiotic recombination intermediates

heterochromatin

sister chromatid segregation

neuron migration

DNA binding

chromatin binding

DNA topoisomerase activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

cytosol

DNA metabolic process

DNA topological change

axonogenesis

isomerase activity

B cell differentiation

B cell differentiation

forebrain development

positive regulation of single stranded viral RNA replication via double stranded DNA intermediate

metal ion binding

 
1419494_a_at Tpd52 tumor protein D52 3 -8926529, -8926529, -8926529 BC002036 32

calcium ion binding

protein binding

cytoplasm

cytoplasm

endoplasmic reticulum

positive regulation of cell population proliferation

B cell differentiation

identical protein binding

protein homodimerization activity

protein homodimerization activity

synapse

synapse

synapse

perinuclear region of cytoplasm

glutamatergic synapse

glutamatergic synapse

glutamatergic synapse

 
1425028_a_at Tpm2 tropomyosin 2, beta 4 -43513725 BC024358 71

actin binding

structural constituent of cytoskeleton

protein binding

cytoplasm

cytoskeleton

muscle thin filament tropomyosin

actin filament

muscle contraction

muscle contraction

actin filament organization

actin cytoskeleton

identical protein binding

protein homodimerization activity

regulation of ATP-dependent activity

protein heterodimerization activity

actin filament binding

actin filament binding

04260

05410

05414

1454851_at Nr2c2 nuclear receptor subfamily 2, group C, member 2 6 92091417, 92092432 AV162817 113

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nuclear receptor activity

protein binding

nucleus

nucleoplasm

regulation of DNA-templated transcription

spermatogenesis

zinc ion binding

cerebellum development

cell differentiation

cell differentiation

lipopolysaccharide-mediated signaling pathway

p38MAPK cascade

positive regulation of embryonic development

positive regulation of embryonic development

sequence-specific DNA binding

positive regulation of myoblast differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

positive regulation of behavior

anatomical structure development

meiotic cell cycle

sequence-specific double-stranded DNA binding

 
1453181_x_at Plscr1 phospholipid scramblase 1 9 92250193 BF319989 43

magnesium ion binding

DNA-binding transcription activator activity, RNA polymerase II-specific

virus receptor activity

DNA binding

nuclease activity

epidermal growth factor receptor binding

calcium ion binding

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

Golgi apparatus

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

phosphatidylserine biosynthetic process

lipid transport

acute-phase response

immune response

zinc ion binding

membrane

hydrolase activity

plasma membrane phospholipid scrambling

plasma membrane phospholipid scrambling

SH3 domain binding

phospholipid scramblase activity

phospholipid scramblase activity

enzyme binding

myeloid cell differentiation

negative regulation of protein binding

lead ion binding

regulation of mast cell activation

response to interferon-alpha

CD4 receptor binding

positive regulation of apoptotic process

negative regulation of viral genome replication

positive regulation of innate immune response

membrane raft

mercury ion binding

perinuclear region of cytoplasm

defense response to virus

regulation of Fc receptor mediated stimulatory signaling pathway

collagen-containing extracellular matrix

phosphatidylserine exposure on apoptotic cell surface

phosphatidylserine exposure on apoptotic cell surface

phosphatidylserine exposure on apoptotic cell surface

cellular response to lipopolysaccharide

cellular response to cytokine stimulus

intrinsic apoptotic signaling pathway

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

 
1448361_at Ttc3 tetratricopeptide repeat domain 3 16 94370738 BB833716 33

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleoplasm

nucleolus

cytoplasm

vacuole

Golgi apparatus

cytosol

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

transferase activity

negative regulation of axon extension

negative regulation of neuron differentiation

metal ion binding

protein K48-linked ubiquitination

 
1416119_at Txn1 thioredoxin 1 4 -57943372 NM_011660 146

negative regulation of transcription by RNA polymerase II

protein binding

extracellular region

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

cytosol

cytosol

cytosol

response to radiation

protein-disulfide reductase activity

protein-disulfide reductase activity

enzyme binding

axon

dendrite

positive regulation of peptidyl-serine phosphorylation

protein homodimerization activity

neuronal cell body

positive regulation of DNA binding

cell redox homeostasis

cell redox homeostasis

negative regulation of protein export from nucleus

protein-disulfide reductase (NAD(P)) activity

cellular detoxification of hydrogen peroxide

response to nitric oxide

positive regulation of peptidyl-cysteine S-nitrosylation

 
1450484_a_at Cmpk2 cytidine/uridine monophosphate kinase 2 12 26469214 AK004595 20

nucleotide binding

cytidylate kinase activity

cytidylate kinase activity

nucleoside diphosphate kinase activity

nucleoside diphosphate kinase activity

thymidylate kinase activity

thymidylate kinase activity

ATP binding

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

pyrimidine nucleotide biosynthetic process

dUDP biosynthetic process

dUDP biosynthetic process

dTDP biosynthetic process

dTDP biosynthetic process

dTTP biosynthetic process

UMP/dUMP kinase activity

kinase activity

phosphorylation

transferase activity

UMP kinase activity

nucleoside monophosphate phosphorylation

nucleoside monophosphate kinase activity

cellular response to lipopolysaccharide

00240

01100

1448230_at Usp10 ubiquitin specific peptidase 10 8 119910359 NM_009462 51

p53 binding

cysteine-type endopeptidase activity

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

endosome

early endosome

early endosome

cytosol

cytosol

DNA repair

proteolysis

autophagy

DNA damage response

peptidase activity

cysteine-type peptidase activity

regulation of autophagy

regulation of autophagy

protein deubiquitination

protein deubiquitination

hydrolase activity

cytosolic ribosome

DNA damage response, signal transduction by p53 class mediator

DNA damage response, signal transduction by p53 class mediator

protein-containing complex

monoubiquitinated protein deubiquitination

negative regulation of canonical NF-kappaB signal transduction

transmembrane transporter binding

intermediate filament cytoskeleton

negative regulation of stress granule assembly

cellular response to interleukin-1

rescue of stalled ribosome

molecular function inhibitor activity

 
1419063_at Ugt8a UDP galactosyltransferase 8A 3 -125865271 NM_011674 68

protein localization to paranode region of axon

2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity

2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity

endoplasmic reticulum

endoplasmic reticulum

lipid metabolic process

sphingolipid metabolic process

galactosylceramide biosynthetic process

galactosylceramide biosynthetic process

cytoskeleton organization

ceramide glucosyltransferase activity

UDP-glycosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

glycolipid biosynthetic process

membrane

transferase activity

glycosyltransferase activity

paranodal junction assembly

myelination

N-acylsphingosine galactosyltransferase activity

neuron projection morphogenesis

00600

01100

1448562_at Upp1 uridine phosphorylase 1 11 9118007, 9118102, 9118506 NM_009477 47

catalytic activity

uridine phosphorylase activity

uridine phosphorylase activity

uridine phosphorylase activity

uridine phosphorylase activity

nucleoplasm

cytoplasm

cytosol

cytosol

uridine catabolic process

uridine catabolic process

uridine catabolic process

pyrimidine nucleotide metabolic process

CMP catabolic process

dCMP catabolic process

thymidine phosphorylase activity

nucleoside metabolic process

nucleotide catabolic process

transferase activity

glycosyltransferase activity

pentosyltransferase activity

identical protein binding

UMP salvage

UMP catabolic process

dTMP catabolic process

dUMP catabolic process

uridine metabolic process

deoxyuridine phosphorylase activity

00240

00983

01100

1421863_at Vamp1 vesicle-associated membrane protein 1 6 125215580 AK018783 44

SNAP receptor activity

mitochondrion

plasma membrane

vesicle fusion

cell surface

membrane

synaptic vesicle priming

synaptic vesicle priming

vesicle-mediated transport

syntaxin binding

SNARE complex

cytoplasmic vesicle

neuromuscular junction

neuromuscular junction

regulation of synaptic vesicle fusion to presynaptic active zone membrane

regulation of synaptic vesicle fusion to presynaptic active zone membrane

SNARE complex assembly

SNARE complex assembly

specific granule membrane

neuron projection

synapse

tertiary granule membrane

presynapse

glutamatergic synapse

glutamatergic synapse

04130

1435244_at Vav2 vav 2 oncogene 2 -27262103 BF535947 109

angiogenesis

phosphotyrosine residue binding

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

epidermal growth factor receptor binding

protein binding

cytoplasm

cytoplasm

cytosol

plasma membrane

small GTPase-mediated signal transduction

cell migration

cell migration

cell projection assembly

lamellipodium assembly

intracellular signal transduction

regulation of GTPase activity

regulation of GTPase activity

metal ion binding

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

04062

04510

04650

04660

04662

04664

04666

04670

04810

1451562_at Ggact gamma-glutamylamine cyclotransferase 14 -122890859 BC006662 12

cytosol

lyase activity

cellular modified amino acid catabolic process

gamma-glutamylaminecyclotransferase activity

 
1435375_at Otulinl OTU deubiquitinase with linear linkage specificity like 15 -27655070 BM224662 16

molecular_function

nucleus

nuclear envelope

cytoplasm

endoplasmic reticulum

biological_process

membrane

cytoplasmic side of endoplasmic reticulum membrane

 
1455555_at Vipr1 vasoactive intestinal peptide receptor 1 9 121642715 BF224468 46

transmembrane signaling receptor activity

G protein-coupled receptor activity

vasoactive intestinal polypeptide receptor activity

vasoactive intestinal polypeptide receptor activity

plasma membrane

plasma membrane

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

G protein-coupled peptide receptor activity

membrane

peptide hormone binding

peptide hormone binding

receptor complex

04080

1422921_at Vpreb3 V-set pre-B cell surrogate light chain 3 10 75948299 NM_009514 18

immunoglobulin production

negative regulation of immunoglobulin production

molecular_function

extracellular space

endoplasmic reticulum

immune response

 
1455197_at Rnd1 Rho family GTPase 1 15 -98669204 BE852181 19

nucleotide binding

GTPase activity

GTPase activity

signaling receptor binding

GTP binding

GTP binding

cytoplasm

cytosol

cytosol

cytoskeleton

plasma membrane

plasma membrane

adherens junction

actin filament organization

actin filament organization

negative regulation of cell adhesion

signal transduction

small GTPase-mediated signal transduction

actin cytoskeleton

membrane

neuron remodeling

cell migration

protein kinase binding

regulation of actin cytoskeleton organization

intracellular membrane-bounded organelle

04360

1455337_at Fgd4 FYVE, RhoGEF and PH domain containing 4 16 -16416914, -16416914, -16416914 BQ175875 32

actin binding

guanyl-nucleotide exchange factor activity

cytoplasm

cytoplasm

cytoskeleton

cytoskeleton organization

regulation of cell shape

lamellipodium

lamellipodium assembly

microspike assembly

filopodium

cell projection

positive regulation of JUN kinase activity

positive regulation of JNK cascade

filopodium assembly

metal ion binding

actin filament binding

 
1434513_at Atp13a3 ATPase type 13A3 16 -30312423 BQ030867 16

nucleotide binding

transporter activity

ATP binding

endosome

intracellular calcium ion homeostasis

polyamine transmembrane transporter activity

ABC-type putrescine transporter activity

P-type ion transporter activity

membrane

ATP hydrolysis activity

ATPase-coupled monoatomic cation transmembrane transporter activity

ATPase-coupled monoatomic cation transmembrane transporter activity

early endosome membrane

late endosome membrane

late endosome membrane

metal ion binding

recycling endosome membrane

P-type transmembrane transporter activity

polyamine transmembrane transport

 
1437223_s_at Xbp1 X-box binding protein 1 11 5520640 AV051768 402

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

angiogenesis

regulation of cell growth

liver development

positive regulation of protein phosphorylation

endothelial cell proliferation

endothelial cell proliferation

protease binding

glandular epithelial cell maturation

positive regulation of immunoglobulin production

positive regulation of immunoglobulin production

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

cytosol

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

transcription by RNA polymerase II

ubiquitin-dependent protein catabolic process

lipid metabolic process

autophagy

apoptotic process

response to unfolded protein

multicellular organism development

muscle organ development

positive regulation of cell population proliferation

response to xenobiotic stimulus

regulation of autophagy

positive regulation of autophagy

negative regulation of myotube differentiation

protein transport

membrane

protein kinase binding

cell differentiation

positive regulation of cell migration

negative regulation of transforming growth factor beta receptor signaling pathway

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

endoplasmic reticulum unfolded protein response

exocrine pancreas development

chromatin DNA binding

ubiquitin protein ligase binding

regulation of protein stability

protein destabilization

protein destabilization

cellular response to nutrient

positive regulation of TOR signaling

positive regulation of interleukin-6 production

cellular response to insulin stimulus

cellular response to oxidative stress

response to endoplasmic reticulum stress

response to endoplasmic reticulum stress

intracellular triglyceride homeostasis

positive regulation of vascular wound healing

cellular response to vascular endothelial growth factor stimulus

phosphatidylinositol 3-kinase regulatory subunit binding

cellular response to glucose starvation

positive regulation of protein import into nucleus

cholesterol homeostasis

identical protein binding

histone deacetylase binding

negative regulation of apoptotic process

phosphatidylinositol 3-kinase/protein kinase B signal transduction

sequence-specific DNA binding

sequence-specific DNA binding

ubiquitin-like protein ligase binding

positive regulation of MHC class II biosynthetic process

positive regulation of B cell differentiation

positive regulation of T cell differentiation

positive regulation of fat cell differentiation

positive regulation of angiogenesis

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein heterodimerization activity

vascular endothelial growth factor receptor signaling pathway

neuron development

response to electrical stimulus

fatty acid homeostasis

sterol homeostasis

serotonin secretion, neurotransmission

adipose tissue development

epithelial cell maturation involved in salivary gland development

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

negative regulation of ERK1 and ERK2 cascade

cellular response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to amino acid stimulus

cellular response to fructose stimulus

cellular response to glucose stimulus

cellular response to interleukin-4

cellular response to peptide hormone stimulus

cellular response to fluid shear stress

cellular response to laminar fluid shear stress

RNA polymerase II transcription regulator complex

positive regulation of plasma cell differentiation

negative regulation of endoplasmic reticulum unfolded protein response

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of protein acetylation

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of lactation

response to insulin-like growth factor stimulus

cellular response to leukemia inhibitory factor

sequence-specific double-stranded DNA binding

positive regulation of hepatocyte proliferation

positive regulation of endothelial cell apoptotic process

04141

1451006_at Xdh xanthine dehydrogenase 17 -73883894 AV286265 95

allantoin metabolic process

allantoin metabolic process

allantoin metabolic process

negative regulation of protein phosphorylation

negative regulation of endothelial cell proliferation

xanthine dehydrogenase activity

xanthine dehydrogenase activity

xanthine dehydrogenase activity

xanthine dehydrogenase activity

xanthine oxidase activity

xanthine oxidase activity

xanthine oxidase activity

iron ion binding

protein binding

extracellular region

extracellular space

extracellular space

cytoplasm

peroxisome

cytosol

cytosol

cytosol

guanine catabolic process

guanine catabolic process

inosine catabolic process

inosine catabolic process

inosine catabolic process

deoxyinosine catabolic process

deoxyinosine catabolic process

deoxyinosine catabolic process

adenosine catabolic process

adenosine catabolic process

adenosine catabolic process

deoxyadenosine catabolic process

deoxyguanosine catabolic process

AMP catabolic process

AMP catabolic process

IMP catabolic process

IMP catabolic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

lactation

hypoxanthine catabolic process

hypoxanthine catabolic process

hypoxanthine catabolic process

xanthine catabolic process

xanthine catabolic process

xanthine catabolic process

response to aluminum ion

negative regulation of gene expression

iron-sulfur cluster assembly

oxidoreductase activity

sarcoplasmic reticulum

molybdenum ion binding

regulation of epithelial cell differentiation

identical protein binding

protein homodimerization activity

molybdopterin cofactor binding

amide catabolic process

amide catabolic process

amide catabolic process

negative regulation of endothelial cell differentiation

GMP catabolic process

dGMP catabolic process

dAMP catabolic process

metal ion binding

nitrite reductase (NO-forming) activity

flavin adenine dinucleotide binding

iron-sulfur cluster binding

2 iron, 2 sulfur cluster binding

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

hypoxanthine dehydrogenase activity

hypoxanthine dehydrogenase activity

hypoxanthine dehydrogenase activity

hypoxanthine oxidase activity

hypoxanthine oxidase activity

hypoxanthine oxidase activity

FAD binding

positive regulation of p38MAPK cascade

negative regulation of vascular endothelial growth factor signaling pathway

positive regulation of reactive oxygen species metabolic process

negative regulation of vasculogenesis

00230

00232

00983

01100

04146

1425058_at Zfp472 zinc finger protein 472 17 32965830 BC023090 18

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1439505_at Clic5 chloride intracellular channel 5 17 44188571 AA210377 35

response to dietary excess

diet induced thermogenesis

chloride channel activity

chloride channel activity

cytoplasm

cytoplasm

mitochondrion

Golgi apparatus

cytoskeleton

plasma membrane

plasma membrane

monoatomic ion transport

chloride transport

chloride transport

visual perception

sensory perception of sound

sensory perception of sound

protein localization

actin cytoskeleton

membrane

membrane

stereocilium

stereocilium bundle

monoatomic ion transmembrane transport

monoatomic ion channel complex

chloride channel complex

neuromuscular process controlling balance

response to stimulus

auditory receptor cell stereocilium organization

 
1459805_x_at Dus3l dihydrouridine synthase 3 like 17 56764750 BB482412 20

tRNA dihydrouridine synthesis

mRNA processing

regulation of translation

tRNA processing

oxidoreductase activity

tRNA dihydrouridine synthase activity

tRNA dihydrouridine synthase activity

metal ion binding

flavin adenine dinucleotide binding

tRNA-dihydrouridine47 synthase activity

mRNA dihydrouridine synthase activity

 
1424641_a_at Thoc1 THO complex 1 18 9958179 BC024951 36

transcription export complex

THO complex

THO complex part of transcription export complex

THO complex part of transcription export complex

chromosome, telomeric region

DNA binding

RNA binding

protein binding

nucleus

cytoplasm

mRNA processing

mRNA export from nucleus

mRNA export from nucleus

apoptotic process

signal transduction

RNA splicing

nuclear speck

regulation of DNA-templated transcription elongation

regulation of apoptotic process

mRNA transport

03013

03040

1428837_at Klhl14 kelch-like 14 18 -21550378 AK018108 18

protein binding

cytoplasm

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

cytosol

actin cytoskeleton

membrane

aggresome

neuron projection

neuron projection

neuronal cell body

neuronal cell body

 
1451277_at Ptgr3 prostaglandin reductase 3 18 84088157 BC025897 18

mitochondrion

peroxisome

lipid metabolic process

zinc ion binding

oxidoreductase activity

13-prostaglandin reductase activity

13-prostaglandin reductase activity

negative regulation of fat cell differentiation

15-oxoprostaglandin 13-oxidase activity

 
1433537_at Atrx ATRX, chromatin remodeler X -105797614 AV112912 138

nucleotide binding

meiotic spindle organization

nuclear chromosome

condensed chromosome, centromeric region

chromosome, telomeric region

heterochromatin

DNA binding

chromatin binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

pericentric heterochromatin

pericentric heterochromatin

DNA repair

chromatin organization

nucleosome assembly

chromatin remodeling

chromatin remodeling

transcription by RNA polymerase II

DNA damage response

spermatogenesis

positive regulation of nuclear cell cycle DNA replication

DNA translocase activity

nuclear body

PML body

hydrolase activity

DNA damage response, signal transduction by p53 class mediator

forebrain development

replication fork processing

replication fork processing

chromatin DNA binding

subtelomeric heterochromatin formation

subtelomeric heterochromatin formation

positive regulation of telomere maintenance

methylated histone binding

methylated histone binding

post-embryonic forelimb morphogenesis

multicellular organism growth

histone binding

histone binding

histone binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

Sertoli cell development

chromo shadow domain binding

chromosome organization involved in meiotic cell cycle

protein localization to chromosome, telomeric region

seminiferous tubule development

cellular response to hydroxyurea

chromosome, subtelomeric region

ATP-dependent chromatin remodeler activity

negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric

 
1460366_at Eml3 echinoderm microtubule associated protein like 3 19 8929693, 8929662 BC022146 16

microtubule cytoskeleton organization

nucleus

cytoplasm

spindle

cytoskeleton

microtubule

spindle microtubule

cell cycle

mitotic metaphase chromosome alignment

microtubule binding

microtubule cytoskeleton

midbody

protein self-association

cell division

mitotic spindle

regulation of mitotic spindle assembly

mitotic spindle microtubule

 
1434245_a_at Cyb561a3 cytochrome b561 family, member A3 19 10577156, 10577447 BB218627 14

nucleolus

lysosome

lysosomal membrane

lysosomal membrane

endosome

intracellular iron ion homeostasis

membrane

oxidoreductase activity

oxidoreductase activity

late endosome membrane

intracellular membrane-bounded organelle

metal ion binding

transmembrane ascorbate ferrireductase activity

 
1433771_at Abhd17b abhydrolase domain containing 17B 19 21653308 AV173092 18

protein depalmitoylation

protein depalmitoylation

protein depalmitoylation

endosome

plasma membrane

plasma membrane

proteolysis

serine-type peptidase activity

palmitoyl-(protein) hydrolase activity

palmitoyl-(protein) hydrolase activity

palmitoyl-(protein) hydrolase activity

endosome membrane

postsynaptic density

membrane

hydrolase activity

cell projection

synapse

postsynaptic membrane

recycling endosome membrane

postsynaptic density membrane

postsynaptic recycling endosome membrane

glutamatergic synapse

regulation of postsynapse organization

regulation of postsynapse organization

regulation of protein localization to synapse

negative regulation of protein localization to microtubule

regulation of dendritic spine maintenance

positive regulation of protein localization to endosome

 
1427318_s_at Myof myoferlin 19 -37899035 BI555209 45

plasma membrane repair

plasma membrane repair

phospholipid binding

phospholipid binding

phospholipid binding

nucleus

plasma membrane

plasma membrane

caveola

glycerol metabolic process

membrane

regulation of vascular endothelial growth factor receptor signaling pathway

cytoplasmic vesicle

T-tubule organization

T-tubule organization

centriolar satellite

cellular response to heat

intracellular membrane-bounded organelle

metal ion binding

muscle cell development

membrane fusion

 
1454708_at Ablim1 actin-binding LIM protein 1 19 -57032732, -57032732, -57032732, -57032732, -57032732 BG065289 51

stress fiber

stress fiber

actin binding

protein binding

cytoplasm

cytoskeleton

transcription by RNA polymerase II

cytoskeleton organization

axon guidance

postsynaptic density

actin cytoskeleton

actin cytoskeleton

lamellipodium

lamellipodium assembly

lamellipodium assembly

positive regulation of transcription by RNA polymerase II

metal ion binding

actin filament binding

cilium assembly

cilium assembly

04360

1419922_s_at Atrnl1 attractin like 1 19 57611033 AW555641 20

Notch binding

protein binding

plasma membrane

G protein-coupled receptor signaling pathway

membrane

carbohydrate binding

 
1455544_at Zranb3 zinc finger, RAN-binding domain containing 3 1 -127954178, -127954178, -127954178 BM228797 21

nucleotide binding

nucleic acid binding

catalytic activity

helicase activity

nuclease activity

endonuclease activity

DNA endonuclease activity

DNA endonuclease activity

ATP binding

nucleus

nucleoplasm

chromosome

DNA repair

DNA repair

DNA damage response

metabolic process

zinc ion binding

response to UV

hydrolase activity

replication fork processing

replication fork processing

DNA rewinding

ATP-dependent DNA/DNA annealing activity

nuclear replication fork

nuclear replication fork

negative regulation of DNA recombination

metal ion binding

K63-linked polyubiquitin modification-dependent protein binding

replication fork reversal

ATP-dependent chromatin remodeler activity

 
1457035_at Ifi207 interferon activated gene 207 1 -173723427 AI607873 13

negative regulation of transcription by RNA polymerase II

activation of innate immune response

activation of innate immune response

double-stranded DNA binding

double-stranded DNA binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

transcription factor binding

monocyte differentiation

positive regulation of interleukin-1 beta production

cellular response to interferon-beta

cellular response to glucose starvation

identical protein binding

negative regulation of DNA binding

negative regulation of viral genome replication

negative regulation of gene expression, epigenetic

negative regulation of innate immune response

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

defense response to virus

cellular response to ionizing radiation

intrinsic apoptotic signaling pathway by p53 class mediator

activation of cysteine-type endopeptidase activity

negative regulation of AIM2 inflammasome complex assembly

negative regulation of cysteine-type endopeptidase activity

 
1423962_at Wdr26 WD repeat domain 26 1 -181173225 BC020044 29

ubiquitin ligase complex

molecular_function

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

GID complex

proteasome-mediated ubiquitin-dependent protein catabolic process

 
1455816_a_at Kctd3 potassium channel tetramerisation domain containing 3 1 -188971095, -188971097 BB321232 18

molecular_function

protein binding

plasma membrane

biological_process

membrane

protein homooligomerization

 
1424706_at Zfp51 zinc finger protein 51 17 21450373 BC011183 19

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1425495_at Zfp62 zinc finger protein 62 11 49203291, 49203730, 49204318 BC022935 23

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleus

nucleus

regulation of transcription by RNA polymerase II

metal ion binding

 
1433564_at Dgkd diacylglycerol kinase, delta 1 87853286 BB094429 35

nucleotide binding

ATP-dependent diacylglycerol kinase activity

ATP-dependent diacylglycerol kinase activity

ATP-dependent diacylglycerol kinase activity

ATP binding

cytoplasm

cytosol

plasma membrane

clathrin-coated pit

lipid metabolic process

phosphatidic acid biosynthetic process

endocytosis

signal transduction

protein kinase C-activating G protein-coupled receptor signaling pathway

protein transport

membrane

kinase activity

phosphorylation

transferase activity

kinase binding

cytoplasmic vesicle

intracellular signal transduction

identical protein binding

protein homodimerization activity

positive regulation of epidermal growth factor receptor signaling pathway

diacylglycerol metabolic process

diacylglycerol metabolic process

diacylglycerol metabolic process

lipid phosphorylation

lipid phosphorylation

lipid phosphorylation

metal ion binding

protein heterodimerization activity

negative regulation of protein kinase C signaling

positive regulation of clathrin-dependent endocytosis

00561

00564

01100

04070

1437870_at Slco4c1 solute carrier organic anion transporter family, member 4C1 1 -96818783 AV024403 28

plasma membrane

monoatomic ion transport

multicellular organism development

spermatogenesis

organic anion transmembrane transporter activity

sodium-independent organic anion transmembrane transporter activity

organic anion transport

membrane

basolateral plasma membrane

basolateral plasma membrane

transmembrane transporter activity

cell differentiation

sodium-independent organic anion transport

transmembrane transport

 
1436312_at Ikzf1 IKAROS family zinc finger 1 11 11690176, 11685924 AV317621 243

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

natural killer cell differentiation

DNA binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

transcription regulator complex

pericentric heterochromatin

pericentric heterochromatin

cytoplasm

cytosol

chromatin organization

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cell cycle

multicellular organism development

poly-pyrimidine tract binding

positive regulation of gene expression

protein domain specific binding

hemopoiesis

lymphocyte differentiation

B cell differentiation

T cell differentiation

erythrocyte differentiation

forebrain development

positive regulation of transcription elongation by RNA polymerase II

protein-containing complex

protein-DNA complex

amacrine cell differentiation

positive regulation of multicellular organism growth

positive regulation of multicellular organism growth

identical protein binding

sequence-specific DNA binding

establishment of protein localization

positive regulation of neutrophil differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of RNA polymerase II transcription preinitiation complex assembly

positive regulation of transcription by RNA polymerase II

metal ion binding

lymph node development

thymus development

Peyer's patch development

gland development

retinal bipolar neuron differentiation

 
1436649_at Ikzf3 IKAROS family zinc finger 3 11 -98464692 BB151746 57

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

regulation of transcription by RNA polymerase II

response to bacterium

B cell differentiation

T cell differentiation

regulation of B cell proliferation

B cell activation

identical protein binding

protein homodimerization activity

histone deacetylase binding

regulation of apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

regulation of B cell differentiation

regulation of lymphocyte differentiation

positive regulation of transcription by RNA polymerase II

metal ion binding

protein heterodimerization activity

promoter-specific chromatin binding

 
1451451_at Gca grancalcin 2 62664326 BC021450 21

calcium ion binding

calcium ion binding

cytoplasm

cytosol

cytosol

plasma membrane

membrane

protein homodimerization activity

metal ion binding

protein heterodimerization activity

 
1451141_at Mettl8 methyltransferase 8, methylcytidine 2 -70964560, -70964561 BC004636 21

histone acetyltransferase activity

nucleus

cytoplasm

mitochondrion

skeletal muscle tissue development

tRNA processing

methyltransferase activity

mRNA methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

transferase activity

methylation

fat cell differentiation

tRNA (cytidine-3-)-methyltransferase activity

positive regulation of mitochondrial translation

mitochondrial tRNA modification

mRNA methylation

mRNA methylation

tRNA C3-cytosine methylation

 
1455080_at Ppp1r16b protein phosphatase 1, regulatory subunit 16B 2 158667134, 158666732 BB375209 25

positive regulation of endothelial cell proliferation

enzyme inhibitor activity

nucleus

cytoplasm

plasma membrane

membrane

nuclear speck

myosin phosphatase regulator activity

protein phosphatase regulator activity

regulation of protein dephosphorylation

positive regulation of protein dephosphorylation

negative regulation of protein dephosphorylation

cell projection

perinuclear region of cytoplasm

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

establishment of endothelial barrier

establishment of endothelial barrier

establishment of endothelial barrier

negative regulation of peptidyl-serine dephosphorylation

positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of sprouting angiogenesis

 
1452922_at Ppp1r3d protein phosphatase 1, regulatory subunit 3D 2 -178411205 AK011539 12

protein phosphatase type 1 complex

phosphoprotein phosphatase activity

regulation of glycogen biosynthetic process

regulation of glycogen biosynthetic process

regulation of glycogen catabolic process

protein phosphatase 1 binding

enzyme binding

glycogen granule

glycogen binding

04910

1425062_at Fcrl1 Fc receptor-like 1 3 87376386, 87376386 BF163263 18

plasma membrane

cell surface

coreceptor activity

membrane

B cell activation

 
1455046_a_at Pogz pogo transposable element with ZNF domain 3 94837436 BI250645 44

double-strand break repair via homologous recombination

chromatin

nucleic acid binding

DNA binding

nucleus

nucleus

nucleoplasm

chromosome

cytoplasm

cytosol

DNA repair

DNA recombination

DNA damage response

cell cycle

mitotic sister chromatid cohesion

positive regulation of transcription by RNA polymerase II

metal ion binding

cell division

kinetochore assembly

 
1451932_a_at Adamtsl4 ADAMTS-like 4 3 -95676200 BC016215 23

protease binding

epithelial cell development

extracellular region

interstitial matrix

apoptotic process

extracellular matrix organization

extracellular matrix organization

extracellular matrix

identical protein binding

positive regulation of apoptotic process

pigment cell development

 
1435174_at Rsbn1 rosbin, round spermatid basic protein 1 3 103914119 AW546080 23

protein binding

nucleus

nucleus

chromatin organization

biological_process

oxidoreductase activity

histone H4K20 demethylase activity

metal ion binding

dioxygenase activity

 
1452717_at Slc25a24 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24 3 109123148 BM230959 25

adenine nucleotide transmembrane transporter activity

ATP transmembrane transporter activity

ATP transmembrane transporter activity

calcium ion binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial transport

antiporter activity

ADP transport

ATP transport

membrane

cellular response to oxidative stress

metal ion binding

adenine nucleotide transport

transmembrane transport

cellular response to calcium ion

ATP:inorganic phosphate antiporter activity

ADP:inorganic phosphate antiporter activity

mitochondrial ATP transmembrane transport

 
1434380_at Gbp7 guanylate binding protein 7 3 142530335 BM241271 19

nucleotide binding

activation of innate immune response

immune system process

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

membrane

hydrolase activity

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

defense response to bacterium

defense response to protozoan

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

innate immune response

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

defense response to virus

cytolysis in another organism

cellular response to type II interferon

cellular response to type II interferon

 
1437760_at Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 4 47091922 AV376137 22

molecular_function

polypeptide N-acetylgalactosaminyltransferase activity

polypeptide N-acetylgalactosaminyltransferase activity

Golgi apparatus

Golgi apparatus

protein O-linked glycosylation

biological_process

membrane

transferase activity

glycosyltransferase activity

carbohydrate binding

metal ion binding

00512

01100

1426315_a_at Tmem268 transmembrane protein 268 4 63558762, 63560226 AV326978 12

molecular_function

cellular_component

biological_process

membrane

 
1433968_a_at Megf9 multiple EGF-like-domains 9 4 -70431926 BQ174710 22

extracellular matrix structural constituent

basement membrane

basement membrane

axon guidance

animal organ morphogenesis

tissue development

membrane

 
1437395_at Tut4 terminal uridylyl transferase 4 4 108460007, 108459409 BE370775 33

oocyte maturation

cytokine production

nucleic acid binding

protein binding

nucleus

nucleolus

cytoplasm

cytoplasm

cytosol

cytosol

zinc ion binding

miRNA metabolic process

miRNA metabolic process

miRNA catabolic process

transferase activity

nucleotidyltransferase activity

stem cell population maintenance

regulatory ncRNA-mediated gene silencing

pre-miRNA processing

RNA 3'-end processing

RNA 3'-end processing

regulation of lipopolysaccharide-mediated signaling pathway

negative regulation of NF-kappaB transcription factor activity

positive regulation of interleukin-6 production

miRNA binding

cytoplasmic ribonucleoprotein granule

metal ion binding

RNA uridylyltransferase activity

RNA uridylyltransferase activity

RNA uridylyltransferase activity

RNA uridylyltransferase activity

interleukin-6-mediated signaling pathway

uridylyltransferase activity

uridylyltransferase activity

RNA 3' uridylation

RNA 3' uridylation

RNA 3' uridylation

retrotransposon silencing by mRNA destabilization

polyuridylation-dependent mRNA catabolic process

 
1440819_s_at Szt2 SZT2 subunit of KICSTOR complex 4 -118362739 BB541793 28

lysosome

lysosomal membrane

peroxisome

peroxisome

central nervous system development

post-embryonic development

membrane

corpus callosum morphogenesis

response to nutrient levels

cellular response to amino acid starvation

cellular response to glucose starvation

pigmentation

protein localization to lysosome

GATOR2 complex

KICSTOR complex

regulation of superoxide dismutase activity

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

GATOR1 complex

 
1435362_at Foxj3 forkhead box J3 4 119539660, 119542335 BB026073 38

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

male meiosis I

spermatogenesis

cell differentiation

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

meiotic cell cycle

sequence-specific double-stranded DNA binding

 
1435087_at Zfp362 zinc finger protein 362 4 -128773084 BI409907 7

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

regulation of transcription by RNA polymerase II

 
1428467_at Tardbp TAR DNA binding protein 4 -148612381 AK004440 286

RNA polymerase II cis-regulatory region sequence-specific DNA binding

negative regulation of protein phosphorylation

nucleic acid binding

DNA binding

double-stranded DNA binding

RNA binding

RNA binding

RNA binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

perichromatin fibrils

cytoplasm

mitochondrion

mRNA processing

lipid binding

RNA splicing

RNA splicing

gene expression

regulation of gene expression

negative regulation of gene expression

nuclear speck

regulation of protein stability

regulation of protein stability

positive regulation of insulin secretion

interchromatin granule

positive regulation of protein import into nucleus

regulation of circadian rhythm

identical protein binding

regulation of apoptotic process

intracellular non-membrane-bounded organelle

negative regulation by host of viral transcription

rhythmic process

regulation of cell cycle

3'-UTR-mediated mRNA destabilization

3'-UTR-mediated mRNA stabilization

nuclear inner membrane organization

pre-mRNA intronic binding

molecular condensate scaffold activity

amyloid fibril formation

 
1423919_at Haus3 HAUS augmin-like complex, subunit 3 5 -34153896 BC027393 26

cytoplasm

centrosome

centrosome

cytoskeleton

microtubule

cell cycle

centrosome cycle

centrosome cycle

spindle assembly

spindle assembly

cell division

HAUS complex

HAUS complex

mitotic spindle

mitotic spindle microtubule

 
1437184_at Guf1 GUF1 homolog, GTPase 5 69556923 BI789973 18

nucleotide binding

GTPase activity

GTP binding

mitochondrion

mitochondrion

mitochondrial inner membrane

translation

membrane

hydrolase activity

positive regulation of translation

mitochondrial ribosome binding

 
1434311_at Cnot6l CCR4-NOT transcription complex, subunit 6-like 5 -96070332, -96070332, -96070332 BB025078 43

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

nuclear-transcribed mRNA poly(A) tail shortening

catalytic activity

nuclease activity

exonuclease activity

poly(A)-specific ribonuclease activity

poly(A)-specific ribonuclease activity

poly(A)-specific ribonuclease activity

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

cytosol

mRNA processing

regulation of translation

positive regulation of cell population proliferation

positive regulation of cell population proliferation

positive regulation of cytoplasmic mRNA processing body assembly

hydrolase activity

CCR4-NOT complex

CCR4-NOT complex

regulatory ncRNA-mediated gene silencing

metal ion binding

mRNA destabilization

03018

1451335_at Plac8 placenta-specific 8 5 -100553725, -100553725 AF263458 39

chromatin binding

protein binding

nucleus

transcription by RNA polymerase II

transcription by RNA polymerase II

positive regulation of cell population proliferation

response to cold

negative regulation of multicellular organism growth

defense response to bacterium

negative regulation of apoptotic process

negative regulation of apoptotic process

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

brown fat cell differentiation

positive regulation of cold-induced thermogenesis

 
1454799_at Gpat3 glycerol-3-phosphate acyltransferase 3 5 100846228 AV300264 22

1-acylglycerol-3-phosphate O-acyltransferase activity

glycerol-3-phosphate O-acyltransferase activity

protein binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

glycerol-3-phosphate metabolic process

lipid metabolic process

O-acyltransferase activity

phospholipid biosynthetic process

membrane

transferase activity

acyltransferase activity

triglyceride biosynthetic process

triglyceride biosynthetic process

regulation of TOR signaling

sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

00561

00564

01100

1455370_at A630023P12Rik RIKEN cDNA A630023P12 gene 5 110514922 AI451630 10

molecular_function

cellular_component

biological_process

 
1424339_at Oasl1 2'-5' oligoadenylate synthetase-like 1 5 114923239 AB067533 28

immune system process

DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

nucleus

nucleoplasm

nucleoplasm

nucleolus

cytoplasm

cytosol

cytosol

response to virus

membrane

nucleotidyltransferase activity

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

defense response to virus

defense response to virus

regulation of ribonuclease activity

interleukin-27-mediated signaling pathway

positive regulation of RIG-I signaling pathway

 
1428346_at Trafd1 TRAF type zinc finger domain containing 1 5 -121371724, -121371724 AK003586 21

protein binding

mitochondrion

zinc ion binding

negative regulation of innate immune response

negative regulation of innate immune response

metal ion binding

 
1438675_at Sfswap splicing factor SWAP 5 129501230, 129501239 BB278628 26

alternative mRNA splicing, via spliceosome

mRNA 5'-splice site recognition

mRNA 5'-splice site recognition

RNA binding

protein binding

nucleus

RNA processing

mRNA processing

RNA splicing

negative regulation of mRNA splicing, via spliceosome

 
1427327_at Pilra paired immunoglobin-like type 2 receptor alpha 5 -137821951 BB775785 28

protein binding

signal transduction

membrane

MHC class I protein binding

 
1456762_at Gimap6 GTPase, IMAP family member 6 6 -48701582 BM237714 18

nucleotide binding

molecular_function

GTP binding

cytoplasm

cytosol

cytosol

biological_process

 
1438630_x_at Mat2a methionine adenosyltransferase 2A 6 -72432795 AV260654 50

nucleotide binding

methionine adenosyltransferase activity

methionine adenosyltransferase activity

methionine adenosyltransferase activity

ATP binding

cytosol

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

S-adenosylmethionine biosynthetic process

one-carbon metabolic process

circadian rhythm

response to xenobiotic stimulus

response to hormone

amino acid binding

transferase activity

protein hexamerization

small molecule binding

identical protein binding

metal ion binding

methionine adenosyltransferase complex

methionine adenosyltransferase complex

protein heterooligomerization

response to cAMP

cellular response to leukemia inhibitory factor

00270

01100

1451125_at Paip2b poly(A) binding protein interacting protein 2B 6 -83806058 BC017133 21

mRNA regulatory element binding translation repressor activity

cytoplasm

regulation of translation

poly(A) binding

negative regulation of translation

negative regulation of translation

translation repressor activity

negative regulation of translational initiation

 
1426988_at Klhl42 kelch-like 42 6 147091074 BB795533 16

protein polyubiquitination

protein polyubiquitination

ubiquitin-protein transferase activity

cytoplasm

cytoskeleton

cell cycle

Cul3-RING ubiquitin ligase complex

Cul3-RING ubiquitin ligase complex

regulation of microtubule-based process

regulation of microtubule-based process

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

cell division

 
1456777_at Mgam maltase-glucoamylase 6 40628830, 40628830 BB072761 19

maltose catabolic process

glucan 1,4-alpha-glucosidase activity

alpha-1,4-glucosidase activity

alpha-1,4-glucosidase activity

alpha-1,4-glucosidase activity

amylase activity

apical plasma membrane

maltose alpha-glucosidase activity

alpha-glucosidase activity

dextrin catabolic process

00052

00500

01100

04973

1425128_at B3gnt8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 7 25627623 BC025206 13

Golgi membrane

Golgi apparatus

protein glycosylation

protein O-linked glycosylation

membrane

protein N-acetylglucosaminyltransferase activity

protein N-acetylglucosaminyltransferase activity

transferase activity

glycosyltransferase activity

hexosyltransferase activity

poly-N-acetyllactosamine biosynthetic process

poly-N-acetyllactosamine biosynthetic process

 
1425380_at Rasgrp4 RAS guanyl releasing protein 4 7 29134932 AF331457 24

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

nucleoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

small GTPase-mediated signal transduction

Ras protein signal transduction

cell population proliferation

response to extracellular stimulus

membrane

cell differentiation

positive regulation of GTPase activity

positive regulation of Ras protein signal transduction

metal ion binding

04010

1425216_at Ffar2 free fatty acid receptor 2 7 -30818356, -30818356, -30818356, -30818356, -30818356 AV370830 103

leukocyte chemotaxis involved in inflammatory response

immune system process

mucosal immune response

regulation of acute inflammatory response

positive regulation of cytokine production involved in immune response

cell surface pattern recognition receptor signaling pathway

positive regulation of acute inflammatory response to non-antigenic stimulus

G protein-coupled receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

inflammatory response

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

lipid binding

membrane

lipid storage

lipid storage

positive regulation of insulin secretion

positive regulation of chemokine production

positive regulation of interleukin-8 production

glucose homeostasis

glucose homeostasis

cell projection

fat cell differentiation

negative regulation of insulin secretion

negative regulation of insulin secretion

cellular response to fatty acid

cellular response to fatty acid

cellular response to fatty acid

cellular response to fatty acid

regulation of peptide hormone secretion

regulation of peptide hormone secretion

ligand-gated ion channel signaling pathway

 
1460620_at Zfp592 zinc finger protein 592 7 80993683 BB668116 30

DNA binding

protein binding

nucleus

PH domain binding

insulin receptor substrate binding

negative regulation of insulin receptor signaling pathway

metal ion binding

regulation of peptidyl-tyrosine phosphorylation

 
1452857_at Crebzf CREB/ATF bZIP transcription factor 7 90442780 AW546339 31

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

mitochondrion

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

response to virus

regulation of gene expression

identical protein binding

sequence-specific DNA binding

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

regulation of DNA-binding transcription factor activity

RNA polymerase II transcription regulator complex

 
1455452_x_at Kctd14 potassium channel tetramerisation domain containing 14 7 97451333, 97453203 AW552116 14

molecular_function

cellular_component

biological_process

 
1451342_at Spon1 spondin 1, (f-spondin) extracellular matrix protein 7 113765997 BC020531 54

extracellular matrix structural constituent

protein binding

extracellular region

cell adhesion

cell adhesion

positive regulation of protein processing

protein processing

extracellular matrix

positive regulation of protein binding

metal ion binding

LBD domain binding

collagen-containing extracellular matrix

negative regulation of amyloid-beta formation

positive regulation of amyloid precursor protein catabolic process

 
1428539_at Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase 7 -118131311 AK011909 32

nucleotide binding

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

protein serine/threonine kinase activity

protein serine/threonine kinase activity

diacylglycerol-dependent serine/threonine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

DNA repair

protein phosphorylation

DNA damage response

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

regulation of telomere maintenance

chromatoid body

telomeric DNA binding

protein autophosphorylation

phosphatidylinositol phosphate biosynthetic process

metal ion binding

03015

1455141_at Tnrc6a trinucleotide repeat containing 6a 7 123123884 BI080625 40

P-body

P-body

P-body

nucleic acid binding

RNA binding

nucleoplasm

nucleoplasm

cytoplasm

Golgi apparatus

cytosol

regulation of translation

endoderm development

cellular response to starvation

RISC complex

regulatory ncRNA-mediated gene silencing

maintenance of protein location in cell

miRNA-mediated post-transcriptional gene silencing

miRNA-mediated post-transcriptional gene silencing

miRNA-mediated gene silencing by inhibition of translation

intracellular membrane-bounded organelle

perinuclear region of cytoplasm

molecular adaptor activity

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

 
1433598_at Arglu1 arginine and glutamate rich 1 8 -8666575 BG093966 20

nucleoplasm

nucleoplasm

mitochondrion

mitochondrion

cytosol

 
1424599_at Fgl1 fibrinogen-like protein 1 8 -41191433 BC021946 28

adaptive immune response

immune system process

signaling receptor binding

protein binding

extracellular region

extracellular region

extracellular space

cell-matrix adhesion

cholesterol metabolic process

regulation of glucose metabolic process

response to stilbenoid

identical protein binding

regulation of immune response

regulation of immune response

negative regulation of T cell activation

negative regulation of T cell activation

adipose tissue development

collagen-containing extracellular matrix

platelet aggregation

hepatocyte proliferation

 
1451777_at Ddx60 DExD/H box helicase 60 8 61928086 BC013672 19

double-stranded DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

protein binding

cytoplasm

cytoplasm

cytoplasm

cytosol

response to virus

intermediate filament cytoskeleton

defense response to virus

defense response to virus

positive regulation of MDA-5 signaling pathway

positive regulation of RIG-I signaling pathway

 
1435798_a_at Sugp2 SURP and G patch domain containing 2 8 70234204, 70234204 BB772209 27

molecular_function

nucleic acid binding

RNA binding

nucleus

nucleoplasm

nucleoplasm

RNA processing

mRNA processing

biological_process

RNA splicing

nuclear body

 
1438577_at Inpp4b inositol polyphosphate-4-phosphatase, type II 8 81342561, 81342561 BB376947 33

cytoplasm

lipid metabolic process

intracellular calcium ion homeostasis

lipid binding

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity

hydrolase activity

phosphatidylinositol bisphosphate phosphatase activity

phosphatidylinositol trisphosphate phosphatase activity

negative regulation of osteoclast differentiation

negative regulation of osteoclast differentiation

regulation of nucleocytoplasmic transport

regulation of bone remodeling

phosphatidylinositol dephosphorylation

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

00562

01100

04070

1424831_at Cpne2 copine II 8 94533027 BC023348 21

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

nucleus

cytoplasm

plasma membrane

plasma membrane

membrane

metal ion binding

cellular response to calcium ion

cellular response to calcium ion

 
1437709_x_at Ttc13 tetratricopeptide repeat domain 13 8 -124671326 BB492914 13

molecular_function

cellular_component

biological_process

 
1435397_at Zbtb44 zinc finger and BTB domain containing 44 9 31030643 AV146691 23

molecular_function

DNA binding

nucleus

biological_process

metal ion binding

 
1426232_at Msantd2 Myb/SANT-like DNA-binding domain containing 2 9 37489320 BC024479 19

molecular_function

cellular_component

biological_process

 
1428749_at Dmxl2 Dmx-like 2 9 -54365157 AK018275 38

vacuolar acidification

chemical synaptic transmission

spermatogenesis

brain development

sensory perception of smell

synaptic vesicle

membrane

corpus callosum development

small GTPase binding

cytoplasmic vesicle

glucose homeostasis

RAVE complex

synapse

neuronal dense core vesicle

 
1426556_at Zfp280d zinc finger protein 280D 9 72274887 BG066777 23

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

regulation of DNA-templated transcription

metal ion binding

 
1436033_at Atosa atos homolog A 9 74952879, 74976110, 74953052 BG276629 16

molecular_function

cellular_component

nucleus

biological_process

 
1456735_x_at Pxylp1 2-phosphoxylose phosphatase 1 9 -96823342 BB458645 18

Golgi apparatus

Golgi apparatus

glycosaminoglycan biosynthetic process

glycosaminoglycan biosynthetic process

positive regulation of heparan sulfate proteoglycan biosynthetic process

membrane

dephosphorylation

hydrolase activity

phosphatase activity

phosphatase activity

chondroitin sulfate proteoglycan biosynthetic process

chondroitin sulfate proteoglycan biosynthetic process

 
1433520_at Scap SREBF chaperone 9 110333355, 110333287 BI412871 80

Golgi membrane

response to hypoxia

protein binding

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

lipid metabolic process

immune response

steroid metabolic process

cholesterol metabolic process

lipid binding

cholesterol binding

membrane

regulation of fatty acid metabolic process

cytoplasmic vesicle

response to insulin

SREBP signaling pathway

sterol binding

SREBP-SCAP complex

protein-containing complex

regulation of fatty acid biosynthetic process

cellular lipid metabolic process

protein-containing complex binding

regulation of cholesterol biosynthetic process

regulation of cholesterol biosynthetic process

positive regulation of cholesterol biosynthetic process

 
1433769_at Als2cl ALS2 C-terminal like 9 110880173, 110880321 BM201174 20

GTPase activator activity

protein binding

cytoplasm

cytoplasm

endosome organization

protein localization

endosomal transport

small GTPase binding

small GTPase binding

cytoplasmic vesicle

cytoplasmic vesicle

identical protein binding

regulation of GTPase activity

 
1434331_at Ago1 argonaute RISC catalytic subunit 1 4 -126435012, -126435012 BG072783 58

P-body

nuclear-transcribed mRNA catabolic process

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II complex binding

core promoter sequence-specific DNA binding

nucleic acid binding

RNA binding

RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

regulation of translation

RNA secondary structure unwinding

miRNA metabolic process

positive regulation of gene expression

RISC complex

RISC complex

RISC complex

negative regulation of angiogenesis

regulatory ncRNA-mediated gene silencing

pre-miRNA processing

pre-miRNA processing

regulatory ncRNA-mediated post-transcriptional gene silencing

miRNA processing

miRNA binding

miRNA binding

miRNA binding

miRNA-mediated gene silencing by inhibition of translation

cytoplasmic ribonucleoprotein granule

cytoplasmic ribonucleoprotein granule

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

RISC-loading complex

RISC complex assembly

positive regulation of non-canonical NF-kappaB signal transduction

ribonucleoprotein complex

 
1454714_x_at Phgdh 3-phosphoglycerate dehydrogenase 3 -98313170 AA561726 78

phosphoglycerate dehydrogenase activity

phosphoglycerate dehydrogenase activity

phosphoglycerate dehydrogenase activity

glutamine metabolic process

glycine metabolic process

L-serine metabolic process

L-serine biosynthetic process

threonine metabolic process

amino acid biosynthetic process

gamma-aminobutyric acid metabolic process

regulation of gene expression

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

taurine metabolic process

spinal cord development

glial cell development

neural tube development

neurogenesis

neuron projection development

myelin sheath

NAD binding

G1 to G0 transition

00260

01100

1454897_at Slc9a7 solute carrier family 9 (sodium/hydrogen exchanger), member 7 X -20098850 AV330057 17

endosome

Golgi apparatus

trans-Golgi network

plasma membrane

plasma membrane

monoatomic ion transport

monoatomic cation transport

potassium ion transport

sodium ion transport

regulation of pH

antiporter activity

sodium:proton antiporter activity

sodium:proton antiporter activity

potassium:proton antiporter activity

potassium:proton antiporter activity

membrane

intracellular membrane-bounded organelle

regulation of intracellular pH

recycling endosome

recycling endosome membrane

transmembrane transport

potassium ion transmembrane transport

sodium ion import across plasma membrane

proton transmembrane transport

regulation of Golgi lumen acidification

 
1454882_at L3mbtl3 L3MBTL3 histone methyl-lysine binding protein 10 -26274467, -26274467 BB022070 23

chromatin binding

chromatin binding

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

chromatin organization

regulation of DNA-templated transcription

zinc ion binding

myeloid cell differentiation

myeloid cell differentiation

macrophage differentiation

granulocyte differentiation

histone binding

identical protein binding

erythrocyte maturation

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

metal ion binding

regulation of DNA methylation-dependent heterochromatin formation

methylation-dependent protein binding

regulation of ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process

 
1444107_at Mideas mitotic deacetylase associated SANT domain protein 12 -84149173, -84149173 BB091357 21

histone deacetylase complex

transcription corepressor activity

nucleoplasm

transcription regulator complex

regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

 
1421366_at Clec5a C-type lectin domain family 5, member a 6 -40574897 NM_021364 31

virus receptor activity

virus receptor activity

virus receptor activity

positive regulation of cytokine production

osteoblast development

immune system process

protein binding

cytosol

plasma membrane

cell surface

membrane

myeloid cell differentiation

carbohydrate binding

negative regulation of myeloid cell apoptotic process

negative regulation of apoptotic process

innate immune response

innate immune response

innate immune response

 
1455945_at Zfp58 zinc finger protein 58 13 -67490166 AV282347 16

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

metal ion binding

 
1452163_at Ets1 E26 avian leukemia oncogene 1, 5' domain 9 32696036, 32636240 BB151715 259

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription corepressor binding

DNA-binding transcription activator activity, RNA polymerase II-specific

immune system process

nucleic acid binding

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

transcription regulator complex

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

positive regulation of cell population proliferation

positive regulation of endothelial cell migration

positive regulation of gene expression

regulation of extracellular matrix disassembly

cell differentiation

positive regulation of cell migration

nuclear receptor coactivator activity

PML body organization

histone acetyltransferase binding

identical protein binding

regulation of apoptotic process

positive regulation of blood vessel endothelial cell migration

sequence-specific DNA binding

sequence-specific DNA binding

positive regulation of erythrocyte differentiation

regulation of angiogenesis

positive regulation of angiogenesis

negative regulation of cell cycle

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

response to antibiotic

cell motility

negative regulation of inflammatory response

positive regulation of inflammatory response

RNA polymerase II-specific DNA-binding transcription factor binding

DNA-binding transcription factor binding

positive regulation of miRNA transcription

positive regulation of leukocyte adhesion to vascular endothelial cell

sequence-specific double-stranded DNA binding

04320

05211

1430986_at Farsb phenylalanyl-tRNA synthetase, beta subunit 1 -78424744, -78417957 AK012154 35

nucleotide binding

magnesium ion binding

RNA binding

aminoacyl-tRNA ligase activity

phenylalanine-tRNA ligase activity

phenylalanine-tRNA ligase activity

ATP binding

cytoplasm

translation

phenylalanyl-tRNA aminoacylation

phenylalanyl-tRNA aminoacylation

phenylalanine-tRNA ligase complex

phenylalanine-tRNA ligase complex

ligase activity

metal ion binding

protein heterotetramerization

00970

1453851_a_at Gadd45g growth arrest and DNA-damage-inducible 45 gamma 13 51846674 AK007410 77

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

negative regulation of protein kinase activity

apoptotic process

multicellular organism development

cell differentiation

type II interferon production

identical protein binding

positive regulation of apoptotic process

positive regulation of MAPK cascade

T-helper 1 cell differentiation

positive regulation of JNK cascade

regulation of cell cycle

regulation of cell cycle

positive regulation of cold-induced thermogenesis

positive regulation of p38MAPK cascade

04010

04110

04115

1418216_at Ggt5 gamma-glutamyltransferase 5 10 75589380 NM_011820 23

peptidyltransferase activity

leukotriene-C(4) hydrolase

leukotriene-C(4) hydrolase

leukotriene-C(4) hydrolase

plasma membrane

plasma membrane

plasma membrane

proteolysis

amino acid metabolic process

fatty acid metabolic process

glutathione biosynthetic process

glutathione catabolic process

glutathione catabolic process

inflammatory response

inflammatory response

peptidase activity

membrane

transferase activity

acyltransferase activity

hydrolase activity

leukotriene biosynthetic process

glutathione hydrolase activity

glutathione hydrolase activity

leukotriene C4 gamma-glutamyl transferase activity

leukotriene D4 biosynthetic process

leukotriene D4 biosynthetic process

leukotriene D4 biosynthetic process

leukotriene D4 biosynthetic process

00430

00460

00480

00590

01100

1436395_at Card6 caspase recruitment domain family, member 6 15 -5097438 BB766747 18

molecular_function

cytoplasm

regulation of canonical NF-kappaB signal transduction

04621

1457264_at Phf20l1 PHD finger protein 20-like 1 15 66577571 AV349060 21

molecular_function

nucleus

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein catabolic process

NSL complex

metal ion binding

methylation-dependent protein binding

 
1453196_a_at Oasl2 2'-5' oligoadenylate synthetase-like 2 5 114896933 BQ033138 26

nucleotide binding

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

immune system process

RNA binding

double-stranded RNA binding

double-stranded RNA binding

ATP binding

nucleoplasm

cytosol

purine nucleotide biosynthetic process

response to virus

membrane

transferase activity

nucleotidyltransferase activity

negative regulation of viral genome replication

innate immune response

metal ion binding

defense response to virus

defense response to virus

regulation of ribonuclease activity

interleukin-27-mediated signaling pathway

 
1436608_at Pced1b PC-esterase domain containing 1B 15 97247106 BB457436 13

molecular_function

cellular_component

biological_process

 
1449380_at Pacsin1 protein kinase C and casein kinase substrate in neurons 1 17 27685238, 27655590 BI731319 49

protein binding

phospholipid binding

phospholipid binding

phospholipid binding

cytoplasm

cytoplasm

cytoplasm

endosome

plasma membrane

plasma membrane

endocytosis

cytoskeleton organization

cytoskeleton organization

actin filament organization

signal transduction

cytoskeletal protein binding

lipid binding

membrane

regulation of endocytosis

COPI-coated vesicle

cytoplasmic vesicle

ruffle membrane

identical protein binding

cell projection

neuron projection

myelin sheath

axon terminus

synapse

synapse

negative regulation of endocytosis

perinuclear region of cytoplasm

synaptic vesicle endocytosis

synaptic vesicle endocytosis

neuron development

neuron projection morphogenesis

neuron projection morphogenesis

protein localization to membrane

protein localization to plasma membrane

plasma membrane tubulation

plasma membrane tubulation

plasma membrane tubulation

photoreceptor ribbon synapse

presynapse

presynaptic endocytic zone

postsynaptic density membrane

glutamatergic synapse

regulation of postsynaptic neurotransmitter receptor internalization

positive regulation of dendrite development

positive regulation of dendrite development

 
1434510_at Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 19 32620004, 32595714 BF780807 67

sulfate assimilation

sulfate assimilation

sulfate assimilation

nucleotide binding

catalytic activity

adenylylsulfate kinase activity

adenylylsulfate kinase activity

adenylylsulfate kinase activity

sulfate adenylyltransferase (ATP) activity

sulfate adenylyltransferase (ATP) activity

ATP binding

cytosol

blood coagulation

metabolic process

kinase activity

phosphorylation

transferase activity

nucleotidyltransferase activity

hormone metabolic process

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process

bone development

00230

00450

00920

01100

1440226_at Zfp760 zinc finger protein 760 17 21707740 BB088782 14

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1424672_at Dmxl1 Dmx-like 1 18 49832996 BC020141 20

molecular_function

vacuolar acidification

RAVE complex

 
1439831_at Iigp1c interferon inducible GTPase 1C 18 60212076 AW111920 13

GTPase activity

endoplasmic reticulum membrane

defense response

cellular response to interferon-beta

cellular response to interferon-beta

 
1456126_at Malt1 MALT1 paracaspase 18 65430989 BB485735 110

fibrillar center

B-1 B cell differentiation

protease binding

polkadots

immune system process

positive regulation of T cell cytokine production

endopeptidase activity

cysteine-type endopeptidase activity

ubiquitin-protein transferase activity

protein binding

nucleus

cytoplasm

cytosol

cytosol

cytosol

proteolysis

proteolysis

apoptotic process

canonical NF-kappaB signal transduction

activation of NF-kappaB-inducing kinase activity

peptidase activity

response to fungus

hydrolase activity

kinase activator activity

lipopolysaccharide-mediated signaling pathway

CBM complex

positive regulation of interleukin-1 beta production

positive regulation of interleukin-2 production

protein-containing complex

small molecule binding

T cell proliferation

B cell activation

B cell activation

identical protein binding

regulation of apoptotic process

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

protein self-association

innate immune response

innate immune response

T cell receptor signaling pathway

T cell receptor signaling pathway

T cell receptor signaling pathway

regulation of T cell receptor signaling pathway

positive regulation of T cell activation

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

nuclear export

proteolysis involved in protein catabolic process

cellular response to lipopolysaccharide

positive regulation of T-helper 17 cell differentiation

04660

04662

1421923_at Sh3bp5 SH3-domain binding protein 5 (BTK-associated) 14 -31372613, -31372613 BQ179335 30

protein kinase inhibitor activity

protein kinase inhibitor activity

guanyl-nucleotide exchange factor activity

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

negative regulation of protein kinase activity

membrane

nuclear body

SH3 domain binding

cytoplasmic vesicle membrane

cytoplasmic vesicle

intracellular signal transduction

intracellular signal transduction

 
1449163_at Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 7 -141091174 NM_023059 68

negative regulation of cytokine-mediated signaling pathway

acute-phase response

signal transduction

membrane

negative regulation of chemokine production

negative regulation of DNA-binding transcription factor activity

 
1450024_at Sufu SUFU negative regulator of hedgehog signaling 19 46396895 AJ308624 125

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

neural tube closure

heart looping

ventricular septum development

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

cilium

regulation of DNA-templated transcription

smoothened signaling pathway

multicellular organism development

determination of left/right symmetry

beta-catenin binding

transcription factor binding

transcription factor binding

protein kinase binding

spinal cord dorsal/ventral patterning

smoothened signaling pathway involved in ventral spinal cord interneuron specification

smoothened signaling pathway involved in spinal cord motor neuron cell fate specification

aorta development

cytoplasmic sequestering of transcription factor

cytoplasmic sequestering of transcription factor

skin development

negative regulation of smoothened signaling pathway

negative regulation of smoothened signaling pathway

coronary vasculature development

GLI-SUFU complex

negative regulation of ubiquitin-dependent protein catabolic process

04340

05200

05217

1438687_at Lax1 lymphocyte transmembrane adaptor 1 1 -133679028, -133679028 BE630983 17

adaptive immune response

immune system process

immunoglobulin production

Golgi apparatus

cytosol

plasma membrane

plasma membrane

immune response

immune response

membrane

protein kinase binding

intracellular signal transduction

intracellular signal transduction

B cell activation

SH2 domain binding

negative regulation of MAP kinase activity

lymphocyte activation

lymphocyte activation

antigen receptor-mediated signaling pathway

antigen receptor-mediated signaling pathway

negative regulation of T cell activation

negative regulation of T cell activation

regulation of lymphocyte activation

 
1419132_at Tlr2 toll-like receptor 2 3 -83836271 NM_011905 1959

lipopolysaccharide binding

amyloid-beta binding

amyloid-beta binding

microglial cell activation

positive regulation of cytokine production

toll-like receptor signaling pathway

toll-like receptor signaling pathway

response to molecule of fungal origin

immune system process

positive regulation of leukocyte migration

regulation of dendritic cell cytokine production

cell surface pattern recognition receptor signaling pathway

MyD88-dependent toll-like receptor signaling pathway

transmembrane signaling receptor activity

protein binding

cytoplasm

Golgi apparatus

plasma membrane

plasma membrane

leukotriene metabolic process

nitric oxide biosynthetic process

defense response

inflammatory response

inflammatory response

immune response

signal transduction

I-kappaB phosphorylation

learning

negative regulation of cell population proliferation

response to bacterium

external side of plasma membrane

cell surface

positive regulation of gene expression

macrophage cytokine production

macrophage cytokine production

microglia development

membrane

positive regulation of Wnt signaling pathway

negative regulation of actin filament polymerization

cytoplasmic vesicle

central nervous system myelin formation

response to bacterial lipoprotein

response to peptidoglycan

chemokine production

interleukin-17 production

interleukin-6 production

interleukin-6 production

tumor necrosis factor production

negative regulation of interleukin-12 production

negative regulation of interleukin-17 production

positive regulation of chemokine production

positive regulation of chemokine production

positive regulation of interferon-beta production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-18 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

toll-like receptor 2 signaling pathway

Toll-like receptor binding

Toll-like receptor 1-Toll-like receptor 2 protein complex

Toll-like receptor 2-Toll-like receptor 6 protein complex

Toll-like receptor 2-Toll-like receptor 6 protein complex

signaling receptor activity

toll-like receptor TLR6:TLR2 signaling pathway

pattern recognition receptor activity

pattern recognition receptor activity

detection of triacyl bacterial lipopeptide

detection of diacyl bacterial lipopeptide

triacyl lipopeptide binding

triacyl lipopeptide binding

triacyl lipopeptide binding

diacyl lipopeptide binding

identical protein binding

peptidoglycan binding

cell projection

receptor complex

cell body

protein-containing complex binding

protein-containing complex binding

innate immune response

membrane raft

positive regulation of nitric oxide biosynthetic process

positive regulation of transcription by RNA polymerase II

nitric oxide metabolic process

positive regulation of oligodendrocyte differentiation

positive regulation of inflammatory response

positive regulation of inflammatory response

negative regulation of phagocytosis

negative regulation of phagocytosis

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

leukocyte migration

positive regulation of NF-kappaB transcription factor activity

positive regulation of nitric-oxide synthase biosynthetic process

negative regulation of synapse assembly

positive regulation of macrophage cytokine production

positive regulation of macrophage cytokine production

ERK1 and ERK2 cascade

positive regulation of ERK1 and ERK2 cascade

response to fatty acid

lipoteichoic acid binding

cellular response to bacterial lipopeptide

cellular response to bacterial lipopeptide

cellular response to lipoteichoic acid

cellular response to lipoteichoic acid

cellular response to peptidoglycan

cellular response to type II interferon

lipopeptide binding

cellular response to diacyl bacterial lipopeptide

cellular response to triacyl bacterial lipopeptide

xenophagy

positive regulation of non-canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction

positive regulation of neutrophil migration

positive regulation of cellular response to macrophage colony-stimulating factor stimulus

positive regulation of xenophagy

positive regulation of matrix metallopeptidase secretion

neutrophil migration

04145

04620

05140

05142

05144

05145

05146

05323

1452960_at Scyl3 SCY1-like 3 (S. cerevisiae) 1 163929764, 163929099 BB274851 17

Golgi membrane

protein kinase activity

protein binding

ATP binding

cytoplasm

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

cytosol

protein phosphorylation

inflammatory response

protein localization

spinal cord motor neuron differentiation

lamellipodium

identical protein binding

cell projection

neuron development

 
1436317_at Pgap1 post-GPI attachment to proteins 1 1 -54472999 BM115569 27

endoplasmic reticulum

endoplasmic reticulum

GPI anchor metabolic process

GPI anchor biosynthetic process

endoplasmic reticulum to Golgi vesicle-mediated transport

sensory perception of sound

embryonic pattern specification

embryonic pattern specification

anterior/posterior axis specification

anterior/posterior axis specification

protein transport

membrane

hydrolase activity

hydrolase activity, acting on ester bonds

forebrain regionalization

forebrain regionalization

phosphatidylinositol deacylase activity

phosphatidylinositol deacylase activity

head development

head development

positive regulation of ER to Golgi vesicle-mediated transport

00563

01100

1418191_at Usp18 ubiquitin specific peptidase 18 6 121245905 NM_011909 78

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

protein binding

nucleus

nucleus

cytosol

cytosol

proteolysis

peptidase activity

cysteine-type peptidase activity

response to bacterium

protein deubiquitination

protein deubiquitination

hydrolase activity

ISG15-specific peptidase activity

ISG15-specific peptidase activity

response to stilbenoid

intracellular membrane-bounded organelle

molecular adaptor activity

 
1456147_at St8sia6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 2 -13654935 BB486599 22

ganglioside biosynthetic process

blastocyst hatching

alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity

Golgi apparatus

protein glycosylation

protein glycosylation

N-glycan processing

protein O-linked glycosylation

lipid metabolic process

sialyltransferase activity

glycoprotein metabolic process

glycolipid biosynthetic process

oligosaccharide metabolic process

oligosaccharide metabolic process

membrane

carbohydrate biosynthetic process

transferase activity

glycosyltransferase activity

 
1450777_at Xrn2 5'-3' exoribonuclease 2 2 147012998 NM_011917 37

3'-5'-RNA exonuclease activity

nuclear-transcribed mRNA catabolic process

transcription termination site sequence-specific DNA binding

nucleic acid binding

DNA binding

RNA binding

nuclease activity

exonuclease activity

5'-3' RNA exonuclease activity

5'-3' RNA exonuclease activity

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

nucleobase-containing compound metabolic process

DNA repair

DNA recombination

DNA-templated transcription termination

termination of RNA polymerase II transcription

mRNA processing

microtubule-based process

spermatogenesis

5'-3' exonuclease activity

RNA metabolic process

aggresome

hydrolase activity

identical protein binding

metal ion binding

03008

03018

1433657_at Fam78a family with sequence similarity 78, member A 2 -32050054, -32050054, -32050054, -32066884 BI111848 11

molecular_function

cellular_component

biological_process

 
1449414_at Zfp53 zinc finger protein 53 17 21488987 NM_013843 19

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

protein binding

nucleus

regulation of transcription by RNA polymerase II

 
1448760_at Zfp68 zinc finger protein 68 5 -138603651 NM_013844 29

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1434418_at Cers6 ceramide synthase 6 2 68861440 BQ176664 43

DNA binding

protein binding

endoplasmic reticulum

lipid metabolic process

inflammatory response

membrane

transferase activity

sphingolipid biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

positive regulation of oligodendrocyte apoptotic process

 
1447788_s_at Tspyl3 TSPY-like 3 2 -153222369 BB308532 10

chromatin

molecular_function

chromatin binding

nucleus

biological_process

histone binding

 
1456328_at Bank1 B cell scaffold protein with ankyrin repeats 1 3 -136053363 AI451642 24

MAPK cascade

protease binding

signaling receptor binding

signaling receptor binding

protein binding

signal transduction

response to bacterium

interleukin-6 production

negative regulation of interleukin-6 production

signaling adaptor activity

B cell activation

B cell activation

phospholipase binding

positive regulation of MAPK cascade

phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of translational initiation

perinuclear region of cytoplasm

positive regulation of peptidyl-tyrosine phosphorylation

negative regulation of B cell activation

negative regulation of B cell activation

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

protein tyrosine kinase binding

protein tyrosine kinase binding

 
1433441_at Fbxl5 F-box and leucine-rich repeat protein 5 5 -43757748, -43744617 BQ173911 33

iron ion binding

nucleus

cytoplasm

intracellular iron ion homeostasis

protein ubiquitination

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

protein catabolic process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein catabolic process

metal ion binding

perinuclear region of cytoplasm

iron-sulfur cluster binding

multicellular organismal-level iron ion homeostasis

multicellular organismal-level iron ion homeostasis

 
1455026_at Sbno1 strawberry notch 1 5 -124368701, -124368701 BE947961 25

nucleus

regulation of DNA-templated transcription

regulation of DNA-templated transcription

chromatin DNA binding

histone binding

 
1456061_at Gimap8 GTPase, IMAP family member 8 6 48647360, 48647233, 48647360 BM243674 14

nucleotide binding

GTP binding

cytoplasm

mitochondrion

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

regulation of T cell apoptotic process

 
1452463_x_at Igk immunoglobulin kappa chain complex 6   BG966217 218    
1426774_at Parp12 poly (ADP-ribose) polymerase family, member 12 6 -39086411 BM227980 28

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

cellular_component

nucleus

nucleus

transferase activity

glycosyltransferase activity

nucleotidyltransferase activity

metal ion binding

protein auto-ADP-ribosylation

NAD+-protein ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

 
1435955_at Siglecg sialic acid binding Ig-like lectin G 7 43408279, 43408238 BE447170 38

hematopoietic progenitor cell differentiation

adaptive immune response

immune system process

negative regulation of immunoglobulin production

protein binding

plasma membrane

plasma membrane

cell adhesion

cell adhesion

membrane

phosphatase binding

carbohydrate binding

regulation of B cell proliferation

regulation of B cell proliferation

sialic acid binding

sialic acid binding

SH2 domain binding

innate immune response

regulation of immune response

negative regulation of calcium-mediated signaling

negative regulation of inflammatory response to wounding

 
1436590_at Ppp1r3b protein phosphatase 1, regulatory subunit 3B 8 35375758, 35376661 BG071940 21

protein phosphatase type 1 complex

protein phosphatase type 1 complex

phosphoprotein phosphatase activity

carbohydrate metabolic process

glycogen metabolic process

regulation of glycogen biosynthetic process

regulation of glycogen biosynthetic process

regulation of glycogen catabolic process

protein phosphatase 1 binding

protein phosphatase regulator activity

enzyme binding

glycogen granule

[phosphorylase] phosphatase activity

glycogen binding

04910

1442434_at Prag1 PEAK1 related kinase activating pseudokinase 1 8 36094827 BM195829 23

protein kinase activity

protein kinase activity

protein binding

ATP binding

nucleus

cytoplasm

focal adhesion

protein phosphorylation

protein phosphorylation

regulation of cell shape

regulation of Notch signaling pathway

negative regulation of neuron projection development

cell migration

positive regulation of Rho protein signal transduction

identical protein binding

anchoring junction

regulation of cell motility

 
1456485_at Npat nuclear protein in the AT region 9 53537046 BM207451 31

in utero embryonic development

transcription coregulator activity

transcription coactivator activity

transcription corepressor activity

nucleus

nucleus

nucleoplasm

cytoplasm

cell cycle

Cajal body

cell cycle G1/S phase transition

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

Gemini of coiled bodies

 
1427197_at Atr ataxia telangiectasia and Rad3 related 9 95857596 AF236887 150

DNA damage checkpoint signaling

DNA damage checkpoint signaling

DNA damage checkpoint signaling

nucleotide binding

telomere maintenance

male germ cell nucleus

XY body

DNA binding

protein kinase activity

protein kinase activity

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nuclear envelope

nucleoplasm

nucleoplasm

chromosome

Golgi apparatus

nucleobase-containing compound metabolic process

DNA repair

double-strand break repair

protein phosphorylation

protein phosphorylation

DNA damage response

DNA damage response

embryo implantation

negative regulation of DNA replication

response to mechanical stimulus

kinase activity

phosphorylation

PML body

transferase activity

peptidyl-serine phosphorylation

replication fork processing

positive regulation of telomere maintenance via telomerase

MutLalpha complex binding

MutSalpha complex binding

cellular response to UV

histone H2AXS139 kinase activity

regulation of protein binding

positive regulation of DNA damage response, signal transduction by p53 class mediator

protein autophosphorylation

nuclear membrane disassembly

chromosome organization

protein localization to chromosome, telomeric region

ATR-ATRIP complex

ATR-ATRIP complex

cellular response to gamma radiation

replicative senescence

site of DNA damage

establishment of RNA localization to telomere

positive regulation of telomerase catalytic core complex assembly

regulation of double-strand break repair

04110

04115

1423411_at Rbm47 RNA binding motif protein 47 5 -66016548, -66016548, -66016548 BI099836 30

regulation of alternative mRNA splicing, via spliceosome

hematopoietic progenitor cell differentiation

nucleic acid binding

RNA binding

RNA binding

mRNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

mRNA processing

RNA splicing

cytidine to uridine editing

cytidine to uridine editing

cytidine to uridine editing

enzyme binding

apolipoprotein B mRNA editing enzyme complex

positive regulation of interleukin-10 production

positive regulation of type I interferon-mediated signaling pathway

3'-UTR-mediated mRNA stabilization

3'-UTR-mediated mRNA stabilization

enzyme-substrate adaptor activity

enzyme-substrate adaptor activity

 
1433811_at Mllt6 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 11 97663411 BG245272 28

renal system process

nucleus

chromatin organization

regulation of transcription by RNA polymerase II

positive regulation of sodium ion transport

nucleosome binding

nucleosome binding

negative regulation of urine volume

renal sodium excretion

renal potassium excretion

histone binding

histone binding

positive regulation of transcription by RNA polymerase II

renal water absorption

 
1425225_at Fcgr4 Fc receptor, IgG, low affinity IV 1 171018925 BC027310 55

antibody-dependent cellular cytotoxicity

immune system process

dendritic cell antigen processing and presentation

extracellular space

plasma membrane

plasma membrane

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

IgE receptor activity

IgG receptor activity

IgG receptor activity

low-affinity IgG receptor activity

IgE binding

IgG binding

Fc-gamma receptor III complex

GPI anchor binding

perforin production

neutrophil activation

natural killer cell degranulation

positive regulation of bone resorption

cellular response to lipopolysaccharide

immune receptor activity

immune receptor activity

Fc receptor-mediated immune complex endocytosis

04145

04380

04650

05140

05150

05322

1435264_at Emilin2 elastin microfibril interfacer 2 17 -71252171, -71252171 BB811788 29

extracellular region

collagen trimer

cell adhesion

extracellular matrix constituent conferring elasticity

positive regulation of blood coagulation

negative regulation of cell migration

positive regulation of apoptotic process

positive regulation of angiogenesis

collagen-containing extracellular matrix

collagen-containing extracellular matrix

positive regulation of defense response to bacterium

positive regulation of platelet aggregation

 
1425374_at Oas3 2'-5' oligoadenylate synthetase 3 5 -120753097 AB067534 20

nucleotide binding

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

immune system process

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

ATP binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

cytosol

plasma membrane

response to virus

membrane

transferase activity

nucleotidyltransferase activity

positive regulation of interferon-beta production

positive regulation of tumor necrosis factor production

negative regulation of chemokine (C-X-C motif) ligand 9 production

RIG-I signaling pathway

MDA-5 signaling pathway

defense response to bacterium

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

metal ion binding

defense response to virus

defense response to virus

negative regulation of type I interferon-mediated signaling pathway

regulation of ribonuclease activity

regulation of ribonuclease activity

positive regulation of monocyte chemotactic protein-1 production

negative regulation of chemokine (C-C motif) ligand 5 production

negative regulation of IP-10 production

negative regulation of chemokine (C-X-C motif) ligand 2 production

05160

1425065_at Oas2 2'-5' oligoadenylate synthetase 2 5 -120730332 AB067535 29

nucleotide binding

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

2'-5'-oligoadenylate synthetase activity

immune system process

RNA binding

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

ATP binding

nucleoplasm

cytoplasm

cytosol

RNA catabolic process

response to virus

response to bacterium

membrane

transferase activity

nucleotidyltransferase activity

positive regulation of interferon-beta production

positive regulation of tumor necrosis factor production

defense response to bacterium

negative regulation of viral genome replication

innate immune response

metal ion binding

perinuclear region of cytoplasm

defense response to virus

defense response to virus

type I interferon-mediated signaling pathway

regulation of ribonuclease activity

interleukin-27-mediated signaling pathway

interleukin-27-mediated signaling pathway

regulation of lactation

05160

1427994_at Cd300lf CD300 molecule like family member F 11 -115116213 BM230330 57

virus receptor activity

phosphatidylserine binding

immune system process

transmembrane signaling receptor activity

interleukin-4 receptor binding

protein binding

plasma membrane

plasma membrane

lipid binding

membrane

osteoclast differentiation

negative regulation of mast cell activation

negative regulation of mast cell activation

negative regulation of MyD88-dependent toll-like receptor signaling pathway

TRIF-dependent toll-like receptor signaling pathway

interleukin-13-mediated signaling pathway

identical protein binding

ceramide binding

ceramide binding

positive regulation of interleukin-4-mediated signaling pathway

negative regulation of apoptotic cell clearance

positive regulation of apoptotic cell clearance

positive regulation of apoptotic cell clearance

 
1455735_at Ap1s3 adaptor-related protein complex AP-1, sigma 3 1 -79606875 AW259574 20

molecular_function

lysosomal membrane

early endosome

Golgi apparatus

clathrin-coated pit

protein targeting

intracellular protein transport

protein transport

membrane

vesicle-mediated transport

vesicle-mediated transport

membrane coat

AP-1 adaptor complex

cytoplasmic vesicle

trans-Golgi network membrane

clathrin adaptor activity

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

platelet dense granule organization

melanosome assembly

04142

1419722_at Klk8 kallikrein related-peptidase 8 7 43797576 NM_008940 54

serine-type endopeptidase activity

serine-type endopeptidase activity

extracellular region

extracellular space

cytoplasm

cytoplasm

proteolysis

memory

memory

peptidase activity

peptidase activity

serine-type peptidase activity

response to wounding

hydrolase activity

secretory granule

keratinocyte proliferation

neuron projection morphogenesis

neuron projection morphogenesis

regulation of synapse organization

synapse organization

serine protease inhibitor complex

 
1427711_a_at Ceacam1 CEA cell adhesion molecule 1 7 -25461701 X15351 158

regulation of cell growth

blood vessel development

negative regulation of cytokine production

regulation of immune system process

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

actin binding

granulocyte colony-stimulating factor receptor binding

protein binding

calmodulin binding

extracellular space

plasma membrane

plasma membrane

plasma membrane

cell-cell junction

adherens junction

negative regulation of protein kinase activity

cell adhesion

signal transduction

external side of plasma membrane

basal plasma membrane

cell surface

cell surface

cell surface

regulation of endothelial cell migration

bile acid transmembrane transporter activity

bile acid and bile salt transport

membrane

basolateral plasma membrane

apical plasma membrane

lateral plasma membrane

kinase binding

protein kinase binding

protein phosphatase binding

cell junction

negative regulation of granulocyte differentiation

filamin binding

cytoplasmic vesicle

negative regulation of interleukin-1 production

cellular response to insulin stimulus

GPI anchor binding

Toll-like receptor binding

common myeloid progenitor cell proliferation

insulin receptor internalization

granulocyte colony-stimulating factor signaling pathway

regulation of epidermal growth factor receptor signaling pathway

regulation of epidermal growth factor receptor signaling pathway

T cell receptor complex

negative regulation of T cell proliferation

identical protein binding

protein homodimerization activity

cell projection

negative regulation of vascular permeability

positive regulation of MAP kinase activity

protein-containing complex binding

cell-cell junction organization

regulation of endothelial cell differentiation

negative regulation of osteoclast differentiation

negative regulation of fatty acid biosynthetic process

negative regulation of bone resorption

protein heterodimerization activity

protein dimerization activity

negative regulation of lipid biosynthetic process

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

ciliary membrane

regulation of blood vessel remodeling

transforming growth factor beta ligand-receptor complex

anchoring junction

regulation of ERK1 and ERK2 cascade

negative regulation of platelet aggregation

cell-cell adhesion via plasma-membrane adhesion molecules

insulin catabolic process

insulin catabolic process

regulation of homophilic cell adhesion

positive regulation of homophilic cell adhesion

regulation of sprouting angiogenesis

protein tyrosine kinase binding

protein tyrosine kinase binding

protein tyrosine kinase binding

negative regulation of hepatocyte proliferation

negative regulation of hepatocyte proliferation

positive regulation of vasculogenesis

 
1417074_at Ceacam10 CEA cell adhesion molecule 10 7 24777203, 24777166 NM_007675 20

regulation of immune system process

plasma membrane

signal transduction

cell surface

protein tyrosine kinase binding

 
1419515_at Fgd2 FYVE, RhoGEF and PH domain containing 2 17 29360913 NM_013710 25

ruffle

guanyl-nucleotide exchange factor activity

nucleus

cytoplasm

cytoplasm

endosome

early endosome

cytoskeleton

plasma membrane

cytoskeleton organization

membrane

cell projection

positive regulation of JUN kinase activity

filopodium assembly

metal ion binding

phosphatidylinositol phosphate binding

 
1457666_s_at Ifi202b interferon activated gene 202B 1 -173962568 AV229143 54

cellular response to interferon-beta

04623

1424850_at Map3k1 mitogen-activated protein kinase kinase kinase 1 13 -111746427 L13103 113

MAPK cascade

nucleotide binding

protein polyubiquitination

morphogenesis of an epithelial sheet

epithelial cell morphogenesis

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

JUN kinase kinase kinase activity

JUN kinase kinase kinase activity

MAP kinase kinase activity

MAP kinase kinase kinase activity

ubiquitin-protein transferase activity

protein binding

ATP binding

cytoplasm

cytosol

protein phosphorylation

ubiquitin-dependent protein catabolic process

transforming growth factor beta receptor signaling pathway

JNK cascade

cytoskeletal protein binding

zinc ion binding

JUN kinase binding

apoptotic mitochondrial changes

kinase activity

phosphorylation

transferase activity

protein kinase binding

cell junction

regulation of cell migration

positive regulation of actin filament polymerization

mitogen-activated protein kinase kinase binding

filamentous actin

negative regulation of actin filament bundle assembly

wound healing

camera-type eye development

positive regulation of apoptotic process

positive regulation of MAPK cascade

positive regulation of JUN kinase activity

protein-containing complex binding

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of JNK cascade

sphingolipid binding

metal ion binding

positive regulation of viral transcription

mitogen-activated protein kinase binding

eyelid development in camera-type eye

positive regulation of canonical Wnt signaling pathway

04010

04120

04622

04722

04912

1455597_at Map3k2 mitogen-activated protein kinase kinase kinase 2 18 32163088 AV024458 52

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein binding

ATP binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

protein phosphorylation

kinase activity

phosphorylation

transferase activity

protein kinase binding

intracellular signal transduction

metal ion binding

04010

04540

04912

1459800_s_at Map3k4 mitogen-activated protein kinase kinase kinase 4 17 -12227620, -12227620 AV079128 82

MAPK cascade

nucleotide binding

placenta development

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

protein binding

ATP binding

cytoplasm

cytoplasm

protein phosphorylation

response to UV-C

regulation of gene expression

kinase activity

phosphorylation

transferase activity

male germ-line sex determination

positive regulation of telomere maintenance via telomerase

intracellular signal transduction

positive regulation of JUN kinase activity

positive regulation of JUN kinase activity

positive regulation of JUN kinase activity

metal ion binding

determination of dorsal identity

positive regulation of telomerase activity

chorionic trophoblast cell differentiation

positive regulation of p38MAPK cascade

positive regulation of telomere capping

04010

04912

1439323_a_at Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 7 28982049, 28982853 BB546619 41

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

ATP binding

cytoplasm

protein phosphorylation

protein phosphorylation

protein phosphorylation

JNK cascade

cell population proliferation

MAP kinase kinase kinase kinase activity

MAP kinase kinase kinase kinase activity

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

intracellular signal transduction

intracellular signal transduction

positive regulation of MAPK cascade

protein autophosphorylation

cellular response to phorbol 13-acetate 12-myristate

04010

1434833_at Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 19 6341159 BB667222 17

nucleotide binding

immune system process

protein kinase activity

protein serine/threonine kinase activity

ATP binding

cytoplasm

cytoplasm

Golgi apparatus

plasma membrane

protein phosphorylation

protein phosphorylation

vesicle targeting

MAP kinase kinase kinase kinase activity

MAP kinase kinase kinase kinase activity

membrane

kinase activity

phosphorylation

transferase activity

mitogen-activated protein kinase kinase kinase binding

intracellular signal transduction

intracellular signal transduction

positive regulation of JUN kinase activity

innate immune response

positive regulation of JNK cascade

04010

1448871_at Mapk13 mitogen-activated protein kinase 13 17 28769316 NM_011950 68

MAPK cascade

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

MAP kinase activity

ATP binding

nucleus

nucleoplasm

cytoplasm

protein phosphorylation

response to osmotic stress

cell cycle

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

positive regulation of interleukin-6 production

cellular response to UV

intracellular signal transduction

stress-activated MAPK cascade

cellular response to hydrogen peroxide

cellular response to interleukin-1

cellular response to sorbitol

cellular response to anisomycin

cellular response to sodium arsenite

04010

04370

04380

04620

04621

04622

04660

04664

04670

04722

04912

04914

05014

05140

05142

05145

05160

1419165_at Zfp260 zinc finger protein 260 7 30095075 D45210 24

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

nucleoplasm

cytosol

regulation of transcription by RNA polymerase II

multicellular organism development

metal ion binding

 
1452261_at Shprh SNF2 histone linker PHD RING helicase 10 11149429, 11149429, 11149429 BC006883 24

nucleotide binding

protein polyubiquitination

protein polyubiquitination

nucleosome

DNA binding

helicase activity

ubiquitin-protein transferase activity

ATP binding

cellular_component

DNA repair

nucleosome assembly

DNA damage response

DNA damage response

transferase activity

hydrolase activity

ubiquitin protein ligase binding

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ATP-dependent chromatin remodeler activity

 
1427417_at Scml4 Scm polycomb group protein like 4 10 42860511, 42860511 BB212066 14

chromatin binding

nucleus

nucleus

histone binding

negative regulation of DNA-templated transcription

 
1446715_at Abca13 ATP-binding cassette, sub-family A member 13 11 9191941 BB503961 22

nucleotide binding

lipid transporter activity

ATP binding

lipid transport

lipid transport

membrane

ATP hydrolysis activity

cytoplasmic vesicle

positive regulation of cholesterol transport

positive regulation of cholesterol transport

ceramide transport

ATPase-coupled transmembrane transporter activity

intracellular membrane-bounded organelle

transmembrane transport

intracellular vesicle

intracellular vesicle

ABC-type transporter activity

positive regulation of synaptic vesicle endocytosis

02010

1458148_at Nlrc3 NLR family, CARD domain containing 3 16 -3945006 BB466171 31

nucleotide binding

protein binding

ATP binding

cytoplasm

cytoplasm

cytosol

cytosol

canonical NF-kappaB signal transduction

canonical NF-kappaB signal transduction

canonical NF-kappaB signal transduction

regulation of protein ubiquitination

regulation of protein ubiquitination

negative regulation of NF-kappaB transcription factor activity

negative regulation of NF-kappaB transcription factor activity

response to lipopolysaccharide

negative regulation of interferon-alpha production

negative regulation of interferon-beta production

negative regulation of interleukin-1 beta production

negative regulation of interleukin-12 production

negative regulation of interleukin-6 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor production

centriolar satellite

intracellular signal transduction

phosphatidylinositol 3-kinase regulatory subunit binding

T cell activation

negative regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

intracellular membrane-bounded organelle

negative regulation of innate immune response

negative regulation of fibroblast proliferation

perinuclear region of cytoplasm

negative regulation of epithelial cell proliferation

negative regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

molecular function inhibitor activity

negative regulation of cytokine production involved in inflammatory response

negative regulation of NLRP3 inflammasome complex assembly

negative regulation of non-canonical NF-kappaB signal transduction

 
1422013_at Clec4a2 C-type lectin domain family 4, member a2 6 123122689, 123123315 NM_011999 32

adaptive immune response

immune system process

calcium ion binding

mannose binding

plasma membrane

external side of plasma membrane

membrane

carbohydrate binding

carbohydrate binding

carbohydrate binding

innate immune response

metal ion binding

antifungal innate immune response

 
1442339_at Stfa2l1 stefin A2 like 1 16 36156810 BB667930 10

cornified envelope

protease binding

cysteine-type endopeptidase inhibitor activity

cysteine-type endopeptidase inhibitor activity

extracellular space

nucleoplasm

cytoplasm

cytosol

cytosol

negative regulation of peptidase activity

peptide cross-linking

keratinocyte differentiation

negative regulation of proteolysis

cell-cell adhesion

peptidase inhibitor complex

 
1455745_at Cln8 CLN8 transmembrane ER and ERGIC protein 8 14888535 BM249363 87

protein binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

phospholipid metabolic process

phospholipid metabolic process

phospholipid metabolic process

ceramide metabolic process

apoptotic process

mitochondrial membrane organization

lysosome organization

nervous system development

nervous system development

visual perception

adult walking behavior

cholesterol metabolic process

associative learning

adult locomotory behavior

regulation of cell size

macromolecule catabolic process

membrane

protein metabolic process

spinal cord motor neuron differentiation

somatic motor neuron differentiation

protein catabolic process

social behavior

negative regulation of neuron apoptotic process

photoreceptor cell maintenance

musculoskeletal movement

neuromuscular process controlling posture

neuromuscular process controlling balance

negative regulation of transferase activity

neuron apoptotic process

glutamate reuptake

lipid homeostasis

retina development in camera-type eye

neurofilament cytoskeleton organization

ceramide binding

ceramide binding

retinal rod cell apoptotic process

 
1435641_at Mgat4a mannoside acetylglucosaminyltransferase 4, isoenzyme A 1 -37439339, -37439339 BB109391 21

extracellular region

endoplasmic reticulum

endoplasmic reticulum-Golgi intermediate compartment

Golgi apparatus

Golgi stack

protein glycosylation

protein N-linked glycosylation

protein N-linked glycosylation

N-glycan processing

acetylglucosaminyltransferase activity

acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity

membrane

transferase activity

glycosyltransferase activity

metal ion binding

00510

01100

1433794_at Setx senataxin 2 29124991 BM211942 43

MAPK cascade

nucleotide binding

nuclear chromosome

chromosome, telomeric region

transcription termination site sequence-specific DNA binding

transcription termination site sequence-specific DNA binding

RNA binding

helicase activity

protein binding

ATP binding

nucleus

nucleoplasm

chromosome

cytoplasm

DNA repair

double-strand break repair

DNA recombination

DNA-templated transcription termination

termination of RNA polymerase II transcription

termination of RNA polymerase II transcription

mRNA splice site recognition

DNA damage response

spermatogenesis

nervous system development

circadian rhythm

fibroblast growth factor receptor signaling pathway

positive regulation of neuron projection development

nuclear body

nuclear body

hydrolase activity

cell differentiation

axon

growth cone

positive regulation of RNA splicing

cellular response to oxidative stress

identical protein binding

cell projection

negative regulation of apoptotic process

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular response to fibroblast growth factor stimulus

intercellular bridge

positive regulation of transcription by RNA polymerase II

rhythmic process

positive regulation of termination of DNA-templated transcription

cellular response to hydrogen peroxide

cellular response to retinoic acid

positive regulation of DNA-templated transcription initiation

positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled

 
1435655_at Rpl12 ribosomal protein L12 2 32961711 BG807990 38

cytoplasmic translation

RNA binding

structural constituent of ribosome

structural constituent of ribosome

protein binding

nucleus

nucleolus

cytoplasm

cytosol

ribosome

translation

translation

postsynaptic density

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic ribosome

synapse

synapse

synapse

large ribosomal subunit rRNA binding

large ribosomal subunit rRNA binding

presynapse

postsynapse

translation at presynapse

translation at postsynapse

ribonucleoprotein complex

03010

1456038_at Fbxl4 F-box and leucine-rich repeat protein 4 4 22357542 BB003709 20

autophagy of mitochondrion

autophagy of mitochondrion

nucleus

cytoplasm

mitochondrion

mitochondrial intermembrane space

nuclear speck

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

 
1439464_s_at Tex10 testis expressed gene 10 4 -48430857 AV278060 25

nucleus

nucleus

nucleoplasm

cytoplasm

mitochondrion

MLL1 complex

MLL1 complex

 
1435004_at Pank4 pantothenate kinase 4 4 154964122 BM119773 25

nucleotide binding

pantothenate kinase activity

pantothenate kinase activity

ATP binding

extracellular space

nucleus

cytoplasm

cytosol

cytosol

cytosol

coenzyme A biosynthetic process

coenzyme A biosynthetic process

coenzyme A catabolic process

coenzyme A catabolic process

hydrolase activity

phosphatase activity

metal ion binding

00770

01100

1434935_at Aak1 AP2 associated kinase 1 6 86849504, 86849283, 86849504 BG067888 36

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

Notch binding

ATP binding

cytosol

plasma membrane

clathrin-coated pit

protein phosphorylation

protein phosphorylation

endocytosis

membrane

kinase activity

phosphorylation

transferase activity

cell leading edge

regulation of protein localization

AP-2 adaptor complex binding

AP-2 adaptor complex binding

cell projection

terminal bouton

intracellular membrane-bounded organelle

calyx of Held

synapse

positive regulation of Notch signaling pathway

protein stabilization

clathrin complex

presynapse

presynapse

presynapse

presynaptic endocytosis

presynaptic endocytosis

presynaptic endocytosis

regulation of clathrin-dependent endocytosis

regulation of clathrin-dependent endocytosis

 
1456411_at Rccd1 RCC1 domain containing 1 7 -80316615 BM218704 14

molecular_function

chromosome

cytosol

plasma membrane

chromatin organization

biological_process

 
1434945_at Lpcat2 lysophosphatidylcholine acyltransferase 2 8 92855332 AW743924 26

1-acylglycerol-3-phosphate O-acyltransferase activity

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

Golgi stack

lipid droplet

plasma membrane

lipid metabolic process

platelet activating factor biosynthetic process

O-acyltransferase activity

phospholipid biosynthetic process

membrane

transferase activity

acyltransferase activity

phosphatidylcholine acyl-chain remodeling

lysophosphatidic acid acyltransferase activity

metal ion binding

1-alkenylglycerophosphocholine O-acyltransferase activity

1-acylglycerophosphocholine O-acyltransferase activity

1-acylglycerophosphocholine O-acyltransferase activity

1-alkylglycerophosphocholine O-acetyltransferase activity

plasmalogen synthase activity

membrane organization

00564

00565

01100

1433661_at Nlrx1 NLR family member X1 9 -44252712, -44252712, -44252712 BB830346 63

nucleotide binding

immune system process

protein binding

ATP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

plasma membrane

macrophage cytokine production

negative regulation of macrophage cytokine production

membrane

interferon-beta production

interleukin-6 production

negative regulation of interferon-beta production

negative regulation of interleukin-6 production

negative regulation of RIG-I signaling pathway

negative regulation of canonical NF-kappaB signal transduction

negative regulation of canonical NF-kappaB signal transduction

innate immune response

negative regulation of innate immune response

negative regulation of inflammatory response

04622

1418398_a_at Tspan32 tetraspanin 32 7 143005658, 143005045 AF175771 32

molecular_function

intracellular anatomical structure

cytoskeleton organization

integrin-mediated signaling pathway

blood coagulation

hemostasis

cell surface

membrane

negative regulation of myeloid dendritic cell activation

T cell proliferation

negative regulation of T cell proliferation

defense response to protozoan

regulation of defense response to virus

integrin alphaIIb-beta3 complex

platelet aggregation

 
1433966_x_at Asns asparagine synthetase 6 -7675164 AV212753 41

nucleotide binding

asparagine synthase (glutamine-hydrolyzing) activity

asparagine synthase (glutamine-hydrolyzing) activity

ATP binding

cytosol

cytosol

cytosol

asparagine biosynthetic process

asparagine biosynthetic process

glutamine metabolic process

amino acid biosynthetic process

ligase activity

cellular response to glucose starvation

identical protein binding

negative regulation of apoptotic process

positive regulation of mitotic cell cycle

00250

00910

01100

1418397_at Zfp275 zinc finger protein 275 X 73342619, 73342620 BC019962 33

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1443932_at Klhdc1 kelch domain containing 1 12 69241831 BQ176961 10

cytoplasm

cytosol

Cul5-RING ubiquitin ligase complex

ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

ubiquitin ligase-substrate adaptor activity

 
1454826_at Zbtb11 zinc finger and BTB domain containing 11 16 55973803 BM195115 21

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleoplasm

regulation of DNA-templated transcription

metal ion binding

 
1430154_at Vps13a vacuolar protein sorting 13A 19 -16615365 AI666321 32

molecular_function

mitochondrion

mitochondrial outer membrane

lysosome

lysosomal membrane

endosome

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

lipid droplet

protein targeting to vacuole

lipid transport

autophagy

autophagy

nervous system development

locomotory behavior

endosome membrane

membrane

flagellated sperm motility

sperm mitochondrion organization

dense core granule

cytoplasmic vesicle

mitochondrial membrane

social behavior

mitochondria-associated endoplasmic reticulum membrane

protein retention in Golgi apparatus

sperm midpiece

neuronal dense core vesicle lumen

lysosomal protein catabolic process

 
1426956_a_at Trp53bp1 transformation related protein 53 binding protein 1 2 -121194834 AJ414734 200

DNA damage checkpoint signaling

chromosome, centromeric region

kinetochore

chromosome, telomeric region

chromosome, telomeric region

p53 binding

DNA binding

damaged DNA binding

transcription coregulator activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

replication fork

chromosome

cytoplasm

DNA repair

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

double-strand break repair via nonhomologous end joining

regulation of DNA-templated transcription

DNA damage response

transcription factor binding

nuclear body

nuclear body

methylated histone binding

methylated histone binding

site of double-strand break

site of double-strand break

telomeric DNA binding

histone binding

sequence-specific DNA binding

positive regulation of isotype switching

positive regulation of isotype switching

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

protein homooligomerization

RNA polymerase II-specific DNA-binding transcription factor binding

ubiquitin modification-dependent histone binding

double-strand break repair via classical nonhomologous end joining

histone reader activity

DNA repair complex

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair via homologous recombination

 
1430700_a_at Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 17 43568450 AK005158 59

1-alkyl-2-acetylglycerophosphocholine esterase activity

1-alkyl-2-acetylglycerophosphocholine esterase activity

phospholipid binding

extracellular region

extracellular space

lipid metabolic process

inflammatory response

phospholipid catabolic process

lipid catabolic process

hydrolase activity

low-density lipoprotein particle

high-density lipoprotein particle

low-density lipoprotein particle remodeling

lipid oxidation

plasma lipoprotein particle oxidation

phosphatidylcholine catabolic process

platelet activating factor metabolic process

calcium-independent phospholipase A2 activity

platelet activating factor catabolic process

positive regulation of monocyte chemotaxis

00565

01100

1460407_at Spib Spi-B transcription factor (Spi-1/PU.1 related) 7 -44525994 BM244106 62

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

immature B cell differentiation

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

transcription regulator complex

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cell differentiation

macrophage differentiation

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
1459522_s_at Gyg1 glycogenin 1 3 -20122083, -20122082 AU017667 41

glucose binding

cytoplasm

glycogen biosynthetic process

glycogen biosynthetic process

glycogen biosynthetic process

glycogenin glucosyltransferase activity

glycogenin glucosyltransferase activity

transferase activity

glycosyltransferase activity

glycosyltransferase activity

manganese ion binding

protein homodimerization activity

metal ion binding

UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity

 
1423298_at Add3 adducin 3 19 53140442, 53142755, 53143996 BM239842 36

condensed nuclear chromosome

actin binding

protein kinase C binding

structural constituent of cytoskeleton

calmodulin binding

cytoplasm

cytoskeleton

cytoskeleton

plasma membrane

plasma membrane

brush border

cell-cell junction

cell cortex

response to xenobiotic stimulus

postsynaptic density

postsynaptic density

membrane

positive regulation of vasoconstriction

actin filament binding

barbed-end actin filament capping

positive regulation of cytoskeleton organization

 
1457753_at Tlr13 toll-like receptor 13 X 106143274 BI655907 34

toll-like receptor signaling pathway

toll-like receptor signaling pathway

immune system process

MyD88-dependent toll-like receptor signaling pathway

RNA binding

transmembrane signaling receptor activity

protein binding

cytoplasm

endosome

inflammatory response

inflammatory response

immune response

signal transduction

response to virus

membrane

rRNA binding

toll-like receptor 13 signaling pathway

signaling receptor activity

identical protein binding

regulation of MAPK cascade

innate immune response

 
1435357_at Rsrp1 arginine/serine rich protein 1 4 134923624 BE652553 21

spliceosomal complex assembly

molecular_function

cellular_component

nucleus

biological_process

 
1437478_s_at Efhd2 EF hand domain containing 2 4 -141858141 AA409309 52

calcium ion binding

calcium ion binding

protein binding

membrane

metal ion binding

 
1417953_at Fam3c FAM3 metabolism regulating signaling molecule C 6 -22306521 AK016470 41

molecular_function

extracellular region

extracellular space

Golgi apparatus

multicellular organism development

biological_process

carbohydrate binding

cytoplasmic vesicle

 
1456531_x_at Prpf19 pre-mRNA processing factor 19 19 10898644, 10895230 BB458578 44

DNA damage checkpoint signaling

protein polyubiquitination

spliceosomal tri-snRNP complex assembly

spliceosomal complex assembly

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

Prp19 complex

Prp19 complex

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

DNA replication factor A complex

spliceosomal complex

cytoplasm

cytoplasm

cytoskeleton

DNA repair

double-strand break repair via nonhomologous end joining

mRNA processing

DNA damage response

protein localization

RNA splicing

lipid biosynthetic process

proteasomal protein catabolic process

proteasomal protein catabolic process

protein ubiquitination

nuclear speck

transferase activity

ubiquitin-ubiquitin ligase activity

site of double-strand break

identical protein binding

positive regulation of mRNA splicing, via spliceosome

positive regulation of astrocyte differentiation

ubiquitin protein ligase activity

protein K63-linked ubiquitination

U2-type catalytic step 1 spliceosome

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

03040

04120

1420129_s_at Rtcb RNA 2',3'-cyclic phosphate and 5'-OH ligase 10 -85938636 AA409545 39

nucleotide binding

tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate

in utero embryonic development

placenta development

RNA ligase (ATP) activity

RNA ligase (ATP) activity

GTP binding

nucleus

nucleus

nuclear envelope

nucleoplasm

cytoplasm

cytoplasm

endoplasmic reticulum membrane

cytosol

tRNA splicing, via endonucleolytic cleavage and ligation

RNA processing

tRNA processing

RNA ligase activity

ligase activity

vinculin binding

intracellular membrane-bounded organelle

metal ion binding

tRNA-splicing ligase complex

tRNA-splicing ligase complex

 
1434746_at Mga MAX gene associated 2 119897227 BG797579 52

chromatin

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

cell fate specification

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

transcription regulator complex

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

protein dimerization activity

MLL1 complex

MLL1 complex

cellular response to leukemia inhibitory factor

 
1453365_at Rabgap1l RAB GTPase activating protein 1-like 1 -160219173, -160256571 AK018430 27

GTPase activator activity

GTPase activator activity

nucleus

endosome

early endosome

Golgi apparatus

endocytosis

protein transport

small GTPase binding

small GTPase binding

regulation of protein localization

megakaryocyte development

regulation of GTPase activity

 
1415936_at Bcar3 breast cancer anti-estrogen resistance 3 3 122483568, 122419756 NM_013867 27

phosphotyrosine residue binding

lens morphogenesis in camera-type eye

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

focal adhesion

epidermal growth factor receptor signaling pathway

small GTPase-mediated signal transduction

positive regulation of cell population proliferation

insulin receptor signaling pathway

membrane

kinase binding

positive regulation of peptidyl-serine phosphorylation

positive regulation of peptidyl-serine phosphorylation

positive regulation of MAPK cascade

positive regulation of GTPase activity

anchoring junction

endothelin receptor signaling pathway

 
1425553_s_at Hip1r huntingtin interacting protein 1 related 5 123973627 AA590970 47

actin binding

protein binding

phospholipid binding

phosphatidylinositol-4,5-bisphosphate binding

phosphatidylinositol-3,4,5-trisphosphate binding

cytoplasm

cytosol

cytoskeleton

plasma membrane

clathrin-coated pit

cell cortex

endocytosis

endocytosis

receptor-mediated endocytosis

receptor-mediated endocytosis

activation of cysteine-type endopeptidase activity involved in apoptotic process

activation of cysteine-type endopeptidase activity involved in apoptotic process

actin filament organization

postsynaptic density

membrane

apical plasma membrane

SH3 domain binding

regulation of endocytosis

clathrin-coated vesicle

clathrin-coated vesicle

clathrin-coated vesicle

clathrin binding

clathrin binding

negative regulation of actin filament polymerization

negative regulation of actin filament polymerization

cytoplasmic vesicle

clathrin light chain binding

clathrin light chain binding

positive regulation of protein binding

ruffle membrane

dendrite cytoplasm

regulation of actin cytoskeleton organization

regulation of actin cytoskeleton organization

negative regulation of Arp2/3 complex-mediated actin nucleation

phosphatidylinositol binding

clathrin adaptor activity

clathrin adaptor activity

clathrin adaptor activity

identical protein binding

protein homodimerization activity

protein homodimerization activity

neuronal cell body

positive regulation of apoptotic process

negative regulation of apoptotic process

dendritic spine

intracellular membrane-bounded organelle

phosphatidylinositol-3,4-bisphosphate binding

phosphatidylinositol-3,4-bisphosphate binding

positive regulation of epidermal growth factor receptor signaling pathway

protein heterodimerization activity

clathrin coat assembly

clathrin coat assembly

perinuclear region of cytoplasm

protein stabilization

actin filament binding

actin filament binding

actin filament binding

digestive system development

regulation of gastric acid secretion

membrane organization

phosphatidylinositol-3,5-bisphosphate binding

phosphatidylinositol-3,5-bisphosphate binding

synaptic membrane

postsynapse

glutamatergic synapse

postsynapse organization

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of clathrin coat assembly

regulation of clathrin-dependent endocytosis

positive regulation of clathrin-dependent endocytosis

positive regulation of platelet-derived growth factor receptor-beta signaling pathway

 
1452469_a_at Smtn smoothelin 11 -3517521 BF578669 32

negative regulation of systemic arterial blood pressure

actin binding

cytoplasm

microtubule organizing center

cytoskeleton

actin cytoskeleton organization

filamentous actin

positive regulation of cardiac muscle contraction

 
1419574_at Zfp292 zinc finger protein 292 4 -34803109 NM_013889 35

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA binding

nucleus

nucleus

regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

 
1417928_at Pdlim4 PDZ and LIM domain 4 11 -54054927 NM_019417 40

stress fiber

stress fiber

actin binding

protein binding

nucleus

cytoplasm

endosome

cytoskeleton

adherens junction

heart development

actin cytoskeleton

membrane

protein phosphatase binding

protein phosphatase binding

Z disc

lamellipodium

actin cytoskeleton organization

actin cytoskeleton organization

early endosome lumen

filamentous actin

filamentous actin

recycling endosome lumen

protein homodimerization activity

actinin binding

cell projection

neuron projection

dendritic spine

synapse

postsynaptic membrane

metal ion binding

perinuclear region of cytoplasm

muscle alpha-actinin binding

alpha-actinin binding

positive regulation of stress fiber assembly

muscle structure development

excitatory chemical synaptic transmission

 
1416858_a_at Fkbp3 FK506 binding protein 3 12 -65062431 NM_013902 35

peptidyl-prolyl cis-trans isomerase activity

protein binding

nucleus

isomerase activity

 
1448420_a_at Fbxl12 F-box and leucine-rich repeat protein 12 9 -20637748, -20637748 NM_013911 25

ubiquitin ligase complex

cytoplasm

ubiquitin-dependent protein catabolic process

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

 
1425086_a_at Slamf6 SLAM family member 6 1 171917461, 171917461 AF248636 48

natural killer cell differentiation

natural killer cell proliferation

adaptive immune response

immune system process

plasma membrane

plasma membrane

external side of plasma membrane

membrane

positive regulation of type II interferon production

positive regulation of type II interferon production

positive regulation of interleukin-17 production

T cell activation

innate immune response

positive regulation of natural killer cell mediated cytotoxicity

T-helper 17 cell lineage commitment

T-helper 17 cell lineage commitment

 
1417010_at Zbtb18 zinc finger and BTB domain containing 18 1 177444660, 177445820, 177444652, 177442350, 177442350, 177444937 NM_013915 46

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

heterochromatin

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

in utero embryonic development

DNA binding

nucleus

nucleus

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

multicellular organism development

skeletal muscle tissue development

nuclear speck

cerebellum development

hippocampus development

cerebral cortex development

sequence-specific DNA binding

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

metal ion binding

neuron development

homeostasis of number of cells

regulation of cell division

sequence-specific double-stranded DNA binding

 
1421998_at Tor3a torsin family 3, member A 1 -156653616 NM_023141 24

nucleotide binding

protein binding

ATP binding

nuclear envelope

cytoplasm

endoplasmic reticulum

endoplasmic reticulum lumen

endoplasmic reticulum lumen

endoplasmic reticulum lumen

ATP hydrolysis activity

 
1447854_s_at H2bc21 H2B clustered histone 21 3 96221071 AV127319 25

nucleosome

lipopolysaccharide binding

innate immune response in mucosa

DNA binding

protein binding

extracellular space

nucleus

nucleoplasm

nucleoplasm

chromosome

cytosol

plasma membrane

negative regulation of tumor necrosis factor-mediated signaling pathway

antibacterial humoral response

structural constituent of chromatin

killing of cells of another organism

CENP-A containing nucleosome

protein heterodimerization activity

defense response to Gram-negative bacterium

defense response to Gram-positive bacterium

antimicrobial humoral immune response mediated by antimicrobial peptide

05322

1434521_at Rfx7 regulatory factor X, 7 9 72532239 BB148972 22

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

RNA polymerase II core promoter sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

sequence-specific double-stranded DNA binding

 
1441516_a_at C130050O18Rik RIKEN cDNA C130050O18 gene 5 139406386, 139405283 BB527707 10

molecular_function

cellular_component

biological_process

 
1454795_at Cobll1 Cobl-like 1 2 -65088338 AV080881 17

actin monomer binding

 
1417321_at Zcchc7 zinc finger, CCHC domain containing 7 4 44756558 NM_138590 24

molecular_function

nucleic acid binding

RNA binding

nucleus

nucleolus

cytosol

biological_process

zinc ion binding

TRAMP complex

metal ion binding

nuclear mRNA surveillance of mRNA 3'-end processing

nuclear polyadenylation-dependent rRNA catabolic process

nuclear polyadenylation-dependent snoRNA catabolic process

nuclear polyadenylation-dependent snRNA catabolic process

nuclear polyadenylation-dependent tRNA catabolic process

nuclear polyadenylation-dependent CUT catabolic process

03018

1426550_at Sidt1 SID1 transmembrane family, member 1 16 -44240179 AI449329 21

RNA binding

double-stranded RNA binding

double-stranded RNA binding

lysosome

plasma membrane

cholesterol binding

membrane

RNA transport

RNA transmembrane transporter activity

 
1437514_at Trem6l triggering receptor expressed on myeloid cells-like 6 17 48316161 BB134165 11

cell surface

signaling receptor activity

 
1434397_at Zdhhc17 zinc finger, DHHC domain containing 17 10 -110941779, -110941779 BM248633 46

Golgi membrane

Golgi membrane

signaling receptor binding

protein binding

Golgi apparatus

Golgi apparatus

plasma membrane

axonogenesis

membrane

palmitoyltransferase activity

palmitoyltransferase activity

palmitoyltransferase activity

transferase activity

acyltransferase activity

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein palmitoylation

protein palmitoylation

protein-cysteine S-myristoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

Golgi-associated vesicle membrane

cytoplasmic vesicle

identical protein binding

lipoprotein transport

cell projection

regulation of programmed cell death

intracellular membrane-bounded organelle

synapse

regulation of neurotrophin TRK receptor signaling pathway

regulation of ERK1 and ERK2 cascade

protein-cysteine S-stearoyltransferase activity

 
1427202_at Etfbkmt electron transfer flavoprotein beta subunit lysine methyltransferase 6 149141512 AV002340 15

cytoplasm

mitochondrion

mitochondrial matrix

mitochondrial matrix

methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

protein-lysine N-methyltransferase activity

protein-lysine N-methyltransferase activity

protein-lysine N-methyltransferase activity

transferase activity

peptidyl-lysine methylation

peptidyl-lysine trimethylation

peptidyl-lysine trimethylation

peptidyl-lysine trimethylation

heat shock protein binding

methylation

protein-containing complex

negative regulation of electron transfer activity

negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase

negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase

 
1435266_at Scai suppressor of cancer cell invasion 2 -39066214 BB495464 24

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

DNA-templated transcription

negative regulation of signal transduction

membrane

negative regulation of cell migration

negative regulation of cell migration

nuclear membrane

negative regulation of Rho protein signal transduction

 
1455132_at Rasal3 RAS protein activator like 3 17 -32390658, -32390658 AV312663 20

GTPase activator activity

cytoplasm

identical protein binding

regulation of GTPase activity

negative regulation of Ras protein signal transduction

positive regulation of NK T cell proliferation

cytoplasmic side of membrane

 
1455340_at Dennd5b DENN domain containing 5B 6 -148988068 BB763709 18

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

membrane

small GTPase binding

small GTPase binding

positive regulation of triglyceride transport

 
1437202_at Mysm1 myb-like, SWIRM and MPN domains 1 4 -94942040 BB494594 49

immune system process

DNA binding

transcription coactivator activity

transcription coactivator activity

nucleus

nucleoplasm

nucleolus

cytoplasm

chromatin organization

chromatin remodeling

chromatin remodeling

proteolysis

peptidase activity

metallopeptidase activity

hydrolase activity

regulation of cell migration

protein-containing complex

histone binding

histone binding

pigmentation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

regulation of hair follicle development

metal-dependent deubiquitinase activity

histone H2A deubiquitinase activity

regulation of hemopoiesis

 
1442023_at A530030E21Rik RIKEN cDNA A530030E21 gene 16   BB220605 7

molecular_function

cellular_component

biological_process

 
1437699_at E430014B02Rik RIKEN cDNA E430014B02 gene 17   BB031353 7

molecular_function

cellular_component

biological_process

 
1454788_at Arl4c ADP-ribosylation factor-like 4C 1 -88698225 BQ176306 23

nucleotide binding

GTPase activity

GTP binding

GTP binding

cytoplasm

cytoplasm

cytosol

plasma membrane

intracellular protein transport

membrane

endocytic recycling

endocytic recycling

cell projection

alpha-tubulin binding

 
1428162_at Lrif1 ligand dependent nuclear receptor interacting factor 1 3 106721681, 106684986 AK008209 16

chromosome, telomeric region

Barr body

Barr body

protein binding

nucleus

nucleoplasm

chromosome

regulation of DNA-templated transcription

dosage compensation by inactivation of X chromosome

centriolar satellite

nuclear retinoic acid receptor binding

 
1437356_at Gpr183 G protein-coupled receptor 183 14 -121952330 BM242490 67

adaptive immune response

B cell activation involved in immune response

mature B cell differentiation involved in immune response

immune system process

dendritic cell chemotaxis

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

humoral immune response

signal transduction

G protein-coupled receptor signaling pathway

oxysterol binding

oxysterol binding

T cell chemotaxis

membrane

osteoclast differentiation

leukocyte chemotaxis

leukocyte chemotaxis

positive regulation of B cell proliferation

positive regulation of B cell proliferation

dendritic cell homeostasis

cell chemotaxis

T follicular helper cell differentiation

positive regulation of ERK1 and ERK2 cascade

regulation of astrocyte chemotaxis

 
1443698_at Xaf1 XIAP associated factor 1 11 72301628 BB645745 21

nucleus

nucleoplasm

cytoplasm

mitochondrion

mitochondrion

apoptotic process

negative regulation of protein-containing complex assembly

negative regulation of type I interferon production

response to interferon-beta

metal ion binding

molecular sequestering activity

 
1453160_at Med13 mediator complex subunit 13 11 -86267032 BB244704 36

transcription coregulator activity

transcription coactivator activity

transcription coactivator activity

nucleus

nucleoplasm

nucleoplasm

regulation of transcription by RNA polymerase II

mediator complex

mediator complex

mediator complex

cholesterol homeostasis

negative regulation of DNA-binding transcription factor activity

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

nuclear thyroid hormone receptor binding

positive regulation of transcription initiation by RNA polymerase II

triglyceride homeostasis

CKM complex

 
1428172_at Prpf39 pre-mRNA processing factor 39 12 65036333 BB460975 18

commitment complex

mRNA 5'-splice site recognition

nucleus

U1 snRNP

RNA processing

mRNA processing

RNA splicing

pre-mRNA 5'-splice site binding

U2-type prespliceosome

 
1435090_at Tubgcp6 tubulin, gamma complex component 6 15 -89099097 BB477000 16

microtubule cytoskeleton organization

mitotic cell cycle

spindle pole

equatorial microtubule organizing center

gamma-tubulin complex

gamma-tubulin ring complex

cytoplasm

centrosome

centrosome

microtubule organizing center

cytoskeleton

microtubule

microtubule nucleation

microtubule nucleation

microtubule binding

cytoplasmic microtubule organization

gamma-tubulin binding

gamma-tubulin binding

microtubule minus-end binding

spindle assembly

meiotic cell cycle

 
1438296_at Slc2a4rg-ps Slc2a4 regulator, pseudogene 2 181384249 BE632919 7    
1452868_at Usp24 ubiquitin specific peptidase 24 4 106316212 AK012842 26

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

nucleus

cytosol

proteolysis

peptidase activity

cysteine-type peptidase activity

protein deubiquitination

protein deubiquitination

hydrolase activity

 
1438148_at Cxcl3 C-X-C motif chemokine ligand 3 5 90786100 BB829808 23

cytokine activity

protein binding

extracellular region

extracellular space

extracellular space

chemotaxis

defense response

inflammatory response

inflammatory response

immune response

positive regulation of cytosolic calcium ion concentration

chemokine activity

chemokine activity

chemokine activity

neutrophil chemotaxis

neutrophil chemotaxis

neutrophil chemotaxis

CXCR chemokine receptor binding

antimicrobial humoral immune response mediated by antimicrobial peptide

chemokine-mediated signaling pathway

cellular response to lipopolysaccharide

 
1454762_at Xkrx X-linked Kx blood group related, X-linked X -134149042 BM932447 14

molecular_function

cellular_component

biological_process

membrane

 
1438195_at Gpd1l glycerol-3-phosphate dehydrogenase 1-like 9 -114899338 BB727537 22

regulation of heart rate

cytoplasm

cytosol

plasma membrane

carbohydrate metabolic process

glycerol-3-phosphate metabolic process

NADH metabolic process

glycerol-3-phosphate dehydrogenase complex

positive regulation of sodium ion transport

membrane

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

sodium channel regulator activity

NAD metabolic process

negative regulation of peptidyl-serine phosphorylation

protein homodimerization activity

transmembrane transporter binding

glycerol-3-phosphate catabolic process

glycerol-3-phosphate dehydrogenase [NAD(P)+] activity

NAD binding

regulation of ventricular cardiac muscle cell membrane depolarization

ventricular cardiac muscle cell action potential

negative regulation of protein kinase C signaling

positive regulation of protein localization to cell surface

regulation of sodium ion transmembrane transporter activity

00564

1434394_at N4bp2 NEDD4 binding protein 2 5 65763520 AV116077 20

endonuclease activity

endonuclease activity

DNA endonuclease activity

protein binding

ATP binding

cytosol

ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity

 
1435463_s_at Myo1d myosin ID 11 -80482126 C76327 37

microfilament motor activity

microfilament motor activity

nucleotide binding

cytoskeletal motor activity

actin binding

protein binding

calmodulin binding

ATP binding

cytoplasm

cytoplasm

endosome

plasma membrane

plasma membrane

microvillus

brush border

brush border

endocytosis

actin filament organization

protein transport

actin cytoskeleton

membrane

basolateral plasma membrane

myosin complex

protein domain specific binding

actin filament-based movement

axon

axolemma

cytoplasmic vesicle

cell projection

neuron projection

neuronal cell body

neuronal cell body

myelin sheath

myelin sheath

myelin sheath

plasma membrane raft

calcium-dependent protein binding

actin filament binding

actin filament binding

cellular localization

apical dendrite

 
1435432_at Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 1 89454810 BE688580 33

nucleotide binding

GTPase activity

GTPase activity

GTPase activator activity

GTPase activator activity

GTP binding

phospholipid binding

cytoplasm

cytosol

protein transport

metal ion binding

activation of GTPase activity

04144

1434681_at Txlng taxilin gamma X -162778916, -162788789 BG069603 26

protein binding

nucleus

cytoplasm

cytosol

cell cycle

regulation of cell cycle process

membrane

syntaxin binding

regulation of bone mineralization

nuclear membrane

nuclear membrane

regulation of cell cycle

regulation of cell cycle

DNA-binding transcription factor binding

 
1416958_at Nr1d2 nuclear receptor subfamily 1, group D, member 2 14 -18204055 NM_011584 72

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nuclear receptor activity

nuclear receptor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of DNA-templated transcription

zinc ion binding

hormone-mediated signaling pathway

regulation of lipid metabolic process

cell differentiation

regulation of circadian rhythm

regulation of circadian rhythm

sequence-specific DNA binding

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

metal ion binding

rhythmic process

circadian behavior

regulation of inflammatory response

negative regulation of inflammatory response

lipid homeostasis

energy homeostasis

sequence-specific double-stranded DNA binding

regulation of skeletal muscle cell differentiation

 
1444090_at Pram1 PML-RAR alpha-regulated adaptor molecule 1 17 33638094, 33638055 AI561611 18

plasma membrane

plasma membrane

integrin-mediated signaling pathway

integrin-mediated signaling pathway

lipid binding

protein kinase binding

protein-containing complex

regulation of neutrophil degranulation

T cell receptor signaling pathway

protein localization to plasma membrane

 
1431997_at 3000002C10Rik glyceraldehyde-3-phosphate dehydrogenase pseudogene 9 -109830153 AK013857 11    
1445687_at Milr1 mast cell immunoglobulin like receptor 1 11 106751225, 106751225 BE629676 20

protein binding

extracellular region

plasma membrane

membrane

negative regulation of mast cell activation

mast cell degranulation

 
1428279_a_at Atxn7l1 ataxin 7-like 1 12 33147685, 33302514, 33315404, 33314296, 33146970, 33146967 AK013145 16

molecular_function

cellular_component

biological_process

 
1455530_at Ighd immunoglobulin heavy constant delta 12   BE686052 34

antigen binding

antigen binding

external side of plasma membrane

immunoglobulin mediated immune response

immunoglobulin mediated immune response

somatic hypermutation of immunoglobulin genes

B cell receptor complex

positive regulation of B cell proliferation

positive regulation of interleukin-1 production

B cell proliferation

regulation of immune response

regulation of immune response

 
1437060_at Olfm4 olfactomedin 4 14 80000301 AV290148 51

structural molecule activity

protein binding

extracellular region

extracellular space

extracellular space

extracellular space

nucleoplasm

mitochondrion

cytosol

plasma membrane

immune response

cell adhesion

signal transduction

protein-containing complex

specific granule

negative regulation of canonical NF-kappaB signal transduction

intercellular bridge

cadherin binding

perinuclear region of cytoplasm

negative regulation of immune response

positive regulation of substrate adhesion-dependent cell spreading

 
1435550_at Kmt2d lysine (K)-specific methyltransferase 2D 15 -98831668 BB702910 100

transcription cis-regulatory region binding

DNA-binding transcription activator activity, RNA polymerase II-specific

oocyte growth

in utero embryonic development

transcription coactivator activity

protein binding

nucleus

nucleoplasm

chromatin organization

methyltransferase activity

positive regulation of cell population proliferation

regulation of gene expression

transferase activity

heterochromatin formation

methylation

positive regulation of intracellular estrogen receptor signaling pathway

histone methyltransferase complex

histone binding

histone H3K4 methyltransferase activity

histone H3K4 methyltransferase activity

response to estrogen

MLL3/4 complex

MLL3/4 complex

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

metal ion binding

oogenesis

histone H3K4 monomethyltransferase activity

 
1456792_at Tbc1d2 TBC1 domain family, member 2 4 -46604389 BG967046 17

GTPase activator activity

GTPase activator activity

nucleoplasm

cytoplasm

cytosol

plasma membrane

cell junction

cytoplasmic vesicle

positive regulation of GTPase activity

cadherin binding

anchoring junction

activation of GTPase activity

 
1435391_at Rbm33 RNA binding motif protein 33 5 28317188 BM236842 23

molecular_function

nucleic acid binding

RNA binding

RNA binding

cellular_component

nucleus

cytoplasm

RNA export from nucleus

biological_process

protein-macromolecule adaptor activity

oxidative single-stranded RNA demethylation

regulation of mRNA stability

lncRNA binding

N6-methyladenosine-containing RNA reader activity

 
1428492_at Glipr2 GLI pathogenesis-related 2 4 43957701 BM208214 26

Golgi membrane

extracellular region

extracellular space

Golgi apparatus

positive regulation of epithelial cell migration

positive regulation of epithelial to mesenchymal transition

membrane

protein homodimerization activity

positive regulation of ERK1 and ERK2 cascade

 
1436941_at Nxpe3 neurexophilin and PC-esterase domain family, member 3 16 -55839952 BB626288 11

molecular_function

cellular_component

biological_process

 
1455291_s_at Znrf2 zinc and ring finger 2 6 54816915 BG071922 20

fibrillar center

nucleoplasm

cytoplasm

cytoplasm

lysosome

endosome

plasma membrane

membrane

membrane

transferase activity

cytoplasmic vesicle membrane

protein-containing complex

cell projection

proteasome-mediated ubiquitin-dependent protein catabolic process

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

synapse

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

protein K48-linked ubiquitination

 
1434301_at Lratd2 LRAT domain containing 1 15 -60818995 BE303700 17

molecular_function

cytoplasm

plasma membrane

biological_process

 
1435754_at Zyg11b zyg-ll family member B, cell cycle regulator 4 -108227754 BQ180736 17

protein quality control for misfolded or incompletely synthesized proteins

Cul2-RING ubiquitin ligase complex

Cul2-RING ubiquitin ligase complex

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

 
1428231_at Cpsf6 cleavage and polyadenylation specific factor 6 10 -117344667, -117344666 BB425379 43

nucleic acid binding

RNA binding

mRNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleoplasm

perichromatin fibrils

cytoplasm

mRNA cleavage and polyadenylation specificity factor complex

mRNA cleavage and polyadenylation specificity factor complex

mRNA cleavage factor complex

mRNA processing

nuclear speck

mRNA 3'-end processing

interchromatin granule

paraspeckles

ribosomal large subunit binding

positive regulation of RNA export from nucleus

localization

protein tetramerization

protein heterotetramerization

mRNA alternative polyadenylation

mRNA alternative polyadenylation

messenger ribonucleoprotein complex assembly

exon-exon junction complex binding

ribonucleoprotein complex

03015

1457285_at Zscan26 zinc finger and SCAN domain containing 26 13 -21442180 BB354728 14

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

nucleoplasm

cytosol

regulation of transcription by RNA polymerase II

metal ion binding

 
1455324_at Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 16 -45959260 BQ176176 16

molecular_function

cellular_component

nucleus

lipid metabolic process

signal transduction

phosphoric diester hydrolase activity

phosphoric diester hydrolase activity

biological_process

lipid catabolic process

hydrolase activity

 
1434046_at AA467197 expressed sequence AA467197 2 122637886 BG961961 18

nucleus

mitochondrion

mitochondrial respiratory chain complex IV

response to bacterium

 
1455518_at Zdhhc18 zinc finger, DHHC domain containing 18 4 -133606991 BB324402 18

immune system process

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

protein targeting to membrane

protein localization

membrane

palmitoyltransferase activity

palmitoyltransferase activity

transferase activity

acyltransferase activity

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein-cysteine S-palmitoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

innate immune response

negative regulation of innate immune response

negative regulation of cGAS/STING signaling pathway

 
1449222_at Ebi3 Epstein-Barr virus induced gene 3 17 55952622 NM_015766 106

cytokine receptor activity

cytokine receptor activity

cytokine activity

protein binding

extracellular region

extracellular space

external side of plasma membrane

membrane

cytokine-mediated signaling pathway

cytokine binding

T cell proliferation

receptor complex

interleukin-27 receptor binding

 
1419681_a_at Prok2 prokineticin 2 6 -99711298 NM_015768 66

angiogenesis

G protein-coupled receptor binding

G protein-coupled receptor binding

endothelial cell proliferation

endothelial cell proliferation

epicardium-derived cardiac endothelial cell differentiation

extracellular region

chemotaxis

neuropeptide signaling pathway

spermatogenesis

circadian rhythm

negative regulation of apoptotic process

positive regulation of smooth muscle contraction

rhythmic process

coronary vasculature development

vasculogenesis involved in coronary vascular morphogenesis

epicardium-derived cardiac vascular smooth muscle cell differentiation

 
1434958_at Sacs sacsin 14 61138456, 61138456 BG075163 30

nucleus

cytoplasm

mitochondrion

Hsp70 protein binding

Hsp70 protein binding

identical protein binding

low-density lipoprotein particle receptor binding

protein-folding chaperone binding

proteasome binding

negative regulation of inclusion body assembly

 
1419212_at Icosl icos ligand 10 78069367 NM_015790 119

regulation of cytokine production

adaptive immune response

immune system process

signaling receptor binding

signaling receptor binding

protein binding

plasma membrane

plasma membrane

signal transduction

external side of plasma membrane

external side of plasma membrane

membrane

positive regulation of interleukin-4 production

positive regulation of activated T cell proliferation

T cell activation

B cell activation

identical protein binding

intracellular membrane-bounded organelle

isotype switching

T cell receptor signaling pathway

04514

04672

1456388_at Atp11a ATPase, class VI, type 11A 8 12757015 AV378604 36

nucleotide binding

magnesium ion binding

in utero embryonic development

transporter activity

ATP binding

endosome

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

plasma membrane

plasma membrane

lipid transport

positive regulation of myotube differentiation

positive regulation of myotube differentiation

phospholipid transport

membrane

ATP hydrolysis activity

intracellular membrane-bounded organelle

phospholipid translocation

metal ion binding

recycling endosome

recycling endosome

phosphatidylethanolamine flippase activity

regulation of membrane lipid distribution

ATPase-coupled intramembrane lipid transporter activity

ATPase-coupled intramembrane lipid transporter activity

phosphatidylserine flippase activity

phospholipid-translocating ATPase complex

 
1417009_at C1ra complement component 1, r subcomponent A 6 124512620 NM_023143 22

immune system process

serine-type endopeptidase activity

serine-type endopeptidase activity

calcium ion binding

extracellular region

extracellular space

extracellular space

proteolysis

complement activation

complement activation, classical pathway

peptidase activity

serine-type peptidase activity

hydrolase activity

zymogen activation

zymogen activation

identical protein binding

innate immune response

molecular sequestering activity

04145

04610

05150

05322

1456698_s_at Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like 5 -100033578 BB711246 41

nucleic acid binding

DNA binding

double-stranded DNA binding

single-stranded DNA binding

RNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

poly(A) binding

poly(A) binding

regulation of gene expression

regulation of gene expression

mRNA metabolic process

poly(G) binding

poly(G) binding

synapse

synapse

 
1449508_at Il27ra interleukin 27 receptor, alpha 8 -84030285 NM_016671 162

negative regulation of cellular extravasation

positive regulation of T-helper 1 type immune response

negative regulation of type 2 immune response

protein binding

extracellular region

cytoplasm

plasma membrane

external side of plasma membrane

membrane

cytokine-mediated signaling pathway

cytokine binding

negative regulation of interleukin-17 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

positive regulation of type II interferon production

receptor complex

negative regulation of neuron apoptotic process

interleukin-27 receptor activity

interleukin-27 receptor activity

regulation of isotype switching to IgG isotypes

defense response to Gram-positive bacterium

negative regulation of T-helper 17 type immune response

negative regulation of T cell extravasation

 
1434390_at Hnrnpu heterogeneous nuclear ribonucleoprotein U 1 -178326733, -178321107 BB200448 88

negative regulation of transcription by RNA polymerase II

nucleotide binding

nuclear chromosome

alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

chromosome, centromeric region

kinetochore

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II complex binding

TFIIH-class transcription factor complex binding

DNA binding

chromatin binding

double-stranded DNA binding

single-stranded DNA binding

transcription corepressor activity

RNA binding

RNA binding

RNA binding

RNA binding

double-stranded RNA binding

single-stranded RNA binding

mRNA 3'-UTR binding

actin binding

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

spliceosomal complex

chromosome

telomerase holoenzyme complex

cytoplasm

centrosome

cytosol

cytoskeleton

chromatin organization

mRNA processing

cell cycle

multicellular organism development

regulation of mitotic cell cycle

poly(A) binding

RNA splicing

dosage compensation by inactivation of X chromosome

cell surface

positive regulation of gene expression

mRNA metabolic process

nuclear matrix

nuclear speck

snRNA binding

poly(C) RNA binding

cell differentiation

dendrite

midbody

chromatin DNA binding

negative regulation of telomere maintenance via telomerase

dendrite cytoplasm

circadian regulation of gene expression

protein-containing complex

negative regulation of kinase activity

poly(G) binding

negative regulation of transcription elongation by RNA polymerase II

pre-mRNA binding

cytoplasmic ribonucleoprotein granule

identical protein binding

ribonucleoprotein complex binding

sequence-specific DNA binding

protein-containing complex binding

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

mRNA stabilization

rhythmic process

cell division

maintenance of protein location in nucleus

cardiac muscle cell development

telomerase RNA binding

CRD-mediated mRNA stabilization

CRD-mediated mRNA stability complex

catalytic step 2 spliceosome

cellular response to glucocorticoid stimulus

cellular response to dexamethasone stimulus

mitotic spindle

positive regulation of brown fat cell differentiation

RNA polymerase II transcription regulator complex

inactive sex chromosome

inactive sex chromosome

dendritic transport of messenger ribonucleoprotein complex

dendritic transport of messenger ribonucleoprotein complex

RNA polymerase II C-terminal domain binding

lncRNA binding

negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

regulation of mitotic spindle assembly

regulation of chromatin organization

positive regulation of attachment of mitotic spindle microtubules to kinetochore

protein localization to spindle microtubule

mitotic spindle midzone

RNA localization to chromatin

mitotic spindle microtubule

cellular response to leukemia inhibitory factor

sequence-specific double-stranded DNA binding

promoter-specific chromatin binding

promoter-specific chromatin binding

promoter-specific chromatin binding

adaptive thermogenesis

ribonucleoprotein complex

ribonucleoprotein complex

ribonucleoprotein complex

positive regulation of stem cell proliferation

negative regulation of stem cell differentiation

negative regulation of stem cell differentiation

positive regulation of cytoplasmic translation

03040

1433640_at Fubp1 far upstream element (FUSE) binding protein 1 3 152210421 BG070740 55

RNA polymerase II cis-regulatory region sequence-specific DNA binding

nucleic acid binding

DNA binding

RNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of gene expression

positive regulation of gene expression

synapse

synapse

somatic stem cell division

developmental cell growth

hematopoietic stem cell proliferation

positive regulation of Schwann cell migration

 
1453239_a_at Ankrd22 ankyrin repeat domain 22 19 -34122548 AK012869 15

molecular_function

cellular_component

biological_process

 
1429005_at Mfhas1 malignant fibrous histiocytoma amplified sequence 1 8 35587788 BB107412 18

nucleotide binding

immune system process

GTP binding

cytoplasm

defense response

inflammatory response

inflammatory response

signal transduction

negative regulation of signal transduction

erythrocyte differentiation

ubiquitin protein ligase binding

regulation of toll-like receptor signaling pathway

negative regulation of toll-like receptor 2 signaling pathway

negative regulation of toll-like receptor 2 signaling pathway

positive regulation of toll-like receptor 2 signaling pathway

positive regulation of toll-like receptor 2 signaling pathway

negative regulation of toll-like receptor 4 signaling pathway

negative regulation of protein dephosphorylation

regulation of macrophage activation

innate immune response

innate immune response

positive regulation of JNK cascade

negative regulation of inflammatory response

protein phosphatase 2A binding

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of ERK1 and ERK2 cascade

negative regulation of protein localization to nucleus

positive regulation of p38MAPK cascade

 
1435342_at Kcnk6 potassium inwardly-rectifying channel, subfamily K, member 6 7 -29221927 BG069589 21

regulation of systemic arterial blood pressure

negative regulation of systemic arterial blood pressure

potassium channel activity

plasma membrane

outward rectifier potassium channel activity

potassium ion leak channel activity

stabilization of membrane potential

regulation of resting membrane potential

potassium ion transmembrane transport

 
1438000_x_at Zfp622 zinc finger protein 622 15 25984365 BB026724 21

nucleic acid binding

nucleus

nucleoplasm

nucleolus

cytoplasm

Golgi apparatus

cytosol

zinc ion binding

intrinsic apoptotic signaling pathway in response to oxidative stress

preribosome, large subunit precursor

positive regulation of kinase activity

ribosome biogenesis

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

positive regulation of apoptotic process

positive regulation of MAPK cascade

positive regulation of JNK cascade

metal ion binding

preribosome binding

 
1419985_s_at Ccdc69 coiled-coil domain containing 69 11 -55049737 C87579 14

nucleus

cytoplasm

cytoplasm

cytoskeleton

microtubule binding

spindle midzone

spindle midzone assembly

 
1424333_at Trmt10c tRNA methyltransferase 10C, mitochondrial RNase P subunit 16 -56033719 BC023147 26

tRNA binding

tRNA binding

mitochondrial RNA 5'-end processing

nucleus

nucleoplasm

nucleoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

tRNA processing

methyltransferase activity

transferase activity

mitochondrial ribonuclease P complex

methylation

mitochondrial nucleoid

identical protein binding

tRNA methyltransferase complex

tRNA (guanosine(9)-N1)-methyltransferase activity

positive regulation of mitochondrial translation

positive regulation of mitochondrial translation

mitochondrial tRNA methylation

mRNA methylation

mitochondrial tRNA processing

mitochondrial tRNA 5'-end processing

mitochondrial tRNA 5'-end processing

tRNA (adenine(9)-N1)-methyltransferase activity

mitochondrial tRNA 3'-end processing

 
1433557_at Cbx7 chromobox 7 15 -79915806 AV024881 60

negative regulation of transcription by RNA polymerase II

chromatin

heterochromatin

chromatin binding

RNA binding

single-stranded RNA binding

protein binding

nucleus

nucleus

nucleoplasm

chromosome

cytosol

chromatin organization

PcG protein complex

positive regulation of transcription elongation by RNA polymerase II

methylated histone binding

PRC1 complex

sebaceous gland development

 
1430447_a_at Lair1 leukocyte-associated Ig-like receptor 1 7 -4007072 AK017222 32

plasma membrane

plasma membrane

membrane

 
1416708_a_at Gramd1a GRAM domain containing 1A 7 -31130126 NM_027898 25

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

cytosol

plasma membrane

plasma membrane

plasma membrane

lipid transport

autophagy

lipid binding

cholesterol binding

cholesterol binding

membrane

cytoplasmic vesicle

intracellular sterol transport

organelle membrane contact site

cellular response to cholesterol

cholesterol transfer activity

cholesterol transfer activity

endoplasmic reticulum-plasma membrane contact site

endoplasmic reticulum-plasma membrane contact site

 
1417168_a_at Usp2 ubiquitin specific peptidase 2 9 44069428, 44084919, 44067020 AI553394 50

negative regulation of transcription by RNA polymerase II

cysteine-type deubiquitinase activity

protein binding

nucleus

cytoplasm

cytoplasm

centrosome

proteolysis

cell cycle

muscle organ development

peptidase activity

cysteine-type peptidase activity

membrane

protein deubiquitination

protein deubiquitination

hydrolase activity

cyclin binding

ubiquitin protein ligase binding

circadian regulation of gene expression

identical protein binding

entrainment of circadian clock by photoperiod

locomotor rhythm

positive regulation of mitotic cell cycle

metal ion binding

perinuclear region of cytoplasm

rhythmic process

circadian behavior

negative regulation of skeletal muscle tissue development

positive regulation of skeletal muscle tissue development

protein stabilization

negative regulation of calcium ion transport

 
1420477_at Nap1l1 nucleosome assembly protein 1-like 1 10 111473226 BG064031 48

chromatin

chromatin binding

protein binding

nucleus

nucleus

cytoplasm

nucleosome assembly

nucleosome assembly

nervous system development

kinase binding

histone binding

positive regulation of neurogenesis

histone chaperone activity

positive regulation of neural precursor cell proliferation

 
1450784_at Reck reversion-inducing-cysteine-rich protein with kazal motifs 4 43875529 NM_016678 66

blood vessel maturation

blood vessel maturation

blood vessel maturation

sprouting angiogenesis

endopeptidase inhibitor activity

endopeptidase inhibitor activity

endopeptidase inhibitor activity

serine-type endopeptidase inhibitor activity

protein binding

plasma membrane

plasma membrane

plasma membrane

embryo implantation

metalloendopeptidase inhibitor activity

negative regulation of peptidase activity

coreceptor activity

membrane

Wnt signaling pathway

Wnt-protein binding

extracellular matrix organization

extracellular matrix organization

negative regulation of cell migration

peptidase inhibitor activity

embryonic forelimb morphogenesis

positive regulation of Notch signaling pathway

regulation of angiogenesis

canonical Wnt signaling pathway

regulation of establishment of blood-brain barrier

positive regulation of canonical Wnt signaling pathway

side of membrane

negative regulation of metalloendopeptidase activity

negative regulation of metalloendopeptidase activity

negative regulation of metalloendopeptidase activity

Wnt signalosome

 
1448221_at Ddx39b DEAD box helicase 39b 17 35241745, 35242816 BC011067 44

nucleotide binding

spliceosomal complex assembly

transcription export complex

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

RNA helicase activity

RNA helicase activity

mRNA binding

helicase activity

ATP binding

nucleus

spliceosomal complex

U4 snRNP

U6 snRNP

cytoplasm

mRNA processing

mRNA export from nucleus

mRNA export from nucleus

ATP-dependent activity, acting on RNA

RNA splicing

RNA secondary structure unwinding

nuclear matrix

nuclear speck

nuclear speck

hydrolase activity

ATP hydrolysis activity

U6 snRNA binding

U4 snRNA binding

protein-containing complex

identical protein binding

ATP-dependent protein binding

protein-containing complex binding

positive regulation of translation

mRNA transport

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of vascular associated smooth muscle cell proliferation

positive regulation of DNA biosynthetic process

03013

03015

03040

1423103_at Rfx5 regulatory factor X, 5 (influences HLA class II expression) 3 94954107, 94954515 BB392192 32

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

intracellular membrane-bounded organelle

sequence-specific DNA binding

positive regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulator complex

sequence-specific double-stranded DNA binding

04612

05340

1427564_at Diaph2 diaphanous related formin 2 X 129749741 Y15910 41

actin binding

protein binding

nucleolus

endoplasmic reticulum

actin filament

multicellular organism development

protein localization

cellular component organization

axon midline choice point recognition

actin cytoskeleton organization

actin filament polymerization

actin filament polymerization

cell differentiation

small GTPase binding

intracellular membrane-bounded organelle

ephrin receptor signaling pathway

oogenesis

negative regulation of neuron projection regeneration

multicellular organismal locomotion

neuron projection retraction

04810

1417244_a_at Irf7 interferon regulatory factor 7 7 -141263182 NM_016850 270

chromatin

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription factor activity, RNA polymerase II-specific

cis-regulatory region sequence-specific DNA binding

immune system process

immune system process

cytoplasmic pattern recognition receptor signaling pathway

regulation of adaptive immune response

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of gene expression

immunoglobulin mediated immune response

positive regulation of type I interferon production

positive regulation of type I interferon production

positive regulation of type I interferon production

type I interferon production

positive regulation of interferon-alpha production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interferon-beta production

regulation of MyD88-dependent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway

innate immune response

regulation of innate immune response

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

defense response to virus

defense response to virus

type I interferon-mediated signaling pathway

positive regulation of type I interferon-mediated signaling pathway

sequence-specific double-stranded DNA binding

04620

04622

04623

05160

1439953_at Pmm2 phosphomannomutase 2 16 8637706 BB709170 28

phosphomannomutase activity

phosphomannomutase activity

nucleoplasm

cytoplasm

cytosol

cytosol

mannose metabolic process

protein N-linked glycosylation

GDP-mannose biosynthetic process

isomerase activity

neuronal cell body

metal ion binding

00051

00520

01100

1422576_at Atxn10 ataxin 10 15 85336254 NM_016843 42

protein binding

cytoplasm

cytosol

cytosol

plasma membrane

nervous system development

enzyme binding

dendrite

neuron projection development

neuron projection development

identical protein binding

neuronal cell body

perinuclear region of cytoplasm

cilium assembly

 
1418301_at Irf6 interferon regulatory factor 6 1 193153111 NM_016851 93

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

immune system process

DNA binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

cell population proliferation

negative regulation of cell population proliferation

negative regulation of keratinocyte proliferation

cell differentiation

keratinocyte differentiation

sequence-specific DNA binding

skin development

skin development

keratinocyte proliferation

keratinocyte proliferation

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

cell development

roof of mouth development

limb development

mammary gland epithelial cell differentiation

stem cell proliferation

cranial skeletal system development

sequence-specific double-stranded DNA binding

negative regulation of stem cell proliferation

 
1436598_at Icos inducible T cell co-stimulator 1 60977913 AV313923 224

T cell tolerance induction

T cell tolerance induction

protein binding

plasma membrane

external side of plasma membrane

membrane

T cell costimulation

T cell costimulation

cell-cell adhesion

cell-cell adhesion

04514

04660

04672

05340

1422850_at Pabpn1 poly(A) binding protein, nuclear 1 14 54894142 AV028400 55

MAPK cascade

nucleic acid binding

RNA binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytosol

mRNA processing

poly(A) binding

poly(A) binding

poly(A)+ mRNA export from nucleus

regulation of mRNA 3'-end processing

nuclear inclusion body

protein self-association

RNA polymerase binding

cellular response to lipopolysaccharide

positive regulation of polynucleotide adenylyltransferase activity

ribonucleoprotein complex

ribonucleoprotein complex

03015

1427736_a_at Ccrl2 C-C motif chemokine receptor-like 2 9 -111054833, -111054833, -111054833 AJ318863 39

G protein-coupled receptor activity

chemokine receptor activity

cytoplasm

plasma membrane

chemotaxis

inflammatory response

inflammatory response

immune response

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

external side of plasma membrane

membrane

C-C chemokine receptor activity

C-C chemokine receptor activity

calcium-mediated signaling

C-C chemokine binding

chemokine receptor binding

chemokine receptor binding

CCR chemokine receptor binding

cell chemotaxis

chemokine-mediated signaling pathway

 
1416441_at Cpq carboxypeptidase Q 15 33083128 BB468025 16

carboxypeptidase activity

extracellular region

extracellular space

extracellular space

extracellular space

cytoplasm

lysosome

lysosome

endoplasmic reticulum

Golgi apparatus

proteolysis

proteolysis

thyroid hormone generation

thyroid hormone generation

peptidase activity

metallopeptidase activity

hydrolase activity

protein homodimerization activity

peptide catabolic process

peptide catabolic process

intracellular membrane-bounded organelle

metal ion binding

metallodipeptidase activity

metallodipeptidase activity

 
1417793_at Irgm2 immunity-related GTPase family M member 2 11 58214976 NM_019440 27

autophagosome assembly

Golgi membrane

Golgi membrane

nucleotide binding

autophagosome membrane

positive regulation of protein phosphorylation

immune system process

GTPase activity

GTPase activity

GTPase activity

GTPase activity

G protein activity

GTP binding

cytoplasm

mitochondrion

vacuolar membrane

endoplasmic reticulum membrane

Golgi apparatus

cytosol

cytosol

defense response

response to bacterium

positive regulation of autophagy

positive regulation of peptidyl-threonine phosphorylation

membrane

hydrolase activity

protein kinase binding

protein-macromolecule adaptor activity

cytoplasmic vesicle

killing of cells of another organism

protein destabilization

negative regulation of type I interferon production

positive regulation of peptidyl-serine phosphorylation

cellular response to interferon-beta

defense response to bacterium

defense response to protozoan

negative regulation of canonical NF-kappaB signal transduction

regulation of protein-containing complex assembly

protein serine/threonine kinase activator activity

protein targeting to vacuolar membrane

innate immune response

negative regulation of defense response to virus

CARD domain binding

negative regulation of inflammatory response

protein stabilization

defense response to Gram-negative bacterium

BH3 domain binding

positive regulation of type II interferon-mediated signaling pathway

regulation of protein complex stability

protein lipidation involved in autophagosome assembly

CAMKK-AMPK signaling cascade

protein-containing complex assembly

nucleotide-binding oligomerization domain containing 2 signaling pathway

protein targeting to vacuole involved in autophagy

cellular response to lipopolysaccharide

positive regulation of protein serine/threonine kinase activity

positive regulation of mitochondrial fission

cellular response to virus

negative regulation of cGAS/STING signaling pathway

negative regulation of non-canonical inflammasome complex assembly

negative regulation of NLRP3 inflammasome complex assembly

positive regulation of autophagosome maturation

positive regulation of mitophagy

cardiolipin binding

positive regulation of xenophagy

positive regulation of lysosome organization

 
1460283_at Mefv Mediterranean fever 16 -3707214 NM_019453 37

pattern recognition receptor signaling pathway

immune system process

actin binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

cytoskeleton

microtubule

microtubule associated complex

inflammatory response

zinc ion binding

regulation of gene expression

positive regulation of autophagy

protein ubiquitination

cytoplasmic vesicle

regulation of interleukin-1 beta production

negative regulation of interleukin-1 beta production

negative regulation of interleukin-12 production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-1 beta production

response to type II interferon

identical protein binding

cell projection

innate immune response

innate immune response

metal ion binding

negative regulation of inflammatory response

positive regulation of inflammatory response

ubiquitin protein ligase activity

canonical inflammasome complex

pyroptosis

negative regulation of macrophage inflammatory protein 1 alpha production

negative regulation of cytokine production involved in inflammatory response

negative regulation of NLRP3 inflammasome complex assembly

pyroptosome complex assembly

positive regulation of cysteine-type endopeptidase activity

04621

1425814_a_at Calcrl calcitonin receptor-like 2 -84330626 AF209905 47

angiogenesis

angiogenesis

adrenomedullin receptor activity

adrenomedullin receptor activity

calcitonin gene-related peptide receptor activity

calcitonin gene-related peptide receptor activity

calcitonin gene-related peptide receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

calcitonin receptor activity

cytoplasm

lysosome

endosome

endoplasmic reticulum

plasma membrane

plasma membrane

calcium ion transport

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

heart development

cell population proliferation

positive regulation of cell population proliferation

protein transport

membrane

receptor internalization

negative regulation of smooth muscle contraction

smooth muscle cell proliferation

cellular response to sucrose stimulus

neuronal dense core vesicle

adrenomedullin receptor complex

positive regulation of vascular associated smooth muscle cell proliferation

CGRP receptor complex

calcitonin gene-related peptide receptor signaling pathway

adrenomedullin binding

adrenomedullin receptor signaling pathway

adrenomedullin receptor signaling pathway

vascular associated smooth muscle cell proliferation

04080

04270

1416996_at Tbc1d8 TBC1 domain family, member 8 1 -39371495, -39371495, -39373312 BC005421 19

GTPase activator activity

GTPase activator activity

activation of GTPase activity

 
1417894_at Adgrg3 adhesion G protein-coupled receptor G3 8 95017691 NM_025309 22

transmembrane signaling receptor activity

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

plasma membrane

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

membrane

B cell differentiation

regulation of cell migration

negative regulation of CREB transcription factor activity

negative regulation of non-canonical NF-kappaB signal transduction

 
1416381_a_at Prdx5 peroxiredoxin 5 19 -6906696 BC008174 73

RNA polymerase III transcription regulatory region sequence-specific DNA binding

peroxidase activity

signaling receptor binding

signaling receptor binding

protein binding

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

peroxisome

peroxisome

peroxisomal matrix

peroxisomal matrix

cytosol

response to oxidative stress

response to oxidative stress

thioredoxin peroxidase activity

thioredoxin peroxidase activity

antioxidant activity

antioxidant activity

negative regulation of transcription by RNA polymerase III

oxidoreductase activity

cytoplasmic vesicle

positive regulation of collagen biosynthetic process

cellular response to oxidative stress

cellular response to oxidative stress

cellular response to reactive oxygen species

hydrogen peroxide catabolic process

hydrogen peroxide catabolic process

hydrogen peroxide catabolic process

identical protein binding

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

negative regulation of apoptotic process

intracellular membrane-bounded organelle

cell redox homeostasis

perinuclear region of cytoplasm

negative regulation of oxidoreductase activity

regulation of apoptosis involved in tissue homeostasis

NADPH oxidation

peroxynitrite reductase activity

thioredoxin-dependent peroxiredoxin activity

reactive nitrogen species metabolic process

04146

1433977_at Hs3st3b1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 11 -63884692 BG918344 28

branching involved in ureteric bud morphogenesis

Golgi apparatus

plasma membrane

glycosaminoglycan biosynthetic process

protein sulfation

sulfotransferase activity

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

heparan sulfate proteoglycan biosynthetic process

membrane

transferase activity

[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

00534

1451564_at Parp14 poly (ADP-ribose) polymerase family, member 14 16 -35832877 BC021340 33

immune system process

transcription corepressor activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

cytosol

plasma membrane

negative regulation of gene expression

negative regulation of gene expression

transferase activity

glycosyltransferase activity

nucleotidyltransferase activity

enzyme binding

positive regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein

innate immune response

negative regulation of type II interferon-mediated signaling pathway

negative regulation of type II interferon-mediated signaling pathway

protein poly-ADP-ribosylation

protein poly-ADP-ribosylation

NAD+ binding

positive regulation of interleukin-4-mediated signaling pathway

positive regulation of interleukin-4-mediated signaling pathway

NAD+-protein ADP-ribosyltransferase activity

NAD+-protein ADP-ribosyltransferase activity

 
1418392_a_at Gbp3 guanylate binding protein 3 3 142560355, 142560043 NM_018734 28

nucleotide binding

activation of innate immune response

immune system process

GTPase activity

GTPase activity

GTP binding

GTP binding

nucleus

cytoplasm

Golgi apparatus

cytosol

cytosol

plasma membrane

membrane

hydrolase activity

symbiont-containing vacuole membrane

cytoplasmic vesicle

cytoplasmic vesicle

cellular response to interferon-beta

defense response to bacterium

identical protein binding

protein homodimerization activity

defense response to protozoan

defense response to protozoan

adhesion of symbiont to host

innate immune response

perinuclear region of cytoplasm

defense response to Gram-positive bacterium

defense response to Gram-positive bacterium

cytolysis in another organism

cellular response to lipopolysaccharide

cellular response to type II interferon

cellular response to type II interferon

cellular response to tumor necrosis factor

positive regulation of pyroptosis

 
1423191_at Fnbp4 formin binding protein 4 2 90745557 AK013152 27

protein binding

nucleoplasm

biological_process

 
1432195_s_at Ccnl2 cyclin L2 4 155812488 AK008585 28

cyclin-dependent protein kinase holoenzyme complex

protein binding

nucleus

nucleus

nucleoplasm

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cyclin-dependent protein serine/threonine kinase regulator activity

cyclin-dependent protein serine/threonine kinase regulator activity

regulation of apoptotic process

intracellular membrane-bounded organelle

regulation of RNA splicing

regulation of centrosome cycle

regulation of cell cycle

 
1418131_at Samhd1 SAM domain and HD domain, 1 2 -157119560, -157097533 NM_018851 51

nucleotide binding

double-strand break repair via homologous recombination

immune system process

nucleic acid binding

single-stranded DNA binding

RNA binding

catalytic activity

GTP binding

nucleus

nucleus

nucleoplasm

chromosome

plasma membrane

dGTP catabolic process

dGTP catabolic process

DNA replication

DNA repair

DNA damage response

metabolic process

zinc ion binding

dGTPase activity

dGTPase activity

dGTPase activity

deoxyribonucleotide catabolic process

somatic hypermutation of immunoglobulin genes

hydrolase activity

triphosphoric monoester hydrolase activity

triphosphoric monoester hydrolase activity

dGTP binding

site of double-strand break

identical protein binding

innate immune response

regulation of innate immune response

regulation of innate immune response

dATP catabolic process

metal ion binding

protein homotetramerization

protein homotetramerization

defense response to virus

defense response to virus

negative regulation of type I interferon-mediated signaling pathway

negative regulation of type I interferon-mediated signaling pathway

tetraspanin-enriched microdomain

DNA strand resection involved in replication fork processing

 
1434434_s_at Tcerg1 transcription elongation regulator 1 (CA150) 18 42511486 AW557777 40

negative regulation of transcription by RNA polymerase II

DNA-binding transcription factor activity

transcription coregulator activity

transcription coregulator activity

transcription corepressor activity

nucleus

nucleus

nucleoplasm

DNA-templated transcription

regulation of DNA-templated transcription

mRNA processing

RNA splicing

nuclear matrix

identical protein binding

ubiquitin-like protein conjugating enzyme binding

positive regulation of transcription by RNA polymerase II

RNA polymerase II-specific DNA-binding transcription factor binding

RNA polymerase binding

RNA polymerase binding

proline-rich region binding

03040

1436038_a_at Pigp phosphatidylinositol glycan anchor biosynthesis, class P 16 -94364451, -94364451, -94364451, -94364451, -94358762 BF318238 22

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

GPI anchor biosynthetic process

GPI anchor biosynthetic process

GPI anchor biosynthetic process

membrane

phosphatidylinositol N-acetylglucosaminyltransferase activity

00563

01100

1417523_at Plek pleckstrin 11 -16971205 AF181829 19

protein kinase C binding

cytoplasm

plasma membrane

vesicle docking involved in exocytosis

integrin-mediated signaling pathway

positive regulation of platelet activation

negative regulation of inositol phosphate biosynthetic process

positive regulation of inositol-polyphosphate 5-phosphatase activity

cell projection organization

actin cytoskeleton organization

positive regulation of actin filament depolymerization

positive regulation of actin filament depolymerization

phospholipase C-inhibiting G protein-coupled receptor signaling pathway

cortical actin cytoskeleton organization

ruffle organization

positive regulation of actin filament bundle assembly

ruffle membrane

positive regulation of integrin activation

intracellular signal transduction

protein homodimerization activity

phosphatidylinositol-3,4-bisphosphate binding

negative regulation of G protein-coupled receptor signaling pathway

phosphatidylinositol metabolic process

regulation of cell diameter

thrombin-activated receptor signaling pathway

thrombin-activated receptor signaling pathway

platelet aggregation

protein kinase C signaling

protein secretion by platelet

 
1448706_at Tdp2 tyrosyl-DNA phosphodiesterase 2 13 24831658 NM_019551 32

magnesium ion binding

single-stranded DNA binding

single-stranded DNA binding

catalytic activity

nuclease activity

endonuclease activity

nucleus

nucleoplasm

cytoplasm

cytoplasm

DNA repair

double-strand break repair

double-strand break repair

DNA damage response

phosphoric diester hydrolase activity

aggresome

nuclear body

PML body

PML body

hydrolase activity

manganese ion binding

tyrosyl-RNA phosphodiesterase activity

metal ion binding

neuron development

5'-tyrosyl-DNA phosphodiesterase activity

5'-tyrosyl-DNA phosphodiesterase activity

 
1422624_at Rev1 REV1, DNA directed polymerase 1 -38052785 NM_019570 60

DNA binding

damaged DNA binding

DNA-directed DNA polymerase activity

protein binding

nucleus

DNA repair

DNA damage response

response to UV

transferase activity

nucleotidyltransferase activity

deoxycytidyl transferase activity

deoxycytidyl transferase activity

error-prone translesion synthesis

error-prone translesion synthesis

metal ion binding

error-free translesion synthesis

DNA biosynthetic process

 
1451146_at Zfp386 zinc finger protein 386 (Kruppel-like) 12 116047723 BC004747 21

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

chromatin binding

double-stranded DNA binding

nucleus

regulation of transcription by RNA polymerase II

 
1429710_at Styx serine/threonine/tyrosine interaction protein 14 45351185 BB812465 17

pseudophosphatase activity

protein binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

spermatogenesis

negative regulation of protein binding

negative regulation of protein binding

MAPK export from nucleus

negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process

regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade

F-box domain binding

F-box domain binding

 
1419665_a_at Nupr1 nuclear protein transcription regulator 1 7 -126623245 NM_019738 71

acute inflammatory response

DNA binding

chromatin binding

transcription coactivator activity

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

protein acetylation

negative regulation of cell population proliferation

male gonad development

response to toxic substance

regulation of autophagy

negative regulation of autophagy

negative regulation of autophagy

negative regulation of cardiac muscle cell apoptotic process

acetyltransferase activator activity

positive regulation of protein modification process

protein-DNA complex

skeletal muscle cell differentiation

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of apoptotic process

negative regulation of DNA-binding transcription factor activity

positive regulation of neuron apoptotic process

fibroblast apoptotic process

intercellular bridge

negative regulation of cell cycle

negative regulation of cell cycle

negative regulation of cell cycle

positive regulation of cell cycle

negative regulation of glycolytic process

fibroblast proliferation

negative regulation of fibroblast proliferation

perinuclear region of cytoplasm

negative regulation of epithelial cell proliferation

negative regulation of programmed necrotic cell death

protein-containing complex assembly

positive regulation of neuroinflammatory response

positive regulation of proteasomal protein catabolic process

negative regulation of autophagosome assembly

positive regulation of oxidative phosphorylation

negative regulation of epithelial cell apoptotic process

negative regulation of type B pancreatic cell proliferation

regulation of response to endoplasmic reticulum stress

regulation of female gonad development

positive regulation of fibroblast apoptotic process

positive regulation of intrinsic apoptotic signaling pathway

 
1460329_at B4galt6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 18 -20684598 BG066773 29

lactosylceramide biosynthetic process

Golgi apparatus

Golgi apparatus

carbohydrate metabolic process

lipid metabolic process

sphingolipid metabolic process

glycosphingolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity

ganglioside biosynthetic process via lactosylceramide

membrane

transferase activity

glycosyltransferase activity

central nervous system neuron axonogenesis

central nervous system myelination

sphingolipid biosynthetic process

neuron maturation

metal ion binding

glycosylation

00600

01100

1424973_at Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 5 -145977193, -145977193 AF204959 18

monooxygenase activity

iron ion binding

endoplasmic reticulum

steroid metabolic process

testosterone 16-alpha-hydroxylase activity

steroid hydroxylase activity

retinoic acid 4-hydroxylase activity

response to bacterium

membrane

oxidoreductase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

heme binding

intracellular membrane-bounded organelle

metal ion binding

testosterone 6-beta-hydroxylase activity

testosterone 6-beta-hydroxylase activity

aromatase activity

oxidative demethylation

estrogen 16-alpha-hydroxylase activity

estrogen 2-hydroxylase activity

00140

00591

00830

00980

00982

00983

01100

1433669_at Akap8 A kinase anchor protein 8 17 -32303671 BB037566 50

chromatin

condensed chromosome

condensed chromosome

female pronucleus

immune system process

DNA binding

chromatin binding

double-stranded DNA binding

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

mitotic chromosome condensation

mitotic chromosome condensation

zinc ion binding

protein transport

nuclear matrix

nuclear matrix

nuclear matrix

negative regulation of tumor necrosis factor production

protein kinase A regulatory subunit binding

protein kinase A regulatory subunit binding

histone deacetylase binding

cell cycle G2/M phase transition

innate immune response

metal ion binding

NF-kappaB binding

cellular response to lipopolysaccharide

cellular response to prostaglandin E stimulus

 
1417124_at Dstn destrin 2 143915330 NM_019771 76

cytokinesis

actin binding

cytoplasm

cytoplasm

actin cytoskeleton

actin cytoskeleton

actin filament depolymerization

actin filament depolymerization

actin filament fragmentation

actin filament fragmentation

positive regulation of actin filament depolymerization

cortical actin cytoskeleton

cell motility

actin filament severing

actin filament binding

actin filament binding

actin filament binding

 
1454811_a_at Serinc1 serine incorporator 1 10 -57515774 AV026664 26

endoplasmic reticulum

endoplasmic reticulum membrane

plasma membrane

plasma membrane

lipid metabolic process

phosphatidylserine metabolic process

sphingolipid metabolic process

phospholipid biosynthetic process

membrane

membrane

enzyme binding

protein-macromolecule adaptor activity

membrane biogenesis

 
1416983_s_at Foxo1 forkhead box O1 3 52268336 AI462296 820

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

transcription coactivator binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

blood vessel development

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

regulation of gluconeogenesis

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

autophagy

apoptotic process

DNA damage response

beta-catenin binding

transcription factor binding

insulin receptor signaling pathway

insulin receptor signaling pathway

insulin receptor signaling pathway

cellular response to starvation

gene expression

positive regulation of autophagy

cell differentiation

chromatin DNA binding

ubiquitin protein ligase binding

response to insulin

cellular response to insulin stimulus

negative regulation of stress-activated MAPK cascade

cellular response to oxidative stress

regulation of cell population proliferation

glucose homeostasis

positive regulation of apoptotic process

negative regulation of apoptotic process

sequence-specific DNA binding

sequence-specific DNA binding

negative regulation of fat cell differentiation

positive regulation of gluconeogenesis

positive regulation of gluconeogenesis

positive regulation of protein catabolic process

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

negative regulation of insulin secretion

protein phosphatase 2A binding

canonical Wnt signaling pathway

response to fatty acid

cellular response to hyperoxia

cellular response to nitric oxide

negative regulation of canonical Wnt signaling pathway

neuronal stem cell population maintenance

negative regulation of cardiac muscle hypertrophy in response to stress

promoter-specific chromatin binding

regulation of neural precursor cell proliferation

regulation of reactive oxygen species metabolic process

04910

05200

05215

1423350_at Socs5 suppressor of cytokine signaling 5 17 87107678 AA510713 35

epidermal growth factor receptor binding

protein binding

cytoplasm

phosphatidylinositol 3-kinase complex

epidermal growth factor receptor signaling pathway

negative regulation of epidermal growth factor-activated receptor activity

receptor signaling pathway via JAK-STAT

negative regulation of signal transduction

kinase inhibitor activity

cytokine-mediated signaling pathway

receptor tyrosine kinase binding

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of interleukin-6 production

intracellular signal transduction

positive regulation of T-helper 1 cell differentiation

negative regulation of T-helper 2 cell differentiation

phosphatidylinositol phosphate biosynthetic process

1-phosphatidylinositol-3-kinase regulator activity

negative regulation of inflammatory response

cellular response to low-density lipoprotein particle stimulus

negative regulation of monocyte chemotactic protein-1 production

vascular endothelial cell response to fluid shear stress

negative regulation of endothelial cell activation

04630

1422064_a_at Zbtb20 zinc finger and BTB domain containing 20 16 43247283, 42907644 AY028963 339

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

regulation of cytokine production

regulation of immune system process

DNA binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

negative regulation of gene expression

nuclear body

positive regulation of interferon-beta production

positive regulation of interferon-beta production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of glycolytic process

negative regulation of DNA-templated transcription

metal ion binding

positive regulation of lipid biosynthetic process

lipid homeostasis

cellular response to glucose stimulus

sequence-specific double-stranded DNA binding

 
1447806_s_at Srpk3 serine/arginine-rich protein specific kinase 3 X 73774404 BB036235 18

nucleotide binding

spliceosomal complex assembly

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

protein phosphorylation

multicellular organism development

muscle organ development

skeletal muscle tissue development

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

cell differentiation

intracellular signal transduction

regulation of mRNA processing

muscle tissue development

 
1422852_at Cib2 calcium and integrin binding family member 2 9 -54544793 NM_019686 32

magnesium ion binding

magnesium ion binding

photoreceptor outer segment

photoreceptor inner segment

integrin binding

calcium ion binding

calcium ion binding

calcium ion binding

cytoplasm

cytoplasm

cytosol

plasma membrane

muscle tendon junction

positive regulation of cytosolic calcium ion concentration

membrane

neuromuscular junction

stereocilium

stereocilium

stereocilium

cuticular plate

sarcolemma

protein homodimerization activity

cell projection

protein-containing complex binding

photoreceptor cell maintenance

metal ion binding

calcium ion homeostasis

calcium ion homeostasis

cellular response to ATP

cell periphery

 
1425518_at Rapgef4 Rap guanine nucleotide exchange factor (GEF) 4 2 71981214, 72054616, 71981214 AK004874 94

nucleotide binding

photoreceptor outer segment

photoreceptor inner segment

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

protein binding

cytoplasm

cytosol

plasma membrane

brush border

exocytosis

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

small GTPase-mediated signal transduction

Ras protein signal transduction

postsynaptic density

positive regulation of smooth muscle cell migration

membrane

basolateral plasma membrane

apical plasma membrane

calcium-ion regulated exocytosis

regulation of exocytosis

insulin secretion

axon

dendrite

growth cone

cAMP binding

cAMP binding

protein-macromolecule adaptor activity

small GTPase binding

positive regulation of insulin secretion

protein-containing complex

intracellular signal transduction

neuronal cell body

dendritic spine

positive regulation of GTPase activity

cone cell pedicle

protein-containing complex binding

hormone secretion

positive regulation of protein secretion

regulation of dendrite development

negative regulation of synaptic transmission

excitatory synapse

hippocampal mossy fiber to CA3 synapse

hippocampal mossy fiber to CA3 synapse

regulation of synaptic vesicle cycle

regulation of synaptic vesicle cycle

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

glutamatergic synapse

regulation of postsynapse organization

positive regulation of neuronal action potential

04670

1436819_at Septin6 septin 6 X -36911271, -36913443 BG920446 63

nucleotide binding

chromosome, centromeric region

kinetochore

GTPase activity

protein binding

GTP binding

chromosome

cytoplasm

cytoskeleton

cilium

septin ring

septin ring

cell cycle

spermatogenesis

synaptic vesicle

microtubule cytoskeleton

cell differentiation

septin complex

septin complex

septin complex

motile cilium

cell division site

cleavage furrow

septin collar

cell projection

axon terminus

cell division

molecular adaptor activity

cilium assembly

cytoskeleton-dependent cytokinesis

sperm annulus

presynapse

 
1415897_a_at Mgst1 microsomal glutathione S-transferase 1 6 138141586, 138140526 BI150149 32

glutathione transferase activity

glutathione transferase activity

glutathione transferase activity

glutathione peroxidase activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

peroxisomal membrane

endoplasmic reticulum

glutathione metabolic process

response to xenobiotic stimulus

response to organonitrogen compound

membrane

transferase activity

response to lipopolysaccharide

glutathione transport

identical protein binding

glutathione binding

apical part of cell

cellular response to lipid hydroperoxide

00480

00980

00982

1420330_at Clec4e C-type lectin domain family 4, member e 6 -123281788 NM_019948 103

positive regulation of cytokine production

pattern recognition receptor signaling pathway

T cell differentiation involved in immune response

immune system process

calcium ion binding

protein binding

plasma membrane

immune response

external side of plasma membrane

membrane

carbohydrate binding

carbohydrate binding

phagocytic vesicle membrane

signaling receptor activity

Fc-gamma receptor signaling pathway

pattern recognition receptor activity

pattern recognition receptor activity

pattern recognition receptor activity

defense response to bacterium

cell projection

innate immune response

innate immune response

metal ion binding

glycolipid binding

antifungal innate immune response

antifungal innate immune response

 
1425951_a_at Clec4n C-type lectin domain family 4, member n 6 123229842 AF240358 96

positive regulation of cytokine production

response to yeast

detection of yeast

stimulatory C-type lectin receptor signaling pathway

adaptive immune response

immune system process

calcium ion binding

protein binding

mannose binding

plasma membrane

plasma membrane

external side of plasma membrane

membrane

carbohydrate binding

carbohydrate binding

carbohydrate binding

pattern recognition receptor activity

pattern recognition receptor activity

positive regulation of canonical NF-kappaB signal transduction

innate immune response

metal ion binding

positive regulation of peptidyl-tyrosine phosphorylation

defense response to fungus

antifungal innate immune response

antifungal innate immune response

positive regulation of intracellular signal transduction

positive regulation of T-helper 17 type immune response

 
1420699_at Clec7a C-type lectin domain family 7, member a 6 -129461590, -129461590 NM_020008 251

cell activation

opsonin binding

(1->3)-beta-D-glucan binding

(1->3)-beta-D-glucan binding

(1->3)-beta-D-glucan binding

(1->3)-beta-D-glucan immune receptor activity

response to yeast

detection of yeast

stimulatory C-type lectin receptor signaling pathway

response to molecule of fungal origin

leukocyte activation involved in immune response

immune system process

positive regulation of cytokine production involved in immune response

positive regulation of dendritic cell cytokine production

positive regulation of dendritic cell cytokine production

cell surface pattern recognition receptor signaling pathway

protein binding

cytoplasm

plasma membrane

plasma membrane

phagocytosis, recognition

phagocytosis, recognition

phagocytosis, recognition

phagocytosis, engulfment

inflammatory response

cell recognition

positive regulation of cell population proliferation

positive regulation of cell population proliferation

external side of plasma membrane

cell surface

cell surface

positive regulation of gene expression

membrane

detection of fungus

detection of fungus

carbohydrate binding

polysaccharide binding

positive regulation of cell migration

positive regulation of cell migration

positive regulation of protein-containing complex assembly

detection of molecule of fungal origin

detection of molecule of fungal origin

detection of molecule of fungal origin

positive regulation of type II interferon production

positive regulation of interleukin-1 beta production

positive regulation of interleukin-10 production

positive regulation of interleukin-10 production

positive regulation of interleukin-12 production

positive regulation of interleukin-2 production

positive regulation of interleukin-2 production

positive regulation of interleukin-23 production

positive regulation of interleukin-6 production

positive regulation of interleukin-6 production

positive regulation of interleukin-8 production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor production

positive regulation of stress-activated MAPK cascade

positive regulation of superoxide anion generation

pattern recognition receptor activity

pattern recognition receptor activity

pattern recognition receptor activity

pattern recognition receptor activity

identical protein binding

regulation of canonical NF-kappaB signal transduction

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

innate immune response

positive regulation of nitric oxide biosynthetic process

metal ion binding

positive regulation of peptidyl-tyrosine phosphorylation

positive regulation of phagocytosis

positive regulation of phagocytosis

positive regulation of phagocytosis

positive regulation of calcium-mediated signaling

positive regulation of DNA-binding transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of lymphocyte activation

positive regulation of lymphocyte activation

positive regulation of killing of cells of another organism

positive regulation of killing of cells of another organism

positive regulation of respiratory burst

antifungal innate immune response

antifungal innate immune response

regulation of calcineurin-NFAT signaling cascade

cellular response to molecule of fungal origin

cellular response to molecule of fungal origin

cellular response to molecule of fungal origin

positive regulation of monocyte chemotactic protein-1 production

positive regulation of wound healing

positive regulation of wound healing

cell-cell adhesion

positive regulation of cytokine production involved in inflammatory response

positive regulation of cytokine production involved in inflammatory response

positive regulation of cell maturation

positive regulation of T-helper 17 type immune response

04145

1437270_a_at Clcf1 cardiotrophin-like cytokine factor 1 19 4214388, 4214237 BB825816 35

positive regulation of immunoglobulin production

positive regulation of type 2 immune response

signaling receptor binding

cytokine activity

cytokine activity

cytokine activity

ciliary neurotrophic factor receptor binding

ciliary neurotrophic factor receptor binding

protein binding

extracellular region

extracellular region

extracellular space

cell surface receptor signaling pathway

receptor signaling pathway via JAK-STAT

receptor signaling pathway via JAK-STAT

positive regulation of cell population proliferation

B cell differentiation

positive regulation of B cell proliferation

positive regulation of B cell proliferation

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

positive regulation of tyrosine phosphorylation of STAT protein

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

positive regulation of isotype switching to IgE isotypes

positive regulation of astrocyte differentiation

regulation of inflammatory response

positive regulation of corticotropin-releasing hormone secretion

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of ERK1 and ERK2 cascade

CRLF-CLCF1 complex

CRLF-CLCF1 complex

CRLF-CLCF1 complex

CNTFR-CLCF1 complex

CNTFR-CLCF1 complex

negative regulation of motor neuron apoptotic process

04060

04630

1423323_at Tacstd2 tumor-associated calcium signal transducer 2 6 -67534058 AV241768 35

extracellular space

extracellular space

nucleus

nucleus

plasma membrane

basal plasma membrane

negative regulation of epithelial cell migration

membrane

lateral plasma membrane

regulation of epithelial cell proliferation

negative regulation of stress fiber assembly

ureteric bud morphogenesis

negative regulation of branching involved in ureteric bud morphogenesis

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of ruffle assembly

negative regulation of cell motility

positive regulation of stem cell differentiation

positive regulation of stem cell differentiation

 
1440315_at Mbnl1 muscleblind like splicing regulator 1 3 60501178, 60472829 BB202204 102

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

regulatory region RNA binding

in utero embryonic development

RNA binding

RNA binding

double-stranded RNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytosol

mRNA splice site recognition

mRNA processing

nervous system development

skeletal muscle tissue development

RNA splicing

cytoplasmic stress granule

embryonic limb morphogenesis

regulation of RNA splicing

regulation of RNA splicing

myoblast differentiation

metal ion binding

 
1449738_s_at Supt20 SPT20 SAGA complex component 3 54692814, 54695122, 54693104 C80158 29

SAGA complex

SAGA complex

transcription coregulator activity

transcription coregulator activity

regulation of DNA repair

regulation of transcription by RNA polymerase II

multicellular organism development

gastrulation

regulation of RNA splicing

positive regulation of gluconeogenesis

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

SAGA-type complex

 
1440284_at Stap1 signal transducing adaptor family member 1 5 86071745 AI506066 27

phosphotyrosine residue binding

transmembrane receptor protein tyrosine kinase adaptor activity

macrophage colony-stimulating factor receptor binding

protein binding

nucleus

nucleoplasm

cytoplasm

mitochondrion

cytosol

transmembrane receptor protein tyrosine kinase signaling pathway

transmembrane receptor protein tyrosine kinase signaling pathway

response to bacterium

positive regulation of gene expression

negative regulation of macrophage chemotaxis

protein kinase binding

protein kinase binding

myeloid cell differentiation

protein tyrosine kinase activator activity

protein-macromolecule adaptor activity

receptor tyrosine kinase binding

protein-containing complex

centriolar satellite

signaling adaptor activity

signaling adaptor activity

negative regulation of phosphorylation

positive regulation of B cell receptor signaling pathway

positive regulation of B cell receptor signaling pathway

positive regulation of phagocytosis, engulfment

cellular response to lipopolysaccharide

negative regulation of ruffle assembly

negative regulation of macrophage colony-stimulating factor signaling pathway

positive regulation of microglial cell activation

negative regulation of microglial cell migration

positive regulation of microglial cell mediated cytotoxicity

 
1436959_x_at Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor 2 25054378 BB311061 39

euchromatin

protein binding

nucleus

nucleus

nucleus

nuclear envelope

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

postsynaptic density

membrane

nuclear matrix

dendrite

cortical cytoskeleton

nuclear membrane

positive regulation of protein dephosphorylation

cell projection

neuron projection

dendritic spine

perikaryon

regulation of neuron apoptotic process

synapse

regulation of neuronal synaptic plasticity

calcium-dependent protein binding

regulation of dendrite morphogenesis

cellular response to amino acid stimulus

cellular response to electrical stimulus

cellular response to gonadotropin stimulus

apical dendrite

postsynapse

glutamatergic synapse

postsynapse to nucleus signaling pathway

regulation of neuron migration

positive regulation of neuron migration

positive regulation of neuron migration

 
1425890_at Ly6i lymphocyte antigen 6 family member I 15 -74979533 AF232024 13

plasma membrane

plasma membrane

membrane

acetylcholine receptor inhibitor activity

acetylcholine receptor binding

acetylcholine receptor signaling pathway

side of membrane

 
1449015_at Retnla resistin like alpha 16 48842608 NM_020509 89

hormone activity

extracellular region

extracellular space

 
1423108_at Slc25a20 solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20 9 108662135 AV008091 36

in utero embryonic development

mitochondrion

mitochondrion

mitochondrial envelope

mitochondrial inner membrane

cytosol

mitochondrial transport

lipid transport

acyl carnitine transmembrane transporter activity

acyl carnitine transmembrane transporter activity

membrane

carnitine transmembrane transport

carnitine transmembrane transport

 
1426100_a_at Tk2 thymidine kinase 2, mitochondrial 8 -104226690 AF105217 37

nucleotide binding

deoxycytidine kinase activity

deoxycytidine kinase activity

thymidine kinase activity

thymidine kinase activity

thymidine kinase activity

ATP binding

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

nucleobase-containing compound metabolic process

mitochondrial DNA replication

deoxyribonucleotide metabolic process

kinase activity

phosphorylation

transferase activity

deoxynucleoside kinase activity

deoxynucleoside kinase activity

mitochondrial DNA metabolic process

deoxycytidine metabolic process

thymidine metabolic process

DNA biosynthetic process

00240

00983

01100

1421479_at Zfp318 zinc finger protein 318 17 46383765 NM_021346 28

nucleic acid binding

protein binding

nucleus

nucleoplasm

nucleoplasm

cytosol

zinc ion binding

protein homodimerization activity

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

metal ion binding

protein heterodimerization activity

meiotic cell cycle

 
1423182_at Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 11 61142483, 61126754 AK004668 86

B cell homeostasis

B cell homeostasis

B cell homeostasis

hematopoietic progenitor cell differentiation

hematopoietic progenitor cell differentiation

adaptive immune response

immune system process

plasma membrane

external side of plasma membrane

membrane

negative regulation of B cell proliferation

negative regulation of B cell proliferation

04060

04672

05340

1456261_at Sh3kbp1 SH3-domain kinase binding protein 1 X 159942692, 159627271, 159840467, 159708600, 159627283 BB766215 54

protein binding

cytoplasm

cytoskeleton

cell-cell junction

endocytosis

apoptotic process

cytoskeleton organization

actin filament organization

regulation of cell shape

membrane

cell migration

cell migration

SH3 domain binding

endocytic vesicle

cytoplasmic vesicle

ubiquitin protein ligase binding

neuron projection

synapse

positive regulation of B cell activation

molecular adaptor activity

ubiquitin-dependent endocytosis

anchoring junction

04144

1429947_a_at Zbp1 Z-DNA binding protein 1 2 -173206611, -173213735 AK008179 85

activation of innate immune response

activation of innate immune response

immune system process

DNA binding

DNA binding

DNA binding

left-handed Z-DNA binding

RNA binding

double-stranded RNA binding

double-stranded RNA adenosine deaminase activity

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

apoptotic process

programmed cell death

identical protein binding

positive regulation of apoptotic process

positive regulation of apoptotic process

innate immune response

regulation of inflammatory response

positive regulation of inflammatory response

defense response to fungus

defense response to virus

defense response to virus

defense response to virus

positive regulation of type I interferon-mediated signaling pathway

positive regulation of type I interferon-mediated signaling pathway

positive regulation of necroptotic process

positive regulation of necroptotic process

positive regulation of necroptotic process

pyroptosis

antiviral innate immune response

regulation of interleukin-1-mediated signaling pathway

04623

1452966_at Bcl11b B cell leukemia/lymphoma 11B 12 -107910402 AK020296 764

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription activator activity, RNA polymerase II-specific

keratinocyte development

epithelial cell morphogenesis

DNA-binding transcription factor activity

protein binding

intracellular anatomical structure

nucleus

nucleus

transcription by RNA polymerase II

transcription by RNA polymerase II

transcription by RNA polymerase II

apoptotic process

axonogenesis

negative regulation of cell population proliferation

post-embryonic development

regulation of gene expression

regulation of keratinocyte proliferation

SWI/SNF complex

SWI/SNF complex

regulation of lipid metabolic process

striatal medium spiny neuron differentiation

commitment of neuronal cell to specific neuron type in forebrain

central nervous system neuron differentiation

post-embryonic camera-type eye development

T cell differentiation in thymus

T cell receptor V(D)J recombination

hematopoietic stem cell migration

odontogenesis of dentin-containing tooth

neuron projection

positive T cell selection

sequence-specific DNA binding

skin development

regulation of neuron differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

alpha-beta T cell differentiation

metal ion binding

thymus development

T cell apoptotic process

negative regulation of T cell apoptotic process

thymocyte apoptotic process

negative regulation of thymocyte apoptotic process

olfactory bulb axon guidance

lymphoid lineage cell migration into thymus

sequence-specific double-stranded DNA binding

 
1447284_at Trem1 triggering receptor expressed on myeloid cells 1 17 48232738 BB784999 126

cytokine production

positive regulation of cell-matrix adhesion

adaptive immune response

cytokine production involved in immune response

cytokine production involved in immune response

immune system process

transmembrane signaling receptor activity

extracellular space

plasma membrane

cell surface

positive regulation of cardiac muscle cell apoptotic process

positive regulation of macrophage chemotaxis

membrane

neutrophil chemotaxis

neutrophil chemotaxis

chemokine production

chemokine production

innate immune response

neutrophil-mediated killing of gram-negative bacterium

neutrophil-mediated killing of gram-negative bacterium

neutrophil extravasation

scaffold protein binding

receptor decoy activity

neutrophil migration

 
1460271_at Trem3 triggering receptor expressed on myeloid cells 3 17 48247728 NM_021407 23

cytokine production

cytokine production involved in immune response

cytokine production involved in immune response

protein binding

plasma membrane

membrane

cell migration

neutrophil chemotaxis

neutrophil chemotaxis

chemokine production

chemokine production

positive regulation of innate immune response

neutrophil-mediated killing of gram-negative bacterium

neutrophil-mediated killing of gram-negative bacterium

neutrophil extravasation

 
1421977_at Mmp19 matrix metallopeptidase 19 10 128790909, 128790954 AF153199 33

angiogenesis

metalloendopeptidase activity

metalloendopeptidase activity

metalloendopeptidase activity

extracellular region

extracellular region

extracellular space

extracellular space

plasma membrane

proteolysis

multicellular organism development

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

hydrolase activity

cell differentiation

extracellular matrix organization

collagen catabolic process

collagen catabolic process

extracellular matrix

metal ion binding

side of membrane

 
1460174_at Dexi dexamethasone-induced transcript 16 -10530206 NM_021428 17

molecular_function

cellular_component

biological_process

 
1416799_at Trpm7 transient receptor potential cation channel, subfamily M, member 7 2 -126791557 AV320241 146

nucleotide binding

ruffle

actin binding

protein kinase activity

protein serine/threonine kinase activity

monoatomic ion channel activity

monoatomic cation channel activity

calcium channel activity

calcium channel activity

calcium channel activity

protein binding

ATP binding

plasma membrane

protein phosphorylation

monoatomic ion transport

calcium ion transport

calcium ion transport

calcium ion transport

memory

intracellular magnesium ion homeostasis

programmed cell death

membrane

kinase activity

phosphorylation

calcium-dependent cell-matrix adhesion

transferase activity

myosin binding

synaptic vesicle membrane

actomyosin structure organization

monoatomic ion transmembrane transport

neuronal cell body

positive regulation of apoptotic process

varicosity

protein autophosphorylation

metal ion binding

protein tetramerization

transmembrane transport

necroptotic process

calcium ion transmembrane transport

monoatomic cation transmembrane transport

 
1420641_a_at Sqor sulfide quinone oxidoreductase 2 122771712, 122781998, 122765358 AF174535 26

mitochondrion

mitochondrion

mitochondrial inner membrane

oxidoreductase activity

quinone binding

sulfide oxidation, using sulfide:quinone oxidoreductase

sulfide oxidation, using sulfide:quinone oxidoreductase

sulfide:quinone oxidoreductase activity

sulfide:quinone oxidoreductase activity

FAD binding

glutathione-dependent sulfide quinone oxidoreductase activity

 
1418530_at Nup160 nucleoporin 160 2 90677214 NM_021512 31

kinetochore

nucleus

nuclear envelope

nuclear pore

nuclear pore

nuclear pore

nuclear pore

mRNA export from nucleus

mRNA export from nucleus

nucleocytoplasmic transport

protein transport

structural constituent of nuclear pore

structural constituent of nuclear pore

structural constituent of nuclear pore

nuclear pore outer ring

mRNA transport

nephron development

03013

1417190_at Nampt nicotinamide phosphoribosyltransferase 12 32820334 AW989410 189

nucleotide binding

microglial cell activation

cytokine activity

extracellular region

extracellular space

nucleus

cytoplasm

cytosol

circadian rhythm

NAD biosynthetic process

NAD biosynthetic process

negative regulation of autophagy

regulation of lung blood pressure

nuclear speck

transferase activity

glycosyltransferase activity

pyridine nucleotide biosynthetic process

cell junction

circadian regulation of gene expression

identical protein binding

identical protein binding

positive regulation of transcription by RNA polymerase II

nicotinamide phosphoribosyltransferase activity

nicotinamide phosphoribosyltransferase activity

nicotinamide phosphoribosyltransferase activity

rhythmic process

positive regulation of smooth muscle cell proliferation

positive regulation of nitric-oxide synthase biosynthetic process

heterocyclic compound binding

negative regulation of cellular senescence

00760

1417710_at Mettl9 methyltransferase like 9 7 121034444 NM_021554 19

mitochondrion

endoplasmic reticulum

methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

transferase activity

methylation

protein-L-histidine N-pros-methyltransferase activity

protein-L-histidine N-pros-methyltransferase activity

 
1423467_at Ms4a4b membrane-spanning 4-domains, subfamily A, member 4B 19 11443557 BB199001 20

Golgi apparatus

plasma membrane

plasma membrane

 
1417719_at Sap30 sin3 associated polypeptide 8 -57482701 NM_021788 31

histone deacetylase complex

histone deacetylase complex

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

DNA binding

transcription coregulator activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleoplasm

regulation of DNA-templated transcription

negative regulation of cell migration

negative regulation of transforming growth factor beta receptor signaling pathway

skeletal muscle cell differentiation

metal ion binding

modulation by host of symbiont transcription

Sin3-type complex

negative regulation of stem cell population maintenance

positive regulation of stem cell population maintenance

 
1419043_a_at Iigp1 interferon inducible GTPase 1 18 60376028, 60373615 BM239828 45

nucleotide binding

immune system process

GTPase activity

GTPase activity

GTPase activity

protein binding

GTP binding

nucleus

cytoplasm

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

Golgi apparatus

defense response

response to bacterium

regulation of autophagy

membrane

hydrolase activity

GDP binding

cytokine-mediated signaling pathway

symbiont-containing vacuole membrane

cellular response to interferon-beta

cellular response to interferon-beta

identical protein binding

identical protein binding

defense response to protozoan

innate immune response

defense response to Gram-negative bacterium

 
1422478_a_at Acss2 acyl-CoA synthetase short-chain family member 2 2 155518042 NM_019811 51

nucleotide binding

chromatin binding

transcription coactivator activity

acetate-CoA ligase activity

acetate-CoA ligase activity

acetate-CoA ligase activity

acetate-CoA ligase activity

protein binding

ATP binding

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

acetyl-CoA biosynthetic process

acetyl-CoA biosynthetic process

lipid metabolic process

long-term memory

lipid biosynthetic process

ligase activity

acetate biosynthetic process

propionate biosynthetic process

propionate-CoA ligase activity

00010

00620

00640

01100

1419714_at Cd274 CD274 antigen 19 29367437 NM_021893 509

adaptive immune response

immune system process

positive regulation of tolerance induction to tumor cell

transcription coactivator activity

protein binding

nucleoplasm

endosome

plasma membrane

immune response

immune response

signal transduction

cell surface receptor signaling pathway

cell surface receptor signaling pathway

external side of plasma membrane

external side of plasma membrane

cell surface

actin cytoskeleton

membrane

positive regulation of cell migration

T cell costimulation

T cell costimulation

early endosome membrane

negative regulation of type II interferon production

negative regulation of interleukin-10 production

positive regulation of interleukin-10 production

response to cytokine

TRIF-dependent toll-like receptor signaling pathway

positive regulation of T cell proliferation

positive regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of T cell proliferation

negative regulation of activated T cell proliferation

recycling endosome membrane

extracellular exosome

cellular response to lipopolysaccharide

negative regulation of tumor necrosis factor superfamily cytokine production

positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD8-positive, alpha-beta T cell activation

04514

1451370_at Ccdc107 coiled-coil domain containing 107 4 43493364 BC027414 12

molecular_function

cellular_component

biological_process

membrane

 
1441887_x_at Gm6377 predicted gene 6377 X 109196755 BB548587 11

molecular_function

cellular_component

regulation of lysosomal lumen pH

 
1438238_at 2010315B03Rik RIKEN cDNA 2010315B03 gene 9 -124291803 BB744779 10

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity

regulation of transcription by RNA polymerase II

 
1426607_at Tmem267 transmembrane protein 267 13 119488472, 119488085 BG068672 13

molecular_function

cellular_component

biological_process

membrane

 
1449976_a_at Gpr35 G protein-coupled receptor 35 1 92978902, 92973118, 92975346 NM_022320 42

G protein-coupled receptor activity

G protein-coupled receptor activity

chemokine receptor activity

plasma membrane

plasma membrane

cytoskeleton organization

signal transduction

G protein-coupled receptor signaling pathway

positive regulation of cytosolic calcium ion concentration

membrane

positive regulation of Rho protein signal transduction

macrophage chemotaxis

chemokine-mediated signaling pathway

negative regulation of voltage-gated calcium channel activity

negative regulation of neuronal action potential

04080

1418206_at Sdf2l1 stromal cell-derived factor 2-like 1 16 -17130137 NM_022324 21

endoplasmic reticulum

endoplasmic reticulum

membrane

endoplasmic reticulum chaperone complex

response to endoplasmic reticulum stress

ERAD pathway

regulation of apoptotic process

chaperone cofactor-dependent protein refolding

protein-folding chaperone binding

ATPase binding

misfolded protein binding

cellular response to misfolded protein

protein folding chaperone complex

 
1435517_x_at Ralb v-ral simian leukemia viral oncogene B 1 -119470304 BB465250 33

nucleotide binding

regulation of exocyst assembly

positive regulation of protein phosphorylation

GTPase activity

GTPase activity

G protein activity

GTP binding

GTP binding

plasma membrane

plasma membrane

apoptotic process

cell cycle

signal transduction

Ras protein signal transduction

cellular response to starvation

membrane

hydrolase activity

GDP binding

GDP binding

midbody

receptor internalization

ubiquitin protein ligase binding

negative regulation of protein binding

positive regulation of protein binding

positive regulation of epidermal growth factor receptor signaling pathway

ATPase binding

cell division

regulation of exocyst localization

cellular response to exogenous dsRNA

positive regulation of protein serine/threonine kinase activity

positive regulation of autophagosome assembly

05200

05212

1416863_at Abhd8 abhydrolase domain containing 8 8 -71456699 NM_022419 18

catalytic activity

hydrolase activity

 
1418797_at Ms4a8a membrane-spanning 4-domains, subfamily A, member 8A 19 -11067470 NM_022430 14

plasma membrane

plasma membrane

cell surface receptor signaling pathway

membrane

 
1417527_at Ap3m2 adaptor-related protein complex 3, mu 2 subunit 8 -22787353 BC027301 26

early endosome

Golgi apparatus

intracellular protein transport

endocytosis

anterograde axonal transport

protein transport

membrane

synaptic vesicle coating

vesicle-mediated transport

AP-3 adaptor complex

clathrin adaptor complex

cytoplasmic vesicle

cytoplasmic vesicle

clathrin-coated vesicle cargo loading, AP-3-mediated

synaptic vesicle recycling

intracellular transport

anterograde synaptic vesicle transport

04142

1437236_a_at Zfp110 zinc finger protein 110 7 12834760 AV263718 33

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

chromatin binding

neurotrophin p75 receptor binding

protein binding

nucleus

cytoplasm

cytosol

chromatin remodeling

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

apoptotic process

sequence-specific DNA binding

regulation of JNK cascade

metal ion binding

neuron apoptotic process

extrinsic apoptotic signaling pathway

retinal cell apoptotic process

sequence-specific double-stranded DNA binding

04722

1420697_at Slc15a3 solute carrier family 15, member 3 19 10842543 NM_023044 18

immune system process

lysosome

lysosomal membrane

lysosomal membrane

lysosomal membrane

endosome

oligopeptide transport

endosome membrane

protein transport

symporter activity

peptidoglycan transmembrane transporter activity

peptide transport

peptidoglycan transport

membrane

transmembrane transporter activity

intracellular membrane-bounded organelle

innate immune response

transmembrane transport

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

dipeptide transmembrane transporter activity

dipeptide transmembrane transporter activity

dipeptide import across plasma membrane

dipeptide import across plasma membrane

 
1415682_at Xpo7 exportin 7 14 -70662125, -70662125 NM_023045 34

nuclear export signal receptor activity

nuclear export signal receptor activity

protein binding

nucleus

nuclear pore

nuclear pore

cytoplasm

cytoplasm

protein export from nucleus

protein export from nucleus

intracellular protein transport

nucleocytoplasmic transport

protein transport

small GTPase binding

nuclear transport

 
1440845_at Tmem243 transmembrane protein 243, mitochondrial 5 9100736 BB323696 11

molecular_function

cellular_component

biological_process

 
1448263_a_at Cndp2 CNDP dipeptidase 2 18 -84667464, -84667464 NM_023149 41

carboxypeptidase activity

nucleoplasm

cytoplasm

cytosol

cytosol

proteolysis

proteolysis

proteolysis

peptidase activity

metallopeptidase activity

hydrolase activity

dipeptidase activity

dipeptidase activity

dipeptidase activity

metal ion binding

metallodipeptidase activity

alanylglutamate dipeptidase activity

 
1447678_at Hsd17b14 hydroxysteroid (17-beta) dehydrogenase 14 7 45554927 BB399925 14

estradiol 17-beta-dehydrogenase [NAD(P)] activity

estradiol 17-beta-dehydrogenase [NAD(P)] activity

cytosol

cytosol

steroid catabolic process

steroid catabolic process

identical protein binding

testosterone 17-beta-dehydrogenase (NADP+) activity

 
1419103_a_at Abhd6 abhydrolase domain containing 6 14 8002887, 8002965 NM_025341 41

catalytic activity

phospholipase activity

mitochondrion

mitochondrion

lysosome

lysosomal membrane

endosome

lipid metabolic process

phospholipid catabolic process

membrane

hydrolase activity

negative regulation of cell migration

late endosome membrane

AMPA glutamate receptor complex

postsynaptic membrane

acylglycerol catabolic process

acylglycerol catabolic process

acylglycerol catabolic process

positive regulation of lipid biosynthetic process

acylglycerol lipase activity

acylglycerol lipase activity

acylglycerol lipase activity

acylglycerol lipase activity

monoacylglycerol catabolic process

long-term synaptic depression

glutamatergic synapse

glutamatergic synapse

GABA-ergic synapse

regulation of retrograde trans-synaptic signaling by endocanabinoid

regulation of retrograde trans-synaptic signaling by endocanabinoid

negative regulation of cold-induced thermogenesis

regulation of endocannabinoid signaling pathway

lysobisphosphatidic acid metabolic process

 
1428797_at Setd6 SET domain containing 6 8 95715912 AK010304 22

protein binding

nucleus

nucleus

nucleoplasm

cytosol

methyltransferase activity

protein-lysine N-methyltransferase activity

protein-lysine N-methyltransferase activity

transferase activity

peptidyl-lysine methylation

peptidyl-lysine monomethylation

peptidyl-lysine monomethylation

stem cell population maintenance

negative regulation of NF-kappaB transcription factor activity

methylation

stem cell differentiation

regulation of inflammatory response

NF-kappaB binding

S-adenosyl-L-methionine binding

 
1434484_at Wfdc21 WAP four-disulfide core domain 21 11 83746939 AV006463 13

serine-type endopeptidase inhibitor activity

extracellular region

extracellular space

extracellular space

enzyme activator activity

antibacterial humoral response

peptidase inhibitor activity

response to lipopolysaccharide

response to tumor necrosis factor

innate immune response

white fat cell differentiation

 
1423754_at Ifitm3 interferon induced transmembrane protein 3 7 -141009589 BC010291 97

immune system process

nucleus

cytoplasm

lysosome

lysosomal membrane

endosome

endoplasmic reticulum

plasma membrane

plasma membrane

plasma membrane

receptor-mediated endocytosis

negative regulation of cell population proliferation

response to virus

cell surface

membrane

cytoplasmic vesicle

early endosome membrane

protein-containing complex

response to type II interferon

response to interferon-alpha

response to interferon-beta

negative regulation of viral genome replication

innate immune response

apical part of cell

negative regulation of viral entry into host cell

negative regulation of viral entry into host cell

defense response to virus

defense response to virus

defense response to virus

defense response to virus

type I interferon-mediated signaling pathway

type I interferon-mediated signaling pathway

 
1428883_at Maco1 macoilin 1 4 -134802760, -134802759 AK003528 25

nucleus

endoplasmic reticulum

chemotaxis

brain development

microtubule binding

membrane

neuronal signal transduction

neuronal signal transduction

axon

rough endoplasmic reticulum membrane

rough endoplasmic reticulum membrane

nuclear membrane

nuclear membrane

neuron projection

neuron projection terminus

synapse

 
1429520_a_at Acer3 alkaline ceramidase 3 7 -98213809, -98213809 BE573407 19

Golgi membrane

calcium ion binding

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

lipid metabolic process

sphingolipid metabolic process

ceramide metabolic process

inflammatory response

zinc ion binding

positive regulation of cell population proliferation

membrane

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

N-acylsphingosine amidohydrolase activity

myelination

regulation of programmed cell death

sphingosine biosynthetic process

sphingosine biosynthetic process

ceramide catabolic process

ceramide catabolic process

metal ion binding

phytoceramidase activity

phytoceramidase activity

phytoceramidase activity

phytosphingosine biosynthetic process

phytosphingosine biosynthetic process

dihydroceramidase activity

ceramidase activity

00600

1448919_at Cd302 CD302 antigen 2 -60251992 NM_025422 16

cytoplasm

cell cortex

phagocytosis

external side of plasma membrane

membrane

filopodium

carbohydrate binding

signaling receptor activity

cell projection

 
1424683_at Retreg1 reticulophagy regulator 1 15 25933551, 25940825, 25843297, 25940701, 25942678 BC019494 34

mitophagy

protein binding

nucleolus

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

Golgi apparatus

cis-Golgi network

autophagy

endoplasmic reticulum organization

membrane

nuclear body

sensory perception of pain

collagen catabolic process

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

protein self-association

white fat cell differentiation

reticulophagy

reticulophagy

reticulophagy

reticulophagy

endoplasmic reticulum-autophagosome adaptor activity

 
1438413_at Senp7 SUMO1/sentrin specific peptidase 7 16 56075403, 56057529, 56075403, 56075479 AV231698 28

immune system process

protein binding

nucleus

nucleus

cytoplasm

cytoplasm

proteolysis

peptidase activity

cysteine-type peptidase activity

hydrolase activity

protein desumoylation

protein desumoylation

innate immune response

SUMO-specific endopeptidase activity

SUMO-specific endopeptidase activity

antiviral innate immune response

 
1416775_at Dmac2 distal membrane arm assembly complex 2 7 25619492, 25619413 NM_025504 13

mitochondrion

mitochondrial respiratory chain complex I

SCF ubiquitin ligase complex

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

mitochondrial respiratory chain complex I assembly

mitochondrial respiratory chain complex I assembly

 
1426440_at Dhrs7 dehydrogenase/reductase 7 12 -72650352 AK009385 19

carbonyl reductase (NADPH) activity

endoplasmic reticulum

endoplasmic reticulum membrane

membrane

oxidoreductase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

retinol metabolic process

NADP-retinol dehydrogenase activity

 
1435346_at Ccdc82 coiled-coil domain containing 82 9 13246955 BE352816 12

molecular_function

nucleus

biological_process

 
1417138_s_at Polr2e polymerase (RNA) II (DNA directed) polypeptide E 10 -80035952 NM_025554 24

DNA-directed RNA polymerase complex

RNA polymerase I activity

RNA polymerase II activity

RNA polymerase III activity

DNA binding

DNA-directed 5'-3' RNA polymerase activity

nucleus

nucleoplasm

nucleoplasm

RNA polymerase II, core complex

RNA polymerase II, core complex

RNA polymerase III complex

RNA polymerase III complex

RNA polymerase I complex

RNA polymerase I complex

DNA-templated transcription

transcription elongation by RNA polymerase I

transcription by RNA polymerase II

transcription by RNA polymerase II

tRNA transcription by RNA polymerase III

RPAP3/R2TP/prefoldin-like complex

00230

00240

01100

03020

05016

1455170_at 2810001G20Rik RIKEN cDNA 2810001G20 gene 11 64079483 BB250227 12

molecular_function

cellular_component

biological_process

 
1417075_at Fam136a family with sequence similarity 136, member A 6 86365645, 86365470 NM_025591 18

molecular_function

cytoplasm

cytoplasm

mitochondrion

biological_process

 
1436153_a_at Zmynd11 zinc finger, MYND domain containing 11 13 -9684835, -9684835, -9684835, -9684835 BB561053 27

DNA binding

double-stranded DNA binding

transcription corepressor activity

protein binding

nucleus

nucleus

nucleoplasm

chromosome

chromatin organization

zinc ion binding

zinc ion binding

regulation of signal transduction

regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II

methylated histone binding

methylated histone binding

methylated histone binding

histone binding

negative regulation of canonical NF-kappaB signal transduction

negative regulation of JNK cascade

metal ion binding

defense response to virus

negative regulation of extrinsic apoptotic signaling pathway

 
1425193_at Sppl2a signal peptide peptidase like 2A 2 -126890394 BC026578 34

lysosome

lysosomal membrane

lysosomal membrane

endosome

late endosome

plasma membrane

proteolysis

membrane protein ectodomain proteolysis

peptidase activity

membrane

hydrolase activity

Golgi-associated vesicle membrane

Golgi-associated vesicle membrane

membrane protein intracellular domain proteolysis

late endosome membrane

membrane protein proteolysis

membrane protein proteolysis

membrane protein proteolysis

aspartic endopeptidase activity, intramembrane cleaving

aspartic endopeptidase activity, intramembrane cleaving

protein homodimerization activity

intracellular membrane-bounded organelle

regulation of immune response

regulation of immune response

lumenal side of endoplasmic reticulum membrane

cytoplasmic side of endoplasmic reticulum membrane

 
1437041_at Pnisr PNN interacting serine/arginine-rich 4 21848047 BB120903 22

molecular_function

nucleus

nucleoplasm

cytosol

plasma membrane

biological_process

nuclear speck

nuclear speck

presynaptic active zone

 
1438442_at Sike1 suppressor of IKBKE 1 3 102995739 AI450236 14

molecular_function

cytoplasm

biological_process

protein kinase binding

small GTPase binding

04622

1434662_at Atg4a autophagy related 4A, cysteine peptidase X 140956906, 140953844 BM237732 16

autophagosome assembly

autophagosome assembly

mitophagy

cysteine-type endopeptidase activity

cytoplasm

C-terminal protein lipidation

proteolysis

autophagy

cysteine-type peptidase activity

protein processing

protein-phosphatidylethanolamide deconjugating activity

protein-phosphatidylethanolamide deconjugating activity

piecemeal microautophagy of the nucleus

aggrephagy

protein delipidation

protein delipidation

04140

1442219_at Gm8369 predicted gene 8369 19 11492037 BB218965 9

molecular_function

Golgi apparatus

plasma membrane

biological_process

 
1425738_at Igkv3-12 immunoglobulin kappa variable 3-12 6   M35669 3

immunoglobulin production

extracellular space

extracellular space

immune response

monomeric IgA immunoglobulin complex

secretory IgA immunoglobulin complex

pentameric IgM immunoglobulin complex

 
1418778_at Mcub mitochondrial calcium uniporter dominant negative beta subunit 3 -129914959 NM_025779 23

protein binding

nucleoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

monoatomic ion transport

calcium ion transport

mitochondrial calcium ion transmembrane transport

membrane

calcium channel inhibitor activity

calcium channel inhibitor activity

calcium channel complex

calcium import into the mitochondrion

intracellular membrane-bounded organelle

mitochondrial calcium ion homeostasis

mitochondrial calcium ion homeostasis

uniplex complex

uniplex complex

 
1455817_x_at Zxdb zinc finger, X-linked, duplicated B X 94724568 AI661029 11

transcription coregulator activity

transcription coactivator activity

nucleus

nucleus

regulation of transcription by RNA polymerase II

metal ion binding

C2H2 zinc finger domain binding

 
1435002_at Zfp507 zinc finger protein 507 7 -35772345 BM249415 22

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

nucleus

regulation of DNA-templated transcription

metal ion binding

 
1454650_at Trim35 tripartite motif-containing 35 14 66297024 BQ175280 32

protein binding

nucleus

cytoplasm

cytoplasm

apoptotic process

zinc ion binding

negative regulation of cell population proliferation

protein ubiquitination

transferase activity

myeloid cell apoptotic process

positive regulation of myeloid cell apoptotic process

positive regulation of apoptotic process

positive regulation of apoptotic process

suppression of viral release by host

innate immune response

innate immune response

negative regulation of mitotic cell cycle

metal ion binding

ubiquitin protein ligase activity

 
1460672_at 2410002F23Rik RIKEN cDNA 2410002F23 gene 7 44246721 BC016099 18

molecular_function

cellular_component

Golgi apparatus

biological_process

response to virus

 
1429473_at Zfp869 zinc finger protein 869 8 -69705136, -69705137 AV292561 18

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleus

nucleus

regulation of transcription by RNA polymerase II

retrotransposon silencing

 
1417978_at Eif4e3 eukaryotic translation initiation factor 4E member 3 6 -99625136 BC027014 23

RNA 7-methylguanosine cap binding

RNA binding

translation initiation factor activity

translation initiation factor activity

translation

translational initiation

translational initiation

regulation of translation

eukaryotic translation initiation factor 4F complex

 
1451346_at Mtap methylthioadenosine phosphorylase 4 89137369 BG075139 38

catalytic activity

nucleus

nucleoplasm

cytoplasm

cytosol

cytosol

purine ribonucleoside salvage

nucleoside metabolic process

transferase activity

glycosyltransferase activity

pentosyltransferase activity

S-methyl-5-thioadenosine phosphorylase activity

S-methyl-5-thioadenosine phosphorylase activity

L-methionine salvage from methylthioadenosine

methylation

00270

01100

1448689_at Rras2 related RAS viral (r-ras) oncogene 2 7 -114046781 NM_025846 49

nucleotide binding

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

intracellular anatomical structure

Golgi apparatus

plasma membrane

plasma membrane

signal transduction

Ras protein signal transduction

Ras protein signal transduction

membrane

cell migration

hydrolase activity

GDP binding

Schwann cell migration

positive regulation of Schwann cell migration

04010

04530

04810

1423986_a_at Shisa5 shisa family member 5 9 109054865, 109038566, 109051156, 109051095, 109040413, 109052853 BC010238 22

nucleus

nuclear envelope

endoplasmic reticulum

endoplasmic reticulum

apoptotic process

membrane

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

WW domain binding

intrinsic apoptotic signaling pathway by p53 class mediator

04115

1439387_x_at Ctu2 cytosolic thiouridylase subunit 2 8 122476142 BB253397 15

tRNA binding

tRNA wobble uridine modification

tRNA wobble position uridine thiolation

cytoplasm

cytosol

tRNA processing

sulfurtransferase activity

protein-containing complex

tRNA thio-modification

04122

1417840_at Cep19 centrosomal protein 19 16 32099788 NM_025892 18

spindle pole

spindle pole

molecular_function

nucleoplasm

cytoplasm

centrosome

centrosome

centriole

centriole

cytoskeleton

cilium

cell projection organization

microtubule anchoring at centrosome

microtubule anchoring at centrosome

ciliary basal body

ciliary basal body

cell projection

cilium assembly

vesicle targeting, trans-Golgi to periciliary membrane compartment

vesicle targeting, trans-Golgi to periciliary membrane compartment

 
1437862_at Rbm25 RNA binding motif protein 25 12 83635709, 83632242 AI159652 31

regulation of alternative mRNA splicing, via spliceosome

regulation of alternative mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

mRNA binding

mRNA binding

nucleus

cytoplasm

mRNA processing

apoptotic process

RNA splicing

nuclear speck

regulation of apoptotic process

03040

1431694_a_at Ctnnbip1 catenin beta interacting protein 1 4 149518240, 149545116 AK003595 41

negative regulation of transcription by RNA polymerase II

branching involved in ureteric bud morphogenesis

regulation of vascular permeability involved in acute inflammatory response

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytosol

beta-catenin binding

beta-catenin binding

beta-catenin binding

anterior/posterior pattern specification

Wnt signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of Wnt signaling pathway

negative regulation of Wnt signaling pathway

beta-catenin destruction complex

beta-catenin destruction complex

negative regulation of protein-containing complex assembly

negative regulation of protein binding

negative regulation of DNA binding

negative regulation of DNA-binding transcription factor activity

negative regulation of DNA-binding transcription factor activity

positive regulation of monocyte differentiation

positive regulation of osteoblast differentiation

negative regulation of smooth muscle cell proliferation

negative regulation of transcription initiation by RNA polymerase II

armadillo repeat domain binding

negative regulation of mesenchymal cell proliferation

negative regulation of canonical Wnt signaling pathway

beta-catenin-ICAT complex

04310

1423569_at Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) 2 -122594472 AW108522 43

kidney development

mitochondrion

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial intermembrane space

cytosol

creatine metabolic process

creatine biosynthetic process

creatine biosynthetic process

response to nutrient

learning or memory

response to organic substance

muscle atrophy

amidinotransferase activity

amidinotransferase activity

glycine amidinotransferase activity

membrane

transferase activity

response to peptide hormone

response to mercury ion

positive regulation of cold-induced thermogenesis

00260

00330

01100

1417777_at Ptgr1 prostaglandin reductase 1 4 -58965589 BC014865 19

cytoplasm

lipid metabolic process

fatty acid metabolic process

prostaglandin metabolic process

prostaglandin metabolic process

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

2-alkenal reductase [NAD(P)+] activity

2-alkenal reductase (NADP+) activity

13-prostaglandin reductase activity

15-oxoprostaglandin 13-oxidase activity

15-oxoprostaglandin 13-oxidase activity

 
1452067_at Naaa N-acylethanolamine acid amidase 5 -92257659 BI106821 30

cytoplasm

lysosome

lysosome

lipid metabolic process

fatty acid metabolic process

sphingosine metabolic process

membrane

lipid catabolic process

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

N-acylsphingosine amidohydrolase activity

fatty acid amide hydrolase activity

N-(long-chain-acyl)ethanolamine deacylase activity

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

ceramidase activity

DNA-binding transcription factor binding

 
1433688_x_at Rpl14 ribosomal protein L14 9 120571516 BE993872 44

cytoplasmic translation

RNA binding

RNA binding

structural constituent of ribosome

structural constituent of ribosome

structural constituent of ribosome

cytoplasm

cytosol

ribosome

rRNA processing

translation

postsynaptic density

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

cytosolic ribosome

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

synapse

synapse

synapse

presynapse

postsynapse

translation at presynapse

translation at postsynapse

ribonucleoprotein complex

03010

1437878_s_at Ttc14 tetratricopeptide repeat domain 14 3 33800182 BB711506 19

nucleic acid binding

protein binding

cellular_component

biological_process

 
1438037_at Herc6 hect domain and RLD 6 6 57580991 AW208668 20

hematopoietic progenitor cell differentiation

immune system process

ubiquitin-protein transferase activity

nucleoplasm

cytoplasm

cytoplasm

cytosol

ubiquitin-dependent protein catabolic process

response to bacterium

protein ubiquitination

protein ubiquitination

transferase activity

cyclin binding

innate immune response

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
1430526_a_at Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 19 26605159, 26748402, 26748164 AK011935 131

nucleotide binding

chromatin

chromatin

transcription cis-regulatory region binding

DNA binding

DNA binding

chromatin binding

transcription coactivator activity

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromatin organization

nucleosome assembly

chromatin remodeling

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

nervous system development

ATP-dependent activity, acting on DNA

cell population proliferation

positive regulation of cell population proliferation

negative regulation of cell population proliferation

negative regulation of cell population proliferation

SWI/SNF complex

SWI/SNF complex

hydrolase activity

regulation of mitotic metaphase/anaphase transition

negative regulation of cell growth

brahma complex

aortic smooth muscle cell differentiation

histone binding

intracellular membrane-bounded organelle

intermediate filament cytoskeleton

positive regulation of T cell differentiation

negative regulation of cell differentiation

positive regulation of cell differentiation

positive regulation of myoblast differentiation

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

fibroblast proliferation

negative regulation of fibroblast proliferation

hematopoietic stem cell homeostasis

regulation of G0 to G1 transition

SWI/SNF superfamily-type complex

npBAF complex

npBAF complex

nBAF complex

nBAF complex

bBAF complex

GBAF complex

ATP-dependent chromatin remodeler activity

positive regulation of stem cell population maintenance

regulation of G1/S transition of mitotic cell cycle

positive regulation of double-strand break repair

regulation of nucleotide-excision repair

 
1417364_at Eef1g eukaryotic translation elongation factor 1 gamma 19 8967040 AF321126 42

translation elongation factor activity

nucleus

cytoplasm

cytoplasm

endoplasmic reticulum

translation

translational elongation

translational elongation

 
1453731_a_at Dram2 DNA-damage regulated autophagy modulator 2 3 106547797 AK015888 20

photoreceptor inner segment

molecular_function

cytoplasm

lysosome

lysosome

Golgi apparatus

plasma membrane

autophagy

apoptotic process

visual perception

regulation of autophagy

regulation of autophagy

membrane

apical plasma membrane

intracellular membrane-bounded organelle

photoreceptor cell maintenance

photoreceptor cell maintenance

photoreceptor cell maintenance

 
1417062_at Armc10 armadillo repeat containing 10 5 21646005 NM_026034 23

p53 binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

membrane

positive regulation of growth rate

negative regulation of apoptotic process

DNA binding domain binding

negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator

 
1448829_at Smc6 structural maintenance of chromosomes 6 12 11265885, 11265885, 11265885 AV281575 32

nucleotide binding

DNA secondary structure binding

telomere maintenance via recombination

double-strand break repair via homologous recombination

chromosome, centromeric region

chromosome, telomeric region

chromosome, telomeric region

sex chromosome

damaged DNA binding

single-stranded DNA binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromosome

DNA repair

double-strand break repair

DNA recombination

DNA damage response

PML body

PML body

ATP hydrolysis activity

Smc5-Smc6 complex

Smc5-Smc6 complex

Smc5-Smc6 complex

ubiquitin protein ligase binding

interchromatin granule

site of double-strand break

site of double-strand break

negative regulation by host of viral genome replication

positive regulation of chromosome segregation

cellular senescence

mitotic spindle pole

 
1417372_a_at Peli1 pellino 1 11 21091323 BC016515 81

protein polyubiquitination

positive regulation of cytokine production

ubiquitin-protein transferase activity

protein binding

nucleus

regulation of Toll signaling pathway

transferase activity

positive regulation of B cell proliferation

positive regulation of protein ubiquitination

negative regulation of NF-kappaB transcription factor activity

response to lipopolysaccharide

response to lipopolysaccharide

positive regulation of toll-like receptor 3 signaling pathway

positive regulation of toll-like receptor 4 signaling pathway

T cell proliferation

T cell activation

negative regulation of T cell proliferation

positive regulation of canonical NF-kappaB signal transduction

proteasome-mediated ubiquitin-dependent protein catabolic process

response to dsRNA

negative regulation of T cell activation

positive regulation of B cell activation

negative regulation of necroptotic process

negative regulation of necroptotic process

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

protein K63-linked ubiquitination

protein K48-linked ubiquitination

protein K48-linked ubiquitination

protein K48-linked ubiquitination

 
1451965_at LOC672450 V(kappa) gene product 6   AY058908 1    
1416766_at Mtarc2 mitochondrial amidoxime reducing component 2 1 -184813065, -184813065 NM_133684 29

catalytic activity

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

mitochondrial inner membrane

peroxisome

nitric oxide biosynthetic process

nitrate reductase activity

nitrate reductase activity

membrane

oxidoreductase activity

oxidoreductase activity, acting on other nitrogenous compounds as donors

molybdenum ion binding

molybdenum ion binding

pyridoxal phosphate binding

nitrate metabolic process

nitrate metabolic process

molybdopterin cofactor binding

molybdopterin cofactor binding

cellular detoxification of nitrogen compound

nitrite reductase activity

 
1455500_at Rnf213 ring finger protein 213 11 119390098 AW556558 46

nucleotide binding

angiogenesis

angiogenesis

sprouting angiogenesis

sprouting angiogenesis

immune system process

catalytic activity

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

ATP binding

nucleolus

nucleolus

cytoplasm

lipid droplet

cytosol

cytosol

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

lipid metabolic process

metabolic process

protein ubiquitination

transferase activity

hydrolase activity

ATP hydrolysis activity

regulation of lipid metabolic process

defense response to bacterium

defense response to bacterium

metal ion binding

protein autoubiquitination

ubiquitin protein ligase activity

protein K63-linked ubiquitination

xenophagy

lipid ubiquitination

lipid ubiquitination

lipid droplet formation

negative regulation of non-canonical Wnt signaling pathway

negative regulation of non-canonical Wnt signaling pathway

 
1417780_at Cers4 ceramide synthase 4 8 4493404 BB006809 34

DNA binding

endoplasmic reticulum

lipid metabolic process

membrane

transferase activity

sphingolipid biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

ceramide biosynthetic process

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

sphingosine N-acyltransferase activity

 
1429503_at Dipk1a divergent protein kinase domain 1A 5 -107908041 AK013580 21

molecular_function

cellular_component

endoplasmic reticulum

biological_process

membrane

 
1418007_at Paxbp1 PAX3 and PAX7 binding protein 1 16 -91014036 BM932567 27

mRNA splicing, via spliceosome

DNA binding

nucleus

nucleus

transcription by RNA polymerase II

muscle organ development

transcription factor binding

regulation of skeletal muscle satellite cell proliferation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

histone methyltransferase binding

positive regulation of myoblast proliferation

 
1448960_at Cxxc5 CXXC finger 5 18 35830313, 35829787, 35854686 NM_133687 42

negative regulation of transcription by RNA polymerase II

DNA binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

zinc ion binding

methyl-CpG binding

methyl-CpG binding

regulation of generation of precursor metabolites and energy

sequence-specific DNA binding

metal ion binding

DNA-binding transcription factor binding

 
1456739_x_at Armcx2 armadillo repeat containing, X-linked 2 X -134804141 BB392869 19

molecular_function

mitochondrion

mitochondrion

mitochondrial outer membrane

biological_process

membrane

 
1417066_at Coq8a coenzyme Q8A 1 -180165237, -180165237, -180166613 AK014605 24

nucleotide binding

ATP binding

mitochondrion

mitochondrion

ubiquinone biosynthetic process

ubiquinone biosynthetic process

membrane

kinase activity

phosphorylation

transferase activity

ADP binding

 
1429642_at Zfand4 zinc finger, AN1-type domain 4 6 116264218, 116266531 AK012639 13

molecular_function

cellular_component

biological_process

zinc ion binding

metal ion binding

 
1428821_at Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 2 -26593056 AK010891 35

positive regulation of cytokine production

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

1-acylglycerol-3-phosphate O-acyltransferase activity

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

lipid metabolic process

phosphatidic acid biosynthetic process

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

membrane

transferase activity

acyltransferase activity

triglyceride biosynthetic process

triglyceride biosynthetic process

00561

00564

01100

04975

1436419_a_at 1700097N02Rik RIKEN cDNA 1700097N02 gene 17 -30622440 AA266367 11

molecular_function

cellular_component

biological_process

 
1435351_at Bend5 BEN domain containing 5 4 111415005 AA189197 12

molecular_function

DNA binding

Golgi apparatus

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

 
1456446_at 4930523C07Rik RIKEN cDNA 4930523C07 gene 1 160044379, 160044379 BM246687 9

molecular_function

cellular_component

biological_process

 
1424802_a_at Luc7l3 LUC7-like 3 (S. cerevisiae) 11 -94291072 AW536179 25

DNA binding

mRNA binding

mRNA binding

nucleus

nucleoplasm

U1 snRNP

U1 snRNP

mRNA splice site recognition

mRNA splice site recognition

mRNA processing

RNA splicing

nuclear speck

U2-type prespliceosome

 
1453939_x_at Gm9706 predicted gene 9706 17   AK019325 7    
1448747_at Fbxo32 F-box protein 32 15 -58175878 AF441120 102

protein binding

nucleus

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

negative regulation of cardiac muscle hypertrophy

positive regulation of cardiac muscle cell apoptotic process

response to electrical stimulus involved in regulation of muscle adaptation

muscle atrophy

response to denervation involved in regulation of muscle adaptation

protein ubiquitination

protein ubiquitination

SCF ubiquitin ligase complex

SCF ubiquitin ligase complex

Z disc

cellular response to dexamethasone stimulus

 
1421457_a_at Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 16 -75858793 NM_023380 24

phosphotyrosine residue binding

phosphotyrosine residue binding

negative regulation of adaptive immune response

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cell projection

negative regulation of peptidyl-tyrosine phosphorylation

negative regulation of peptidyl-tyrosine phosphorylation

negative regulation of B cell activation

negative regulation of B cell activation

 
1437297_at Chd8 chromodomain helicase DNA binding protein 8 14 -52198150 BB409788 84

negative regulation of transcription by RNA polymerase II

nucleotide binding

chromatin

in utero embryonic development

startle response

p53 binding

DNA binding

DNA binding

DNA binding

chromatin binding

chromatin binding

chromatin binding

helicase activity

protein binding

ATP binding

nucleus

nucleus

nucleus

nucleoplasm

chromatin organization

chromatin remodeling

chromatin remodeling

mRNA processing

brain development

brain development

brain development

beta-catenin binding

Wnt signaling pathway

hydrolase activity

ATP hydrolysis activity

negative regulation of Wnt signaling pathway

protein-containing complex

methylated histone binding

social behavior

histone binding

histone binding

histone binding

negative regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase III

digestive tract development

digestive tract development

digestive tract development

prepulse inhibition

armadillo repeat domain binding

MLL1 complex

MLL1 complex

negative regulation of canonical Wnt signaling pathway

negative regulation of canonical Wnt signaling pathway

ATP-dependent chromatin remodeler activity

ATP-dependent chromatin remodeler activity

negative regulation of fibroblast apoptotic process

04310

1418580_at Rtp4 receptor transporter protein 4 16 23609918 BC024872 18

detection of chemical stimulus involved in sensory perception of bitter taste

detection of chemical stimulus involved in sensory perception of bitter taste

protein binding

cytoplasm

cytoplasm

protein targeting to membrane

protein targeting to membrane

membrane

olfactory receptor binding

metal ion binding

protein insertion into membrane

defense response to virus

 
1426221_at Vwa5a von Willebrand factor A domain containing 5A 9 38718267 BC004727 21

molecular_function

extracellular matrix structural constituent

nucleoplasm

biological_process

collagen-containing extracellular matrix

 
1422678_at Dgat2 diacylglycerol O-acyltransferase 2 7 -99153662 AK002443 73

2-acylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

diacylglycerol O-acyltransferase activity

cytoplasm

mitochondrion

endoplasmic reticulum

endoplasmic reticulum

endoplasmic reticulum membrane

endoplasmic reticulum membrane

endoplasmic reticulum membrane

lipid droplet

lipid droplet

cytosol

glycerol metabolic process

lipid metabolic process

monoacylglycerol biosynthetic process

diacylglycerol biosynthetic process

O-acyltransferase activity

positive regulation of triglyceride biosynthetic process

membrane

membrane

transferase activity

acyltransferase activity

triglyceride biosynthetic process

triglyceride biosynthetic process

triglyceride biosynthetic process

triglyceride biosynthetic process

lipid storage

lipid storage

low-density lipoprotein particle clearance

long-chain fatty-acyl-CoA metabolic process

long-chain fatty-acyl-CoA metabolic process

intracellular triglyceride homeostasis

cholesterol homeostasis

protein homodimerization activity

intracellular membrane-bounded organelle

positive regulation of gluconeogenesis

negative regulation of fatty acid oxidation

diacylglycerol metabolic process

diacylglycerol metabolic process

diacylglycerol metabolic process

perinuclear region of cytoplasm

retinol O-fatty-acyltransferase activity

regulation of lipoprotein metabolic process

fatty acid homeostasis

fat pad development

cellular response to oleic acid

regulation of cholesterol metabolic process

regulation of plasma lipoprotein particle levels

perinuclear endoplasmic reticulum membrane

00561

01100

04975

1456377_x_at Limd2 LIM domain containing 2 11 -106156253, -106156253, -106156253 AV010467 23

molecular_function

nucleus

nucleoplasm

cytoplasm

cytosol

plasma membrane

biological_process

actin cytoskeleton

metal ion binding

actin filament binding

actin filament bundle assembly

 
1460224_at Snx2 sorting nexin 2 18 53176291 BC006960 31

epidermal growth factor receptor binding

insulin receptor binding

cytoplasm

lysosome

endosome

endosome

intracellular protein transport

lipid binding

endosome membrane

endosome membrane

protein transport

membrane

membrane

retromer complex

retromer, tubulation complex

protein-containing complex

early endosome to Golgi transport

phosphatidylinositol binding

phosphatidylinositol binding

retrograde transport, endosome to Golgi

identical protein binding

protein homodimerization activity

cell projection

protein heterodimerization activity

lamellipodium morphogenesis

transferrin receptor binding

leptin receptor binding

 
1416527_at Rab32 RAB32, member RAS oncogene family 10 -10545038 NM_026405 41

nucleotide binding

GTPase activity

GTPase activity

protein binding

GTP binding

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

early endosome

endoplasmic reticulum

Golgi apparatus

trans-Golgi network

trans-Golgi network

intracellular protein transport

mitochondrion organization

endomembrane system

membrane

vesicle-mediated transport

antigen processing and presentation

GTP-dependent protein binding

cytoplasmic vesicle

vesicle

melanosome organization

melanosome membrane

endosome to melanosome transport

AP-1 adaptor complex binding

AP-3 adaptor complex binding

BLOC-2 complex binding

melanosome

melanosome

melanosome

mitochondria-associated endoplasmic reticulum membrane

phagocytic vesicle

protein localization to membrane

phagosome maturation

melanosome assembly

 
1452732_at Asprv1 aspartic peptidase, retroviral-like 1 6 86628173 AK004007 19

aspartic-type endopeptidase activity

aspartic-type endopeptidase activity

proteolysis

peptidase activity

membrane

protein processing

protein processing

hydrolase activity

skin development

 
1425684_at Akr1b10 aldo-keto reductase family 1, member B10 6 34384246 BB493454 16

retinal dehydrogenase activity

alditol:NADP+ 1-oxidoreductase activity

estradiol 17-beta-dehydrogenase [NAD(P)] activity

extracellular region

mitochondrion

mitochondrion

mitochondrion

lysosome

cytosol

cytosol

alcohol dehydrogenase (NADP+) activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

geranylgeranyl reductase activity

indanol dehydrogenase activity

NADP-retinol dehydrogenase activity

 
1424039_at Saraf store-operated calcium entry-associated regulatory factor 8 34154578 BC022616 22

endoplasmic reticulum

endoplasmic reticulum membrane

monoatomic ion transport

calcium ion transport

membrane

endoplasmic reticulum-plasma membrane contact site

regulation of store-operated calcium entry

regulation of store-operated calcium entry

 
1416939_at Ppa1 pyrophosphatase (inorganic) 1 10 61648620 NM_026438 37

magnesium ion binding

inorganic diphosphate phosphatase activity

inorganic diphosphate phosphatase activity

cytoplasm

phosphate-containing compound metabolic process

phosphate-containing compound metabolic process

pyrophosphatase activity

hydrolase activity

metal ion binding

00190

1433530_at Rpl41 ribosomal protein L41 10 -128548109 BI694945 26

cytoplasmic translation

structural constituent of ribosome

cytoplasm

cytosol

ribosome

translation

cytosolic large ribosomal subunit

cytosolic large ribosomal subunit

ribonucleoprotein complex

03010

1416431_at Tubb6 tubulin, beta 6 class V 18 67390730 NM_026473 43

nucleotide binding

microtubule cytoskeleton organization

mitotic cell cycle

GTPase activity

structural constituent of cytoskeleton

structural constituent of cytoskeleton

GTP binding

GTP binding

cytoplasm

cytoplasm

cytoskeleton

microtubule

microtubule

microtubule-based process

microtubule cytoskeleton

intercellular bridge

metal ion binding

mitotic spindle

04145

04540

1416713_at Tppp3 tubulin polymerization-promoting protein family member 3 8 -105467491 NM_026481 32

microtubule bundle formation

microtubule bundle formation

cytoplasm

cytoskeleton

microtubule

microtubule

embryo implantation

tubulin binding

tubulin binding

positive regulation of protein polymerization

decidualization

microtubule polymerization

microtubule polymerization

perinuclear region of cytoplasm

microtubule bundle

 
1417153_at Nacc2 nucleus accumbens associated 2, BEN and BTB (POZ) domain containing 2 -26055535, -26055535 NM_026495 24

negative regulation of transcription by RNA polymerase II

chromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleolus

mitochondrion

negative regulation of cell population proliferation

protein-containing complex localization

protein homodimerization activity

histone deacetylase binding

protein-containing complex binding

negative regulation of DNA-templated transcription

protein homooligomerization

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

 
1417126_a_at Rpl22l1 ribosomal protein L22 like 1 3 28805507 NM_026517 25

cytoplasmic translation

RNA binding

structural constituent of ribosome

structural constituent of ribosome

cytosol

ribosome

translation

ribonucleoprotein complex

03010

1449415_at Chd1l chromodomain helicase DNA binding protein 1-like 3 -97560747 NM_026539 28

nucleotide binding

nucleotide binding

DNA helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

chromosome

cytosol

plasma membrane

DNA repair

chromatin remodeling

chromatin remodeling

DNA damage response

DNA damage response

hydrolase activity

ATP hydrolysis activity

nucleosome binding

site of double-strand break

site of DNA damage

histone reader activity

ATP-dependent chromatin remodeler activity

poly-ADP-D-ribose modification-dependent protein binding

 
1423803_s_at Nop53 NOP53 ribosome biogenesis factor 7 -15937835 BC017637 23

ribosomal large subunit assembly

ribosomal large subunit assembly

negative regulation of transcription by RNA polymerase II

fibrillar center

regulation of protein phosphorylation

p53 binding

protein binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

cytosol

DNA repair

rRNA processing

DNA damage response

mitotic G2 DNA damage checkpoint signaling

5S rRNA binding

5S rRNA binding

negative regulation of protein-containing complex assembly

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

rDNA heterochromatin

regulation of RIG-I signaling pathway

ribosome biogenesis

identical protein binding

regulation of apoptotic process

intracellular membrane-bounded organelle

protein stabilization

regulation of cell cycle

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular response to hypoxia

regulation of signal transduction by p53 class mediator

negative regulation of signal transduction by p53 class mediator

negative regulation of transcription of nucleolar large rRNA by RNA polymerase I

protein localization to nucleolus

positive regulation of protein K63-linked deubiquitination

regulation of aerobic respiration

protein localization to nucleoplasm

 
1416536_at Pwwp3a PWWP domain containing 3A, DNA repair factor 10 80226597 NM_023431 17

nucleus

nucleus

nucleoplasm

cytosol

cytosol

DNA repair

DNA repair

chromatin organization

chromatin organization

DNA damage response

nucleosome binding

nucleosome binding

 
1455203_at A930003A15Rik RIKEN cDNA A930003A15 gene 16 -19876567 BB522820 10

molecular_function

cellular_component

biological_process

 
1434581_at Mturn maturin, neural progenitor differentiation regulator homolog (Xenopus) 6 54681623 BB167663 19

molecular_function

cytoplasm

cytoplasm

multicellular organism development

regulation of signaling

negative regulation of NF-kappaB transcription factor activity

positive regulation of megakaryocyte differentiation

positive regulation of megakaryocyte differentiation

positive regulation of megakaryocyte differentiation

positive regulation of JNK cascade

neuron development

positive regulation of ERK1 and ERK2 cascade

 
1437309_a_at Rpa1 replication protein A1 11 -75300258 BB491281 81

telomere maintenance

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

double-strand break repair via homologous recombination

condensed chromosome

condensed nuclear chromosome

lateral element

male germ cell nucleus

in utero embryonic development

nucleic acid binding

DNA binding

chromatin binding

damaged DNA binding

damaged DNA binding

single-stranded DNA binding

nucleus

nucleus

nucleoplasm

nucleoplasm

DNA replication factor A complex

DNA replication factor A complex

DNA replication

DNA repair

base-excision repair

nucleotide-excision repair

nucleotide-excision repair

mismatch repair

DNA recombination

DNA damage response

telomere maintenance via telomerase

positive regulation of cell population proliferation

PML body

hemopoiesis

protein localization to chromosome

site of double-strand break

single-stranded telomeric DNA binding

metal ion binding

homeostasis of number of cells within a tissue

chromosome organization

meiotic cell cycle

meiotic cell cycle

site of DNA damage

G-rich strand telomeric DNA binding

chromatin-protein adaptor activity

protein localization to site of double-strand break

03030

03420

03430

03440

1431705_a_at Mcoln2 mucolipin 2 3 146150173, 146149832 AK014467 23

adaptive immune response

immune system process

monoatomic cation channel activity

calcium channel activity

lysosome

endosome

plasma membrane

monoatomic ion transport

calcium ion transport

protein transport

membrane

membrane

positive regulation of chemokine production

monoatomic ion transmembrane transport

identical protein binding

innate immune response

recycling endosome

calcium ion transmembrane transport

positive regulation of monocyte chemotactic protein-1 production

positive regulation of macrophage inflammatory protein 1 alpha production

positive regulation of chemokine (C-C motif) ligand 5 production

NAADP-sensitive calcium-release channel activity

macrophage migration

neutrophil migration

regulation of chemokine (C-X-C motif) ligand 2 production

positive regulation of chemokine (C-X-C motif) ligand 2 production

 
1454893_at Entrep3 endosomal transmembrane epsin interactor 3 3 89183142 BB765852 12

molecular_function

cellular_component

biological_process

membrane

WW domain binding

 
1452353_at Gpr155 G protein-coupled receptor 155 2 -73341505 BB762731 14

molecular_function

lysosome

lysosomal membrane

lipid binding

cholesterol binding

membrane

negative regulation of BMP signaling pathway

cellular response to amino acid starvation

intracellular signal transduction

cognition

transmembrane transport

cellular response to cholesterol

positive regulation of TORC1 signaling

 
1435464_at Smim14 small integral membrane protein 14 5 -65446843, -65446843, -65446843, -65446843, -65446843, -65446843 BB701294 21

blastocyst hatching

molecular_function

endoplasmic reticulum

endoplasmic reticulum

membrane

 
1429072_at Col6a4 collagen, type VI, alpha 4 9 -105990317 AK003211 24

collagen binding

extracellular region

collagen trimer

cell adhesion

extracellular matrix structural constituent conferring tensile strength

extracellular matrix organization

extracellular matrix

protein-containing complex

collagen-containing extracellular matrix

04510

04512

04974

1428583_at Nufip2 nuclear FMR1 interacting protein 2 11 77686138 BQ176203 32

RNA binding

RNA binding

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytosol

ribosome

cytoplasmic stress granule

cytoplasmic stress granule

nuclear body

 
1429352_at Mocos molybdenum cofactor sulfurase 18 24653690 AK003797 16

catalytic activity

cellular_component

Mo-molybdopterin cofactor biosynthetic process

Mo-molybdopterin cofactor sulfurase activity

Mo-molybdopterin cofactor sulfurase activity

transferase activity

molybdenum ion binding

pyridoxal phosphate binding

molybdopterin cofactor biosynthetic process

molybdopterin cofactor metabolic process

molybdopterin cofactor metabolic process

molybdenum cofactor sulfurtransferase activity

 
1424254_at Ifitm1 interferon induced transmembrane protein 1 7 140967428, 140968075, 140968027 BC027285 37

ossification

somitogenesis

immune system process

molecular_function

lysosome

lysosomal membrane

early endosome

plasma membrane

plasma membrane

negative regulation of cell population proliferation

response to virus

response to virus

anterior/posterior pattern specification

membrane

negative regulation of cell migration

protein-containing complex

response to type II interferon

response to type II interferon

response to interferon-alpha

response to interferon-alpha

response to interferon-beta

response to interferon-beta

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

positive regulation of osteoblast differentiation

negative regulation of viral entry into host cell

negative regulation of viral entry into host cell

negative regulation of viral entry into host cell

defense response to virus

defense response to virus

type I interferon-mediated signaling pathway

04662

1452646_at Trp53inp2 transformation related protein 53 inducible nuclear protein 2 2 155381855 AK003956 22

autophagosome assembly

autophagosome assembly

osteoblast differentiation

tissue homeostasis

nucleus

nucleus

cytoplasm

autophagosome

autophagosome

cytosol

ubiquitin-dependent protein catabolic process

autophagy

protein localization

macroautophagy

cytoplasmic vesicle

ubiquitin binding

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

negative regulation of protein localization

 
1416617_at Acss1 acyl-CoA synthetase short-chain family member 1 2 -150618110 NM_080575 37

nucleotide binding

acetate-CoA ligase activity

acetate-CoA ligase activity

acetate-CoA ligase activity

ATP binding

mitochondrion

mitochondrion

mitochondrial matrix

mitochondrial matrix

acetyl-CoA biosynthetic process

acetyl-CoA biosynthetic process

acetyl-CoA biosynthetic process

lipid metabolic process

AMP binding

ligase activity

acetate biosynthetic process

acetyl-CoA biosynthetic process from acetate

propionate biosynthetic process

propionate-CoA ligase activity

00010

00620

00640

01100

1419599_s_at Ms4a6d membrane-spanning 4-domains, subfamily A, member 6D 19 -11586605 NM_026835 19

molecular_function

trans-Golgi network

trans-Golgi network

plasma membrane

cell surface receptor signaling pathway

membrane

 
1454857_at Rnf122 ring finger protein 122 8 31111826, 31115052 AW551457 19

cytoplasm

endoplasmic reticulum

Golgi apparatus

negative regulation of mitochondrial membrane potential

membrane

positive regulation of apoptotic process

proteasome-mediated ubiquitin-dependent protein catabolic process

metal ion binding

protein autoubiquitination

ubiquitin protein ligase activity

 
1424509_at Cd177 CD177 antigen 7 -24743982 BC027283 21

protease binding

immune system process

integrin binding

plasma membrane

cell adhesion

leukocyte cell-cell adhesion

leukocyte cell-cell adhesion

membrane

regulation of endocytosis

secretory granule membrane

positive regulation of superoxide anion generation

protein localization to cell surface

positive regulation of neutrophil degranulation

positive regulation of neutrophil degranulation

plasma membrane raft

plasma membrane raft

innate immune response

cell-cell junction maintenance

cell-cell junction maintenance

calcium-dependent protein binding

tertiary granule membrane

neutrophil extravasation

cell-cell adhesion via plasma-membrane adhesion molecules

cell-cell adhesion via plasma-membrane adhesion molecules

regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway

 
1424337_at Snx15 sorting nexin 15 19 -6119398 BC016091 19

nucleolus

cytoplasm

cytosol

plasma membrane

lipid binding

protein transport

membrane

cytoplasmic vesicle

phosphatidylinositol binding

intracellular membrane-bounded organelle

 
1422497_at Slc30a5 solute carrier family 30 (zinc transporter), member 5 13 -100802647 NM_022885 28

Golgi membrane

zinc ion transmembrane transporter activity

zinc ion transmembrane transporter activity

nucleoplasm

nucleolus

endoplasmic reticulum membrane

Golgi apparatus

Golgi apparatus

plasma membrane

GPI anchor biosynthetic process

monoatomic ion transport

monoatomic cation transport

zinc ion transport

intracellular zinc ion homeostasis

intracellular zinc ion homeostasis

monoatomic cation transmembrane transporter activity

response to zinc ion

ER to Golgi transport vesicle membrane

antiporter activity

membrane

apical plasma membrane

zinc efflux transmembrane transporter activity

insulin processing

secretory granule

secretory granule membrane

cytoplasmic vesicle

cytoplasmic vesicle

trans-Golgi network membrane

metal ion binding

transmembrane transport

zinc ion import into organelle

zinc ion import across plasma membrane

zinc:proton antiporter activity

zinc ion import into Golgi lumen

zinc ion import into Golgi lumen

Golgi cis cisterna membrane

 
1434493_at Rbis ribosomal biogenesis factor 3 -14606288, -14606288 BG092222 15

molecular_function

nucleus

nucleoplasm

nucleolus

nucleolus

cytosol

ribosome biogenesis

ribosome biogenesis

 
1429889_at Fcmr Fc fragment of IgM receptor 1 130865776 AK007714 34

polymeric immunoglobulin binding

IgM binding

high-affinity IgM receptor activity

immune system process

immunoglobulin transcytosis in epithelial cells

humoral immune response mediated by circulating immunoglobulin

transmembrane signaling receptor activity

protein binding

lysosomal membrane

plasma membrane

plasma membrane

plasma membrane

external side of plasma membrane

cell surface

membrane

early endosome membrane

trans-Golgi network membrane

trans-Golgi network membrane

regulation of B cell receptor signaling pathway

negative regulation of lymphocyte apoptotic process

Fc receptor-mediated immune complex endocytosis

inhibition of cysteine-type endopeptidase activity involved in apoptotic process

negative regulation of extrinsic apoptotic signaling pathway

 
1428637_at Dyrk2 dual-specificity tyrosine phosphorylation regulated kinase 2 10 -118859348 AK007736 27

ubiquitin ligase complex

nucleotide binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity

protein tyrosine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytoskeleton

protein phosphorylation

apoptotic process

smoothened signaling pathway

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

peptidyl-threonine phosphorylation

peptidyl-tyrosine phosphorylation

manganese ion binding

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

positive regulation of glycogen biosynthetic process

negative regulation of calcineurin-NFAT signaling cascade

ribonucleoprotein complex

 
1430612_at Mcemp1 mast cell expressed membrane protein 1 8 3665761 BB533148 13

molecular_function

cellular_component

biological_process

membrane

identical protein binding

 
1427837_at Igkv15-103 immunoglobulin kappa chain variable 15-103 6   U25103 10

immunoglobulin production

extracellular space

immune response

IgG immunoglobulin complex

 
1427757_at Igk-V21 immunoglobulin kappa chain variable 21 (V21) 6   D29670 22    
1423142_a_at Gtpbp4 GTP binding protein 4 13 -8972477 AI987834 34

regulation of cyclin-dependent protein serine/threonine kinase activity

nucleotide binding

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

RNA binding

GTPase activity

GTPase activity

GTP binding

nucleus

nucleoplasm

nucleolus

nucleolus

cytoplasm

cytosol

negative regulation of DNA replication

negative regulation of cell population proliferation

negative regulation of cell-cell adhesion

negative regulation of cell migration

negative regulation of protein ubiquitination

nuclear membrane

negative regulation of collagen binding

ribosome biogenesis

ribosomal large subunit biogenesis

ribosomal large subunit biogenesis

perinuclear region of cytoplasm

protein stabilization

preribosome binding

03008

1435664_at Zfp397 zinc finger protein 397 18 23954687 AV342828 17

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

nucleolus

cytoplasm

cytosol

plasma membrane

regulation of transcription by RNA polymerase II

microtubule cytoskeleton

protein homodimerization activity

negative regulation of DNA-templated transcription

protein heterodimerization activity

 
1452798_s_at Mapk1ip1 mitogen-activated protein kinase 1 interacting protein 1 7 -138835817 AK009250 19

cellular_component

cytoplasm

cytoskeleton

multicellular organism development

biological_process

identical protein binding

meiotic cell cycle

 
1424921_at Bst2 bone marrow stromal cell antigen 2 8 -71534255 BC008532 50

immune system process

negative regulation of plasmacytoid dendritic cell cytokine production

cytoplasm

endosome

multivesicular body

Golgi apparatus

Golgi apparatus

plasma membrane

metalloendopeptidase inhibitor activity

metalloendopeptidase inhibitor activity

response to virus

response to virus

cell surface

cell surface

cell surface

membrane

apical plasma membrane

negative regulation of cell growth

negative regulation of cell migration

regulation of actin cytoskeleton organization

response to type II interferon

response to interferon-alpha

response to interferon-beta

identical protein binding

protein homodimerization activity

intracellular membrane-bounded organelle

negative regulation of viral genome replication

negative regulation of viral genome replication

innate immune response

innate immune response

innate immune response

defense response to virus

defense response to virus

side of membrane

negative regulation of intracellular transport of viral material

negative regulation of intracellular transport of viral material

negative regulation of intracellular transport of viral material

 
1435020_at Klhdc2 kelch domain containing 2 12 69296680 BE980167 23

protein binding

nucleus

nucleoplasm

nuclear body

Cul2-RING ubiquitin ligase complex

nuclear membrane

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the C-end degron rule pathway

ubiquitin ligase-substrate adaptor activity

 
1449027_at Rhou ras homolog family member U 8 123653928 AF378088 25

G1/S transition of mitotic cell cycle

nucleotide binding

GTPase activity

GTPase activity

GTP binding

GTP binding

Golgi apparatus

plasma membrane

plasma membrane

endocytosis

cytoskeleton organization

actin filament organization

establishment or maintenance of cell polarity

small GTPase-mediated signal transduction

regulation of cell shape

regulation of cell shape

membrane

Rac protein signal transduction

protein kinase binding

actin cytoskeleton organization

Cdc42 protein signal transduction

cell projection

metal ion binding

anchoring junction

 
1452839_at Dph5 diphthamide biosynthesis 5 3 115888182 AK010475 17

cellular_component

methyltransferase activity

transferase activity

protein histidyl modification to diphthamide

methylation

 
1439956_at Ms4a6b membrane-spanning 4-domains, subfamily A, member 6B 19 11518558 BE692425 15

molecular_function

trans-Golgi network

trans-Golgi network

plasma membrane

cell surface receptor signaling pathway

membrane

 
1428947_at Mzb1 marginal zone B and B1 cell-specific protein 1 18 -35647264 AK008016 22

positive regulation of immunoglobulin production

protein binding

extracellular region

extracellular region

extracellular region

cytoplasm

endoplasmic reticulum

endoplasmic reticulum lumen

positive regulation of cell population proliferation

positive regulation of cell population proliferation

regulation of B cell proliferation

regulation of B cell proliferation

integrin activation

endoplasmic reticulum chaperone complex

endoplasmic reticulum chaperone complex

regulation of cell population proliferation

regulation of insulin receptor signaling pathway

 
1453047_at Tspo2 translocator protein 2 17 -48448434 AK011003 12

endoplasmic reticulum

endoplasmic reticulum

plasma membrane

cholesterol binding

cholesterol binding

membrane

organelle membrane

intracellular cholesterol transport

lipid droplet organization

enucleate erythrocyte differentiation

import across plasma membrane

5-aminolevulinic acid import across plasma membrane

5-aminolevulinic acid transmembrane transporter activity

 
1452197_at Smc4 structural maintenance of chromosomes 4 3 69004737 AV172948 40

single strand break repair

nucleotide binding

chromosome, centromeric region

condensed nuclear chromosome

condensin complex

condensin complex

condensin complex

condensin complex

chromatin binding

single-stranded DNA binding

protein binding

ATP binding

nucleus

chromosome

cytoplasm

cytosol

cell cycle

mitotic chromosome condensation

meiotic chromosome condensation

nuclear speck

ATP hydrolysis activity

chromosome condensation

meiotic chromosome segregation

chromosome organization

cell division

kinetochore organization

positive regulation of chromosome segregation

positive regulation of chromosome separation

positive regulation of chromosome condensation

 
1430878_at 2210406H18Rik RIKEN cDNA 2210406H18 gene 7   AV078837 7

molecular_function

cellular_component

biological_process

 
1428512_at Bhlhb9 basic helix-loop-helix domain containing, class B9 X 135885850 AK012577 25

nucleus

nucleus

cytoplasm

cytosol

learning or memory

protein homodimerization activity

negative regulation of neuron apoptotic process

positive regulation of neurogenesis

positive regulation of synapse assembly

positive regulation of dendritic spine morphogenesis

 
1440795_x_at Rabep2 rabaptin, RAB GTPase binding effector protein 2 7 126428766 BB259371 25

GTPase activator activity

cytoplasm

endosome

centrosome

cytosol

cytoskeleton

endocytosis

growth factor activity

protein transport

cell projection organization

ciliary basal body

cell projection

intracellular membrane-bounded organelle

intracellular membrane-bounded organelle

regulation of cilium assembly

 
1428572_at Basp1 brain abundant, membrane attached signal protein 1 15 -25363276 AK011545 45

chromatin

transcription cis-regulatory region binding

transcription cis-regulatory region binding

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

protein binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

plasma membrane

COP9 signalosome

membrane

nuclear matrix

PML body

nuclear speck

protein domain specific binding

cell junction

cell projection

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

podocyte differentiation

 
1423989_at Tecpr1 tectonin beta-propeller repeat containing 1 5 -144194441 BC025567 22

autophagosome membrane

autophagosome membrane

nucleoplasm

lysosome

lysosomal membrane

lysosomal membrane

autophagy

lipid binding

membrane

macroautophagy

cytoplasmic vesicle

phosphatidylinositol-3-phosphate binding

phosphatidylinositol-3-phosphate binding

protein-containing complex

intracellular membrane-bounded organelle

autophagosome maturation

autophagosome maturation

regulation of autophagosome maturation

 
1419033_at Stk26 serine/threonine kinase 26 X 50841370 AW556821 26

Golgi membrane

nucleotide binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

cytoplasm

cytoplasm

Golgi apparatus

Golgi apparatus

Golgi-associated vesicle

cytosol

protein phosphorylation

protein phosphorylation

apoptotic process

cellular response to starvation

membrane

kinase activity

phosphorylation

apical plasma membrane

transferase activity

microvillus assembly

negative regulation of cell migration

negative regulation of cell migration

stress-activated protein kinase signaling cascade

response to hydrogen peroxide

identical protein binding

protein homodimerization activity

regulation of apoptotic process

protein autophosphorylation

metal ion binding

perinuclear region of cytoplasm

cell periphery

 
1429461_at Ints2 integrator complex subunit 2 11 -86210680 AK013101 24

molecular_function

nucleus

cytoplasm

membrane

snRNA processing

integrator complex

integrator complex

snRNA 3'-end processing

 
1429383_at Csnk1g3 casein kinase 1, gamma 3 18 53862112 BM195380 24

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

cytoplasm

cytoplasm

plasma membrane

protein phosphorylation

endocytosis

signal transduction

Wnt signaling pathway

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

positive regulation of canonical Wnt signaling pathway

04340

1426623_a_at Arhgap17 Rho GTPase activating protein 17 7 -123279148 AV351061 36

GTPase activator activity

GTPase activator activity

intracellular anatomical structure

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

bicellular tight junction

actin filament organization

signal transduction

membrane

SH3 domain binding

calcium-ion regulated exocytosis

regulation of actin cytoskeleton organization

regulation of Rac protein signal transduction

positive regulation of GTPase activity

anchoring junction

 
1427050_at Txndc16 thioredoxin domain containing 16 14 -45134447 BC027108 15

molecular_function

extracellular region

endoplasmic reticulum

endoplasmic reticulum lumen

biological_process

 
1447774_x_at Prxl2a peroxiredoxin like 2A 14 -40993734, -40993734, -40993734, -40993734, -40993734 AV332575 26

extracellular region

cytoplasm

cytoplasm

mitochondrion

antioxidant activity

antioxidant activity

regulation of osteoclast differentiation

 
1429413_at Cpm carboxypeptidase M 10 117629499 AK017670 25

carboxypeptidase activity

metallocarboxypeptidase activity

metallocarboxypeptidase activity

extracellular space

plasma membrane

proteolysis

peptide metabolic process

peptidase activity

metallopeptidase activity

zinc ion binding

membrane

protein processing

hydrolase activity

metal ion binding

side of membrane

 
1447100_s_at Fam241a family with sequence similarity 241, member A 3 -127869687 C80506 15

molecular_function

Golgi apparatus

biological_process

membrane

intracellular membrane-bounded organelle

 
1418401_a_at Dusp16 dual specificity phosphatase 16 6 -134715467 NM_130447 40

phosphoprotein phosphatase activity

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

protein dephosphorylation

protein tyrosine/threonine phosphatase activity

JUN kinase binding

dephosphorylation

phosphatase activity

MAP kinase tyrosine/serine/threonine phosphatase activity

MAP kinase tyrosine phosphatase activity

peptidyl-tyrosine dephosphorylation

negative regulation of MAPK cascade

negative regulation of MAPK cascade

negative regulation of JUN kinase activity

MAPK export from nucleus

mitogen-activated protein kinase p38 binding

mitogen-activated protein kinase binding

04010

1430570_at Kynu kynureninase 2 43555324, 43555324, 43555324 AV227891 16

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

cytosol

tryptophan catabolic process

NAD biosynthetic process

hydrolase activity

pyridine nucleotide biosynthetic process

tryptophan catabolic process to kynurenine

tryptophan catabolic process to acetyl-CoA

quinolinate biosynthetic process

pyridoxal phosphate binding

kynureninase activity

kynureninase activity

response to type II interferon

response to vitamin B6

protein homodimerization activity

anthranilate metabolic process

anthranilate metabolic process

3-hydroxykynureninase activity

00380

01100

1428727_at Cep192 centrosomal protein 192 18 67800106 AK014527 25

pericentriolar material

pericentriolar material

cytoplasm

cytoplasm

centrosome

centrosome

centriole

centriole

microtubule nucleation

mitotic spindle assembly checkpoint signaling

centriole replication

centriole replication

response to bacterium

protein kinase binding

phosphatase binding

regulation of centriole replication

regulation of centrosome cycle

regulation of establishment of protein localization

protein localization to centrosome

centrosome-templated microtubule nucleation

centrosome-templated microtubule nucleation

mitotic spindle assembly

mitotic spindle assembly

procentriole

procentriole replication complex

 
1433648_at Spag9 sperm associated antigen 9 11 94044129, 93996090 BM938614 69

negative regulation of protein phosphorylation

MAP-kinase scaffold activity

MAP-kinase scaffold activity

protein binding

cytoplasm

cytoplasm

lysosome

lysosomal membrane

cytosol

cytosol

JUN kinase binding

JUN kinase binding

membrane

vesicle-mediated transport

kinesin binding

kinesin binding

signaling receptor complex adaptor activity

positive regulation of cell migration

lysosome localization

centriolar satellite

retrograde transport, endosome to Golgi

identical protein binding

positive regulation of MAPK cascade

positive regulation of MAPK cascade

negative regulation of neuron differentiation

positive regulation of neuron differentiation

striated muscle cell differentiation

negative regulation of dendrite extension

 
1452974_at Nol8 nucleolar protein 8 13 49653077 AK017551 23

nucleic acid binding

RNA binding

RNA binding

nucleus

chromosome

nucleolus

nucleolus

rRNA processing

protein localization to nucleolus

protein localization to nucleolus

cellular response to leukemia inhibitory factor

 
1424081_at Pcgf6 polycomb group ring finger 6 19 -47033616 BC016195 41

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

protein binding

nucleus

nucleus

chromatin remodeling

regulation of transcription by RNA polymerase II

protein domain specific binding

PcG protein complex

PcG protein complex

PRC1 complex

PRC1 complex

negative regulation of DNA-templated transcription

metal ion binding

 
1439495_at Uvssa UV stimulated scaffold protein A 5 33378695 BB476293 14

RNA polymerase II complex binding

RNA polymerase II complex binding

nucleoplasm

chromosome

chromosome

DNA repair

transcription-coupled nucleotide-excision repair

transcription-coupled nucleotide-excision repair

DNA damage response

response to UV

response to UV

protein ubiquitination

 
1429031_at Zfp626 zinc finger protein 626 7 27807195 BM938256 14

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1453119_at Otud1 OTU domain containing 1 2 19657730 BB530087 24

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

cellular_component

proteolysis

peptidase activity

cysteine-type peptidase activity

hydrolase activity

protein K63-linked deubiquitination

protein K63-linked deubiquitination

 
1431143_x_at Aifm2 apoptosis-inducing factor, mitochondrion-associated 2 10 61715262, 61720648, 61715262 AK017403 31

DNA binding

electron-transferring-flavoprotein dehydrogenase activity

electron-transferring-flavoprotein dehydrogenase activity

protein binding

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

mitochondrion

mitochondrion

mitochondrial outer membrane

lipid droplet

cytosol

plasma membrane

ubiquinone metabolic process

apoptotic mitochondrial changes

apoptotic mitochondrial changes

membrane

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

mitochondrial membrane

vitamin K metabolic process

positive regulation of apoptotic process

positive regulation of apoptotic process

flavin adenine dinucleotide binding

flavin adenine dinucleotide binding

negative regulation of ferroptosis

regulation of cellular response to oxidative stress

cellular detoxification

 
1436925_at Foxn3 forkhead box N3 12 -99195093 AV228812 35

cis-regulatory region sequence-specific DNA binding

DNA binding

DNA-binding transcription factor activity

DNA-binding transcription factor activity

nucleus

nucleus

regulation of DNA-templated transcription

regulation of DNA-templated transcription

cell cycle

mitotic G2 DNA damage checkpoint signaling

sequence-specific DNA binding

negative regulation of DNA-templated transcription

craniofacial suture morphogenesis

 
1427384_at Chd6 chromodomain helicase DNA binding protein 6 2 -160946977 BB529459 25

nucleotide binding

chromatin

transcription coregulator binding

DNA binding

DNA binding

chromatin binding

helicase activity

ATP binding

nucleus

nucleus

nucleoplasm

chromatin organization

chromatin remodeling

ATP-dependent activity, acting on DNA

regulation of gene expression

hydrolase activity

ATP hydrolysis activity

histone binding

cell redox homeostasis

positive regulation of transcription by RNA polymerase II

ATP-dependent chromatin remodeler activity

ATP-dependent chromatin remodeler activity

 
1428579_at Fmnl2 formin-like 2 2 52857867 AK017338 27

actin binding

cytosol

cytoskeleton organization

regulation of cell shape

cellular component organization

cell migration

regulation of cell morphogenesis

actin cytoskeleton organization

cortical actin cytoskeleton organization

cortical actin cytoskeleton organization

small GTPase binding

actin filament binding

 
1428773_s_at Bcor BCL6 interacting corepressor X -12036737, -12036737, -12134453 AK018370 58

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

blastocyst hatching

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

ubiquitin-protein transferase activity

protein binding

nucleus

nucleus

nucleus

nucleoplasm

chromatin organization

heat shock protein binding

histone deacetylase binding

BCOR complex

DNA-binding transcription factor binding

 
1436898_at Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 4 127021300, 127021300 BI738328 95

negative regulation of transcription by RNA polymerase II

alternative mRNA splicing, via spliceosome

alternative mRNA splicing, via spliceosome

double-strand break repair via homologous recombination

chromatin

transcription cis-regulatory region binding

activation of innate immune response

immune system process

nucleic acid binding

DNA binding

chromatin binding

RNA binding

RNA binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

DNA repair

chromatin remodeling

regulation of DNA-templated transcription

mRNA processing

DNA damage response

RNA splicing

nuclear matrix

dendrite

dendrite cytoplasm

paraspeckles

paraspeckles

regulation of circadian rhythm

negative regulation of circadian rhythm

protein homodimerization activity

histone deacetylase binding

innate immune response

positive regulation of sister chromatid cohesion

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

rhythmic process

chromosome organization

regulation of cell cycle

RNA polymerase II transcription regulator complex

dendritic transport of messenger ribonucleoprotein complex

dendritic transport of messenger ribonucleoprotein complex

dendritic transport of messenger ribonucleoprotein complex

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

 
1429387_at Grap GRB2-related adaptor protein 11 61653320 AK018457 18

phosphotyrosine residue binding

epidermal growth factor receptor binding

nucleoplasm

cytoplasm

plasma membrane

signal transduction

COP9 signalosome

membrane

regulation of MAPK cascade

synapse

 
1452952_at Fam217b family with sequence similarity 217, member B 2 178414533 AK018518 9

molecular_function

nucleoplasm

cytosol

biological_process

 
1426276_at Ifih1 interferon induced with helicase C domain 1 2 -62595792 AY075132 168

nucleotide binding

immune system process

DNA binding

RNA binding

RNA helicase activity

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

helicase activity

protein binding

ATP binding

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

zinc ion binding

zinc ion binding

response to virus

response to virus

hydrolase activity

ATP hydrolysis activity

protein sumoylation

protein domain specific binding

interferon-beta production

positive regulation of interferon-alpha production

positive regulation of interferon-beta production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor production

pattern recognition receptor activity

MDA-5 signaling pathway

MDA-5 signaling pathway

identical protein binding

ribonucleoprotein complex binding

negative regulation of viral genome replication

innate immune response

metal ion binding

protein complex oligomerization

defense response to virus

type I interferon-mediated signaling pathway

positive regulation of response to cytokine stimulus

cellular response to exogenous dsRNA

antiviral innate immune response

antiviral innate immune response

04622

1428509_at Myo1e myosin IE 9 70207349 AK018649 55

microfilament motor activity

nucleotide binding

vasculogenesis

in utero embryonic development

kidney development

glomerular filtration

cytoskeletal motor activity

actin binding

calmodulin binding

ATP binding

cytoplasm

cytoplasm

cytoskeleton

plasma membrane

microvillus

brush border

adherens junction

nitrogen compound metabolic process

endocytosis

endocytosis

actin filament organization

lipid binding

actin cytoskeleton

myosin complex

ATP hydrolysis activity

hemopoiesis

cytoplasmic vesicle

cuticular plate

glomerulus development

glomerular basement membrane development

protein-containing complex

phosphatidylinositol binding

post-embryonic hemopoiesis

protein-containing complex binding

clathrin-coated endocytic vesicle

platelet-derived growth factor receptor signaling pathway

actin filament binding

actin filament binding

anchoring junction

podocyte development

 
1429055_at Shtn1 shootin 1 19 -58973357 BB559293 31

protein binding

cytoplasm

cytoplasm

cytoskeleton

microtubule

microtubule associated complex

substrate-dependent cell migration, cell extension

Ras protein signal transduction

multicellular organism development

axonogenesis

microtubule cytoskeleton

kinesin binding

lamellipodium

filopodium

axon

growth cone

growth cone

cell leading edge

cell leading edge

Cdc42 protein signal transduction

netrin-activated signaling pathway

identical protein binding

cell projection

perikaryon

axonal growth cone

axonal growth cone

axonal growth cone

positive regulation of axon extension

perinuclear region of cytoplasm

neuron projection morphogenesis

neuron projection morphogenesis

cell adhesion molecule binding

actin filament binding

membrane depolarization

cytoplasmic actin-based contraction involved in cell motility

endoplasmic reticulum polarization

actin filament bundle retrograde transport

regulation of establishment of cell polarity

regulation of establishment of cell polarity

regulation of neuron migration

positive regulation of neuron migration

positive regulation of neuron migration

positive regulation of neuron migration

 
1424250_a_at Arhgef3 Rho guanine nucleotide exchange factor 3 14 27238009, 27143992, 27361388, 27336036 BC012262 32

guanyl-nucleotide exchange factor activity

cytoplasm

positive regulation of Rho protein signal transduction

intracellular signal transduction

 
1424524_at Dram1 DNA-damage regulated autophagy modulator 1 10 -88322803 BC021433 22

molecular_function

cytoplasm

lysosome

lysosome

autophagy

apoptotic process

regulation of autophagy

regulation of autophagy

membrane

 
1435137_s_at 1200015M12Rik RIKEN cDNA 1200015M12 gene 19   BB119177 9

molecular_function

cellular_component

biological_process

 
1428449_at Gtf3c2 general transcription factor IIIC, polypeptide 2, beta 5 -31156005 AV297256 29

transcription factor TFIIIC complex

transcription factor TFIIIC complex

RNA polymerase III general transcription initiation factor activity

DNA binding

nucleoplasm

transcription by RNA polymerase III

transcription by RNA polymerase III

 
1428385_at Marchf8 membrane associated ring-CH-type finger 8 6 116338021 AK005032 25

protein polyubiquitination

protein polyubiquitination

adaptive immune response

immune system process

antigen processing and presentation of peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II

ubiquitin-protein transferase activity

ubiquitin-protein transferase activity

cytoplasm

lysosome

lysosome

endosome

endoplasmic reticulum

Golgi apparatus

immune response

zinc ion binding

membrane

protein ubiquitination

transferase activity

cytoplasmic vesicle

early endosome membrane

late endosome membrane

MHC protein binding

MHC class II protein binding

negative regulation of MHC class II biosynthetic process

metal ion binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
1452316_at Ints12 integrator complex subunit 12 3 133091854 AK003874 21

molecular_function

nucleus

snRNA processing

integrator complex

integrator complex

snRNA 3'-end processing

metal ion binding

 
1429274_at Lypd6b LY6/PLAUR domain containing 6B 2 49787682 AK009282 18

cellular_component

plasma membrane

membrane

acetylcholine receptor regulator activity

acetylcholine receptor regulator activity

side of membrane

 
1452257_at Bdh1 3-hydroxybutyrate dehydrogenase, type 1 16 31428752, 31422296 BF322712 43

catalytic activity

3-hydroxybutyrate dehydrogenase activity

3-hydroxybutyrate dehydrogenase activity

phospholipid binding

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial inner membrane

lipid metabolic process

metabolic process

steroid metabolic process

membrane

oxidoreductase activity

intracellular membrane-bounded organelle

00072

00650

01100

1431055_a_at Snx10 sorting nexin 10 6 51524259, 51545292, 51524083, 51544522, 51523902 AK010399 37

gastric acid secretion

1-phosphatidylinositol binding

nucleus

nucleus

cytoplasm

endosome

endosome

endoplasmic reticulum

endoplasmic reticulum

centrosome

cytoskeleton

intracellular protein transport

endocytosis

endosome organization

lipid binding

protein transport

membrane

vesicle organization

cellular homeostasis

cell projection organization

secretory granule

osteoclast differentiation

extrinsic component of endosome membrane

phosphatidylinositol binding

bone mineralization involved in bone maturation

tooth eruption

bone resorption

bone remodeling

ATPase binding

establishment of localization in cell

calcium ion homeostasis

cilium assembly

cilium assembly

protein localization to cilium

protein localization to centrosome

apical cytoplasm

ruffle assembly

phosphatidylinositol phosphate binding

cellular response to leukemia inhibitory factor

 
1436759_x_at Cnn3 calponin 3, acidic 3 121426540 AV172168 47

actin binding

calmodulin binding

cytosol

actin filament organization

microtubule binding

actin cytoskeleton

actin cytoskeleton

dendrite

actomyosin structure organization

neuronal cell body

dendritic spine

actin filament binding

postsynapse

glutamatergic synapse

 
1433833_at Fndc3b fibronectin type III domain containing 3B 3 -27416134 BG064539 35

endoplasmic reticulum

fibroblast migration

membrane

substrate adhesion-dependent cell spreading

positive regulation of fat cell differentiation

positive regulation of fat cell differentiation

negative regulation of osteoblast differentiation

positive regulation of fibroblast proliferation

type II pneumocyte differentiation

 
1419307_at Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c 15 -82221741 NM_028075 108

B cell homeostasis

adaptive immune response

immune system process

germinal center formation

positive regulation of germinal center formation

external side of plasma membrane

external side of plasma membrane

membrane

positive regulation of B cell proliferation

positive regulation of B cell proliferation

T cell costimulation

T cell costimulation

T cell costimulation

B cell costimulation

B cell costimulation

positive regulation of type II interferon production

tumor necrosis factor-mediated signaling pathway

signaling receptor activity

T cell proliferation

T cell proliferation

B cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

positive regulation of T cell proliferation

regulation of immune response

04060

04672

05340

1454785_at Dusp11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 6 -85942268 BE951717 18

fibrillar center

RNA binding

polynucleotide 5'-phosphatase activity

polynucleotide 5'-phosphatase activity

phosphoprotein phosphatase activity

protein tyrosine phosphatase activity

nucleus

nucleoplasm

protein dephosphorylation

protein tyrosine/serine/threonine phosphatase activity

dephosphorylation

nuclear speck

hydrolase activity

phosphatase activity

intercellular bridge

 
1451079_at Adpgk ADP-dependent glucokinase 9 59291571 BC021526 30

extracellular region

endoplasmic reticulum

endoplasmic reticulum

carbohydrate metabolic process

glucose metabolic process

glucose metabolic process

glucose metabolic process

glycolytic process

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, alcohol group as acceptor

ADP-specific glucokinase activity

ADP-specific glucokinase activity

ADP-specific glucokinase activity

metal ion binding

00010

01100

1428517_at Wdfy3 WD repeat and FYVE domain containing 3 5 -101832952 AK012075 50

autophagosome membrane

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity

1-phosphatidylinositol binding

nucleus

nuclear envelope

nucleoplasm

nucleolus

cytoplasm

cytoplasm

autophagosome

cytosol

plasma membrane

autophagy

multicellular organism development

lipid binding

membrane

inclusion body

PML body

Atg12-Atg5-Atg16 complex

aggrephagy

aggrephagy

cell projection

metal ion binding

 
1428357_at Tdrp testis development related protein 8 -13952007, -13952007 AK011462 22

molecular_function

nucleus

nucleus

cytoplasm

cytosol

cytosol

spermatogenesis

spermatogenesis

intracellular membrane-bounded organelle

 
1424444_a_at 1600014C10Rik RIKEN cDNA 1600014C10 gene 7 38183786, 38183216 BC019834 15

molecular_function

cytoplasm

mitochondrion

endoplasmic reticulum

cytosol

autophagy

apoptotic process

response to oxidative stress

membrane

mitochondrial membrane

mitochondrial calcium ion homeostasis

 
1433768_at Palld palladin, cytoskeletal associated protein 8 -61514703, -61511430, -61511430, -61511430 BG071905 61

stress fiber

stress fiber

ruffle

podosome

keratinocyte development

epithelial cell morphogenesis

actin binding

nucleus

nucleus

cytoplasm

mitochondrion

cytosol

cytoskeleton

cytoskeleton

actin filament

actin filament

plasma membrane

plasma membrane

focal adhesion

focal adhesion

homophilic cell adhesion via plasma membrane adhesion molecules

axon guidance receptor activity

cytoskeletal protein binding

actin cytoskeleton

cell migration

Z disc

Z disc

lamellipodium

actin cytoskeleton organization

filopodium

axon

axon

growth cone

cell projection

neuronal cell body

neuronal cell body

axonal growth cone

synapse organization

excitatory synapse

anchoring junction

 
1424029_at Tspyl4 TSPY-like 4 10 34297420 BC017540 17

chromatin

molecular_function

chromatin binding

nucleus

nucleus

nucleosome assembly

biological_process

histone binding

 
1428389_s_at Wdr43 WD repeat domain 43 17 71616214 AK012043 25

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

chromatin

RNA polymerase II complex binding

fibrillar center

transcription elongation factor activity

RNA binding

protein binding

nucleus

nucleoplasm

nucleolus

nucleolus

nucleolus

rRNA processing

small-subunit processome

regulation of transcription elongation by RNA polymerase II

ribosome biogenesis

ribosomal small subunit biogenesis

positive regulation of transcription by RNA polymerase I

regulation of stem cell population maintenance

positive regulation of rRNA processing

03008

1428768_at Pan3 PAN3 poly(A) specific ribonuclease subunit 5 147430155 AK012409 23

nucleotide binding

nuclear-transcribed mRNA poly(A) tail shortening

nuclear-transcribed mRNA poly(A) tail shortening

deadenylation-dependent decapping of nuclear-transcribed mRNA

P-body

P-body

RNA binding

poly(A)-specific ribonuclease activity

protein kinase activity

protein binding

ATP binding

nucleus

cytoplasm

mRNA processing

protein phosphorylation

protein targeting

poly(A) binding

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of cytoplasmic mRNA processing body assembly

PAN complex

PAN complex

metal ion binding

03018

1428810_at 2700097O09Rik RIKEN cDNA 2700097O09 gene 12 -55045660 AK012621 20

methyltransferase activity

 
1430195_at 2810043O03Rik RIKEN cDNA 2810043O03 gene 9   BF662697 8

molecular_function

cellular_component

biological_process

 
1426223_at Ttc39c tetratricopeptide repeat domain 39C 18 12643532 BC020021 17

molecular_function

cellular_component

otolith morphogenesis

cilium assembly

 
1429096_at 2810455D13Rik RIKEN cDNA 2810455D13 gene 19   AK013353 7

molecular_function

cellular_component

biological_process

 
1426985_s_at Fam76b family with sequence similarity 76, member B 9 13827715 AV337692 19

nucleus

nuclear speck

nuclear speck

 
1438969_x_at Dhx30 DExH-box helicase 30 9 -110084318, -110084318, -110084318 BB105391 35

nucleotide binding

G-quadruplex RNA binding

nucleic acid binding

DNA helicase activity

chromatin binding

RNA binding

RNA helicase activity

RNA helicase activity

RNA helicase activity

double-stranded RNA binding

helicase activity

ATP binding

intracellular anatomical structure

nucleus

cytoplasm

cytoplasm

cytoplasm

mitochondrion

cytosol

central nervous system development

hydrolase activity

ribonucleoprotein granule

ribosome biogenesis

mitochondrial nucleoid

mitochondrial large ribosomal subunit assembly

 
1435445_at Ccnt2 cyclin T2 1 127774163 AV377237 28

transcription coactivator binding

chromatin binding

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytosol

plasma membrane

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cell cycle

skeletal muscle tissue development

cyclin/CDK positive transcription elongation factor complex

cyclin/CDK positive transcription elongation factor complex

cyclin-dependent protein serine/threonine kinase regulator activity

early viral transcription

late viral transcription

protein kinase binding

positive regulation of DNA-templated transcription, elongation

positive regulation of transcription elongation by RNA polymerase II

positive regulation of transcription by RNA polymerase II

perinuclear region of cytoplasm

regulation of muscle cell differentiation

cell division

cyclin-dependent protein serine/threonine kinase activator activity

RNA polymerase binding

7SK snRNA binding

 
1431050_at Rps6ka5 ribosomal protein S6 kinase, polypeptide 5 12 -100548439 BE291900 109

nucleotide binding

magnesium ion binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein tyrosine kinase activity

protein binding

ATP binding

ATP binding

nucleus

nucleus

nucleoplasm

nucleoplasm

cytoplasm

cytoplasm

regulation of DNA-templated transcription

regulation of DNA-templated transcription

regulation of DNA-templated transcription

protein phosphorylation

protein phosphorylation

inflammatory response

kinase activity

phosphorylation

transferase activity

peptidyl-serine phosphorylation

histone H3S10 kinase activity

intracellular signal transduction

intracellular signal transduction

post-translational protein modification

post-translational protein modification

histone H3S28 kinase activity

histone H3S28 kinase activity

histone H2AS1 kinase activity

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of NF-kappaB transcription factor activity

interleukin-1-mediated signaling pathway

regulation of postsynapse organization

regulation of postsynapse organization

04010

04722

05219

1429954_at Clec4a3 C-type lectin domain family 4, member a3 6 122952514, 122952643 AK014135 12

calcium ion binding

mannose binding

external side of plasma membrane

carbohydrate binding

carbohydrate binding

antifungal innate immune response

 
1455433_at Zfp942 zinc finger protein 942 17 -21926962 BM241540 14

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1434675_at Zfp763 zinc finger protein 763 17 -33016863 BB442939 15

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1454923_at Iws1 IWS1, SUPT6 interacting protein 18 32067733 BQ175964 22

molecular_function

nucleus

nucleus

nucleoplasm

chromatin remodeling

mRNA processing

RNA splicing

regulation of mRNA export from nucleus

poly(A)+ mRNA export from nucleus

regulation of mRNA processing

mRNA transport

transcription elongation-coupled chromatin remodeling

 
1450234_at Ms4a6c membrane-spanning 4-domains, subfamily A, member 6C 19 11469367, 11469367 AF237910 14

trans-Golgi network

trans-Golgi network

plasma membrane

cell surface receptor signaling pathway

membrane

 
1451649_a_at Wdr75 WD repeat domain 75 1 45795165 BC004071 24

RNA binding

nucleus

nucleolus

nucleolus

rRNA processing

small-subunit processome

ribosome biogenesis

ribosomal small subunit biogenesis

positive regulation of transcription by RNA polymerase I

positive regulation of transcription by RNA polymerase I

positive regulation of rRNA processing

positive regulation of rRNA processing

03008

1429396_at Atg16l2 autophagy related 16 like 2 7 -101289615 AK010773 26

autophagosome assembly

autophagosome assembly

autophagosome membrane

protein binding

nucleoplasm

cytoplasm

cytosol

protein transport

macroautophagy

phagophore assembly site membrane

phagophore assembly site membrane

Atg12-Atg5-Atg16 complex

Atg12-Atg5-Atg16 complex

Atg12-Atg5-Atg16 complex

negative stranded viral RNA replication

negative stranded viral RNA replication

 
1428781_at Dmkn dermokine 7 30763755, 30776404, 30763757 BI452905 23

molecular_function

extracellular region

extracellular space

extracellular space

cell differentiation

cornified envelope assembly

cornified envelope assembly

 
1436506_a_at Snhg6 small nucleolar RNA host gene 6 1 -9942024 AW988981 19

molecular_function

cellular_component

biological_process

 
1435040_at Irak3 interleukin-1 receptor-associated kinase 3 10 -120141647, -120141647 AV228493 89

nucleotide binding

magnesium ion binding

magnesium ion binding

positive regulation of cytokine production

negative regulation of cytokine-mediated signaling pathway

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein binding

ATP binding

ATP binding

nucleus

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

plasma membrane

protein phosphorylation

protein phosphorylation

apoptotic process

signal transduction

Toll signaling pathway

response to virus

positive regulation of macrophage tolerance induction

negative regulation of macrophage cytokine production

cytokine-mediated signaling pathway

protein kinase binding

negative regulation of NF-kappaB transcription factor activity

response to peptidoglycan

response to lipopolysaccharide

negative regulation of interleukin-12 production

negative regulation of interleukin-12 production

negative regulation of interleukin-12 production

negative regulation of interleukin-6 production

negative regulation of interleukin-6 production

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor production

negative regulation of tumor necrosis factor production

negative regulation of toll-like receptor signaling pathway

intracellular signal transduction

negative regulation of protein catabolic process

negative regulation of protein catabolic process

protein homodimerization activity

regulation of apoptotic process

negative regulation of protein-containing complex disassembly

regulation of protein-containing complex disassembly

response to exogenous dsRNA

negative regulation of MAP kinase activity

negative regulation of MAP kinase activity

negative regulation of MAP kinase activity

negative regulation of innate immune response

protein autophosphorylation

protein heterodimerization activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

positive regulation of NF-kappaB transcription factor activity

interleukin-1-mediated signaling pathway

interleukin-1-mediated signaling pathway

interleukin-1-mediated signaling pathway

response to interleukin-1

cellular response to lipopolysaccharide

04210

04722

1434468_at Otud4 OTU domain containing 4 8 79639675 BM238914 29

immune system process

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

nucleus

cytoplasm

cytosol

proteolysis

peptidase activity

cysteine-type peptidase activity

protein deubiquitination

hydrolase activity

negative regulation of toll-like receptor signaling pathway

negative regulation of toll-like receptor signaling pathway

negative regulation of toll-like receptor signaling pathway

innate immune response

molecular adaptor activity

K63-linked deubiquitinase activity

K63-linked deubiquitinase activity

K63-linked deubiquitinase activity

protein K63-linked deubiquitination

protein K63-linked deubiquitination

protein K48-linked deubiquitination

positive regulation of DNA demethylation

regulation of protein K48-linked deubiquitination

regulation of protein K48-linked deubiquitination

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

negative regulation of interleukin-1-mediated signaling pathway

 
1429960_at 4930438A08Rik RIKEN cDNA 4930438A08 gene 11 58274827 BB775376 8

L-amino-acid oxidase activity

cellular_component

amino acid catabolic process

polyamine oxidase activity

 
1433590_at Herc3 hect domain and RLD 3 6 58831464, 58833699, 58831464 BM239854 19

cytoplasm

ubiquitin-dependent protein catabolic process

protein ubiquitination

ubiquitin protein ligase activity

04120

1429443_at Cpne4 copine IV 9 104566700, 104569654, 104588057 AK014396 22

protein binding

calcium-dependent phospholipid binding

calcium-dependent phospholipid binding

plasma membrane

metal ion binding

cellular response to calcium ion

 
1448407_at Vsir V-set immunoregulatory receptor 10 60346850 BC003967 56

negative regulation of T cell cytokine production

protein binding

plasma membrane

plasma membrane

plasma membrane

external side of plasma membrane

positive regulation of gene expression

positive regulation of endopeptidase activity

membrane

enzyme binding

positive regulation of cell migration

BMP signaling pathway

BMP signaling pathway

positive regulation of BMP signaling pathway

positive regulation of BMP signaling pathway

zymogen activation

negative regulation of type II interferon production

negative regulation of interleukin-10 production

negative regulation of interleukin-17 production

negative regulation of tumor necrosis factor production

identical protein binding

positive regulation of regulatory T cell differentiation

negative regulation of alpha-beta T cell activation

stem cell differentiation

stem cell differentiation

regulation of immune response

endopeptidase activator activity

positive regulation of collagen catabolic process

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD8-positive, alpha-beta T cell proliferation

positive regulation of stem cell differentiation

 
1424032_at Hvcn1 hydrogen voltage-gated channel 1 5 122210286, 122209728, 122210138 BC021548 68

monoatomic ion channel activity

plasma membrane

monoatomic ion transport

response to pH

response to zinc ion

response to zinc ion

membrane

membrane

apical plasma membrane

voltage-gated monoatomic cation channel activity

voltage-gated proton channel activity

voltage-gated proton channel activity

voltage-gated proton channel activity

positive regulation of superoxide anion generation

monoatomic ion transmembrane transport

monoatomic ion channel complex

identical protein binding

identical protein binding

regulation of intracellular pH

intracellular pH elevation

transmembrane transport

regulation of acrosome reaction

cellular response to zinc ion

cellular response to pH

proton transmembrane transport

proton transmembrane transport

proton transmembrane transport

regulation of reactive oxygen species biosynthetic process

 
1428141_at Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 7 -121986721 AK004632 26

protein binding

endosome

Golgi apparatus

trans-Golgi network

trans-Golgi network

intracellular protein transport

Golgi to plasma membrane transport

protein transport

membrane

vesicle-mediated transport

clathrin-coated vesicle

small GTPase binding

small GTPase binding

protein localization to cell surface

protein localization to cell surface

phosphatidylinositol binding

Golgi to plasma membrane protein transport

ubiquitin binding

04142

1447432_s_at Zfp263 zinc finger protein 263 16 3744098 AI326880 26

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleus

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

sequence-specific DNA binding

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

metal ion binding

sequence-specific double-stranded DNA binding

 
1434949_at Armc8 armadillo repeat containing 8 9 -99478390, -99518244 BE995635 26

ubiquitin ligase complex

molecular_function

nucleus

nucleoplasm

cytoplasm

cytosol

GID complex

proteasome-mediated ubiquitin-dependent protein catabolic process

intracellular membrane-bounded organelle

 
1443609_s_at Syvn1 synovial apoptosis inhibitor 1, synoviolin 19 6047144, 6046575 C85322 87

ubiquitin ligase complex

Hrd1p ubiquitin ligase ERAD-L complex

in utero embryonic development

immature B cell differentiation

protein binding

nucleoplasm

cytoplasm

endoplasmic reticulum

smooth endoplasmic reticulum

ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process

response to unfolded protein

multicellular organism development

endomembrane system

membrane

protein ubiquitination

transferase activity

protein catabolic process

retrograde protein transport, ER to cytosol

ERAD pathway

ERAD pathway

ERAD pathway

Derlin-1 retrotranslocation complex

endoplasmic reticulum quality control compartment

endoplasmic reticulum quality control compartment

endoplasmic reticulum quality control compartment

metal ion binding

protein stabilization

protein stabilization

unfolded protein binding

protein-folding chaperone binding

ATPase binding

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

ubiquitin protein ligase activity

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

protein K48-linked ubiquitination

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

ubiquitin-specific protease binding

04120

04141

1428248_at Nfx1 nuclear transcription factor, X-box binding 1 4 40970942, 40970905 AK005038 34

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

nucleic acid binding

DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleoplasm

nucleolus

cytosol

plasma membrane

zinc ion binding

transferase activity

negative regulation of MHC class II biosynthetic process

metal ion binding

protein autoubiquitination

ubiquitin protein ligase activity

 
1428700_at P2ry13 purinergic receptor P2Y, G-protein coupled 13 3 -59207893 AK008013 44

G protein-coupled receptor activity

endoplasmic reticulum

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway

negative regulation of adenylate cyclase activity

membrane

G protein-coupled purinergic nucleotide receptor activity

G protein-coupled purinergic nucleotide receptor activity

cellular response to organic cyclic compound

04080

1436421_s_at Arpc5l actin related protein 2/3 complex, subunit 5-like 2 39008138 BB403233 25

actin binding

cytoplasm

cytoplasm

cytoskeleton

Arp2/3 protein complex

Arp2/3 protein complex

actin cytoskeleton

cell migration

regulation of actin filament polymerization

Arp2/3 complex-mediated actin nucleation

Arp2/3 complex-mediated actin nucleation

synapse

synapse

actin filament binding

glutamatergic synapse

glutamatergic synapse

04666

04810

05100

1455700_at Mterf2 mitochondrial transcription termination factor 2 10 -85119432, -85119440 BB359043 16

nucleic acid binding

DNA binding

double-stranded DNA binding

mitochondrion

mitochondrion

mitochondrial matrix

regulation of DNA-templated transcription

termination of mitochondrial transcription

mitochondrial nucleoid

 
1429201_at Cyld CYLD lysine 63 deubiquitinase 8 88697027 AK013508 137

immune system process

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

cysteine-type deubiquitinase activity

protein binding

cytoplasm

centrosome

spindle

cytosol

cytosol

cytoskeleton

microtubule

cytoplasmic microtubule

plasma membrane

proteolysis

regulation of mitotic cell cycle

regulation of mitotic cell cycle

peptidase activity

cysteine-type peptidase activity

zinc ion binding

cytoplasmic side of plasma membrane

regulation of tumor necrosis factor-mediated signaling pathway

regulation of tumor necrosis factor-mediated signaling pathway

membrane

Wnt signaling pathway

protein deubiquitination

protein deubiquitination

protein deubiquitination

hydrolase activity

protein kinase binding

midbody

negative regulation of NF-kappaB transcription factor activity

negative regulation of NF-kappaB transcription factor activity

ciliary basal body

cell projection

CD4-positive or CD8-positive, alpha-beta T cell lineage commitment

regulation of protein binding

innate immune response

regulation of B cell differentiation

positive regulation of T cell differentiation

negative regulation of JNK cascade

negative regulation of JNK cascade

metal ion binding

homeostasis of number of cells

regulation of inflammatory response

negative regulation of inflammatory response

regulation of T cell receptor signaling pathway

positive regulation of T cell receptor signaling pathway

regulation of necroptotic process

regulation of necroptotic process

K63-linked deubiquitinase activity

K63-linked deubiquitinase activity

K63-linked deubiquitinase activity

Met1-linked polyubiquitin deubiquitinase activity

proline-rich region binding

necroptotic process

necroptotic process

necroptotic process

regulation of microtubule cytoskeleton organization

protein K63-linked deubiquitination

protein K63-linked deubiquitination

negative regulation of canonical Wnt signaling pathway

ciliary tip

ripoptosome assembly involved in necroptotic process

negative regulation of non-canonical NF-kappaB signal transduction

regulation of cilium assembly

negative regulation of p38MAPK cascade

negative regulation of p38MAPK cascade

positive regulation of protein localization

protein linear deubiquitination

protein linear deubiquitination

K48-linked deubiquitinase activity

negative regulation of interleukin-18-mediated signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of extrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway

04380

04622

1451776_s_at Hopx HOP homeobox 5 -77086985, -77086985 BC024546 162

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

trophectodermal cell differentiation

trophectodermal cell differentiation

DNA binding

protein binding

nucleus

nucleus

nucleus

cytoplasm

regulation of transcription by RNA polymerase II

multicellular organism development

heart development

regulation of heart contraction

cell differentiation

histone deacetylase regulator activity

regulation of protein binding

positive regulation of skeletal muscle tissue regeneration

negative regulation of cell differentiation

lung alveolus development

chaperone-mediated protein complex assembly

positive regulation of striated muscle cell differentiation

positive regulation of gap junction assembly

 
1453485_s_at Mettl23 methyltransferase like 23 11 116843514 AK016897 18

female pronucleus

male pronucleus

protein binding

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytoplasm

chromatin organization

multicellular organism development

methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity

protein-lysine N-methyltransferase activity

transferase activity

peptidyl-lysine methylation

heat shock protein binding

methylation

protein-containing complex

protein-arginine omega-N asymmetric methyltransferase activity

histone H3R17 methyltransferase activity

histone methyltransferase activity

epigenetic programming in the zygotic pronuclei

epigenetic programing of male pronucleus

positive regulation of transcription by RNA polymerase II

cognition

DNA-binding transcription factor binding

 
1428663_at Sgms2 sphingomyelin synthase 2 3 -131318985, -131318985, -131318985, -131318985, -131318985, -131318985 AK017223 71

Golgi membrane

Golgi membrane

ceramide phosphoethanolamine synthase activity

nucleoplasm

Golgi apparatus

plasma membrane

plasma membrane

lipid metabolic process

sphingolipid metabolic process

sphingomyelin biosynthetic process

sphingomyelin biosynthetic process

sphingomyelin biosynthetic process

sphingomyelin biosynthetic process

membrane

kinase activity

phosphorylation

transferase activity

phosphotransferase activity, for other substituted phosphate groups

regulation of bone mineralization

sphingomyelin synthase activity

sphingomyelin synthase activity

sphingomyelin synthase activity

sphingomyelin synthase activity

ceramide biosynthetic process

ceramide biosynthetic process

ceramide cholinephosphotransferase activity

ceramide cholinephosphotransferase activity

ceramide cholinephosphotransferase activity

ceramide phosphoethanolamine biosynthetic process

00600

01100

1430005_a_at Batf2 basic leucine zipper transcription factor, ATF-like 2 19 6164438 AK016990 32

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

DNA-binding transcription factor activity

nucleus

nucleus

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cell differentiation

defense response to protozoan

myeloid dendritic cell differentiation

RNA polymerase II transcription regulator complex

 
1447522_s_at Tnks2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 19 36834231 AI662480 33

protein polyubiquitination

pericentriolar material

telomere maintenance

chromosome, telomeric region

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

nucleus

nucleus

nuclear envelope

chromosome

cytoplasm

cytoplasm

Golgi apparatus

membrane

Wnt signaling pathway

transferase activity

glycosyltransferase activity

nucleotidyltransferase activity

enzyme binding

multicellular organism growth

regulation of multicellular organism growth

metal ion binding

perinuclear region of cytoplasm

protein localization to chromosome, telomeric region

protein localization to chromosome, telomeric region

protein poly-ADP-ribosylation

protein auto-ADP-ribosylation

positive regulation of canonical Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of telomere capping

positive regulation of telomere capping

negative regulation of telomere maintenance via telomere lengthening

NAD+-protein ADP-ribosyltransferase activity

 
1429570_at Mlkl mixed lineage kinase domain-like 8 -111311797 AK018636 217

nucleotide binding

protein binding

ATP binding

ATP binding

nucleus

cytoplasm

cytoplasm

cytosol

plasma membrane

plasma membrane

protein phosphorylation

cell surface receptor signaling pathway

programmed cell death

membrane

protein kinase binding

cell junction

identical protein binding

protein-containing complex binding

defense response to virus

defense response to virus

protein homotrimerization

necroptotic process

necroptotic process

necroptotic signaling pathway

necroptotic signaling pathway

execution phase of necroptosis

execution phase of necroptosis

execution phase of necroptosis

 
1430143_at 4930426D05Rik RIKEN cDNA 4930426D05 gene 18 21651564 AK015205 11

molecular_function

cellular_component

biological_process

 
1433756_at S100pbp S100P binding protein 4 -129148001, -129148001 BI452674 16

molecular_function

nucleus

nucleus

cytosol

cytosol

biological_process

nuclear speck

calcium-dependent protein binding

calcium-dependent protein binding

 
1429319_at Rhoh ras homolog family member H 5 65861219, 65863583 BM243660 35

nucleotide binding

immunological synapse

GTPase activity

GTPase activity

protein binding

GTP binding

GTP binding

cytoplasm

cytoplasm

plasma membrane

plasma membrane

actin filament organization

signal transduction

small GTPase-mediated signal transduction

membrane

kinase inhibitor activity

protein kinase binding

T cell differentiation

negative regulation of canonical NF-kappaB signal transduction

mast cell activation

positive regulation of T cell differentiation

04670

1425294_at Slamf8 SLAM family member 8 1 -172581376 BC024587 18

leukocyte chemotaxis involved in inflammatory response

leukocyte chemotaxis involved in inflammatory response

B-1 B cell lineage commitment

negative regulation of macrophage chemotaxis

membrane

regulation of NAD(P)H oxidase activity

signaling receptor activity

signaling receptor activity

defense response to bacterium

identical protein binding

regulation of kinase activity

regulation of B cell differentiation

regulation of B cell differentiation

negative regulation of respiratory burst involved in inflammatory response

cellular response to xenobiotic stimulus

negative regulation of monocyte chemotaxis

phagosome acidification

negative regulation of neutrophil migration

negative regulation of dendritic cell chemotaxis

 
1435465_at Kbtbd11 kelch repeat and BTB (POZ) domain containing 11 8 15011024 AW049906 22

molecular_function

cellular_component

biological_process

 
1455169_at Rab11fip2 RAB11 family interacting protein 2 (class I) 19 -59902883, -59902883 BG076094 25

phagocytic cup

phagocytic cup

nucleoplasm

endosome

endosome

plasma membrane

phagocytosis

protein transport

membrane

protein kinase binding

establishment of cell polarity

small GTPase binding

TRAM-dependent toll-like receptor 4 signaling pathway

insulin secretion involved in cellular response to glucose stimulus

identical protein binding

protein homodimerization activity

intracellular membrane-bounded organelle

positive regulation of GTPase activity

regulated exocytosis

regulated exocytosis

positive regulation of protein localization to plasma membrane

04144

1433514_at Etnk1 ethanolamine kinase 1 6 143167229 BG066916 35

nucleotide binding

ethanolamine kinase activity

ethanolamine kinase activity

ATP binding

cytoplasm

cytoplasm

lipid metabolic process

phosphatidylethanolamine biosynthetic process

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process

kinase activity

phosphorylation

transferase activity

00564

01100

1453266_at Zbtb4 zinc finger and BTB domain containing 4 11 69765911 BB767069 25

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

nucleus

nucleoplasm

chromosome

cytosol

regulation of DNA-templated transcription

DNA damage response

methyl-CpG binding

methyl-CpNpG binding

nuclear body

protein kinase binding

protein homodimerization activity

sequence-specific DNA binding

negative regulation of DNA-templated transcription

metal ion binding

 
1424713_at Calml4 calmodulin-like 4 9 62858103 AY061807 20

calcium ion binding

calcium ion binding

microvillus

enzyme regulator activity

myosin head/neck binding

brush border assembly

 
1449303_at Sesn3 sestrin 3 9 14276300 NM_030261 34

protein binding

nucleus

cytoplasm

positive regulation of macroautophagy

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor

TORC2 complex

response to insulin

response to insulin

cellular response to amino acid starvation

TORC2 signaling

cellular response to glucose starvation

glucose homeostasis

glucose homeostasis

regulation of insulin receptor signaling pathway

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

GATOR2 complex

leucine binding

cellular response to amino acid stimulus

cellular response to leucine

regulation of response to reactive oxygen species

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

negative regulation of TORC1 signaling

cellular response to leucine starvation

04115

1428651_at Klhl24 kelch-like 24 16 20097553 AK004187 20

cytoplasm

adherens junction

protein ubiquitination

desmosome

Cul3-RING ubiquitin ligase complex

cell projection

intermediate filament organization

protein autoubiquitination

anchoring junction

regulation of kainate selective glutamate receptor activity

 
1435374_at Cdyl2 chromodomain protein, Y chromosome-like 2 8 -116568723 BG071670 20

transcription corepressor activity

nucleus

nucleus

methylated histone binding

 
1427428_at Clec4g C-type lectin domain family 4, member g 8 -3716070 BC025069 24

virus receptor activity

T cell mediated immunity

negative regulation of T cell mediated immunity

negative regulation of T cell mediated immunity

protein binding

mannose binding

plasma membrane

plasma membrane

immune response

external side of plasma membrane

membrane

carbohydrate binding

carbohydrate binding

polysaccharide binding

immature T cell proliferation in thymus

negative regulation of immature T cell proliferation in thymus

negative regulation of T cell proliferation

biological process involved in interspecies interaction between organisms

alpha-beta T cell proliferation

negative regulation of alpha-beta T cell proliferation

symbiont entry into host cell

fructose binding

carbohydrate derivative binding

virus coreceptor activity

positive regulation of viral life cycle

 
1427902_at Srrm2 serine/arginine repetitive matrix 2 17 23803224, 23803186 BQ176063 36

mRNA splicing, via spliceosome

mRNA binding

nucleus

spliceosomal complex

mRNA processing

RNA splicing

Cajal body

nuclear speck

C2H2 zinc finger domain binding

U2-type precatalytic spliceosome

U2-type catalytic step 2 spliceosome

catalytic step 2 spliceosome

 
1428694_at Mir17hg Mir17 host gene (non-protein coding) 14 115044389 AK017164 35

molecular_function

cellular_component

response to wounding

 
1434236_at Zdhhc20 zinc finger, DHHC domain containing 20 14 -57832701 BB667600 21

Golgi membrane

cytoplasm

endoplasmic reticulum

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

plasma membrane

protein targeting to membrane

zinc ion binding

membrane

synaptic vesicle maturation

palmitoyltransferase activity

transferase activity

acyltransferase activity

peptidyl-L-cysteine S-palmitoylation

peptidyl-L-cysteine S-palmitoylation

protein palmitoylation

protein-cysteine S-palmitoyltransferase activity

protein-cysteine S-palmitoyltransferase activity

intracellular membrane-bounded organelle

positive regulation by host of viral process

metal ion binding

 
1452970_at Zmym2 zinc finger, MYM-type 2 14 56886602, 56886602, 56886842 AK017929 42

protein binding

nucleus

zinc ion binding

PML body

ubiquitin conjugating enzyme binding

negative regulation of DNA-templated transcription

metal ion binding

 
1429672_at 5830407E08Rik RIKEN cDNA 5830407E08 gene 2   BB234837 7

molecular_function

cellular_component

biological_process

 
1436491_at Gm11346 X-linked lymphocyte-regulated 5 pseudogene 13 -24598124 BB387637 8    
1441317_x_at Jakmip1 janus kinase and microtubule interacting protein 1 5 37050856, 37085235 BB316060 21

RNA binding

cytoplasm

cytoskeleton

microtubule

microtubule binding

protein transport

microtubule cytoskeleton

membrane

kinesin binding

kinase binding

GABA receptor binding

GABA receptor binding

cognition

ribonucleoprotein complex

 
1428457_at Ttpal tocopherol (alpha) transfer protein-like 2 163602313, 163607211 AK014262 15

molecular_function

biological_process

phosphatidylinositol bisphosphate binding

 
1435959_at Arhgap15 Rho GTPase activating protein 15 2 43787354, 43748823, 43748823 BM246535 24

GTPase activator activity

nucleoplasm

cytoplasm

cytoplasm

plasma membrane

signal transduction

regulation of cell shape

membrane

regulation of GTPase activity

 
1428696_at Rftn1 raftlin lipid raft linker 1 17 -49993306 AK009372 20

membrane raft assembly

T cell antigen processing and presentation

double-stranded RNA binding

cytoplasm

endosome

plasma membrane

membrane

protein transport into membrane raft

positive regulation of interleukin-17 production

protein-containing complex

dsRNA transport

toll-like receptor 3 signaling pathway

positive regulation of growth rate

response to exogenous dsRNA

membrane raft

T cell receptor signaling pathway

B cell receptor signaling pathway

protein localization to membrane raft

 
1456542_s_at Qrsl1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 10 -43874189 BB517855 19

nucleotide binding

catalytic activity

ATP binding

mitochondrion

mitochondrion

mitochondrion

translation

ligase activity

glutamyl-tRNA(Gln) amidotransferase complex

glutamyl-tRNA(Gln) amidotransferase complex

regulation of protein stability

mitochondrial translation

mitochondrial translation

mitochondrial translation

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity

glutaminyl-tRNAGln biosynthesis via transamidation

glutaminyl-tRNAGln biosynthesis via transamidation

 
1453568_at Dapl1 death associated protein-like 1 2 59484652 BE633038 20

cellular_component

apoptotic process

negative regulation of autophagy

cell differentiation

cellular response to amino acid starvation

death domain binding

apoptotic signaling pathway

negative regulation of CD8-positive, alpha-beta T cell activation

 
1435274_at Spopl speckle-type BTB/POZ protein-like 2 -23510053 BQ175341 26

nucleus

nucleus

cytoplasm

regulation of proteolysis

negative regulation of protein ubiquitination

Cul3-RING ubiquitin ligase complex

ubiquitin protein ligase binding

proteasome-mediated ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

 
1417290_at Lrg1 leucine-rich alpha-2-glycoprotein 1 17 -56119677 NM_029796 52

positive regulation of endothelial cell proliferation

positive regulation of endothelial cell proliferation

type II transforming growth factor beta receptor binding

transforming growth factor beta receptor binding

voltage-gated potassium channel activity

extracellular space

extracellular space

voltage-gated potassium channel complex

response to bacterium

positive regulation of epithelial to mesenchymal transition

positive regulation of keratinocyte proliferation

positive regulation of keratinocyte proliferation

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transforming growth factor beta receptor signaling pathway

type I transforming growth factor beta receptor binding

wound healing, spreading of epidermal cells

wound healing, spreading of epidermal cells

intracellular membrane-bounded organelle

transmembrane transporter binding

positive regulation of angiogenesis

positive regulation of angiogenesis

positive regulation of angiogenesis

positive regulation of angiogenesis

brown fat cell differentiation

keratinocyte migration

keratinocyte migration

positive regulation of epithelial cell proliferation involved in wound healing

positive regulation of epithelial cell proliferation involved in wound healing

leukocyte adhesion to vascular endothelial cell

leukocyte adhesion to vascular endothelial cell

potassium channel activator activity

 
1428207_at Bcl7a B cell CLL/lymphoma 7A 5 123344447 AK014498 35

chromatin

molecular_function

chromatin remodeling

regulation of transcription by RNA polymerase II

positive regulation of cell population proliferation

SWI/SNF complex

SWI/SNF complex

SWI/SNF complex

regulation of mitotic metaphase/anaphase transition

negative regulation of cell differentiation

regulation of G0 to G1 transition

GBAF complex

positive regulation of stem cell population maintenance

regulation of G1/S transition of mitotic cell cycle

positive regulation of double-strand break repair

regulation of nucleotide-excision repair

 
1428531_at Ints7 integrator complex subunit 7 1 191575635 BB457797 26

DNA damage checkpoint signaling

molecular_function

nucleus

chromosome

cytoplasm

DNA damage response

snRNA processing

nuclear body

integrator complex

integrator complex

snRNA 3'-end processing

cellular response to ionizing radiation

 
1426978_at Klhl2 kelch-like 2, Mayven 8 -64739674 AW682368 23

stress fiber

actin binding

cytoplasm

cytoskeleton

actin cytoskeleton

protein ubiquitination

Cul3-RING ubiquitin ligase complex

identical protein binding

protein homodimerization activity

cell projection

ubiquitin ligase-substrate adaptor activity

 
1454967_at Crebrf CREB3 regulatory factor 17 26715649 BM246522 26

negative regulation of transcription by RNA polymerase II

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription activator activity, RNA polymerase II-specific

DNA-binding transcription factor activity

nucleus

nucleus

nucleoplasm

cytoplasm

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

response to unfolded protein

nuclear body

nuclear body

response to endoplasmic reticulum stress

maternal behavior

maternal behavior

positive regulation of protein catabolic process

positive regulation of transcription by RNA polymerase II

negative regulation of endoplasmic reticulum unfolded protein response

negative regulation of glucocorticoid mediated signaling pathway

negative regulation of glucocorticoid mediated signaling pathway

positive regulation of prolactin signaling pathway

 
1428407_at Hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 13 -58125878 BG073366 28

nucleic acid binding

RNA binding

mRNA binding

nucleus

nucleus

nucleoplasm

inflammatory response

protein kinase binding

response to lipopolysaccharide

mRNA 3'-UTR AU-rich region binding

mRNA 3'-UTR AU-rich region binding

synapse

synapse

3'-UTR-mediated mRNA stabilization

3'-UTR-mediated mRNA stabilization

ribonucleoprotein complex

 
1434084_at Zfp266 zinc finger protein 266 9 -20495068 BF142017 22

RNA polymerase II transcription regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

nucleus

regulation of transcription by RNA polymerase II

 
1451574_at Bcl9 B cell CLL/lymphoma 9 3 -97203661 BC019641 45

transcription coactivator activity

nucleus

cytoplasm

Golgi apparatus

Golgi apparatus

cis-Golgi network

cis-Golgi network

transcription by RNA polymerase II

beta-catenin binding

beta-catenin binding

myotube differentiation involved in skeletal muscle regeneration

Wnt signaling pathway

sarcoplasm

somatic stem cell population maintenance

skeletal muscle cell differentiation

myoblast differentiation

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

canonical Wnt signaling pathway

canonical Wnt signaling pathway

beta-catenin-TCF complex

beta-catenin-TCF complex

 
1427532_at Trat1 T cell receptor associated transmembrane adaptor 1 16 -48730773 BB622792 15

negative regulation of receptor recycling

negative regulation of receptor recycling

adaptive immune response

immune system process

molecular_function

plasma membrane

membrane

centriolar satellite

T cell receptor complex

T cell receptor complex

positive regulation of calcium-mediated signaling

positive regulation of T cell receptor signaling pathway

positive regulation of T cell receptor signaling pathway

negative regulation of transport

mitotic spindle

 
1434105_at Epm2aip1 EPM2A interacting protein 1 9 111271844 AV340515 23

protein binding

nucleus

cytoplasm

endoplasmic reticulum

glycogen biosynthetic process

response to insulin

identical protein binding

positive regulation of glycogen biosynthetic process

positive regulation of glycogen biosynthetic process

cytoplasmic side of endoplasmic reticulum membrane

positive regulation of glycogen (starch) synthase activity

 
1429088_at Lbh limb-bud and heart 17 72918304 AK007400 32

nucleus

nucleus

nucleus

cytoplasm

regulation of DNA-templated transcription

multicellular organism development

regulation of gene expression

mammary gland development

protein-containing complex

negative regulation of intracellular estrogen receptor signaling pathway

regulation of MAPK cascade

negative regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

mammary gland epithelial cell differentiation

positive regulation of somatic stem cell population maintenance

positive regulation of somatic stem cell division

positive regulation of mammary stem cell proliferation

negative regulation of stem cell differentiation

 
1421144_at Rpgrip1 retinitis pigmentosa GTPase regulator interacting protein 1 14 52110902 NM_023879 48

protein binding

cilium

axoneme

visual perception

thromboxane A2 receptor binding

photoreceptor connecting cilium

photoreceptor connecting cilium

eye photoreceptor cell development

cell projection

neuron projection

retinal rod cell development

response to stimulus

retina development in camera-type eye

neural precursor cell proliferation

non-motile cilium

photoreceptor distal connecting cilium

non-motile cilium assembly

 
1438018_at Hook1 hook microtubule tethering protein 1 4 95967378 BB463518 34

actin binding

protein binding

cytoplasm

cytoplasm

centrosome

cytoskeleton

microtubule

Golgi organization

endosome organization

lysosome organization

multicellular organism development

spermatogenesis

spermatid development

microtubule binding

microtubule binding

microtubule binding

endosome to lysosome transport

protein transport

microtubule cytoskeleton

cell differentiation

cytoskeleton-dependent intracellular transport

cytoskeleton-dependent intracellular transport

HOPS complex

cytoplasmic microtubule organization

cytoplasmic microtubule organization

identical protein binding

protein homodimerization activity

early endosome to late endosome transport

dynein light intermediate chain binding

FHF complex

manchette assembly

protein localization to perinuclear region of cytoplasm

 
1424256_at Rdh12 retinol dehydrogenase 12 12 79208912 BC016204 29

photoreceptor inner segment

NAD-retinol dehydrogenase activity

NAD-retinol dehydrogenase activity

lipid metabolic process

visual perception

visual perception

oxidoreductase activity

retinol metabolic process

retinol metabolic process

response to stimulus

NADP-retinol dehydrogenase activity

cellular detoxification of aldehyde

cellular detoxification of aldehyde

00830

01100

1428789_at Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 1 -156804165, -156804165 AK008856 30

guanyl-nucleotide exchange factor activity

guanyl-nucleotide exchange factor activity

cytoplasm

plasma membrane

plasma membrane

small GTPase-mediated signal transduction

Ras protein signal transduction

membrane

positive regulation of GTPase activity

 
1428004_at Snrnp25 small nuclear ribonucleoprotein 25 (U11/U12) 11 32205414 BC028766 17

mRNA splicing, via spliceosome

molecular_function

nucleus

nucleoplasm

spliceosomal complex

U12-type spliceosomal complex

U12-type spliceosomal complex

cytosol

mRNA processing

biological_process

RNA splicing

intercellular bridge

 
1422952_at Sapcd1 suppressor APC domain containing 1 17 -35025972 NM_023893 16

molecular_function

cellular_component

biological_process

 
1448618_at Mvp major vault protein 7 -126986859 NM_080638 40

nucleus

nucleus

cytoplasm

cytoplasm

cytosol

cytoskeleton

cell population proliferation

protein kinase binding

protein phosphatase binding

negative regulation of protein autophosphorylation

ERBB signaling pathway

negative regulation of epidermal growth factor receptor signaling pathway

identical protein binding

perinuclear region of cytoplasm

negative regulation of protein tyrosine kinase activity

protein activation cascade

ribonucleoprotein complex

 
1427469_at Helz helicase with zinc finger domain 11 107547932 BI251153 28

nucleotide binding

RNA binding

helicase activity

protein binding

ATP binding

nucleus

cytosol

hydrolase activity

regulatory ncRNA-mediated post-transcriptional gene silencing

P granule

metal ion binding

 
1437249_at Skap1 src family associated phosphoprotein 1 11 96464590 BG075562 28

immunological synapse

positive regulation of cell-matrix adhesion

adaptive immune response

immune system process

positive regulation of adaptive immune response

protein binding

nucleus

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

plasma membrane

plasma membrane

plasma membrane

cell-cell junction

membrane

protein kinase binding

protein phosphatase binding

protein-containing complex

positive regulation of integrin activation

positive regulation of cell-cell adhesion mediated by integrin

positive regulation of heterotypic cell-cell adhesion

T cell receptor complex

SH2 domain binding

plasma membrane raft

protein-containing complex binding

positive regulation of cell adhesion

positive regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

T cell receptor signaling pathway

protein localization to plasma membrane

positive regulation of leukocyte cell-cell adhesion

 
1435698_at Rictor RPTOR independent companion of MTOR, complex 2 15 6708380 BQ176694 280

regulation of protein phosphorylation

positive regulation of endothelial cell proliferation

protein binding

cytoskeleton organization

multicellular organism development

embryo development ending in birth or egg hatching

regulation of gene expression

peptidyl-serine phosphorylation

protein kinase binding

actin cytoskeleton organization

positive regulation of cell growth

positive regulation of actin filament polymerization

cellular response to nutrient levels

TOR signaling

TORC2 complex

TORC2 complex

TORC2 complex

positive regulation of TOR signaling

regulation of actin cytoskeleton organization

regulation of peptidyl-serine phosphorylation

TORC2 signaling

TORC2 signaling

regulation of phosphorylation

ribosome binding

negative regulation of apoptotic process

regulation of GTPase activity

protein serine/threonine kinase activator activity

protein serine/threonine kinase activator activity

regulation of inflammatory response

positive regulation of peptidyl-tyrosine phosphorylation

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

molecular adaptor activity

regulation of establishment of cell polarity

04150

1429612_at Eml4 echinoderm microtubule associated protein like 4 17 83350930, 83350940 AK019611 26

microtubule cytoskeleton organization

cytoplasm

microtubule organizing center

cytosol

cytoskeleton

microtubule

negative regulation of microtubule depolymerization

cell cycle

mitotic metaphase chromosome alignment

microtubule binding

attachment of spindle microtubules to kinetochore

microtubule cytoskeleton

microtubule cytoskeleton

midbody

alpha-tubulin binding

protein self-association

beta-tubulin binding

cell division

mitotic spindle

mitotic spindle

 
1452815_at P2ry10 purinergic receptor P2Y, G-protein coupled 10 X 107088491, 107089332 AK020001 15

G protein-coupled receptor activity

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

membrane

positive regulation of Rho protein signal transduction

04080

1434758_at Crispld2 cysteine-rich secretory protein LCCL domain containing 2 8 119992437 BB745401 25

glycosaminoglycan binding

glycosaminoglycan binding

extracellular region

extracellular space

heparin binding

transport vesicle

extracellular matrix organization

extracellular matrix

face morphogenesis

 
1448376_at Wrnip1 Werner helicase interacting protein 1 13 32802029 NM_030215 28

nucleotide binding

DNA synthesis involved in DNA repair

DNA synthesis involved in DNA repair

chromosome, telomeric region

immune system process

DNA binding

protein binding

ATP binding

nucleus

nucleus

nucleus

cytoplasm

DNA replication

DNA-templated DNA replication

DNA repair

DNA damage response

enzyme activator activity

hydrolase activity

ATP hydrolysis activity

single-stranded DNA helicase activity

regulation of DNA-templated DNA replication initiation

identical protein binding

innate immune response

metal ion binding

perinuclear region of cytoplasm

 
1416897_at Parp9 poly (ADP-ribose) polymerase family, member 9 16 35938469 NM_030253 24

DNA damage checkpoint signaling

negative regulation of transcription by RNA polymerase II

positive regulation of defense response to virus by host

immune system process

transcription corepressor activity

transcription corepressor activity

NAD+ ADP-ribosyltransferase activity

NAD+ ADP-ribosyltransferase activity

enzyme inhibitor activity

nucleus

nucleus

nucleoplasm

cytoplasm

cytoplasm

mitochondrion

cytosol

DNA repair

double-strand break repair

DNA damage response

post-transcriptional regulation of gene expression

negative regulation of gene expression

negative regulation of gene expression

transferase activity

glycosyltransferase activity

nucleotidyltransferase activity

enzyme binding

protein-containing complex

positive regulation of chromatin binding

histone binding

positive regulation of tyrosine phosphorylation of STAT protein

negative regulation of catalytic activity

ubiquitin-like protein ligase binding

ubiquitin-like protein ligase binding

innate immune response

positive regulation of DNA-templated transcription

defense response to virus

regulation of response to type II interferon

positive regulation of type II interferon-mediated signaling pathway

positive regulation of type II interferon-mediated signaling pathway

positive regulation of type II interferon-mediated signaling pathway

protein poly-ADP-ribosylation

ADP-D-ribose binding

site of DNA damage

STAT family protein binding

NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity

positive regulation of protein localization to nucleus

NAD+-protein ADP-ribosyltransferase activity

 
1439610_at Rab27b RAB27B, member RAS oncogene family 18 -69979130, -69979130 BE980253 68

nucleotide binding

GTPase activity

GTPase activity

G protein activity

protein binding

GTP binding

GTP binding

GTP binding

endosome

late endosome

Golgi apparatus

Golgi apparatus

Golgi stack

exocytosis

membrane

apical plasma membrane

apical plasma membrane

hydrolase activity

regulation of exocytosis

GDP binding

protein domain specific binding

trans-Golgi network transport vesicle

secretory granule

synaptic vesicle membrane

myosin V binding

multivesicular body membrane

melanosome

melanosome

zymogen granule membrane

positive regulation of exocytosis

positive regulation of exocytosis

synaptic vesicle endocytosis

exocytic vesicle

multivesicular body sorting pathway

anterograde axonal protein transport

04972

1421408_at Igsf6 immunoglobulin superfamily, member 6 7 -121064066 NM_030691 13

molecular_function

cellular_component

biological_process

membrane

 
1446957_s_at N4bp1 NEDD4 binding protein 1 8 -86841138 C81621 30

negative regulation of cytokine production

immune system process

RNA binding

mRNA binding

nuclease activity

RNA nuclease activity

protein binding

nucleus

nucleus

nucleolus

cytoplasm

cytosol

PML body

PML body

hydrolase activity

negative regulation of protein ubiquitination

negative regulation of protein ubiquitination

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

cellular response to UV

cellular response to UV

ubiquitin binding

negative regulation of viral genome replication

innate immune response

regulation of innate immune response

 
1417688_at Fam20c FAM20C, golgi associated secretory pathway kinase 5 138755080 NM_030565 53

Golgi membrane

nucleotide binding

skeletal system development

protease binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

calcium ion binding

ATP binding

extracellular region

extracellular space

extracellular space

extracellular space

nucleoplasm

cytoplasm

endoplasmic reticulum

Golgi apparatus

Golgi apparatus

protein phosphorylation

protein phosphorylation

protein phosphorylation

membrane

kinase activity

phosphorylation

transferase activity

manganese ion binding

positive regulation of bone mineralization

biomineral tissue development

osteoclast maturation

regulation of fibroblast growth factor receptor signaling pathway

protein self-association

positive regulation of osteoblast differentiation

protein autophosphorylation

metal ion binding

regulation of phosphorus metabolic process

enamel mineralization

enamel mineralization

odontoblast differentiation

dentinogenesis

 
1451426_at Dhx58 DExH-box helicase 58 11 -100694883 AF316999 39

nucleotide binding

immune system process

cytoplasmic pattern recognition receptor signaling pathway

DNA binding

RNA binding

RNA helicase activity

double-stranded RNA binding

double-stranded RNA binding

double-stranded RNA binding

single-stranded RNA binding

single-stranded RNA binding

helicase activity

ATP binding

cytoplasm

cytoplasm

zinc ion binding

zinc ion binding

response to virus

response to bacterium

hydrolase activity

ATP hydrolysis activity

negative regulation of type I interferon production

negative regulation of type I interferon production

positive regulation of type I interferon production

negative regulation of MDA-5 signaling pathway

negative regulation of RIG-I signaling pathway

negative regulation of RIG-I signaling pathway

negative regulation of RIG-I signaling pathway

innate immune response

regulation of innate immune response

negative regulation of innate immune response

negative regulation of innate immune response

metal ion binding

defense response to virus

antiviral innate immune response

positive regulation of MDA-5 signaling pathway

positive regulation of RIG-I signaling pathway

04622

1417460_at Ifitm2 interferon induced transmembrane protein 2 7 -140954838 NM_030694 34

immune system process

molecular_function

lysosome

lysosomal membrane

endosome

plasma membrane

plasma membrane

response to virus

membrane

early endosome membrane

late endosome membrane

protein-containing complex

response to type II interferon

response to interferon-alpha

response to interferon-beta

negative regulation of viral genome replication

innate immune response

negative regulation of viral entry into host cell

negative regulation of viral entry into host cell

defense response to virus

defense response to virus

defense response to virus

type I interferon-mediated signaling pathway

 
1449005_at Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 11 120948483, 120949066 NM_030696 79

plasma membrane

plasma membrane

plasma membrane

monocarboxylic acid transmembrane transporter activity

lactate transmembrane transporter activity

symporter activity

lactate:proton symporter activity

lactate:proton symporter activity

monocarboxylic acid transport

monocarboxylic acid transport

membrane

basolateral plasma membrane

basolateral plasma membrane

apical plasma membrane

lateral plasma membrane

transmembrane transporter activity

protein catabolic process

nuclear membrane

lactate transmembrane transport

plasma membrane lactate transport

pyruvate catabolic process

synapse

pyruvate transmembrane transporter activity

transmembrane transport

parallel fiber to Purkinje cell synapse

postsynaptic density membrane

pyruvate transmembrane transport

 
1420591_at Gpr84 G protein-coupled receptor 84 15 -103308234 NM_030720 33

urotensin II receptor activity

G protein-coupled receptor activity

plasma membrane

signal transduction

G protein-coupled receptor signaling pathway

neuropeptide signaling pathway

membrane

receptor complex

 
1456054_a_at Pum1 pumilio RNA-binding family member 1 4 130663320, 130663356 BB314559 61

P-body

RNA binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

mRNA 3'-UTR binding

nucleoplasm

cytoplasm

cytoplasm

cytosol

cytosol

regulation of translation

spermatogenesis

adult locomotory behavior

cytoplasmic stress granule

post-transcriptional regulation of gene expression

post-transcriptional regulation of gene expression

post-transcriptional gene silencing

cell differentiation

axon

miRNA processing

miRNA processing

miRNA binding

regulation of mRNA stability

regulation of mRNA stability

stem cell differentiation

regulation of cell cycle

regulation of chromosome segregation

mRNA destabilization

positive regulation of RIG-I signaling pathway

positive regulation of miRNA-mediated gene silencing

 
1421870_at Trim44 tripartite motif-containing 44 2 -102300118 NM_020267 22

positive regulation of cytokine-mediated signaling pathway

positive regulation of defense response to virus by host

cytoplasm

cytoplasm

zinc ion binding

regulation of gene expression

regulation of gene expression

protein ubiquitination

positive regulation of DNA-templated transcription

metal ion binding

protein stabilization

protein stabilization

ubiquitin protein ligase activity

negative regulation of protein K48-linked ubiquitination

positive regulation of non-canonical NF-kappaB signal transduction

 
1450350_a_at Jdp2 Jun dimerization protein 2 12 85599415, 85600017, 85599104 NM_030887 44

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

RNA polymerase II cis-regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA-binding transcription repressor activity, RNA polymerase II-specific

DNA binding

chromatin binding

double-stranded DNA binding

DNA-binding transcription factor activity

protein binding

nucleus

nucleus

nucleus

chromatin remodeling

regulation of DNA-templated transcription

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cAMP response element binding

protein homodimerization activity

histone deacetylase binding

leucine zipper domain binding

protein-containing complex binding

fat cell differentiation

negative regulation of fat cell differentiation

protein heterodimerization activity

RNA polymerase II transcription regulator complex

histone chaperone activity

sequence-specific double-stranded DNA binding

 
1440818_s_at Sf3b1 splicing factor 3b, subunit 1 1 -54985169 BB161546 67

spliceosomal complex assembly

spliceosomal complex assembly

mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

chromatin

blastocyst formation

chromatin binding

RNA binding

mRNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleus

spliceosomal complex

U2-type spliceosomal complex

U2 snRNP

U2 snRNP

U12-type spliceosomal complex

U12-type spliceosomal complex

nucleolus

chromatin remodeling

mRNA processing

RNA splicing

anterior/posterior pattern specification

nuclear matrix

nuclear speck

small nuclear ribonucleoprotein complex

U11/U12 snRNP

positive regulation of transcription by RNA polymerase I

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase III

U2-type prespliceosome

U2-type precatalytic spliceosome

catalytic step 2 spliceosome

catalytic step 2 spliceosome

B-WICH complex

splicing factor binding

03040

1421463_at Siglece sialic acid binding Ig-like lectin E 7 -43651069 AF329269 55

protein binding

plasma membrane

phagocytosis, engulfment

inflammatory response

cell adhesion

cell adhesion

external side of plasma membrane

membrane

carbohydrate binding

sialic acid binding

sialic acid binding

monosaccharide binding

negative regulation of inflammatory response

negative regulation of phagocytosis, engulfment

negative regulation of phagocytosis, engulfment

 
1449220_at Gimap3 GTPase, IMAP family member 3 6 -48764463 NM_031247 20

mitochondrial genome maintenance

nucleotide binding

temperature homeostasis

positive regulation of natural killer cell cytokine production

positive regulation of humoral immune response mediated by circulating immunoglobulin

protein binding

GTP binding

mitochondrion

mitochondrial outer membrane

endoplasmic reticulum

positive regulation of calcium ion transport into cytosol

membrane

negative regulation of type II interferon production

positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation

myeloid dendritic cell differentiation

T cell homeostasis

negative regulation of apoptotic process

negative regulation of nitric oxide biosynthetic process

positive regulation of gamma-delta T cell differentiation

positive regulation of membrane potential

positive regulation of natural killer cell mediated cytotoxicity

regulation of mitochondrial membrane permeability

negative regulation of T cell activation

negative regulation of lipid catabolic process

 
1438069_a_at Rbm5 RNA binding motif protein 5 9 -107740494 BE446879 34

spliceosomal complex assembly

regulation of alternative mRNA splicing, via spliceosome

mRNA splicing, via spliceosome

nucleic acid binding

RNA binding

RNA binding

mRNA binding

nucleus

nucleus

nucleoplasm

spliceosomal complex

mRNA processing

apoptotic process

RNA splicing

positive regulation of apoptotic process

metal ion binding

 
1437752_at Lin28a lin-28 homolog A 4 -134003329 BB706377 153

P-body

G-quadruplex RNA binding

nucleic acid binding

RNA binding

RNA binding

mRNA binding

mRNA binding

protein binding

nucleus

nucleus

nucleolus

nucleolus

cytoplasm

cytoplasm

cytoplasm

endoplasmic reticulum

rough endoplasmic reticulum

cytosol

germ cell development

germ cell development

zinc ion binding

cytoplasmic stress granule

miRNA metabolic process

miRNA catabolic process

miRNA catabolic process

miRNA catabolic process

negative regulation of translation

stem cell population maintenance

regulatory ncRNA-mediated gene silencing

pre-miRNA processing

pre-miRNA processing

pre-miRNA processing

pre-miRNA processing

RNA 3'-end processing

translation initiation factor binding

positive regulation of TOR signaling

miRNA binding

positive regulation of neuron differentiation

negative regulation of glial cell differentiation

positive regulation of translation

metal ion binding

stem cell differentiation

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of miRNA-mediated gene silencing

pre-miRNA binding

RNA 3' uridylation

cellular response to glucose stimulus

protein-RNA adaptor activity

positive regulation of cell proliferation involved in kidney development

polysome binding

sequence-specific mRNA binding

negative regulation of pre-miRNA processing

positive regulation of cytoplasmic translation

 
1455940_x_at Wdr6 WD repeat domain 6 9 -108572310 BB453609 22

tRNA binding

wobble position ribose methylation

cytoplasm

cytoplasm

cytosol

plasma membrane

cell cycle

tRNA processing

COP9 signalosome

negative regulation of cell population proliferation

negative regulation of autophagy

enzyme regulator activity

tRNA methylation

protein-containing complex

insulin receptor substrate binding

G1 to G0 transition

 
1424711_at Cemip2 cell migration inducing hyaluronidase 2 19 21778339 BC019745 37

angiogenesis

hyalurononglucosaminidase activity

calcium ion binding

nucleolus

cytosol

plasma membrane

multicellular organism development

metabolic process

membrane

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hyaluronan catabolic process

carbohydrate binding

intracellular membrane-bounded organelle

 
1419226_at Cd96 CD96 antigen 16 -46035656 NM_032465 21

natural killer cell cytokine production

cytokine production involved in inflammatory response

negative regulation of natural killer cell cytokine production

protein binding

cytoplasm

inflammatory response

cell adhesion

cell-matrix adhesion

cell-matrix adhesion

membrane

response to lipopolysaccharide

negative regulation of type II interferon production

 
1456426_at Clec2i C-type lectin domain family 2, member i 6 128887586, 128887589 BE686253 22

membrane raft assembly

transmembrane signaling receptor activity

protein binding

endoplasmic reticulum

plasma membrane

external side of plasma membrane

external side of plasma membrane

cell surface

cell surface

membrane

carbohydrate binding

regulation of actin filament polymerization

regulation of interleukin-2 production

regulation of T cell proliferation

receptor clustering

negative regulation of osteoclast differentiation

natural killer cell lectin-like receptor binding

natural killer cell lectin-like receptor binding

natural killer cell lectin-like receptor binding

T cell receptor signaling pathway

positive regulation of immunological synapse formation

 
1455778_at Zkscan8 zinc finger with KRAB and SCAN domains 8 13 -21526419, -21513220 AW208912 22

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA-binding transcription factor activity, RNA polymerase II-specific

regulation of transcription by RNA polymerase II

 
1426536_at Ice2 interactor of little elongation complex ELL subunit 2 9 69397997 BE952805 18

euchromatin

nucleus

nucleoplasm

cytosol

transcription elongation factor complex

Cajal body

nuclear body

histone locus body

snRNA transcription by RNA polymerase II

snRNA transcription by RNA polymerase II

snRNA transcription by RNA polymerase III

snRNA transcription by RNA polymerase III

positive regulation of transcription by RNA polymerase III

positive regulation of transcription by RNA polymerase III

 
1425295_at Rnase2a ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin) 14 -51255261 BC020070 12

innate immune response in mucosa

RNA nuclease activity

RNA nuclease activity

RNA nuclease activity

extracellular space

extracellular space

chemotaxis

defense response to Gram-positive bacterium

 
1418640_at Sirt1 sirtuin 1 10 -63319004 NM_019812 1263

single strand break repair

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

rDNA heterochromatin formation

pyrimidine dimer repair by nucleotide-excision repair

pyrimidine dimer repair by nucleotide-excision repair

DNA synthesis involved in DNA repair

chromatin

chromatin

euchromatin

heterochromatin

heterochromatin

RNA polymerase II cis-regulatory region sequence-specific DNA binding

angiogenesis

angiogenesis

ovulation from ovarian follicle

fibrillar center

intracellular glucose homeostasis

positive regulation of protein phosphorylation

positive regulation of endothelial cell proliferation

p53 binding

p53 binding

p53 binding

positive regulation of adaptive immune response

transcription coactivator activity

transcription corepressor activity

transcription corepressor activity

transcription corepressor activity

histone deacetylase activity

protein binding

nucleus

nucleus

nucleus

nuclear envelope

nuclear inner membrane

nuclear inner membrane

nucleoplasm

nucleoplasm

nucleoplasm

chromatin silencing complex

cytoplasm

mitochondrion

mitochondrion

cytosol

chromatin organization

chromatin remodeling

protein deacetylation

protein deacetylation

protein deacetylation

triglyceride mobilization

apoptotic process

DNA damage response

response to oxidative stress

transforming growth factor beta receptor signaling pathway

multicellular organism development

spermatogenesis

regulation of mitotic cell cycle

muscle organ development

circadian rhythm

positive regulation of cell population proliferation

intrinsic apoptotic signaling pathway in response to DNA damage

cellular response to starvation

positive regulation of heart rate

negative regulation of gene expression

cardiac muscle cell apoptotic process

negative regulation of cardiac muscle cell apoptotic process

regulation of centrosome duplication

negative regulation of triglyceride biosynthetic process

positive regulation of cholesterol efflux

regulation of lipid storage

regulation of glucose metabolic process

positive regulation of neuron projection development

positive regulation of skeletal muscle cell proliferation

positive regulation of macroautophagy

positive regulation of macroautophagy

protein ubiquitination

PML body

transferase activity

nuclear receptor binding

NAD-dependent histone deacetylase activity

NAD-dependent histone deacetylase activity

NAD-dependent histone deacetylase activity

peptidyl-lysine acetylation

deacetylase activity

deacetylase activity

enzyme binding

enzyme binding

protein domain specific binding

cell differentiation

macrophage differentiation

axon

growth cone

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of prostaglandin biosynthetic process

heterochromatin formation

heterochromatin formation

protein destabilization

negative regulation of TOR signaling

negative regulation of TOR signaling

NAD-dependent histone H3K14 deacetylase activity

regulation of endodeoxyribonuclease activity

negative regulation of NF-kappaB transcription factor activity

negative regulation of tumor necrosis factor production

response to insulin

circadian regulation of gene expression

circadian regulation of gene expression

protein-containing complex

leptin-mediated signaling pathway

rDNA heterochromatin

rDNA heterochromatin

protein lysine deacetylase activity

protein lysine deacetylase activity

protein lysine deacetylase activity

regulation of smooth muscle cell apoptotic process

NAD-dependent protein deacetylase activity

NAD-dependent protein deacetylase activity

NAD-dependent protein deacetylase activity

ESC/E(Z) complex

intracellular triglyceride homeostasis

regulation of peroxisome proliferator activated receptor signaling pathway

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cell population proliferation

cellular response to glucose starvation

vasodilation

negative regulation of phosphorylation

negative regulation of phosphorylation

histone binding

response to hydrogen peroxide

behavioral response to starvation

cholesterol homeostasis

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

identical protein binding

regulation of apoptotic process

positive regulation of apoptotic process

positive regulation of apoptotic process

negative regulation of apoptotic process

negative regulation of canonical NF-kappaB signal transduction

proteasome-mediated ubiquitin-dependent protein catabolic process

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

HLH domain binding

protein kinase B binding

bHLH transcription factor binding

negative regulation of DNA-binding transcription factor activity

negative regulation of DNA-binding transcription factor activity

negative regulation of DNA damage response, signal transduction by p53 class mediator

negative regulation of neuron apoptotic process

negative regulation of neuron apoptotic process

positive regulation of blood vessel endothelial cell migration

response to leptin

positive regulation of MHC class II biosynthetic process

response to ethanol

negative regulation of fat cell differentiation

positive regulation of gluconeogenesis

positive regulation of gluconeogenesis

positive regulation of DNA repair

positive regulation of angiogenesis

negative regulation of cell cycle

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

negative regulation of DNA-templated transcription

positive regulation of transcription by RNA polymerase II

positive regulation of transcription by RNA polymerase II

regulation of transcription by glucose

positive regulation of insulin receptor signaling pathway

metal ion binding

NAD-dependent histone H3K9 deacetylase activity

NAD-dependent histone H3K9 deacetylase activity

NAD-dependent histone H4K16 deacetylase activity

rhythmic process

white fat cell differentiation

mitogen-activated protein kinase binding

negative regulation of helicase activity

positive regulation of smooth muscle cell differentiation

neuron apoptotic process

maintenance of nucleus location

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

fatty acid homeostasis

negative regulation of growth hormone secretion

negative regulation of androgen receptor signaling pathway

positive regulation of macrophage cytokine production

positive regulation of cell growth involved in cardiac muscle cell development

eNoSc complex

cellular response to hydrogen peroxide

NAD+ binding

NAD+ binding

lysine-acetylated histone binding

regulation of bile acid biosynthetic process

UV-damage excision repair

cellular response to tumor necrosis factor

cellular response to hypoxia

cellular response to ionizing radiation

regulation of protein serine/threonine kinase activity

positive regulation of protein deacetylation

regulation of brown fat cell differentiation

stress-induced premature senescence

energy homeostasis

protein depropionylation

protein-propionyllysine depropionylase activity

DNA-binding transcription factor binding

DNA repair-dependent chromatin remodeling

histone H4K12 deacetylase activity

histone H3K deacetylase activity

NAD-dependent histone decrotonylase activity

negative regulation of protein localization to nucleus

negative regulation of protein acetylation

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of attachment of mitotic spindle microtubules to kinetochore

negative regulation of reactive oxygen species biosynthetic process

positive regulation of adipose tissue development

cellular response to resveratrol

cellular response to amyloid-beta

keratin filament binding

cellular response to leukemia inhibitory factor

promoter-specific chromatin binding

positive regulation of macrophage apoptotic process

negative regulation of fibroblast apoptotic process

negative regulation of cAMP-dependent protein kinase activity

positive regulation of cAMP-dependent protein kinase activity

positive regulation of cAMP-dependent protein kinase activity

positive regulation of thyroid-stimulating hormone secretion

negative regulation of cellular response to testosterone stimulus

negative regulation of peptidyl-lysine acetylation

negative regulation of cellular senescence

positive regulation of cellular senescence

positive regulation of double-strand break repair

 
1448709_at Arid1a AT-rich interaction domain 1A 4 -133679007, -133679007 NM_033566 160

negative regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

chromatin

chromatin

chromatin

formation of primary germ layer

neural tube closure

cardiac chamber development

optic cup formation involved in camera-type eye development

DNA binding

protein binding

nucleus

nucleoplasm

nucleoplasm

chromatin organization

nucleosome disassembly

chromatin remodeling

chromatin remodeling

chromatin remodeling

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

gastrulation

nervous system development

embryo implantation

SWI/SNF complex

SWI/SNF complex

SWI/SNF complex

SWI/SNF complex

nuclear receptor binding

stem cell population maintenance

regulation of mitotic metaphase/anaphase transition

intracellular estrogen receptor signaling pathway

androgen receptor signaling pathway

forebrain development

nucleosome binding

nucleosome binding

brahma complex

glucocorticoid receptor signaling pathway

positive regulation of T cell differentiation

positive regulation of cell differentiation

positive regulation of myoblast differentiation

positive regulation of DNA-templated transcription

positive regulation of DNA-templated transcription

cardiac muscle cell differentiation

placenta blood vessel development

regulation of G0 to G1 transition

SWI/SNF superfamily-type complex

npBAF complex

npBAF complex

nBAF complex

nBAF complex

nBAF complex

bBAF complex

ATP-dependent chromatin remodeler activity

positive regulation of stem cell population maintenance

regulation of G1/S transition of mitotic cell cycle

positive regulation of double-strand break repair

regulation of nucleotide-excision repair

 
1421968_a_at Nipa2 non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human) 7 -55931265 NM_023647 21

protein binding

endosome

early endosome

plasma membrane

plasma membrane

monoatomic ion transport

magnesium ion transmembrane transporter activity

magnesium ion transport

magnesium ion transport

magnesium ion transport

membrane

membrane

 
1419006_s_at Peli2 pellino 2 14 48120868 NM_033602 25

protein polyubiquitination

protein polyubiquitination

positive regulation of protein phosphorylation

protein binding

cytosol

regulation of Toll signaling pathway

membrane

transferase activity

protein-macromolecule adaptor activity

positive regulation of MAPK cascade

ubiquitin protein ligase activity

ubiquitin protein ligase activity

 
1427322_at Brwd1 bromodomain and WD repeat domain containing 1 16 -96066667, -95992091, -96001547 BQ031260 39

protein binding

nucleus

nucleus

nucleus

nucleoplasm

nucleolus

cytoplasm

cytosol

axoneme

regulation of transcription by RNA polymerase II

regulation of transcription by RNA polymerase II

cytoskeleton organization

cytoskeleton organization

regulation of cell shape

regulation of cell shape

motile cilium

 
1439352_at Trim7 tripartite motif-containing 7 11 48826137, 48837470 BB825733 24

nucleus

nucleus

cytoplasm

cytoplasm

cytoplasm

Golgi apparatus

zinc ion binding

protein ubiquitination

transferase activity

metal ion binding

defense response to virus

ubiquitin protein ligase activity

ubiquitin protein ligase activity

antiviral innate immune response

 
1455189_at Trim33 tripartite motif-containing 33 3 103279292 BB400432 68

DNA binding

protein binding

nucleus

nucleus

nucleoplasm

zinc ion binding

gene expression

protein ubiquitination

transferase activity

regulation of transforming growth factor beta receptor signaling pathway

negative regulation of BMP signaling pathway

metal ion binding

ubiquitin protein ligase activity

co-SMAD binding

R-SMAD binding

promoter-specific chromatin binding

 
1417665_a_at Cpsf1 cleavage and polyadenylation specific factor 1 15 -76595807 NM_053193 27

nucleic acid binding

RNA binding

nucleus

nucleus

nucleoplasm

mRNA cleavage and polyadenylation specificity factor complex

mRNA cleavage and polyadenylation specificity factor complex

mRNA polyadenylation

mRNA processing

enzyme binding

mRNA 3'-UTR AU-rich region binding

03015

1435768_at Arid4b AT-rich interaction domain 4B 13 14063783 AV371758 41

negative regulation of transcription by RNA polymerase II

transcription cis-regulatory region binding

DNA binding

protein binding

nucleus

nucleus

nucleoplasm

mitochondrion

cytosol

DNA methylation

chromatin organization

regulation of transcription by RNA polymerase II

transcription by RNA polymerase II

spermatogenesis

negative regulation of cell migration

negative regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transcription by RNA polymerase II

genomic imprinting

establishment of Sertoli cell barrier

negative regulation of stem cell population maintenance

positive regulation of stem cell population maintenance

 
1459900_at C79468 expressed sequence C79468 6   BQ086025 1    
1433475_a_at Fam8a1 family with sequence similarity 8, member A1 13 46669476 BG075168 15

Hrd1p ubiquitin ligase complex

molecular_function

biological_process

 
1416234_at Lrrc59 leucine rich repeat containing 59 11 94629776 AW476171 24

nucleus

endoplasmic reticulum

membrane

mitochondrial nucleoid

intracellular membrane-bounded organelle

 
1418998_at Kmo kynurenine 3-monooxygenase 1 175632192 NM_133809 39

monooxygenase activity

kynurenine 3-monooxygenase activity

kynurenine 3-monooxygenase activity

kynurenine 3-monooxygenase activity

extracellular space

mitochondrion

mitochondrial outer membrane

mitochondrial outer membrane

mitochondrial inner membrane

tryptophan catabolic process

response to salt stress

positive regulation of glutamate secretion

membrane

NAD(P)H oxidase H2O2-forming activity

oxidoreductase activity

pyridine nucleotide biosynthetic process

NAD metabolic process

quinolinate biosynthetic process

kynurenic acid biosynthetic process

flavin adenine dinucleotide binding

kynurenine metabolic process

kynurenine metabolic process

kynurenine metabolic process

FAD binding

L-kynurenine metabolic process

positive regulation of glutamate secretion, neurotransmission

00380

01100

1430165_at Stk17b serine/threonine kinase 17b (apoptosis-inducing) 1 -53755511 AI661948 36

nucleotide binding

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine kinase activity

ATP binding

nucleus

nucleus

nucleoplasm

plasma membrane

protein phosphorylation

apoptotic process

programmed cell death

actin cytoskeleton

membrane

kinase activity

phosphorylation

transferase activity

intracellular signal transduction

intracellular signal transduction

positive regulation of apoptotic process

Flemming body

positive regulation of fibroblast apoptotic process

 
1427208_at Zfp451 zinc finger protein 451 1 -33761540, -33801959, -33761544 BC024435 31

DNA-binding transcription factor activity, RNA polymerase II-specific

DNA binding

transcription corepressor activity

transcription corepressor activity

nucleus

nucleus

PML body

transferase activity

protein sumoylation

protein sumoylation

negative regulation of transforming growth factor beta receptor signaling pathway

sequence-specific DNA binding

metal ion binding

negative regulation of transcription initiation by RNA polymerase II

negative regulation of transcription initiation by RNA polymerase II

SUMO ligase activity

SUMO ligase activity

transcription regulator inhibitor activity

 
1436999_at Pid1 phosphotyrosine interaction domain containing 1 1 -84036292 AI504908 33

negative regulation of protein phosphorylation

protein binding

cytoplasm

cytoplasm

cytoplasm

mitochondrion organization

positive regulation of gene expression

regulation of cell population proliferation

cellular response to leptin stimulus

positive regulation of transcription by RNA polymerase II

negative regulation of glucose import

negative regulation of glucose import

negative regulation of glucose import

negative regulation of insulin receptor signaling pathway

regulation of mitochondrial membrane potential

positive regulation of fat cell proliferation

cellular response to cytokine stimulus

cellular response to interleukin-6

cellular response to tumor necrosis factor

cellular response to fatty acid

negative regulation of protein localization to plasma membrane

regulation of reactive oxygen species metabolic process

regulation of reactive oxygen species metabolic process

positive regulation of reactive oxygen species metabolic process

negative regulation of ATP biosynthetic process

positive regulation of ATP biosynthetic process

 
1419907_s_at Fcrla Fc receptor-like A 1 -170917593 BB219290 26

transmembrane signaling receptor activity

protein binding

cytoplasm

immune response

cell surface receptor signaling pathway

external side of plasma membrane

cell differentiation

 
1426894_s_at Eeig1 estrogen-induced osteoclastogenesis regulator 1 2 32535358 BC023470 19

molecular_function

protein binding

cellular_component

nucleus

cytoplasm

biological_process

membrane

membrane raft

positive regulation of osteoclast differentiation

 
1433878_at Mrps26 mitochondrial ribosomal protein S26 2 130563756 AI648866 22

nucleoplasm

mitochondrion

mitochondrion

mitochondrial inner membrane

mitochondrial small ribosomal subunit

mitochondrial small ribosomal subunit

ribosome

mitochondrial translation

ribonucleoprotein complex

 
1449628_s_at Stard7 StAR related lipid transfer domain containing 7 2 127270228, 127270228, 127270228 AI852671 27

myeloid dendritic cell activation

cytoplasm

mitochondrion

inflammatory response

lipid binding

T-helper 2 cell cytokine production

type 2 immune response

establishment of skin barrier

mucociliary clearance

 
1427946_s_at Dpyd dihydropyrimidine dehydrogenase 3 118562179 BC028831 23

nucleotide binding

uracil binding

uracil binding

iron ion binding

cytoplasm

cytosol

cytosol

cytosol

purine nucleobase catabolic process

pyrimidine nucleobase catabolic process

pyrimidine nucleobase catabolic process

thymine catabolic process

thymine catabolic process

uracil catabolic process

uracil catabolic process

thymidine catabolic process

CMP catabolic process

dCMP catabolic process

response to nutrient

circadian rhythm

response to xenobiotic stimulus

response to organic cyclic compound

oxidoreductase activity

oxidoreductase activity, acting on the CH-CH group of donors

dihydropyrimidine dehydrogenase (NADP+) activity

dihydropyrimidine dehydrogenase (NADP+) activity

dihydropyrimidine dehydrogenase (NADP+) activity

uracil metabolic process

identical protein binding

protein homodimerization activity

UMP catabolic process

dTMP catabolic process

dUMP catabolic process

metal ion binding

NADP binding

NADP binding

iron-sulfur cluster binding

4 iron, 4 sulfur cluster binding

FAD binding

00240

00410

00770

00983

01100

1423555_a_at Ifi44 interferon-induced protein 44 3 -151730922 BB329808 19

molecular_function

cytoplasm

immune response

response to bacterium

 

1351 Genes